SEC Form SC 13D/A filed by Enzo Biochem Inc. (Amendment)

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

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SCHEDULE 13D/A

(Rule 13d-101)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO §240.13d-1(a)

AND AMENDMENTS THERETO FILED PURSUANT TO §240.13d-2(a)

(Amendment No. 2)

ENZO BIOCHEM, INC.

(Name of Issuer)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13(d)-1(f) or 240.13d-1(g), check the following box. o

(Continued on following pages)

EXPLANATORY NOTE

This Amendment No. 2 (the "Amendment") amends the statement on Schedule 13D originally filed by James G. Wolf on October 1, 2021. This amendment is being filed to report an increase of more than 1% in Mr. Wolf's beneficial ownership of the Common Stock of Enzo Biochem, Inc.

Item 1. Security and Issuer

The class of equity securities to which this Schedule 13D relates is the Common Stock, $0.01 par value, (the "Common Stock") of Enzo Biochem, Inc., a New York corporation (the "Company"). The principal executive offices of the Company are located at 527 Madison Avenue, New York, New York 10022.

Item 2. Identity and Background

Item 3. Source and Amount of Funds or Other Consideration.

The cash used to acquire the shares (a total of $11,949,899) was sourced from the personal funds of the Reporting Person and from the personal funds of certain persons with respect to whose shares the Reporting Person holds voting power and dispositive power.

Item 4. Purpose of Transaction.

The Reporting Person has no plan or proposal which relates to or would result in any of the actions or transactions described in paragraphs (a) through (j) of the instructions to Item 4 of Schedule 13D, except that the Reporting Person may nominate himself for election as a director of the Company at the next annual meeting of shareholders if he is not nominated by the Board of Directors.

Item 5. Interest in Securities of the Issuer.

(a) The information regarding share ownership by the Reporting Person provided on his cover page is incorporated here by reference.

(b) The information regarding share ownership by the Reporting Person provided on his cover page is incorporated here by reference.

(c) During the period since the Reporting Person filed Amendment No. 1 to Schedule 13D, the Reporting Person purchased a total of shares of the Company's common stock on the public market for an aggregate cash amount of $1,695,600.

(d) The right to receive dividends and to receive the proceeds of the sale of the securities is held, as to 400,000 of the shares, by persons other than the Reporting Person.

(e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships

There are no contracts, arrangements, understandings or relationships (legal or otherwise) between the Reporting Person named in Item 2 hereof and any person with respect to any securities of the Company, including but not limited to transfer or voting of any other securities, finder's fees, joint ventures, loan or option arrangements, puts or calls, guarantees of profits, divisions of profits or loss, or the giving or withholding of proxies.

Item 7. Material to be Filed as Exhibits.

None.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.