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    SEC Form SC 13D/A filed by Janux Therapeutics Inc. (Amendment)

    6/5/24 7:28:46 PM ET
    $JANX
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $JANX alert in real time by email
    SC 13D/A 1 tm2416571d1_sc13da.htm SC 13D/A

     

     

    SECURITIES AND EXCHANGE COMMISSION

    WASHINGTON, DC 20549

     

    SCHEDULE 13D

     

    Under the Securities Exchange Act of 1934

    (Amendment No. 3)*

     

    Janux Therapeutics, Inc.

    (Name of Issuer)

     

    Common Stock, par value $0.001

    (Title of Class of Securities)

     

    47103J 105

    (CUSIP Number)

     

    Jay Lichter, Ph.D.

    Avalon Ventures

    1134 Kline Street

    La Jolla, California 92037

    (858) 348-2180

    (Name, Address and Telephone Number of Person
    Authorized to Receive Notices and Communications)

     

    June 3, 2024

    (Date of Event Which Requires Filing of this Statement)

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

     

    * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Avalon Ventures XI, L.P.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    WC

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    3,271,216 shares (2)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    3,271,216 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,271,216 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    6.3% (3)

    14.

    Type of Reporting Person (See Instructions)

    PN

           

    (1)This Schedule 13D is filed by Avalon Ventures XI, L.P. (“Avalon Ventures”), Avalon BioVentures SPV I, L.P. (“ABV SPV”), Avalon BioVentures I, LP (“ABV I”), Avalon Ventures XI GP LLC (“Avalon XI GP”), ABV SPV I GP LLC (“ABV SPV GP”), Avalon BioVentures GP, LLC (“ABV GP”), Kevin Kinsella (“Kinsella”), Richard Levandov (“Levandov”), Braden Bohrmann (“Bohrmann”), Jay Lichter, Ph.D (“Lichter”), Tighe Reardon (“Reardon”), Sergio G. Duron, Ph.D. (“Duron”) and Sanford J. Madigan, Ph.D. (“Madigan” and, with Avalon Ventures, ABV SPV, ABV I, Avalon XI GP, ABV SPV GP, ABV GP, Kinsella, Levandov, Bohrmann, Lichter, Reardon and Duron, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Shares are held by Avalon Ventures. Avalon XI GP is the general partner of Avalon Ventures and may be deemed to have voting and investment power with respect to the shares held by Avalon Ventures. Kinsella, Levandov, Bohrmann and Lichter are the managing members of Avalon XI GP and share voting and investment power with respect to the shares held by Avalon Ventures.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the “SEC”) on May 8, 2024.

     

    2

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Avalon BioVentures SPV I, L.P.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    WC

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    3,340,018 shares (2)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    3,340,018 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,340,018 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    6.4% (3)

    14.

    Type of Reporting Person (See Instructions)

    PN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Shares are held by ABV SPV. ABV SPV GP is the general partner of ABV SPV and may be deemed to have voting and investment power with respect to the shares held by ABV SPV. Lichter and Reardon are the managing members of ABV SPV GP and share voting and investment power with respect to the shares held by ABV SPV.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    3

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Avalon BioVentures I, LP

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    WC

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    633,673 shares (2)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    633,673 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    633,673 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    1.2% (3)

    14.

    Type of Reporting Person (See Instructions)

    PN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Shares are held by ABV I. ABV GP is the general partner of ABV I and may be deemed to have voting and investment power with respect to the shares held by ABV I. Lichter, Reardon, Duron and Madigan are the managing members of ABV GP and share voting and investment power with respect to the shares held by ABV I.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    4

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Avalon Ventures XI GP LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    3,271,216 shares (2)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    3,271,216 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,271,216 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    6.3% (3)

    14.

    Type of Reporting Person (See Instructions)

    OO

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Shares are held by Avalon Ventures. Avalon XI GP is the general partner of Avalon Ventures and may be deemed to have voting and investment power with respect to the shares held by Avalon Ventures. Kinsella, Levandov, Bohrmann and Lichter are the managing members of Avalon XI GP and share voting and investment power with respect to the shares held by Avalon Ventures.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    5

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    ABV SPV I GP LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    3,340,018 shares (2)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    3,340,018 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,340,018 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    6.4% (3)

    14.

    Type of Reporting Person (See Instructions)

    OO

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Shares are held by ABV SPV. ABV SPV GP is the general partner of ABV SPV and may be deemed to have voting and investment power with respect to the shares held by ABV SPV. Lichter and Reardon are the managing members of ABV SPV GP and share voting and investment power with respect to the shares held by ABV SPV.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    6

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Avalon BioVentures GP, LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    633,673 shares (2)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    633,673 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    633,673 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    1.2% (3)

    14.

    Type of Reporting Person (See Instructions)

    OO

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Shares are held by ABV I. ABV GP is the general partner of ABV I and may be deemed to have voting and investment power with respect to the shares held by ABV I. Lichter, Reardon, Duron and Madigan are the managing members of ABV GP and share voting and investment power with respect to the shares held by ABV I.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    7

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Kevin Kinsella

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    6,966 shares

    8.

    Shared Voting Power

    3,271,216 shares (2)

    9.

    Sole Dispositive Power

    6,966 shares

    10.

    Shared Dispositive Power

    3,271,216 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,278,182 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    6.3% (3)

    14.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 3,271,216 shares of Common Stock held by Avalon Ventures. Avalon XI GP is the general partner of Avalon Ventures and may be deemed to have voting and investment power with respect to the shares held by Avalon Ventures. Kinsella, Levandov, Bohrmann and Lichter are the managing members of Avalon XI GP and share voting and investment power with respect to the shares held by Avalon Ventures.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    8

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Richard Levandov

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    5,651 shares

    8.

    Shared Voting Power

    3,271,216 shares (2)

    9.

    Sole Dispositive Power

    5,651 shares

    10.

    Shared Dispositive Power

    3,271,216 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,276,867 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    6.3% (3)

    14.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 3,271,216 shares of Common Stock held by Avalon Ventures. Avalon XI GP is the general partner of Avalon Ventures and may be deemed to have voting and investment power with respect to the shares held by Avalon Ventures. Kinsella, Levandov, Bohrmann and Lichter are the managing members of Avalon XI GP and share voting and investment power with respect to the shares held by Avalon Ventures.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    9

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Braden Bohrmann

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    3,754 shares

    8.

    Shared Voting Power

    3,271,216 shares (2)

    9.

    Sole Dispositive Power

    3,754 shares

    10.

    Shared Dispositive Power

    3,271,216 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,274,970 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    6.3% (3)

    14.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 3,271,216 shares of Common Stock held by Avalon Ventures. Avalon XI GP is the general partner of Avalon Ventures and may be deemed to have voting and investment power with respect to the shares held by Avalon Ventures. Kinsella, Levandov, Bohrmann and Lichter are the managing members of Avalon XI GP and share voting and investment power with respect to the shares held by Avalon Ventures.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    10

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Jay Lichter, Ph.D.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    59,583 shares (2)

    8.

    Shared Voting Power

    7,244,907 shares (3)

    9.

    Sole Dispositive Power

    59,583 shares (2)

    10.

    Shared Dispositive Power

    7,244,907 shares (3)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    7,304,490 shares (2) (3)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    14.1% (4)

    14.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 55,000 shares of Common Stock issuable within 60 days of the date of the filing of this Schedule 13D upon exercise of stock options held by Lichter.

     

    (3)Includes (i) 3,271,216 shares of Common Stock held by Avalon Ventures; (ii) 3,340,018 shares of Common Stock held by ABV SPV; and (iii) 633,673 shares of Common Stock held by ABV I. Avalon XI GP is the general partner of Avalon Ventures. Kinsella, Levandov, Bohrmann and Lichter are the managing members of Avalon XI GP and share voting and investment power with respect to the shares held by Avalon Ventures. ABV SPV GP is the general partner of ABV SPV. Lichter and Reardon are the managing members of ABV SPV GP and share voting and investment power with respect to the shares held by ABV SPV. ABV GP is the general partner of ABV I. Lichter, Reardon, Duron and Madigan are the managing members of ABV GP and share voting and investment power with respect to the shares held by ABV I.

     

    (4)This percentage is calculated based on the sum of (i) 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024; and (ii) 55,000 shares of Common Stock issuable within 60 days of the date of the filing of this Schedule 13D upon exercise of stock options.

     

    11

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Tighe Reardon

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    486,081 shares (2)

    8.

    Shared Voting Power

    3,973,691 shares (3)

    9.

    Sole Dispositive Power

    446,049 shares (2)

    10.

    Shared Dispositive Power

    3,973,691 shares (3)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    4,459,772 shares (2) (3)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    8.5% (4)

    14.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 271,060 shares of Common Stock issuable upon the exercise of stock options held by Reardon that are vested or will vest within 60 days of the date of the filing of this Schedule 13D. Also includes 40,032 shares of Common Stock issuable upon early exercise of stock options held by Reardon that will not vest within 60 days of the date of the filing of this Schedule 13D, for which he is considered to have voting, but not dispositive, power.

     

    (3)Includes (i) 3,340,018 shares of Common Stock held by ABV SPV and (ii) 633,673 shares of Common Stock held by ABV I. ABV SPV GP is the general partner of ABV SPV. Lichter and Reardon are the managing members of ABV SPV GP and share voting and investment power with respect to the shares held by ABV SPV. ABV GP is the general partner of ABV I. Lichter, Reardon, Duron and Madigan are the managing members of ABV GP and share voting and investment power with respect to the shares held by ABV I.

     

    (4)This percentage is calculated based on the sum of (i) 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024; and (ii) 271,060 shares of Common Stock issuable within 60 days of the date of the filing of this Schedule 13D upon exercise of stock options.

     

    12

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Sergio G. Duron, Ph.D.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    92,630 shares

    8.

    Shared Voting Power

    633,673 shares (2)

    9.

    Sole Dispositive Power

    92,630 shares

    10.

    Shared Dispositive Power

    633,673 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    726,303 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    1.4% (3)

    14.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 633,673 shares of Common Stock held by ABV I. ABV GP is the general partner of ABV I and may be deemed to have voting and investment power with respect to the shares held by ABV I. Lichter, Reardon, Duron and Madigan are the managing members of ABV GP and share voting and investment power with respect to the shares held by ABV I.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    13

     

    CUSIP No.   47103J 105
    1.

    Names of Reporting Persons

    Sanford Madigan, Ph.D.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨    (b) x (1)

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    107,810 shares

    8.

    Shared Voting Power

    633,673 shares (2)

    9.

    Sole Dispositive Power

    107,810 shares

    10.

    Shared Dispositive Power

    633,673 shares (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    741,483 shares (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    1.4% (3)

    14.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 633,673 shares of Common Stock held by ABV I. ABV GP is the general partner of ABV I and may be deemed to have voting and investment power with respect to the shares held by ABV I. Lichter, Reardon, Duron and Madigan are the managing members of ABV GP and share voting and investment power with respect to the shares held by ABV I.

     

    (3)This percentage is calculated based on 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024.

     

    14

     

    Explanatory Note: This Amendment No. 3 (“Amendment No. 3”), which amends the Schedule 13D filed with the Securities and Exchange Commission (the “SEC”) on June 25, 2021 and amended on November 16, 2023 and March 4, 2024 (the “Original Schedule 13D”) filed on behalf of Avalon Ventures XI, L.P. (“Avalon Ventures”), Avalon BioVentures SPV I, L.P. (“ABV SPV”), Avalon BioVentures I, LP (“ABV I”), Avalon Ventures XI GP LLC (“Avalon XI GP”), ABV SPV I GP LLC (“ABV SPV GP”), Avalon BioVentures GP, LLC (“ABV GP”), Kevin Kinsella (“Kinsella”), Richard Levandov (“Levandov”), Braden Bohrmann (“Bohrmann”), Jay Lichter, Ph.D (“Lichter”), Tighe Reardon (“Reardon”), Sergio G. Duron, Ph.D. (“Duron”) and Sanford J. Madigan, Ph.D. (“Madigan” and, with Avalon Ventures, ABV SPV, ABV I, Avalon XI GP, ABV SPV GP, ABV GP, Kinsella, Levandov, Bohrmann, Lichter, Reardon and Duron, collectively, the “Reporting Persons”) relates to the common stock, $0.001 par value per share (the “Common Stock”), of Janux Therapeutics, Inc., a Delaware corporation (the “Issuer”). Capitalized terms used but not defined herein have the meanings given to such terms in the Original Schedule 13D.

     

    Item 4.Purpose of Transaction

     

    Item 4 of the Original Schedule 13D is hereby amended and supplemented by adding the following paragraphs at the end of Item 4:

     

    On June 3, 2024, Avalon Ventures sold 677,279 shares of Common Stock, ABV SPV sold 691,525 shares of Common Stock and ABV I sold 131,196 shares of Common Stock, each in a series of block trades at prices ranging from $54.75 to $55.07 per share (a weighted-average price of $54.75 per share).

     

    Item 5.Interest in Securities of the Issuer

     

      (a)– (b).The following information with respect to the ownership of the Common Stock of the Issuer by the persons filing this statement on Schedule 13D is provided as of June 5, 2024:

     

    Reporting Persons  Shares
    Held
    Directly
       Sole
    Voting
    Power
       Shared
    Voting
    Power
       Sole
    Dispositive
    Power
       Shared
    Dispositive
    Power
       Beneficial
    Ownership
       Percentage
    of Class 
    (6)
     
    Avalon Ventures (1)   3,271,216         3,271,216         3,271,216    3,271,216    6.3%
    ABV SPV (2)   3,340,018         3,340,018         3,340,018    3,340,018    6.4%
    ABV I (3)   633,673         633,673         633,673    633,673    1.2%
    Avalon XI GP (1)             3,271,216         3,271,216    3,271,216    6.3%
    ABV SPV GP (2)             3,340,018         3,340,018    3,340,018    6.4%
    ABV GP (3)             633,673         633,673    633,673    1.2%
    Kinsella (1)   6,966    6,966    3,271,216    6,966    3,271,216    3,278,182    6.3%
    Levandov (1)   5,651    5,651    3,271,216    5,651    3,271,216    3,276,867    6.3%
    Bohrmann (1)   3,754    3,754    3,271,216    3,754    3,271,216    3,274,970    6.3%
    Lichter (1) (2) (3) (4)   59,583    59,583    7,244,907    59,583    7,244,907    7,304,490    14.1%
    Reardon (2) (3) (5)   486,081    486,081    3,973,691    446,049    3,973,691    4,459,772    8.5%
    Duron (3)   92,630    92,630    633,673    92,630    633,673    726,303    1.4%
    Madigan (3)   107,810    107,810    633,673    107,810    633,673    741,483    1.4%

     

    (1)Includes 3,271,216 shares of Common Stock held by Avalon Ventures. Avalon XI GP is the general partner of Avalon Ventures and may be deemed to have voting and investment power with respect to the shares held by Avalon Ventures. Kinsella, Levandov, Bohrmann and Lichter are the managing members of Avalon XI GP and share voting and investment power with respect to the shares held by Avalon Ventures.

     

    (2)Includes 3,340,018 shares of Common Stock held by ABV SPV. ABV SPV GP is the general partner of ABV SPV and may be deemed to have voting and investment power with respect to the shares held by ABV SPV. Lichter and Reardon are the managing members of ABV SPV GP and share voting and investment power with respect to the shares held by ABV SPV.

     

    15

     

    (3)Includes 633,673 shares of Common Stock held by ABV I. ABV GP is general partner of ABV I and may be deemed to have voting and investment power with respect to the shares held by ABV I. Lichter, Reardon, Duron and Madigan are the managing members of ABV GP and share voting and investment power with respect to the shares held by ABV I.

     

    (4)Includes 55,000 shares of Common Stock issuable within 60 days of the date of the filing of this Schedule 13D upon exercise of stock options held by Lichter.

     

    (5)Includes 271,060 shares of Common Stock issuable upon the exercise of stock options held by Reardon that are vested or will vest within 60 days of the date of the filing of this Schedule 13D . Also includes 40,032 shares of Common Stock issuable upon early exercise of stock options held by Reardon that will not vest within 60 days of the date of the filing of this Schedule 13D, for which he is considered to have voting, but not dispositive, power.

     

    (6)This percentage is calculated based on the sum of (i) 51,850,667 shares of common stock outstanding as of May 3, 2024, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on May 8, 2024; and (ii) shares of Common Stock issuable upon exercise of stock options, as applicable.

     

    (c)Except as set forth herein, none of the Reporting Persons has effected any transactions in shares of the Issuer’s Common Stock during the last 60 days.

     

    (d)No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by any of the Reporting Persons.

     

    (e)Not applicable.

     

    Item 7.Material to be Filed as Exhibits

     

    A.Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended.

     

    16

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: June 5, 2024

     

    AVALON VENTURES XI, L.P.   AVALON VENTURES XI GP LLC
         
    By: /s/ Tighe Reardon   By: /s/ Tighe Reardon
      Name: Tighe Reardon     Name: Tighe Reardon
      Title: Authorized Signer     Title: Authorized Signer
         
         
    AVALON  BIOVENTURES SPV I, L.P.   ABV SPV I GP LLC
         
    By: /s/ Tighe Reardon   By: /s/ Tighe Reardon
      Name: Tighe Reardon     Name: Tighe Reardon
      Title: Authorized Signer     Title: Authorized Signer
         
         
    AVALON BIOVENTURES I, LP   AVALON BIOVENTURES GP, LLC
         
    By: /s/ Tighe Reardon   By: /s/ Tighe Reardon
      Name: Tighe Reardon     Name: Tighe Reardon
      Title: Authorized Signer     Title: Authorized Signer
         
         
    /s/ Kevin Kinsella   /s/ Tighe Reardon
    Kevin Kinsella   Tighe Reardon
         
         
    /s/ Richard Levandov   /s/ Sergio Duron
    Richard Levandov   Sergio G. Duron, Ph.D.
         
         
    /s/ Braden Bohrmann   /s/ Sanford Madigan
    Braden Bohrmann   Sanford Madigan, Ph.D.
         
         
    /s/ Jay Lichter    
    Jay Lichter, Ph.D.    

     

      ATTENTION  
    Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).

     

    17

     

    Exhibit(s):

      

    AJoint Filing Agreement

     

    18

     

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