SEC Form SC 13D/A filed by Pyxis Oncology Inc. (Amendment)

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934 (Amendment No. 3)*

Pyxis Oncology, Inc.

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

747324101

(CUSIP Number)

Pamela Connealy

Pyxis Oncology, Inc.

321 Harrison Avenue

Boston, MA 02118

(617) 351-2575

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

March 26, 2024

(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

(1) This amount includes 3,085,817 Shares (as defined herein) that are obtainable upon exercise of options and 537,335 Shares obtainable upon vesting of RSUs (as defined herein).

(2) Calculation is based on the sum of (i) 58,133,375 Shares outstanding as of March 20, 2024, as reported in the Issuer’s Annual Report on Form 10-K filed on March 21, 2024, plus (ii) the 3,085,817 Shares issuable upon exercise of options granted to the reporting person, and (iii) the 537,335

Shares issuable upon vesting of RSUs granted to the reporting person, each of (ii) and (iii) which have been added to the total Shares outstanding in accordance with Rule 13d-3(d)(3) under the Act.

Item 1. Security and Issuer

This Amendment No. 3 to Schedule 13D (“Amendment No. 3”) is being filed by the undersigned, pursuant to Rule 13d-2(a) under the Act, with respect to the Common Stock, $0.001 par value per share (the “Shares”), of Pyxis Oncology, Inc. (the “Issuer”), whose principal executive offices are located at 321 Harrison Avenue, Boston, Massachusetts 02118. This Amendment No. 3 amends and supplements the statement on Schedule 13D filed with the U.S. Securities and Exchange Commission (the “SEC”) on October 22, 2021 (the “Original Schedule 13D”), as amended by Amendment No. 1 filed on May 23, 2022 and by Amendment No. 2 filed on April 4, 2023 (together with this Amendment No. 3, the “Schedule 13D”). Capitalized terms used herein and not otherwise defined in this Amendment No. 3 have the meanings previously defined in the Schedule 13D. Except as specifically provided herein, this Amendment No. 3 does not modify any of the information previously reported in the Schedule 13D.

Item 3. Source and Amount of Funds or Other Consideration

Item 3 of the Schedule 13D is hereby amended and supplemented as follows:

In connection with Lara Sullivan's role as Chief Executive Officer of the Issuer, on March 26, 2024, the Issuer granted the reporting person a stock option to purchase 1,071,242 Shares at an exercise price of $3.83 per share. Such stock options vest over a four year period, with 25% vesting on the first anniversary of the grant date, and the remaining 75% vesting in 36 substantially-equal monthly installments thereafter, subject to the reporting person's continued employment through the applicable vesting date.

Item 4. Purpose of Transaction

Item 4 of the Schedule 13D is hereby amended and supplemented as follows:

The response to Item 3 of this Amendment No. 3 is incorporated by reference herein.

Item 5. Interest in Securities of the Issuer

Item 5(a) – (c) of the Schedule 13D is hereby amended and supplemented as follows:

(a, b) As of the date hereof, the Reporting Person may be deemed to be the beneficial owner of 5,489,699 Shares, representing approximately 8.89% of the total number of shares outstanding. This amount includes: (i) an aggregate 3,085,817 Shares obtainable upon exercise of options, certain of which are subject to vesting upon the reporting person's continued employment through the applicable vesting date; and (ii) 537,335 Shares obtainable upon vesting of RSUs, all of which are subject to vesting upon the reporting person's continued employment through the applicable vesting date.

The foregoing beneficial ownership percentage is based on the sum of (i) 58,133,375 Shares outstanding as of March 20, 2024, as reported in the Issuer’s Annual Report on Form 10-K filed on March 21, 2024, plus (ii) the 3,085,817 Shares issuable upon exercise of options granted to the reporting person, and (iii) the 537,335 Shares issuable upon vesting of RSUs granted to the reporting person, each of (ii) and (iii) which have been added to the total Shares outstanding in accordance with Rule 13d-3(d)(3) under the Act.

(c) The response to Item 3 of this Amendment No. 3 is incorporated by reference herein. Other than as disclosed in this Amendment No. 3, there have been no transactions in the Shares by the reporting person effected during the past sixty days.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Attention: Intentional misstatements or omissions of fact constitute federal violations (see 18 U.S.C. 1001).