SEC Form SC 13D/A filed by Imago BioSciences Inc. (Amendment)

The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

  Name of Reporting Persons.

  Frazier Healthcare VII, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  WC

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  2,312,331 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  2,312,331 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  2,312,331 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  6.8% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P. FHM VII, L.P. is the general partner of Frazier Healthcare VII, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Frazier Healthcare VII-A, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  WC

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  658,943 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  658,943 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  658,943 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  1.9% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII-A, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHM VII, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  2,971,274 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  2,971,274 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  2,971,274 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  8.8% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHM VII, L.L.C.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  2,971,274 shares (1)

  Sole Dispositive Power

  0

  Shared Dispositive Power

  2,971,274 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  2,971,274 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  8.8% (2)

  Type of Reporting Person (See Instructions)

  OO

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Frazier Life Sciences Public Fund, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  WC

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  376,098 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  376,098 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  376,098 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  1.1% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 376,098 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHMLSP, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  376,098 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  376,098 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  376,098 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  1.1% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 376,098 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHMLSP, L.L.C.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  376,098 shares (1)

  Sole Dispositive Power

  0

  Shared Dispositive Power

  376,098 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  376,098 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  1.1% (2)

  Type of Reporting Person (See Instructions)

  OO

Consists of 376,098 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Frazier Life Sciences Public Overage Fund, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  WC

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  376,097 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  376,097 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  376,097 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  1.1% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 376,097 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHMLSP Overage, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  376,097 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  376,097 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  376,097 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  1.1% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 376,097 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHMLSP Overage, L.L.C.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  376,097 shares (1)

  Sole Dispositive Power

  0

  Shared Dispositive Power

  376,097 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  376,097 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  1.1% (2)

  Type of Reporting Person (See Instructions)

  OO

Consists of 376,097 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Frazier Life Sciences XI, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  WC

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  178,738 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  178,738 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  178,738 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  0.5% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 178,738 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHMLS XI, L.P.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  178,738 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  178,738 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  178,738 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  0.5% (2)

  Type of Reporting Person (See Instructions)

  PN

Consists of 178,738 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  FHMLS XI, L.L.C.

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  178,738 shares (1)

  Sole Dispositive Power

  0

  Shared Dispositive Power

  178,738 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  178,738 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  0.5% (2)

  Type of Reporting Person (See Instructions)

  OO

Consists of 178,738 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  James N. Topper

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  3,902,207 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  3,902,207 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  3,902,207 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  11.5% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P., (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P., (iii) 376,098 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., (iv) 376,097 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHM VII, L.P. and (v) 178,738 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of both FHMLSP, L.L.C. and FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. and Frazier Life Sciences Public Overage Fund, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Patrick J. Heron

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  3,902,207 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  3,902,207 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  3,902,207 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  11.5% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P., (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P., (iii) 376,098 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., (iv) 376,097 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHM VII, L.P. and (v) 178,738 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of both FHMLSP, L.L.C. and FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. and Frazier Life Sciences Public Overage Fund, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Alan Frazier

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  2,971,274 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  2,971,274 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  2,971,274 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  8.8% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Nader Naini

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  2,971,274 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  2,971,274 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  2,971,274 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  8.8% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Brian Morfitt

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  2,971,274 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  2,971,274 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  2,971,274 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  8.8% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Nathan Every

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  2,971,274 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  2,971,274 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  2,971,274 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  8.8% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 2,312,331 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 658,943 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P., and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Alan Frazier, Nader Naini, Patrick J. Heron, James N. Topper, Nathan Every, and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Albert Cha

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  752,195 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  752,195 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  752,195 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  2.2% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 376,098 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. and (ii) 376,097 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of both FHMLSP, L.L.C. and FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. and Frazier Life Sciences Public Overage Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  James Brush

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  752,195 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  752,195 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  752,195 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  2.2% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of (i) 376,098 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. and (ii) 376,097 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of both FHMLSP, L.L.C. and FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. and Frazier Life Sciences Public Overage Fund, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

  Name of Reporting Persons.

  Daniel Estes

  Check the Appropriate Box if a Member of a Group (See Instructions)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  Source of Funds (See Instructions)

  AF

  Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

  ☐

  Citizenship or Place of Organization

  United States Citizen

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With:

  Sole Voting Power

  0 shares

  Shared Voting Power

  178,738 shares (1)

  Sole Dispositive Power

  0 shares

  Shared Dispositive Power

  178,738 shares (1)

  Aggregate Amount Beneficially Owned by Each Reporting Person

  178,738 shares (1)

  Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

  ☐

  Percent of Class Represented by Amount in Row (11)

  0.5% (2)

  Type of Reporting Person (See Instructions)

  IN

Consists of 178,738 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.

Based on 33,822,201 shares of Common Stock outstanding on November 2, 2022 as set forth in the Issuer’s Quarterly Report on Form 10-Q as filed with the SEC on November 9, 2022.

Name:

Residence or Business Address:

Present principal occupation or employment and the name, principal business and address of any corporation or other organization in which such employment is conducted:

Whether or not, during the last five years, such person has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors) and, if so, give the dates, nature of conviction, name and location of court, and penalty imposed, or other disposition of the case:

Whether or not, during the last five years, such person was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws; and, if so, identify and describe such proceedings and summarize the terms of such judgment, decree or final order:

Citizenship:

Entities:

Individuals:

The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer;

An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries;

A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries;

Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board;

Any material change in the present capitalization or dividend policy of the Issuer;

Any other material change in the Issuer’s business or corporate structure;

Changes in the Issuer’s charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person;

Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association;

A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934, as amended; or

Any action similar to any of those enumerated above.

State the aggregate number and percentage of the class of securities identified pursuant to Item 1 (which may be based on the number of securities outstanding as contained in the most recently available filing with the Commission by the issuer unless the filing person has reason to believe such information is not current) beneficially owned (identifying those shares which there is a right to acquire) by each person named in Item 2. The information should also be furnished with respect to persons who, together with any of the persons named in Item 2, comprise a group within the meaning of Section 13(d)(3) of the Act:

For each person named in response to paragraph (a), indicate the number of shares as to which there is sole power to vote or to direct the vote, shared power to vote or to direct the vote, sole power to dispose or to direct the disposition, or shared power to dispose or to direct the disposition. Provide the applicable information required by Item 2 with respect to each person with whom the power to vote or to direct the vote or to dispose or direct the disposition is shared:

Sole power to vote or to direct the vote: See line 7 of cover sheets.

Shared power to vote or to direct the vote: See line 8 of cover sheets.

Sole power to dispose or to direct the disposition: See line 9 of cover sheets.

Shared power to dispose or to direct the disposition: See line 10 of cover sheets.

Describe any transactions in the class of securities reported on that were effected during the past sixty days or since the most recent filing of Schedule 13D (§240.13d-191), whichever is less, by the persons named in response to paragraph (a):

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)*

Represents the weighted average price per share.

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of
Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)*

Represents the weighted average price per share.

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)*

Represents the weighted average price per share.

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

Date of

Transaction

Type of

Transaction

Quantity

Class of Stock

Price Per Share

(excluding

commissions)

If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than five percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of an employee benefit plan, pension fund or endowment fund is not required:

If applicable, state the date on which the reporting person ceased to be the beneficial owner of more than five percent of the class of securities:

Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

Material to Be Filed as Exhibits

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

FHMLSP, L.P.

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

/s/ Steve R. Bailey

*

*

*

*

*

*

**

**

***

/s/ Steve R. Bailey

This Schedule 13D was executed by Steve R. Bailey on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which was filed with the SEC on March 29, 2016.

This Schedule 13D was executed by Steve R. Bailey on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which was filed with the SEC on August 16, 2021.

This Schedule 13D was executed by Steve R. Bailey on behalf of the individual listed above pursuant to a Power of Attorney, a copy of which was filed with the SEC on April 18, 2022.