• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Dashboard
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlerts
    Company
    AboutQuantisnow PlusContactJobs
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form SC 13D/A filed by PepGen Inc. (Amendment)

    2/13/24 4:16:19 PM ET
    $PEPG
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $PEPG alert in real time by email
    SC 13D/A 1 tm246106d1_sc13da.htm SC 13D/A

     

     

     

      SECURITIES AND EXCHANGE COMMISSION  
      Washington, D.C. 20549  
         
      SCHEDULE 13D/A  

     

    Under the Securities Exchange Act of 1934
    (Amendment No. 2)*

     

    PEPGEN INC.

    (Name of Issuer)

     

    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

     

    713317105

     

    (CUSIP Number)

     

    RA Capital Management, L.P.

    200 Berkeley Street, 18th Floor

    Boston, MA 02116

    Attn: Peter Kolchinsky

    Telephone: 617.778.2500

    (Name, Address and Telephone Number of Person
    Authorized to Receive Notices and Communications)

     

    February 9, 2024

    (Date of Event Which Requires Filing of this Statement)

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Section 240.13d-7 for other parties to whom copies are to be sent.

     

    * The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934, as amended (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

      

     

     

      

    CUSIP No.   713317105
     
      1.

    Names of Reporting Persons.

    RA Capital Management, L.P.

     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  ¨
     
      3. SEC Use Only
     
      4. Source of Funds (See Instructions)
    AF
     
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     o
     
      6. Citizenship or Place of Organization
    Delaware
     
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
     
    8. Shared Voting Power
    10,695,135
     
    9. Sole Dispositive Power
    0
     
    10. Shared Dispositive Power
    10,695,135
     
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
    10,695,135
     
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
     
      13. Percent of Class Represented by Amount in Row (11)
    34.1%
     
      14. Type of Reporting Person (See Instructions)
    IA, PN
               

     

     

     

    CUSIP No.   713317105
     
      1.

    Names of Reporting Persons.

    Peter Kolchinsky

     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  ¨
     
      3. SEC Use Only
     
      4. Source of Funds (See Instructions)
    AF
     
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     o
     
      6. Citizenship or Place of Organization
    United States
     
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
     
    8. Shared Voting Power
    10,695,135
     
    9. Sole Dispositive Power
    0
     
    10. Shared Dispositive Power
    10,695,135
     
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
    10,695,135
     
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
     
      13. Percent of Class Represented by Amount in Row (11)
    34.1%
     
      14. Type of Reporting Person (See Instructions)
    HC, IN
               

     

     

      

    CUSIP No.   713317105
     
      1.

    Names of Reporting Persons.

    Rajeev Shah

     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  ¨
     
      3. SEC Use Only
     
      4. Source of Funds (See Instructions)
    AF
     
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
     
      6. Citizenship or Place of Organization
    United States
     
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
     
    8. Shared Voting Power
    10,695,135
     
    9. Sole Dispositive Power
    0
     
    10. Shared Dispositive Power
    10,695,135
     
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
    10,695,135
     
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
     
      13. Percent of Class Represented by Amount in Row (11)
    34.1%
     
      14. Type of Reporting Person (See Instructions)
    HC, IN
               

     

     

     

    CUSIP No.   713317105
     
      1.

    Names of Reporting Persons.

    RA Capital Healthcare Fund, L.P.

     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  ¨
     
      3. SEC Use Only
     
      4. Source of Funds (See Instructions)
    WC
     
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
     
      6. Citizenship or Place of Organization
    Delaware
     
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
     
    8. Shared Voting Power
    9,179,273
     
    9. Sole Dispositive Power
    0
     
    10. Shared Dispositive Power
    9,179,273
     
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
    9,179,273
     
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
     
      13. Percent of Class Represented by Amount in Row (11)
    29.3%
     
      14. Type of Reporting Person (See Instructions)
    PN
               

     

     

      

    CUSIP No.   713317105
     
      1.

    Names of Reporting Persons.

    RA Capital Nexus Fund, II L.P.

     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  ¨
     
      3. SEC Use Only
     
      4. Source of Funds (See Instructions)
    WC
     
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
     
      6. Citizenship or Place of Organization
    Delaware
     
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
     
    8. Shared Voting Power
    1,302,600
     
    9. Sole Dispositive Power
    0
     
    10. Shared Dispositive Power
    1,302,600
     
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
    1,302,600
     
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
     
      13. Percent of Class Represented by Amount in Row (11)
    4.2%
     
      14. Type of Reporting Person (See Instructions)
    PN
               

     

     

      

    Item 1. Security and Issuer

      

    Item 1 of the Statement is hereby amended and supplemented as follows:

     

    This Amendment No. 2 amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the “SEC”) on May 20, 2022 and amended on June 23, 2022 (as amended, the “Statement”) by RA Capital Management, L.P. (“RA Capital”), Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. (the “Fund”) and RA Capital Nexus Fund II, L.P. (the “Nexus Fund II”) with respect to the common stock, par value $0.0001 per share (the “Common Stock”), of PepGen Inc., a Delaware corporation (the “Issuer”). Unless otherwise defined herein, capitalized terms used in this Amendment No. 2 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged.

     

    Item 2. Identity and Background
     
    Item 2 of the Statement is hereby amended and supplemented as follows:

     

    (a) This Schedule 13D is being filed on behalf of RA Capital, Dr. Kolchinsky, Mr. Shah, the Fund, and the Nexus Fund II.  RA Capital, Dr. Kolchinsky, Mr. Shah, the Fund, and the Nexus Fund II are collectively referred to herein as the “Reporting Persons.”  The agreement among the Reporting Persons to file this Schedule 13D jointly in accordance with Rule 13d-1(k) of the Securities Exchange Act of 1934, as amended, is attached hereto as Exhibit 1.
       
      The Common Stock reported herein includes (i) 9,179,273 shares held by the Fund; (ii) 1,302,600 shares held by the Nexus Fund II; (iii) 207,672 shares held by a separately managed account (the “Account”); and (iv) a total of 5,104 shares underlying vested stock options (right to buy), and 486 shares underlying stock options (right to buy) which shall vest within 60 days of this filing held by Dr. Joshua Resnick for the benefit of RA Capital.
       
      RA Capital Healthcare Fund GP, LLC is the general partner of the Fund  and RA Capital Nexus Fund II GP, LLC is the general partner of the Nexus Fund II. The general partner of RA Capital is RA Capital Management GP, LLC, of which Dr. Kolchinsky and Mr. Shah are the controlling persons. RA Capital serves as investment adviser for the Fund, the Nexus Fund II, and the Account and may be deemed a beneficial owner, for purposes of Section 13(d) of the Securities Exchange Act of 1934 (the “Act”), of any securities of the Issuer held by the Fund, the Nexus Fund II or the Account.  The Fund and the Nexus Fund II have delegated to RA Capital the sole power to vote and the sole power to dispose of all securities held in the Fund and the Nexus Fund II, and each of these funds has divested themselves of voting and investment power over the reported securities they hold and may not revoke that delegation on less than 61 days’ notice. The Fund and the Nexus Fund II disclaim beneficial ownership of the securities they hold for purposes of Section 13(d) of the Act and therefore disclaim any obligation to report ownership of the reported securities under Section 13(d) of the Act. As managers of RA Capital, Dr. Kolchinsky and Mr. Shah may be deemed beneficial owners, for purposes of Section 13(d) of the Act, of any securities of the Issuer beneficially owned by RA Capital.  RA Capital, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of the securities reported in this Statement other than for the purpose of determining their obligations under Section 13(d) of the Act, and the filing of the Statement shall not be deemed an admission that either RA Capital, Dr. Kolchinsky, or Mr. Shah is the beneficial owner of such securities for any other purpose.

      

    (b) The address of the principal business office of each of the Reporting Persons is 200 Berkeley Street, 18th Floor, Boston, MA 02116.

     

    (c) The Fund and the Nexus Fund II are private investment vehicles. RA Capital provides investment management services to the Fund, the Nexus Fund II, and the Account. The principal occupation of Dr. Kolchinsky and Mr. Shah is investment management.

     

    (d) During the last five years, none of the Reporting Persons has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

     

    (e) During the last five years, none of the Reporting Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree of final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

     

    (f) See Item 6 of the cover pages.

     

     

     

     

    Item 3. Source and Amount of Funds or Other Consideration

     

    Item 3 of the Statement is hereby amended and supplemented to add the following:

     

    On February 9, 2024, the Fund purchased 2,557,593 shares of Common Stock in the Issuer’s underwritten public offering (the “February 2024 Public Offering”) at a price of $10.635 per share, for total consideration of $27.2 million. 

     

    Item 5. Interest in Securities of the Issuer

     

    Item 5 of the Statement is hereby amended and supplemented as follows:

     

    (a)The information set forth in rows 11 and 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentage set forth in row 13 is based on 31,343,547 outstanding shares of Common Stock on February 9, 2024 upon the closing of the February 2024 Public Offering, as reported by the Issuer in the final prospectus supplement for the February 2024 Public Offering, filed with the Securities and Exchange Commission on February 7, 2024, and giving effect to stock options, to the extent exercisable within 60 days hereof, as referenced herein.

     

    (b)The information set forth in rows 7 through 10 of the cover pages to this Schedule 13D and Item 2 above is incorporated by reference.

     

    (c)The following table lists the Reporting Persons’ transactions in Common Stock that have not previously been reported during the sixty day period prior to the filing of this amended Schedule 13D:

      

    Transaction Purchaser Date No. Shares Price
    Vest Stock Option (Right to Buy) RA Capital January 6, 2024 243 (1)
    Vest Stock Option (Right to Buy) RA Capital February 6, 2024 243 (1)
    Vest Stock Option (Right to Buy) RA Capital March 6, 2024 243 (1)
    Vest Stock Option (Right to Buy) RA Capital April 6, 2024 243 (1)
    February 2024 Public Offering The Fund February 9, 2024 2,557,593 $10.635

     

    (1)This option represents a right to purchase a total of 11,667 shares of the Issuer’s Common Stock, which began vesting from May 6, 2022 and vested with respect to 25% of the shares on May 6, 2023, with the remainder vesting in 36 equal monthly installments, subject to Dr. Joshua Resnick’s continuous service to the Issuer through each vesting date. These options have an exercise price of $12.00 per share.

     

    (d)No person (other than the Reporting Persons) is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares of Common Stock subject to this Schedule 13D.

     

    (e)As of February 9, 2024, upon the closing of the February 2024 Public Offering, the Nexus Fund II ceased to be the beneficial owner of more than 5% of the Issuer’s Common Stock.

     

     

     

     

    SIGNATURES

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: February 13, 2024

     

     

    RA CAPITAL MANAGEMENT, L.P.  
           
    By: /s/ Peter Kolchinsky  
    Name: Peter Kolchinsky  
    Title: Authorized Signatory  
           
    PETER KOLCHINSKY  
           
    /s/ Peter Kolchinsky  
           
    RAJEEV SHAH  
           
    /s/ Rajeev Shah  
       
       
    RA CAPITAL HEALTHCARE FUND, L.P.  
           
    By: RA Capital Healthcare Fund GP, LLC  
    Its: General Partner  
           
    By: /s/ Peter Kolchinsky  
    Name: Peter Kolchinsky  
    Title: Manager  
           
    RA CAPITAL NEXUS FUND II, L.P.  
           
    By: RA Capital Nexus Fund II GP, LLC  
    Its: General Partner  
           
    By: /s/ Peter Kolchinsky  
    Name: Peter Kolchinsky  
    Title: Manager  

      

     

     

    Get the next $PEPG alert in real time by email

    Chat with this insight

    Save time and jump to the most important pieces.

    Recent Analyst Ratings for
    $PEPG

    DatePrice TargetRatingAnalyst
    12/16/2024$3.00Neutral → Underperform
    BofA Securities
    7/31/2024$12.00Buy → Neutral
    BofA Securities
    12/21/2022$26.00Buy
    H.C. Wainwright
    More analyst ratings

    $PEPG
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • PepGen downgraded by BofA Securities with a new price target

      BofA Securities downgraded PepGen from Neutral to Underperform and set a new price target of $3.00

      12/16/24 12:07:01 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen downgraded by BofA Securities with a new price target

      BofA Securities downgraded PepGen from Buy to Neutral and set a new price target of $12.00

      7/31/24 11:28:59 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • H.C. Wainwright initiated coverage on PepGen with a new price target

      H.C. Wainwright initiated coverage of PepGen with a rating of Buy and set a new price target of $26.00

      12/21/22 9:28:36 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PEPG
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • PepGen Appoints Kasra Kasraian, PhD, as Chief Technology Officer

      PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today announced the appointment of Kasra Kasraian, PhD, as Chief Technology Officer (CTO). Dr. Kasraian brings over 25 years of experience in product and process development, CMC strategy, and technical operations, spanning small and large molecules, as well as cell and gene therapies. "We are pleased to welcome Kasra to our executive leadership team," said James McArthur, PhD, President and Chief Executive Officer of PepGen. "He brings a rare depth of expertise in product

      5/20/25 7:00:00 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen Reports First Quarter 2025 Financial Results and Recent Corporate Highlights

      – Reported positive DM1 patient data with mean splicing correction of 29.1% following a single dose of PGN-EDODM1 at 10 mg/kg – – FREEDOM-DM1 data from 15 mg/kg cohort expected in the second half of 2025 – – CONNECT1-EDO51 data from 10 mg/kg cohort expected in the third quarter of 2025 – PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today reported financial results and recent corporate highlights for the quarter ended March 31, 2025. "Our EDO platform's unique ability to efficiently deliver oligonucleotides into the

      5/8/25 8:00:00 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen to Present at the 24th Annual Needham Virtual Healthcare Conference

      PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today announced that James McArthur, PhD, President and CEO of PepGen, will present at the 24th Annual Needham Virtual Healthcare Conference on Wednesday, April 9, 2025 at 1:30pm ET. A webcast of the corporate presentation will be available on the "Events & Presentations" page within the Investors section of the PepGen website at https://investors.pepgen.com/. A replay of the webcast will be available on the PepGen website for 90 days following the presentation date. About

      4/2/25 4:05:00 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PEPG
    SEC Filings

    See more
    • Amendment: SEC Form SCHEDULE 13G/A filed by PepGen Inc.

      SCHEDULE 13G/A - PepGen Inc. (0001835597) (Subject)

      5/15/25 4:32:37 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SCHEDULE 13G/A filed by PepGen Inc.

      SCHEDULE 13G/A - PepGen Inc. (0001835597) (Subject)

      5/15/25 8:22:12 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen Inc. filed SEC Form 8-K: Results of Operations and Financial Condition, Financial Statements and Exhibits

      8-K - PepGen Inc. (0001835597) (Filer)

      5/8/25 8:05:08 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PEPG
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • Chief Technical Officer Kasraian Kasra was granted 16,750 shares (SEC Form 4)

      4 - PepGen Inc. (0001835597) (Issuer)

      5/21/25 4:47:34 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 3 filed by new insider Kasraian Kasra

      3 - PepGen Inc. (0001835597) (Issuer)

      5/21/25 4:00:51 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • President and CEO Mcarthur James G bought $13,550 worth of shares (10,000 units at $1.35), increasing direct ownership by 10% to 113,913 units (SEC Form 4)

      4 - PepGen Inc. (0001835597) (Issuer)

      4/22/25 7:01:12 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PEPG
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • Amendment: SEC Form SC 13G/A filed by PepGen Inc.

      SC 13G/A - PepGen Inc. (0001835597) (Subject)

      11/14/24 4:31:29 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by PepGen Inc.

      SC 13G - PepGen Inc. (0001835597) (Subject)

      11/14/24 11:10:10 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by PepGen Inc.

      SC 13G/A - PepGen Inc. (0001835597) (Subject)

      11/12/24 8:57:04 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PEPG
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • President and CEO Mcarthur James G bought $13,550 worth of shares (10,000 units at $1.35), increasing direct ownership by 10% to 113,913 units (SEC Form 4)

      4 - PepGen Inc. (0001835597) (Issuer)

      4/22/25 7:01:12 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • President and CEO Mcarthur James G bought $47,725 worth of shares (41,500 units at $1.15), increasing direct ownership by 66% to 103,913 units (SEC Form 4)

      4 - PepGen Inc. (0001835597) (Issuer)

      4/9/25 7:40:15 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Oxford Science Enterprises Plc bought $10,559,640 worth of shares (879,970 units at $12.00), increasing direct ownership by 23% to 4,755,388 units (SEC Form 4) (Amendment)

      4/A - PepGen Inc. (0001835597) (Issuer)

      4/9/24 5:24:38 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PEPG
    Financials

    Live finance-specific insights

    See more
    • PepGen Announces Positive Initial Results, Including Robust Splicing Correction, from Ongoing FREEDOM-DM1 Trial in Patients with DM1

      – Significant mean splicing correction of 29.1% following a single dose of PGN-EDODM1 at 10 mg/kg – – PGN-EDODM1 observed to have favorable emerging safety profile – – Conference call scheduled today at 8:00 a.m. ET – PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today announced initial positive clinical data from the 5 and 10 mg/kg dose cohorts in the ongoing FREEDOM-DM1 Phase 1 trial investigating PGN-EDODM1 in myotonic dystrophy type 1 (DM1). "These results far exceeded our expectations for splicing correctio

      2/24/25 7:00:00 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen Announces Positive Data from Low-Dose Cohort of PGN-EDO51 in Ongoing CONNECT1-EDO51 Phase 2 Clinical Trial for Treatment of Duchenne Muscular Dystrophy

      – PGN-EDO51 at 5 mg/kg was well tolerated, and all patients continued to long-term extension portion of trial. Dosing of second cohort at 10 mg/kg is ongoing – – Four doses of PGN-EDO51 at 5 mg/kg achieved mean exon skipping levels of 2.15% after three months of dosing – – PGN-EDO51 at 5 mg/kg showed mean muscle-adjusted dystrophin level of 1.49%, a 0.70% increase from baseline, after three months of dosing – – PGN-EDO51 at 5 mg/kg showed mean absolute dystrophin level of 0.61%, a 0.26% increase from baseline, after three months of dosing – – Conference call scheduled for 4:30 p.m. ET – PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation

      7/30/24 4:02:00 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen to Host Fourth Quarter and Full Year 2022 Financial Results Call

      BOSTON, March 16, 2023 (GLOBE NEWSWIRE) -- PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, will report its fourth quarter and full year 2022 financial results and provide a corporate update on Thursday, March 23, 2023. PepGen's management will host a conference call and live audio webcast to discuss these results and provide a corporate update at 4:30pm ET. The event will be webcast live under the Events & Presentations section of the Investor Relations section of PepGen's website. A replay of the event will be archived

      3/16/23 8:00:00 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $PEPG
    Leadership Updates

    Live Leadership Updates

    See more
    • PepGen Appoints Kasra Kasraian, PhD, as Chief Technology Officer

      PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today announced the appointment of Kasra Kasraian, PhD, as Chief Technology Officer (CTO). Dr. Kasraian brings over 25 years of experience in product and process development, CMC strategy, and technical operations, spanning small and large molecules, as well as cell and gene therapies. "We are pleased to welcome Kasra to our executive leadership team," said James McArthur, PhD, President and Chief Executive Officer of PepGen. "He brings a rare depth of expertise in product

      5/20/25 7:00:00 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen Announces Appointment of Two New Directors to its Board

      PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today announced the appointments of Lisa Wyman and Mitchell H. Finer, PhD, to its Board of Directors. Ms. Wyman and Dr. Finer are industry veterans, each bringing decades of executive experience in the life sciences to the Company. "We are thrilled to welcome Lisa and Mitch to our Board of Directors," said James McArthur, PhD, President and CEO of PepGen. "Lisa's proven ability to scale manufacturing for mid- to late-stage clinical trials and guide clinical-stage companies

      3/31/25 4:05:00 PM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • PepGen Appoints Paul Streck, M.D., MBA, as Executive Vice President, Head of Research & Development

      PepGen Inc. (NASDAQ:PEPG), a clinical-stage biotechnology company advancing the next generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases, today announced the appointment of Paul Streck, M.D., MBA, as Executive Vice President, Head of Research & Development (R&D), effective immediately. Dr. Streck will join the PepGen Executive Team and will be responsible for leading the R&D organization. "We are very pleased that Paul is joining PepGen at such an important time for the Company," said James McArthur, Ph.D., President and CEO of PepGen. "Throughout his career, Paul has served in leadership roles across both l

      8/20/24 8:00:00 AM ET
      $PEPG
      Biotechnology: Pharmaceutical Preparations
      Health Care