• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Dashboard
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlerts
    Company
    AboutQuantisnow PlusContactJobs
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form SC 13D/A filed by Karuna Therapeutics Inc. (Amendment)

    6/20/23 8:56:55 PM ET
    $KRTX
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $KRTX alert in real time by email
    SC 13D/A 1 tm2319284d2_sc13da.htm SC 13D/A

     

     

     

    SECURITIES AND EXCHANGE COMMISSION

     

    WASHINGTON, D.C. 20549

     

    SCHEDULE 13D

    (RULE 13d-101)

     

    INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a)

    AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a)

     

    (Amendment No. 2)*

     

    Karuna Therapeutics, Inc.

    (Name of Issuer)

     

    Common Stock, $0.0001 par value

    (Title of Class of Securities)
     

    48576A100

    (CUSIP Number)

     

    Nathalie Auber

    Sofinnova Investments, Inc.

    3000 Sand Hill Road, Bldg 4, Suite 250

    Menlo Park, CA 94025

    (650) 681-8420

    (Name, Address and Telephone Number of Person

    Authorized to Receive Notices and Communications)

     

    COPY TO:

    Jonathan Goodwin, Esq.

    c/o Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP

    550 Allerton Street, Redwood City, CA  94063

    (650) 321-2400

     

    June 14, 2023

    (Date of Event Which Requires Filing of This Statement)

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box  ¨

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 240.13d-7 for other parties to whom copies are to be sent.

     

    *The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    This information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

     

    CUSIP NO. 48576A100 13D Page 2 of 15

     

    1

    NAME OF REPORTING PERSON      

    I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

    Sofinnova Venture Partners X, L.P. (“SVP X”)

    2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)      ¨ (b)     x
    3 SEC USE ONLY
    4

    SOURCE OF FUNDS

    WC

    5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6 CITIZENSHIP OR PLACE OF ORGANIZATION    Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY EACH

    REPORTING

    PERSON

    WITH

    7 SOLE VOTING POWER
    1,372,441 shares, except that Sofinnova Management X, L.P. (“SM X LP”), the general partner of SVP X, may be deemed to have sole voting power, Sofinnova Management X-A, L.L.C. (“SM X LLC”), the general partner of SM X LP, may be deemed to have sole voting power, and Dr. James I. Healy (“Healy”) and Dr. Maha Katabi (“Katabi”), the managing members of SM X LLC, may be deemed to have shared power to vote these shares.
    8 SHARED VOTING POWER
    See response to row 7.
    9 SOLE DISPOSITIVE POWER
    1,372,441 shares, except that SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared dispositive power over these shares.
    10 SHARED DISPOSITIVE POWER
    See response to row 9.

    11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,372,441
    12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES ¨
    13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 3.7%
    14 TYPE OF REPORTING PERSON PN

     

     

     

     

    CUSIP NO. 48576A100 13D Page 3 of 15

     

    1

    NAME OF REPORTING PERSON      

    I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

    Sofinnova Management X, L.P. (“SM X LP”)

    2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)      ¨ (b)     x
    3 SEC USE ONLY
    4

    SOURCE OF FUNDS

    AF

    5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6 CITIZENSHIP OR PLACE OF ORGANIZATION    Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY EACH

    REPORTING

    PERSON

    WITH

    7 SOLE VOTING POWER 1,380,466 shares, of which 1,372,441 are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared power to vote these shares.
    8 SHARED VOTING POWER
    See response to row 7.
    9 SOLE DISPOSITIVE POWER
    1,380,466 shares, of which 1,372,441 are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared dispositive power over these shares.
    10 SHARED DISPOSITIVE POWER
    See response to row 9.

    11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,380,466
    12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES ¨
    13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 3.7%
    14 TYPE OF REPORTING PERSON PN

     

     

     

     

    CUSIP NO. 48576A100 13D Page 4 of 15

     

    1

    NAME OF REPORTING PERSON      

    I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

    Sofinnova Management X-A, L.L.C. (“SM X LLC”)

    2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)      ¨ (b)     x
    3 SEC USE ONLY
    4

    SOURCE OF FUNDS

    AF

    5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6 CITIZENSHIP OR PLACE OF ORGANIZATION    Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY EACH

    REPORTING

    PERSON

    WITH

    7 SOLE VOTING POWER 1,380,466 shares, of which 1,372,441 are owned directly by SVP X and 8,025 are owned directly by SM X LP. SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared power to vote these shares.
    8 SHARED VOTING POWER
    See response to row 7.
    9 SOLE DISPOSITIVE POWER
    1,380,466 shares, of which 1,372,441 are owned directly by SVP X and 8,025 are owned directly by SM X LP. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared dispositive power over these shares.
    10 SHARED DISPOSITIVE POWER
    See response to row 9.

    11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,380,466
    12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES ¨
    13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 3.7%
    14 TYPE OF REPORTING PERSON OO

     

     

     

     

    CUSIP NO. 48576A100 13D Page 5 of 15

     

    1

    NAME OF REPORTING PERSON      

    I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

    Dr. Maha Katabi (“Katabi”)

    2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)      ¨ (b)     x
    3 SEC USE ONLY
    4

    SOURCE OF FUNDS

    AF

    5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6 CITIZENSHIP OR PLACE OF ORGANIZATION    Canadian Citizen

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY EACH

    REPORTING

    PERSON

    WITH

    7 SOLE VOTING POWER
    -0-
    8 SHARED VOTING POWER
    1,380,466 shares, of which 1,372,441 are owned directly by SVP X and 8,025 are owned directly by SM X LP. SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Katabi, a managing member of SM X LLC, may be deemed to have shared voting power to vote these shares.
    9 SOLE DISPOSITIVE POWER
    -0-
    10 SHARED DISPOSITIVE POWER
    1,380,466 shares, of which 1,372,441 are owned directly by SVP X and 8,025 are owned directly by SM X LP. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Katabi, a managing member of SM X LLC, may be deemed to have shared dispositive power over these shares.

    11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,380,466
    12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES ¨
    13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 3.7%
    14 TYPE OF REPORTING PERSON IN

     

     

     

     

    CUSIP NO. 48576A100 13D Page 6 of 15

     

    1

    NAME OF REPORTING PERSON      

    I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

    Dr. James I. Healy (“Healy”)

    2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)      ¨ (b)     x
    3 SEC USE ONLY
    4

    SOURCE OF FUNDS

    AF

    5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6 CITIZENSHIP OR PLACE OF ORGANIZATION    U.S. Citizen

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY EACH

    REPORTING

    PERSON

    WITH

    7 SOLE VOTING POWER 58,500 shares, including 26,000 shares subject to stock options that are exercisable by Healy within 60 days of the date of this filing.
    8 SHARED VOTING POWER
    1,381,149 shares, of which 1,372,441 are owned directly by SVP X, 8,025 are owned directly by SM X LP and 683 are owned directly by Sofinnova Synergy Master Fund, LP (“Synergy Fund”). SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Healy, a managing member of SM X LLC and a director of the Issuer, may be deemed to have shared voting power to vote the shares owned directly by SVP X. Sofinnova Synergy Fund GP, LLC (the “Synergy Fund GP”), the general partner of the Synergy Fund, may be deemed to have sole voting power, and Healy, a managing member of the Synergy Fund GP and a director of the Issuer, may be deemed to have shared voting power to vote the shares owned directly by the Synergy Fund.
    9 SOLE DISPOSITIVE POWER
    58,500 shares, including 26,000 shares subject to stock options that are exercisable by Healy within 60 days of the date of this filing.
    10 SHARED DISPOSITIVE POWER
    1,381,149 shares, of which 1,372,441 are owned directly by SVP X, 8,025 are owned directly by SM X LP and 683 are owned directly by the Synergy Fund. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy, a managing member of SM X LLC and a director of the Issuer, may be deemed to have shared dispositive power over the shares owned directly by SVP X. The Synergy Fund GP, the general partner of the Synergy Fund, may be deemed to have sole dispositive power, and Healy, a managing member of the Synergy Fund GP and a director of the Issuer, may be deemed to have shared dispositive power over the shares owned directly by the Synergy Fund.

    11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,439,649
    12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES ¨
    13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 3.8%
    14 TYPE OF REPORTING PERSON IN

     

     

     

     

    CUSIP NO. 48576A100 13D Page 7 of 15

     

    Statement on Schedule 13D

     

    This Amendment No. 2 (“Amendment No. 2”) amends and restates the Statement on Schedule 13D that was initially filed on July 3, 2019 and amended on February 6, 2023 (as amended, the “Original Schedule 13D”). This Amendment No. 2 relates to the beneficial ownership of Common Stock, $0.0001 par value per share (“Common Stock”) of Karuna Therapeutics, Inc., a Delaware corporation (“Issuer”) by Sofinnova Venture Partners X, L.P., a Delaware limited partnership (“SVP X”), Sofinnova Management X, L.P., a Delaware limited partnership (“SM X LP”), Sofinnova Management X-A, L.L.C., a Delaware limited liability company (“SM X LLC”), Dr. James I. Healy (“Healy”), and Dr. Maha Katabi (“Katabi” and collectively with SVP X, SM X LP, SM X LLC, and Healy, the “Reporting Persons”). This Amendment No. 2 is being filed to reflect a pro rata distribution of Common Stock by SVP X.

     

    ITEM 1.SECURITY AND ISSUER.

     

    (a)       The class of equity securities to which this statement relates is the Common Stock of the Issuer.

     

    (b)       The Issuer’s principal executive offices are located at 99 High Street, 26th Floor, Boston, Massachusetts 02110.

     

    ITEM 2.IDENTITY AND BACKGROUND.

     

    (a)       The persons and entities filing this Schedule 13D are SVP X, SM X LP, SM X LLC, Healy, and Katabi. SM X LP, the general partner of SVP X, and SM X LLC, the general partner of SM X LP, may be deemed to have sole power to vote and sole power to dispose of the shares of the Issuer directly owned by SVP X.

     

    (b)       The address of the principal place of business for each of the Reporting Persons is c/o Sofinnova Investments, Inc., 3000 Sand Hill Road, Bldg 4, Suite 250, Menlo Park, California 94025.

     

    (c)       The principal occupation of each of the Reporting Persons is the venture capital investment business. The principal business of SVP X is to make investments in private and public companies, the principal business of SM X LP is to serve as the general partner of SVP X, and the principal business of SM X LLC is to serve as the general partner of SM X LP. Healy and Katabi are the managing members of SM X LLC. Healy is a member of the board of directors of the Issuer.

     

    (d)       During the last five years, none of the Reporting Persons has been convicted in any criminal proceeding (excluding traffic violations or similar misdemeanors).

     

    (e)       During the last five years, none of the Reporting Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

     

    (f)        SVP X is a Delaware limited partnership. SM X LP is a Delaware limited partnership. SM X LLC is a Delaware limited liability company. Healy is a U.S. citizen. Katabi is a Canadian citizen.

     

    ITEM 3.SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

     

    In March 2019, SVP X purchased 792,602 shares of Series B Preferred Stock from the Issuer at a purchase price of $15.14 per share, or $12,000,000 in the aggregate. In connection with the closing of the Issuer’s initial public offering of Common Stock (the “Offering”), the Issuer’s Series B Preferred Stock converted into shares of Common Stock on a 1.2987-for-one basis.

     

    On June 27, 2019, Healy was granted a stock option by the Issuer to purchase 32,500 shares of Common Stock at an exercise price of $16.00 per share. The option shall vest in full upon the earlier of (i) June 27, 2020, and (ii) the next annual meeting of the Issuer’s stockholders. Such option will expire on June 27, 2029. Healy exercised such option on August 5, 2022.

     

     

     

     

    CUSIP NO. 48576A100 13D Page 8 of 15

     

    In connection with the closing of the Offering, SVP X purchased 700,000 shares of Common Stock at $16.00 per share, or $11,200,000 in the aggregate. Such purchase occurred pursuant to and on the terms set forth in the Issuer’s Prospectus filed pursuant to Rule 424(b)(4) on June 28, 2019 with the Securities and Exchange Commission (the “Prospectus”).

     

    On November 25, 2019, SVP X purchased 156,250 shares of Common Stock at a price of $96.00 per share, or $15,000,000.00 in the aggregate.

     

    On June 4, 2020, Healy was granted a stock option by the Issuer to purchase 12,500 shares of Common Stock at an exercise price of $97.59 per share. The option shall vest in full upon the earlier of (i) June 4, 2021, and (ii) the 2021 annual meeting of the Issuer’s stockholders. Such option will expire on June 4, 2030.

     

    On September 4, 2020, SVP X purchased 1,670 shares of Common Stock at a weighted average price of $70.12 per share, or $117,100.40 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $69.66 to $70.61, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On September 4, 2020, SVP X purchased 45,317 shares of Common Stock at a weighted average price of $71.30 per share, or $3,231,102.10 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $70.66 to $71.50, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On September 4, 2020, SVP X purchased 6,461 shares of Common Stock at a weighted average price of $72.73 per share, or $469,908.53 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $72.30 to $73.27, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On September 4, 2020, SVP X purchased 8,330 shares of Common Stock at a weighted average price of $73.59 per share, or $613,004.70 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $73.30 to $74.00, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On September 8, 2020, SVP X purchased 504 shares of Common Stock at a price of $73.00 per share, or $36,792.00 in the aggregate.

     

    On September 9, 2020, SVP X purchased 4,557 shares of Common Stock at a weighted average price of $73.75 per share, or $336,078.75 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $73.37 to $74.00, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On June 16, 2021, Healy was granted a stock option by the Issuer to purchase 8,500 shares of Common Stock at an exercise price of $128.01 per share. The option shall vest in full upon the earlier of (i) June 16, 2022, and (ii) the 2022 annual meeting of the Issuer’s stockholders. Such option will expire on June 15, 2031.

     

     

     

     

    CUSIP NO. 48576A100 13D Page 9 of 15

     

    On June 15, 2022, Healy was granted a stock option by the Issuer to purchase 5,000 shares of Common Stock at an exercise price of $102.96 per share. The option shall vest in full upon the earlier of (i) June 15, 2023, and (ii) the 2023 annual meeting of the Issuer’s stockholders. Such option will expire on June 14, 2032.

     

    On June 29, 2022, SVP X purchased 27,777 shares of Common Stock at a weighted average price of $121.99 per share, or $3,388,516.23 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $121.50 to $122.00, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On June 29, 2022, SVP X purchased 4,039 shares of Common Stock at a weighted average price of $122.95 per share, or $496,595.05 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $122.755 to $123.00, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On June 29, 2022, SVP X purchased 6,832 shares of Common Stock at a weighted average price of $124.73 per share, or $852,155.36 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $124.00 to $124.99, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On June 29, 2022, SVP X purchased 9,129 shares of Common Stock at a price of $125.00 per share, or $1,141,125.00 in the aggregate.

     

    On June 30, 2022, SVP X purchased 48,062 shares of Common Stock at a weighted average price of $122.27 per share, or $5,876,540.74 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $122.145 to $122.962, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On June 30, 2022, SVP X purchased 24,161 shares of Common Stock at a weighted average price of $123.39 per share, or $2,981,225.79 in the aggregate, in open market purchases. These shares were acquired in multiple transactions at prices ranging from $123.21 to $123.50, inclusive. SVP X undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in the previous sentence.

     

    On January 12, 2023, SVP X made a pro rata distribution to its partners, without consideration, of 300,000 shares of Common Stock in accordance with its partnership agreement (the “First SVP X Distribution”). On January 12, 2023, the closing price of the Common Stock was $204.36. In connection with the First SVP X Distribution, SM X LP received 6,027 shares of Common Stock. On January 13, 2023, SM X LP disposed of 6,027 shares of Common Stock at $200.75 per share, or $1,246,055.25 in the aggregate.

     

    On June 14, 2023, SVP X made a pro rata distribution to its partners, without consideration, of 400,000 shares of Common Stock in accordance with its partnership agreement (the “Second SVP X Distribution”). On June 14, 2023, the closing price of the Common Stock was $240.22. In connection with the Second SVP X Distribution, SM X LP received 8,025 shares of Common Stock.

     

    Unless noted above, the source of the funds for all purchases and acquisitions by the Reporting Persons was from working capital. Certain purchases by SVP X were made using its working capital funded partially through a line of credit with Silicon Valley Bank in the normal course of business and then paid down from the proceeds from investor capital calls.

     

    Unless noted above, no part of the purchase price was borrowed by any Reporting Person for the purpose of acquiring any securities discussed in this Item 3.

     

     

     

     

    CUSIP NO. 48576A100 13D Page 10 of 15

     

    ITEM 4.PURPOSE OF TRANSACTION.

     

    The Reporting Persons hold their securities of the Issuer for investment purposes. Depending on the factors discussed herein, the Reporting Persons may, from time to time, acquire additional Common Stock and/or retain and/or sell all or a portion of the Common Stock held by the Reporting Persons in the open market or in privately negotiated transactions, and/or may distribute the Common Stock held by the Reporting Persons to their respective members or limited partners. Any actions the Reporting Persons might undertake will be dependent upon the Reporting Persons’ review of numerous factors, including, among other things, the price levels of the Common Stock, general market and economic conditions, ongoing evaluation of the Issuer’s business, financial condition, operations and prospects; the relative attractiveness of alternative business and investment opportunities, and other future developments. Except as set forth above, the Reporting Persons have no present plans or intentions which would result in or relate to any of the transactions described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

     

    ITEM 5.INTEREST IN SECURITIES OF THE ISSUER.

     

    (a,b)    Regarding aggregate beneficial ownership, see Row 11 of the cover page of each Reporting Person. Regarding percentage beneficial ownership, see Row 13 of the cover page of each Reporting Person. Regarding sole power to vote shares, see Row 7 of the cover page of each Reporting Person. Regarding shared power to vote shares, see Row 8 of the cover page of each Reporting Person. Regarding sole power to dispose of shares, see Row 9 of the cover page of each Reporting Person. Regarding shared power to dispose of shares, see Row 10 of the cover page of each Reporting Person. The percentage listed in Row 13 for each Reporting Person was calculated based upon 37,443,954 shares of Common Stock outstanding as of April 24, 2023, as reported in the Issuer’s Form 10-Q filed on May 4, 2023 with the Securities and Exchange Commission (File No. 001-38958).

     

    (c)       Except as set forth in Item 3 above, the Reporting Persons have not effected any transaction in the securities of the Issuer during the past 60 days.

     

    (d)       Under certain circumstances set forth in the limited partnership agreement of SVP X, the general partner and limited partners of SVP X may be deemed to have the right to receive dividends from, or the proceeds from, the sale of shares of the Issuer owned by such entity of which they are a partner.

     

    (e)       The Reporting Persons ceased to be beneficial owners of more than five percent of the Issuer’s Common Stock on June 14, 2023.

     

     

    ITEM 6.CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO SECURITIES OF THE ISSUER.

     

    SVP X and Healy have agreed that, without the prior written consent of Goldman Sachs & Co. LLC and Citigroup Global Markets, Inc., on behalf of the Issuer’s underwriters, they will not, subject to limited exceptions, during the period ending 180 days after the date set forth on the final Prospectus offer, sell, contract to sell, pledge, grant any option to purchase, make any short sale or otherwise dispose of any shares of Common Stock, or any options or warrants to purchase any shares of Common Stock, or any securities convertible into, exchangeable for or that represent the right to receive shares of Common Stock, whether now owned or hereinafter acquired, owned directly (including holding as a custodian) or with respect to which they have beneficial ownership within the rules and regulations of the Securities and Exchange Commission. Such Lock-Up Agreement is more fully described in the Prospectus and was filed as Annex II to Exhibit 1.1 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863), and such description is incorporated herein by reference.

     

    SVP X is a party to an Amended and Restated Investors’ Rights Agreement among the Issuer, SVP X and other shareholders. Subject to the terms of such Amended and Restated Investors’ Rights Agreement, SVP X can demand that the Issuer file a registration statement or request that its Common Stock be covered by a registration statement that the Issuer is otherwise filing under certain specified circumstances. Such Amended and Restated Investors’ Rights Agreement dated as of March 15, 2019 is more fully described in the Prospectus and was filed as Exhibit 4.2 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863), and such description is incorporated herein by reference.

     

     

     

     

    CUSIP NO. 48576A100 13D Page 11 of 15

     

    Healy, in his capacity as a director of the Issuer, along with the other directors of the Issuer, entered into an Indemnification Agreement with the Issuer. The form of such Indemnification Agreement was filed as Exhibit 10.17 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863), and such description is incorporated herein by reference.

     

    ITEM 7.MATERIAL TO BE FILED AS EXHIBITS.

     

    EXHIBIT A Agreement of Joint Filing
    EXHIBIT B Power of Attorney
    EXHIBIT C Form of Lock-Up Agreement described in Item 6, filed as Annex II of Exhibit 1.1 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863) is incorporated herein by reference.
    EXHIBIT D Amended and Restated Investors’ Rights Agreement described in Item 6, filed as Exhibit 4.2 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863) is incorporated herein by reference.
    EXHIBIT E Form of Indemnification Agreement described in Item 6, filed as Exhibit 10.17 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863) is incorporated herein by reference.

     

     

     

     

    CUSIP NO. 48576A100 13D Page 12 of 15

     

    SIGNATURES

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Date: June 20, 2023

     

      SOFINNOVA VENTURE PARTNERS X, L.P., a Delaware Limited Partnership
       
      By: SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership
      Its: General Partner
       
      By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited
      Liability Company
      Its: General Partner
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact
       
      SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership
       
      By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited
      Liability Company
      Its: General Partner
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact
       
      SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact
       
      DR. JAMES I. HEALY
      DR. MAHA KATABI
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact

     

     

     

     

    CUSIP NO. 48576A100 13D Page 13 of 15

     

    EXHIBIT INDEX

     

    Exhibit   Description 
    A   Agreement of Joint Filing
    B   Power of Attorney
    C   Form of Lock-Up Agreement described in Item 6, filed as Annex II of Exhibit 1.1 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863) is incorporated herein by reference.
    D   Amended and Restated Investors’ Rights Agreement described in Item 6, filed as Exhibit 4.2 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863) is incorporated herein by reference.
    E   Form of Indemnification Agreement described in Item 6, filed as Exhibit 10.17 to the Issuer’s Form S-1 Registration Statement (File No. 333-231863) is incorporated herein by reference.

     

     

     

     

    CUSIP NO. 48576A100 13D Page 14 of 15

     

    exhibit A

     

    Agreement of Joint Filing

     

    The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Karuna Therapeutics, Inc. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D.

     

    Date: June 20, 2023

     

      SOFINNOVA VENTURE PARTNERS X, L.P., a Delaware Limited Partnership
       
      By: SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership
      Its: General Partner
       
      By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited
      Liability Company
      Its: General Partner
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact
       
      SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership
       
      By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited
      Liability Company
      Its: General Partner
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact
       
      SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact
       
      DR. JAMES I. HEALY
      DR. MAHA KATABI
       
      By: /s/ Nathalie Auber
      Nathalie Auber
      Attorney-in-Fact

     

     

     

     

    CUSIP NO. 48576A100 13D Page 15 of 15

     

    exhibit B

     

    Power of Attorney

     

    Nathalie Auber has signed this Schedule 13D as Attorney-in-Fact. Note that copies of the applicable Power of Attorney are already on file with the appropriate agencies. 

     

     

     

    Get the next $KRTX alert in real time by email

    Chat with this insight

    Save time and jump to the most important pieces.

    Recent Analyst Ratings for
    $KRTX

    DatePrice TargetRatingAnalyst
    12/12/2023$291.00Buy
    Citigroup
    12/12/2023$227.00Buy
    Deutsche Bank
    8/22/2023$225.00Overweight
    Wells Fargo
    7/20/2023$280.00Overweight
    Morgan Stanley
    3/8/2023$214.00Neutral
    Cantor Fitzgerald
    1/27/2023$209.00Neutral
    UBS
    1/5/2023$285.00Overweight
    Piper Sandler
    11/1/2022$288.00Buy
    Loop Capital
    More analyst ratings

    $KRTX
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • SEC Form SC 13G filed by Karuna Therapeutics Inc.

      SC 13G - Karuna Therapeutics, Inc. (0001771917) (Subject)

      2/14/24 10:04:40 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed by Karuna Therapeutics Inc. (Amendment)

      SC 13G/A - Karuna Therapeutics, Inc. (0001771917) (Subject)

      2/14/24 10:03:02 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed by Karuna Therapeutics Inc. (Amendment)

      SC 13G/A - Karuna Therapeutics, Inc. (0001771917) (Subject)

      2/12/24 12:25:28 PM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $KRTX
    Financials

    Live finance-specific insights

    See more
    • PureTech Founded Entity Karuna Therapeutics to be Acquired by Bristol Myers Squibb for $14 Billion

      Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Class Treatment for Schizophrenia and as an Adjunctive Therapy, and First-in-Disease Treatment for Alzheimer's Disease Psychosis, with Promise in Additional Neuropsychiatric and Neurodegenerative Indications KarXT Is Expected to Launch in the U.S. for the Treatment of Schizophrenia in Adults with a Prescription Drug User Fee Act Date of September 26, 2024 Bristol Myers Squibb to Host a Conference Call Today at 8:00 a.m. ET PureTech Health plc (NASDAQ:PRTC, LSE: PRTC))) ("PureTech" or the "Company"), a clinical-stage biotherapeutics c

      12/22/23 9:13:00 AM ET
      $BMY
      $KRTX
      $PRTC
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics

      Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Class Treatment for Schizophrenia and as an Adjunctive Therapy, and First-in-Disease Treatment for Alzheimer's Disease Psychosis, with Promise in Additional Neuropsychiatric and Neurodegenerative Indications KarXT Is Expected to Launch in the U.S. for the Treatment of Schizophrenia in Adults with a Prescription Drug User Fee Act Date of September 26, 2024 Bristol Myers Squibb to Host a Conference Call Today at 8:00 a.m. ET Bristol Myers Squibb (NYSE:BMY) and Karuna Therapeutics, Inc. (NASDAQ:KRTX) ("Karuna") today announced that they

      12/22/23 6:59:00 AM ET
      $BMY
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Karuna Therapeutics to Announce Third Quarter 2023 Financial Results and Provide General Business Update on Thursday, November 2, 2023

      Karuna Therapeutics, Inc. (NASDAQ:KRTX), a biopharmaceutical company driven to discover, develop, and deliver transformative medicines for people living with psychiatric and neurological conditions, today announced that it will host a live conference call and webcast on Thursday, November 2, 2023 at 8:00 a.m. ET to review third quarter 2023 financial results and provide a general business update. A live webcast of the presentation will be available on the Investor Relations page of Karuna's website at investors.karunatx.com. A replay of the webcast will also be archived for up to 30 days on Karuna's website following the completion of the event. About Karuna Therapeutics Karuna Therapeu

      10/19/23 6:30:00 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $KRTX
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • PureTech Announces Annual Results for Year Ended December 31, 2023

      Significant operational and clinical progress in 2023 and early 2024 with maturation of Internal Programs,1 launch of two new Founded Entities,2 including a $100 million Series A financing for Seaport, and the $14 billion acquisition of Karuna by Bristol Myers Squibb Robust balance sheet with PureTech level cash, cash equivalents and short-term investments of $326.0 million3 and consolidated cash, cash equivalents and short-term Investments of $327.1 million4 as of December 31, 2023 As of March 31, 2024, PureTech level cash, cash equivalents and short-term investments were $573.3 million,5 enabling the support of Internal Programs and Founded Entities, future innovations, shareholder re

      4/25/24 5:22:00 AM ET
      $AKLI
      $BMY
      $KRTX
      $PRTC
      Medical/Dental Instruments
      Health Care
      Biotechnology: Pharmaceutical Preparations
      Biotechnology: Biological Products (No Diagnostic Substances)
    • Karuna Therapeutics Reports Fourth Quarter and Full Year 2023 Financial Results and Provides General Business Update

      New Drug Application (NDA) for KarXT for the treatment of schizophrenia in adults under review with a Prescription Drug User Fee Act (PDUFA) action date of September 26, 2024 Results from the Phase 3 EMERGENT-2 trial of KarXT in schizophrenia published in The Lancet Announced appointments of Andrew Miller, Ph.D. as President of Research and Development and Mia Kelley, J.D. as General Counsel Previously announced proposed acquisition of Karuna by Bristol Myers Squibb expected to close in the first half of 2024 $1.3 billion in cash, cash equivalents, and available-for-sale investment securities Karuna Therapeutics, Inc. (NASDAQ:KRTX), a biopharmaceutical company driven to discover,

      2/22/24 6:30:00 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PureTech Founded Entity Karuna Therapeutics to be Acquired by Bristol Myers Squibb for $14 Billion

      Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Class Treatment for Schizophrenia and as an Adjunctive Therapy, and First-in-Disease Treatment for Alzheimer's Disease Psychosis, with Promise in Additional Neuropsychiatric and Neurodegenerative Indications KarXT Is Expected to Launch in the U.S. for the Treatment of Schizophrenia in Adults with a Prescription Drug User Fee Act Date of September 26, 2024 Bristol Myers Squibb to Host a Conference Call Today at 8:00 a.m. ET PureTech Health plc (NASDAQ:PRTC, LSE: PRTC))) ("PureTech" or the "Company"), a clinical-stage biotherapeutics c

      12/22/23 9:13:00 AM ET
      $BMY
      $KRTX
      $PRTC
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $KRTX
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • Citigroup initiated coverage on Karuna Therapeutics with a new price target

      Citigroup initiated coverage of Karuna Therapeutics with a rating of Buy and set a new price target of $291.00

      12/12/23 2:26:52 PM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Deutsche Bank initiated coverage on Karuna Therapeutics with a new price target

      Deutsche Bank initiated coverage of Karuna Therapeutics with a rating of Buy and set a new price target of $227.00

      12/12/23 7:55:23 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Wells Fargo initiated coverage on Karuna Therapeutics with a new price target

      Wells Fargo initiated coverage of Karuna Therapeutics with a rating of Overweight and set a new price target of $225.00

      8/22/23 7:25:54 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $KRTX
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • Healy James returned $466,830,870 worth of shares to the company (1,414,639 units at $330.00), closing all direct ownership in the company (SEC Form 4)

      4 - Karuna Therapeutics, Inc. (0001771917) (Issuer)

      3/18/24 4:30:54 PM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pande Atul returned $326,700 worth of shares to the company (990 units at $330.00), closing all direct ownership in the company (SEC Form 4)

      4 - Karuna Therapeutics, Inc. (0001771917) (Issuer)

      3/18/24 4:30:57 PM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Brown Jason Parker returned $6,985,110 worth of shares to the company (21,167 units at $330.00), closing all direct ownership in the company (SEC Form 4)

      4 - Karuna Therapeutics, Inc. (0001771917) (Issuer)

      3/18/24 4:30:42 PM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $KRTX
    Leadership Updates

    Live Leadership Updates

    See more
    • Karuna Therapeutics Announces Leadership Appointments

      Jonathan Rosin appointed to Chief Human Resources Officer Jason Brown promoted to Chief Financial Officer  Karuna Therapeutics, Inc. (NASDAQ:KRTX), a clinical-stage biopharmaceutical company driven to create and deliver transformative medicines for people living with psychiatric and neurological conditions, today announced the appointment of Jonathan Rosin to Chief Human Resources Officer (CHRO) and the promotion of Jason Brown to Chief Financial Officer (CFO). Mr. Brown succeeds Troy Ignelzi, who will remain at Karuna for a transition period through the end of the third quarter of 2023. "These executive appointments are a key part of our transition to a fully integrated organization

      8/3/23 6:30:00 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Karuna Therapeutics Appoints William P. Kane as Chief Commercial Officer

      Karuna Therapeutics, Inc. (NASDAQ:KRTX), a clinical-stage biopharmaceutical company driven to create and deliver transformative medicines for people living with psychiatric and neurological conditions, today announced the appointment of Will Kane as chief commercial officer (CCO), effective February 6, 2023. "The addition of Will to our executive team represents an important step as we execute on our plan to transition Karuna to a fully integrated R&D and commercial organization," said Bill Meury, president and chief executive officer, Karuna Therapeutics. "Will is an exceptional leader and has extensive commercial operations experience, which will be invaluable as we focus our attention o

      1/31/23 6:30:00 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Karuna Therapeutics Appoints Bill Meury as President and Chief Executive Officer

      Mr. Meury is a distinguished pharmaceutical leader with more than 25 years of operational and commercial experience delivering transformative medicines to patients Succeeds current president, chief executive officer, and chairman, Steve Paul, M.D., who will transition to president of research and development and chief scientific officer Christopher Coughlin to assume role of chairman of the board Karuna Therapeutics, Inc. (NASDAQ:KRTX), a clinical-stage biopharmaceutical company driven to create and deliver transformative medicines for people living with psychiatric and neurological conditions, today announced the appointment of Bill Meury as president and chief executive officer (CEO) a

      12/6/22 6:30:00 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $KRTX
    SEC Filings

    See more
    • SEC Form 15-12G filed by Karuna Therapeutics Inc.

      15-12G - Karuna Therapeutics, Inc. (0001771917) (Filer)

      3/28/24 4:06:36 PM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form S-8 POS filed by Karuna Therapeutics Inc.

      S-8 POS - Karuna Therapeutics, Inc. (0001771917) (Filer)

      3/18/24 9:19:16 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form S-8 POS filed by Karuna Therapeutics Inc.

      S-8 POS - Karuna Therapeutics, Inc. (0001771917) (Filer)

      3/18/24 9:19:18 AM ET
      $KRTX
      Biotechnology: Pharmaceutical Preparations
      Health Care