• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Dashboard
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlerts
    Company
    AboutQuantisnow PlusContactJobs
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form SC 13D/A filed by Science 37 Holdings Inc. (Amendment)

    3/14/24 4:17:56 PM ET
    $SNCE
    Computer Software: Prepackaged Software
    Technology
    Get the next $SNCE alert in real time by email
    SC 13D/A 1 sc13d_a.htm AMENDMENT NO. 1

     
    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549



    SCHEDULE 13D/A

    Under the Securities Exchange Act of 1934
        (Amendment No. 1)*  
     
    SCIENCE 37 HOLDINGS, INC.
    (Name of Issuer)


    Common Stock, par value $0.0001 per share
    (Title of Class of Securities)


    808644108
    (CUSIP Number)


    Michael A. Boxer
    Senior Vice President and General Counsel
    Thermo Fisher Scientific Inc.
    168 Third Avenue
    Waltham, Massachusetts 02451
    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)



    With copies to:

    Ting S. Chen
    Bethany A. Pfalzgraf
    Cravath, Swaine & Moore LLP
    Worldwide Plaza
    825 Eighth Avenue
    New York, NY 10019

    March 12, 2024
    (Date of Event which Requires Filing of this Statement)




    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits.  See Rule 13d-7 for other parties to whom copies are to be sent.

    *
    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) or otherwise subject to the liabilities of that section of the Exchange Act but shall be subject to all other provisions of the Exchange Act (however, see the Notes).


     

     
    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    Pharmaceutical Product Development, LLC
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    WC
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
     


    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    Wildcat Acquisition Holdings (UK) Limited
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    United Kingdom
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     




    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    Jaguar Holding Company II
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    CO
     
     
     
     




    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    Jaguar Holding Company I, LLC
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
     0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     




    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    Eagle Holding Company II, LLC
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     



    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    PPD, Inc.
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    CO
     
     
     
     



    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    Thermo Fisher Scientific Powder US Holdings Corp.
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    CO
     
     
     
     




    CUSIP NO. 808644108

    1
    NAMES OF REPORTING PERSONS
     
     
    Thermo Fisher Scientific Inc.
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    CO
     
     
     
     



    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
     
    Fisher Scientific International LLC

     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
     0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     


    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
     
    Fisher Scientific Worldwide Inc.

     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    CO
     
     
     
     
     


    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
    Spectra-Physics Holdings USA, LLC
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Delaware
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     

     


    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
    Thermo Fisher Scientific Powder Holdings I Ltd
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Cayman Islands
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     

     


    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
    Thermo Fisher Scientific Powder Holdings II Ltd
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Cayman Islands
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     

     


    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
    Thermo Fisher Scientific Powder Holdings III Ltd
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Cayman Islands
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     

     


    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
    Thermo Fisher Scientific Powder Holdings IV Ltd
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    Cayman Islands
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     

     


    CUSIP NO. 808644108
     
    1
    NAMES OF REPORTING PERSONS
     
     
    Thermo Fisher Scientific Powder US Holdings Ltd
     
     
     
     
    2
    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (a)
    ☐
     
    (b)
    ☐
     
     
    3
    SEC USE ONLY
     
     
     
     
     
     
     
    4
    SOURCE OF FUNDS (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     
    5
    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)
     
    ☐
     
     
     
     
     
    6
    CITIZENSHIP OR PLACE OF ORGANIZATION
     
     
    United Kingdom
     
     
     
     
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
    7
    SOLE VOTING POWER
     
     
    0
     
     
     
     
    8
    SHARED VOTING POWER
     
     
    0
     
     
     
     
    9
    SOLE DISPOSITIVE POWER
     
     
    0
     
     
     
     
    10
    SHARED DISPOSITIVE POWER
     
     
    0
     
     
     
     
    11
    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     
     
    0
     
     
     
     
    12
    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
     
    ☐
     
     
     
     
     
    13
    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     
     
    0%
     
     
     
     
    14
    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
     
     
    OO
     
     
     
     



    Explanatory Note

    This Amendment No. 1 to Schedule 13D (this “Amendment”) amends and supplements the previously filed statement on Schedule 13D filed on December 20, 2021 (as amended and supplemented from time to time, the “Schedule 13D”).

    Except as set forth below, all Items of the Schedule 13D remain unchanged. Capitalized terms used in this Amendment and not otherwise defined shall have the respective meanings assigned to such terms in the Schedule 13D.

    Item 1. Security and Issuer

    Item 1 of the Schedule 13D is hereby amended and restated as follows:

    The Schedule 13D relates to the common stock, par value $0.0001 per share (“Common Stock”), of Science 37 Holdings, Inc. (formerly known as LifeSci Acquisition II Corp.), a Delaware corporation (the “Issuer”). The principal executive offices of the Issuer are located at 800 Park Offices Drive, Suite 3606, Research Triangle Park, North Carolina 27709.

    Item 2. Identity and Background

    Item 2 of the Schedule 13D is hereby amended and restated as follows:

    This Schedule 13D is filed jointly on behalf of Thermo Fisher Scientific Inc. (“Thermo Fisher”), Thermo Fisher Scientific Powder US Holdings Corp. (“Powder Holdings”),  PPD, Inc. (“PPD”), Eagle Holding Company II, LLC (“Eagle II”), Jaguar Holding Company I, LLC (“Jaguar I”), Jaguar Holding Company II (“Jaguar II”), Wildcat Acquisition Holdings (UK) Limited (“Wildcat”) and Pharmaceutical Product Development, LLC (“Pharma LLC”), Fisher Scientific International LLC (“Scientific International”), Fisher Scientific Worldwide Inc. (“Worldwide”), Spectra-Physics Holdings USA, LLC (“Spectra-Physics”), Thermo Fisher Scientific Powder Holdings I Ltd (“Powder Holdings I”), Thermo Fisher Scientific Powder Holdings II Ltd (“Powder Holdings II”), Thermo Fisher Scientific Powder Holdings III Ltd (“Powder Holdings III”), Thermo Fisher Scientific Powder Holdings IV Ltd (“Powder Holdings IV”), Thermo Fisher Scientific Powder US Holdings Ltd (“US Holdings” and, collectively with Thermo Fisher, Powder Holdings, PPD, Eagle II, Jaguar I, Jaguar II, Wildcat, Pharma LLC, Scientific International, Worldwide, Spectra-Physics, Powder Holdings I, Powder Holdings II, Powder Holdings III and Powder Holdings IV the “Reporting Persons”).

    Thermo Fisher is a Delaware corporation and is a leading supplier of scientific instrumentation, reagents and consumables and software services. Thermo Fisher conducts its business operations through its direct and indirect subsidiaries, including Powder Holdings, for which it is the sole shareholder. Powder Holdings is Delaware corporation whose principal business is serving as the sole shareholder of PPD. PPD is a Delaware corporation and is a leading provider of drug development services to the biopharmaceutical industry. PPD conducts its business operations through its direct and indirect subsidiaries, including Eagle II, for which it serves as sole member. Eagle II is a Delaware limited liability company whose principal business is serving as the sole member of Jaguar I. Jaguar I is a Delaware limited liability company whose principal business is serving as the sole shareholder of Jaguar II. Jaguar II is a Delaware corporation whose principal business is serving as the sole shareholder of Wildcat. Wildcat is a corporation organized under the laws of the United Kingdom whose principal business is serving as the sole member of Pharma LLC. Pharma LLC is a Delaware limited liability company whose principal business is providing of drug development services to the biopharmaceutical industry and investing in securities of the Issuer. Scientific International is a Delaware limited liability company whose principal business is serving as the sole shareholder of Worldwide. Worldwide is a Delaware corporation whose principal business is serving as the sole member of Spectra-Physics. Spectra-Physics is a Delaware limited liability company whose principal business is serving as the sole shareholder of Powder Holdings I. Powder Holdings I is a limited company organized under the laws of the Cayman Islands whose principal business is serving as the 88.24% shareholder of Powder Holdings II. Powder Holdings II is a limited company organized under the laws of the Cayman Islands whose principal business is serving as the sole shareholder of US Holdings. Powder Holdings III is a limited company organized under the laws of the Cayman Islands whose principal business is serving as the sole shareholder of Powder Holdings IV. Powder Holdings IV is a limited company organized under the laws of the Cayman Islands whose principal business is serving as the 11.76% shareholder of Powder Holdings II. US Holdings is a limited company organized under the laws of England and Wales whose principal business is serving as the sole shareholder of Powder Holdings.





    The principal office of each of PPD, Eagle II, Jaguar I, Jaguar II, Pharma LLC and Wildcat is 929 North Front Street, Wilmington, North Carolina 28401 and the principal office of each of Thermo Fisher, Powder Holdings, Scientific International, Worldwide, Spectra-Physics, Powder Holdings I, Powder Holdings II, Powder Holdings III, Powder Holdings IV and US Holdings is 168 Third Avenue, Waltham, Massachusetts 02451.

    Information regarding each director and executive officer of PPD is set forth on Schedule I attached hereto, which is incorporated herein by reference in response to this Item 2. Information regarding each director and executive officer of Thermo Fisher and Powder Holdings is set forth on Schedule II attached hereto, which is incorporated herein by reference in response to this Item 2. Information regarding each director and executive officer of Worldwide Holdings is set forth on Schedule III attached hereto, which is incorporated herein by reference in response to this Item 2.

    To the best knowledge of the Reporting Persons, none of the entities or persons identified in the previous paragraphs of this Item 2 has, during the past five years, been convicted of any criminal proceeding (excluding traffic violations or similar misdemeanors), nor been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

    The Reporting Persons have entered into an agreement of joint filing, a copy of which is attached hereto as Exhibit E.

    Item 3. Source and Amount of Funds or Other Consideration

    Item 3 of the Schedule 13D is hereby amended and supplemented by adding the following paragraphs to the end thereof:

    On December 8, 2023, Science 37 effected a reverse stock split of its common stock at a ratio of 1-for-20 (the “Reverse Stock Split”). As a result of the Reverse Stock Split, the Reporting Persons beneficially owned 868,990 shares of Common Stock.

    On January 28, 2024, eMED, LLC (“eMED”), Marlin Merger Sub Corporation, a Delaware corporation and a wholly owned subsidiary of eMED (“Marlin”), and Science 37 entered into an Agreement and Plan of Merger, dated as of January 28, 2024 (the “eMED Plan of Merger”), which contemplated a tender offer (the “Tender Offer”) to be commenced by Marlin to acquire all shares of Common Stock issued and outstanding. In connection with the eMED Plan of Merger, eMED, Marlin and Pharma LLC entered into a Tender and Support Agreement (the “Tender and Support Agreement”), pursuant to which Pharma LLC agreed to tender all shares of Common Stock that it owned in the Tender Offer.

    After the commencement of the Tender Offer and pursuant to the terms of the Tender and Support Agreement (as described further in Item 6 of the Schedule 13D), Pharma LLC tendered all shares of Common Stock beneficially owned by Thermo Fisher and its subsidiaries in the Tender Offer, and on March 12, 2024, eMED completed the Tender Offer for all the outstanding shares of Common Stock.





    Item 4. Purpose of Transaction

    Item 4 of the Schedule 13D is hereby amended and supplemented by adding the following paragraphs to the end thereof:

    On March 12, 2024, Marlin completed the Tender Offer and accepted for payment all shares of Common Stock validly tendered and not withdrawn, including the shares previously held by Pharma LLC, at a price of $5.75 per share (the “Offer Price”) in cash, without interest and subject to any tax withholding.

    In connection with the completion of the Tender Offer, the 868,990 shares of Common Stock beneficially owned by the Reporting Persons were converted into the right to receive the Offer Price.

    As a result of the completion of the Tender Offer, the Reporting Persons beneficially own no shares of Common Stock.

    Item 5. Interest in Securities of the Issuer

    Items 5(a)-(c) and 5(e) of the Schedule 13D are hereby amended and restated as follows:

    (a), (b) The following disclosure assumes that there are 6,029,528 shares of Common Stock outstanding, as set forth in the Issuer’s Schedule 14D-9 filed with the Securities and Exchange Commission (the “SEC”) on February 12, 2024.

    Pursuant to Rule 13d-3 of the rules and regulations promulgated by the SEC pursuant to the Securities Exchange Act of 1934, as amended (the “Exchange Act”), as of March 12, 2024, the Reporting Persons were deemed to beneficially own 0 shares of Common Stock, representing 0% of shares of Common Stock outstanding.

    None of the persons listed on Schedule I, Schedule II or Schedule III attached hereto is a beneficial owner of Common Stock.

    (c) The response to Item 4 of this Amendment is incorporated by reference herein. Other than as reported in this Amendment, none of the Reporting Persons, nor to their knowledge, any person listed on Schedule I, Schedule II or Schedule III, has effected any transaction in the shares of Common Stock since the filing of Schedule 13D on December 20, 2021.

    (e) As a result of the completion of the Tender Offer, on March 12, 2024, each of the Reporting Persons ceased to be the beneficial owner of more than five percent of the shares of Common Stock. The filing of this Amendment represents the final amendment to the Schedule 13D and constitutes an exit filing for each of the Reporting Persons.

    Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

    Item 6 of the Schedule 13D is hereby amended and supplemented by adding the following paragraphs to the end thereof:

    Tender and Support Agreement

    Pursuant to the Tender and Support Agreement, Pharma LLC agreed to, as promptly as practicable after the commencement of the Tender Offer, but in no event later than the expiration date of such Tender Offer, effect the valid tender of all shares of Common Stock owned by Pharma LLC pursuant to the terms of the Tender Offer. Pharma LLC also agreed not to withdraw such shares from the Tender Offer unless and until the Tender and Support Agreement has been terminated in accordance with the terms thereof. Further, Pharma LLC agreed to, at any annual or special meeting of the stockholders of Science 37, (a) cause all of its shares to be counted as present thereat for purposes of determining a quorum and (b) be present and vote, or deliver a written consent in respect to, all of the shares of Common Stock owned by it against any acquisition proposal or other action that is intended or would reasonably be expected to materially impede or interfere with or materially delay the Tender Offer or any other transactions contemplated by the eMED Plan of Merger. Pursuant to the Tender and Support Agreement, Pharma LLC validly tendered all of its shares of Common Stock in the Tender Offer.



    References to and descriptions of the Tender and Support Agreement set forth above are not intended to be complete and are qualified in their entirety by reference to the full text of such agreement, which is filed as Exhibit F hereto and incorporated by reference herein.

    Item 7. Material to Be Filed as Exhibits

    Item 7 of the Schedule 13D is hereby amended and supplemented by adding the following exhibit:

    E.
    Joint Filing Agreement by and among the Reporting Persons, dated as of March 14, 2024.

    F.
    Tender and Support Agreement, dated January 28, 2024, by and among eMED, LLC, Marlin Merger Sub Corporation and Pharmaceutical Product Development, LLC, (incorporated by reference to Exhibit 10.3 to Science 37’s Current Report on Form 8-K filed on January 29, 2024).



    Signatures

    After reasonable inquiry and to the best of its knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.

    Dated: March 14, 2024


     
    THERMO FISHER SCIENTIFIC INC.
     
         
         
     
    By:
    /s/ Michael Boxer
     
     
    Name:
    Michael Boxer
     
     
    Title:
    Senior Vice President and General Counsel
     


     
    THERMO FISHER SCIENTIFIC POWDER US HOLDINGS CORP.
     
         
         
     
    By:
    /s/ Anthony H. Smith
     
     
    Name:
    Anthony H. Smith
     
     
    Title:
    President
     


     
    PPD, INC.
     
         
         
     
    By:
    /s/ Julia James
     
     
    Name:
    Julia James
     
     
    Title:
    General Counsel and Assistant Secretary
     


     
    EAGLE HOLDING COMPANY II, LLC
     
         
         
     
    By:
    /s/ Julia James
     
     
    Name:
    Julia James
     
     
    Title:
    Executive Vice President, General Counsel and Secretary
     


     
    JAGUAR HOLDING COMPANY I, LLC
     
         
     
    By: Eagle Holding Company II, LLC, its Managing Member
     
         
     
    By:
    /s/ Julia James
     
     
    Name:
    Julia James
     
     
    Title:
    Assistant Secretary
     


     
    JAGUAR HOLDING COMPANY II
     
         
         
     
    By:
    /s/ Julia James  
     
    Name:
    Julia James
     
     
    Title:
    Executive Vice President and General Counsel
     



    [Schedule 13D/A Signature Page]



     
    WILDCAT ACQUISITION HOLDINGS (UK) LIMITED
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Director
     


     
    PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC
     
         
         
     
    By:
    /s/ Julia James
     
     
    Name:
    Julia James
     
     
    Title:
    Executive Vice President, General Counsel and Secretary
     


     
    FISHER SCIENTIFIC INTERNATIONAL LLC
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Vice President and Treasurer
     


     
    FISHER SCIENTIFIC WORLDWIDE INC. 
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Treasurer and Assistant Secretary
     


     
    SPECTRA-PHYSICS HOLDINGS USA, LLC
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Treasurer and Assistant Secretary
     


     
    THERMO FISHER SCIENTIFIC POWDER HOLDINGS I LTD
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Director
     



    [Schedule 13D/A Signature Page]



     
    THERMO FISHER SCIENTIFIC POWDER HOLDINGS II LTD
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Director
     


     
    THERMO FISHER SCIENTIFIC POWDER HOLDINGS III LTD
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Director
     


     
    THERMO FISHER SCIENTIFIC POWDER HOLDINGS IV LTD
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Director
     


     
    THERMO FISHER SCIENTIFIC POWDER US HOLDINGS LTD
     
         
         
     
    By:
    /s/ Anthony H. Smith  
     
    Name:
    Anthony H. Smith
     
     
    Title:
    Director
     



    [Schedule 13D/A Signature Page]



    SCHEDULE I

    Executive Officers and Directors of PPD, Inc.

    The name and principal occupation of each director and executive officer of PPD, Inc. are set forth below. The address for each person listed below is c/o PPD, Inc., 929 North Front Street, Wilmington, North Carolina 28401. All executive officers and directors listed are United States citizens other than Julia James, who is a citizen of the United Kingdom.

    EXECUTIVE OFFICERS:

    Name
    Present Principal Occupation or Employment
       
    Julia L. Chen
    Vice President and Secretary, Thermo Fisher Scientific Inc.
    Michael Boxer
    Senior Vice President and General Counsel, Thermo Fisher Scientific Inc.
    James E. Bruni
    Assistant Secretary, Thermo Fisher Scientific Inc.
    Julia James
    Vice President, Legal, Thermo Fisher Scientific Inc.
    Kelly McGinnis
    Vice President, Finance, Thermo Fisher Scientific Inc.
    Michael K. Michaud
    Assistant Secretary, Thermo Fisher Scientific Inc.
    Anthony Hugh Smith
    Vice President, Tax and Treasury, and Treasurer, Thermo Fisher Scientific Inc.
    Maura A. Spellman
    Assistant Treasurer, Thermo Fisher Scientific Inc.

    DIRECTORS:

    Name
    Present Principal Occupation or Employment
       
    Julia L. Chen
    Vice President and Secretary, Thermo Fisher Scientific Inc.
    Anthony Hugh Smith
    Vice President, Tax and Treasury, and Treasurer, Thermo Fisher Scientific Inc.
    Maura A. Spellman
    Assistant Treasurer, Thermo Fisher Scientific Inc.





    SCHEDULE II

    The name and principal occupation of each director and executive officer of Thermo Fisher Scientific Powder US Holdings Corp. and Thermo Fisher Scientific Inc. are set forth below. The address for each person listed below is c/o Thermo Fisher Scientific Inc., 168 Third Avenue, Waltham, Massachusetts 02451. All executive officers and directors listed are United States citizens other than Lars R. Sørensen, who is a citizen of Denmark, and Dion Weisler, who is a citizen of Australia.

    Thermo Fisher Scientific Powder US Holdings Corp.

    EXECUTIVE OFFICERS:

    Name
    Present Principal Occupation or Employment
       
    Anthony Hugh Smith
    Vice President, Tax and Treasury, and Treasurer, Thermo Fisher Scientific Inc.
    Maura A. Spellman
    Assistant Treasurer, Thermo Fisher Scientific Inc.
    James E. Bruni
    Assistant Secretary, Thermo Fisher Scientific Inc.
    Michael K. Michaud
    Assistant Secretary, Thermo Fisher Scientific Inc.

    DIRECTORS:

    Name
    Present Principal Occupation or Employment
       
    Anthony Hugh Smith
    Vice President, Tax and Treasury, and Treasurer, Thermo Fisher Scientific Inc.


    Thermo Fisher Scientific Inc.

    EXECUTIVE OFFICERS:

    Name
    Present Principal Occupation or Employment
       
    Michael Boxer
    Senior Vice President and General Counsel, Thermo Fisher Scientific Inc.
    Marc N. Casper
    Chairman, President and Chief Executive Officer, Thermo Fisher Scientific Inc.
    Michel Lagarde
    Executive Vice President and Chief Operating Officer, Thermo Fisher Scientific Inc.
    Gianluca Pettiti
     
    Executive Vice President, Thermo Fisher Scientific Inc.
    Stephen Williamson
    Senior Vice President and Chief Financial Officer, Thermo Fisher Scientific Inc.
    Lisa P. Britt
    Senior Vice President and Chief Human Resources Officer, Thermo Fisher Scientific Inc.
    Joseph R. Holmes
    Vice President and Chief Accounting Officer, Thermo Fisher Scientific Inc.

    DIRECTORS:

    Name
    Present Principal Occupation or Employment
       
    Marc N. Casper
    Chairman, President and Chief Executive Officer, Thermo Fisher Scientific Inc.
    Nelson J. Chai
    Retired CFO, Uber Technologies Inc.
    Ruby R. Chandy
    Retired President, Pall Corporation
    C. Martin Harris
    Vice President of the Health Enterprise, Chief Business Officer and Professor, University of Texas Austin, Dell Medical School
    Tyler Jacks
    President, Break Through Cancer
    Jennifer M. Johnson
    President and CEO, Franklin Resources, Inc.





    R. Alexandra Keith
    Chief Executive Officer, P&G Beauty, Proctor & Gamble Company
    James C. Mullen
    Retired Chairman, President and Chief Executive Officer, Editas Medicine, Inc.
    Lars R. Sørensen
    Retired President and CEO of Novo Nordisk A/S
    Debora L. Spar
    Professor, Harvard Business School
    Scott M. Sperling
    Co-Chief Executive Officer, Thomas H. Lee Partners, LP
    Dion J. Weisler
    Retired President and CEO, HP Inc.




    SCHEDULE III

    Executive Officers and Directors of Fisher Scientific Worldwide Inc.

    The name and principal occupation of each director and executive officer of Fisher Scientific Worldwide Inc. are set forth below. The address for each person listed below is c/o Thermo Fisher Scientific Inc., 168 Third Avenue, Waltham, Massachusetts 02451. All executive officers and directors listed are United States citizens.

    EXECUTIVE OFFICERS:

    Name
    Present Principal Occupation or Employment
       
    Julia L. Chen
    Vice President and Secretary, Thermo Fisher Scientific Inc.
    James E. Bruni
    Assistant Secretary, Thermo Fisher Scientific Inc.
    Michael K. Michaud
    Assistant Secretary, Thermo Fisher Scientific Inc.
    John B. Sabo
    Vice President, Legal, Thermo Fisher Scientific Inc.
    Anthony Hugh Smith
    Vice President, Tax and Treasury, and Treasurer, Thermo Fisher Scientific Inc.
    Maura A. Spellman
    Assistant Treasurer, Thermo Fisher Scientific Inc.


    DIRECTORS:

    Name
    Present Principal Occupation or Employment
       
    Julia L. Chen
    Vice President and Secretary, Thermo Fisher Scientific Inc.







    Exhibit E

    JOINT FILING AGREEMENT

    PURSUANT TO RULE 13D-1(K)(1)

    The undersigned acknowledge and agree that the Statement on Schedule 13D filed with the Securities and Exchange Commission on or about the date hereof with respect to the beneficial ownership by the undersigned of the shares of Common Stock, par value $0.0001 per share, of Science 37 Holdings, Inc. is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13D shall be filed on behalf of each of the undersigned that is named as a reporting person in such filing without the necessity of filing an additional joint filing agreement. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the others, except to the extent that it knows or has reason to believe that such information is inaccurate. This joint filing agreement may be executed in any number of counterparts and all of such counterparts taken together shall constitute one and the same instrument.

    Dated: March 14, 2024
     
      THERMO FISHER SCIENTIFIC INC.  
           
           

    By:
    /s/ Michael Boxer  
        Name: Michael Boxer  
        Title:
    Senior Vice President and General Counsel
     
           


      THERMO FISHER SCIENTIFIC POWDER US HOLDINGS CORP.  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title:
    President
     
           


      PPD, INC.  
           
           

    By:
    /s/ Julia James  
        Name:
    Julia James
     
        Title:
    General Counsel and Assistant Secretary
     
           


      EAGLE HOLDING COMPANY II, LLC  
           
           

    By:
    /s/ Julia James  
        Name: Julia James  
        Title:
    Executive Vice President, General Counsel and Secretary
     
           




      JAGUAR HOLDING COMPANY I, LLC  
      By: Eagle Holding Company II, LLC, its Managing Member  
           
           

    By:
    /s/ Julia James  
        Name: Julia James  
        Title: Assistant Secretary  
           


      JAGUAR HOLDING COMPANY II  
           
           

    By:
    /s/ Julia James  
        Name: Julia James  
        Title: Executive Vice President and General Counsel  
           


      WILDCAT ACQUISITION HOLDINGS (UK) LIMITED  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Director  
           


      PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC  
           
           

    By:
    /s/ Julia James  
        Name: Julia James  
        Title:
    Executive Vice President, General Counsel and Secretary
     
           


     


      FISHER SCIENTIFIC INTERNATIONAL LLC  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Vice President and Treasurer  
           


      FISHER SCIENTIFIC WORLDWIDE INC.  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Treasurer and Assistant Secretary  
           


      SPECTRA-PHYSICS HOLDINGS USA, LLC  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Treasurer and Assistant Secretary  
           


      THERMO FISHER SCIENTIFIC POWDER HOLDINGS I LTD  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Director  
           


      THERMO FISHER SCIENTIFIC POWDER HOLDINGS II LTD  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Director  
           


      THERMO FISHER SCIENTIFIC POWDER HOLDINGS III LTD  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Director  
           





      THERMO FISHER SCIENTIFIC POWDER HOLDINGS IV LTD  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Director  
           


      THERMO FISHER SCIENTIFIC POWDER US HOLDINGS LTD  
           
           

    By:
    /s/ Anthony H. Smith  
        Name: Anthony H. Smith  
        Title: Director  
           






    Get the next $SNCE alert in real time by email

    Chat with this insight

    Save time and jump to the most important pieces.

    Recent Analyst Ratings for
    $SNCE

    DatePrice TargetRatingAnalyst
    11/1/2021$15.00Buy
    Lake Street
    11/1/2021$15.00Outperform
    Robert W. Baird
    11/1/2021Outperform
    William Blair
    11/1/2021$15.00Outperform
    Baird
    10/22/2021$14.00Outperform
    Cowen & Co.
    More analyst ratings

    $SNCE
    Leadership Updates

    Live Leadership Updates

    See more
    • Science 37 Appoints Tyler Van Horn as CEO to Lead Next Era of Patient-Access Innovation

      MORRISVILLE, N.C., Jan. 14, 2025 (GLOBE NEWSWIRE) -- Science 37, a leader in enhancing patient access to clinical trials, announces the appointment of Tyler Van Horn as Chief Executive Officer. Formerly the company's Chief Commercial Officer, Van Horn's appointment follows his pivotal role in driving operational excellence and shaping the company's strategic direction to better prioritize client success – initiatives credited with driving growth for the company. Since joining Science 37 in 2021, Van Horn has been a chief architect in assembling and empowering a team capable of matching or surpassing the testing standards and data quality of traditional clinical trial sites. By emphasizing

      1/14/25 8:00:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • Science 37 Appoints SVP, Erica Prowisor, to Bolster Patient Recruitment Velocity, Diversity

      RESEARCH TRIANGLE PARK, N.C., April 25, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (NASDAQ:SNCE), the industry-leading Metasite™, announced today Erica Prowisor as SVP of Patient and Provider Networks to accelerate patient recruitment, ensure participant diversity and gain operational efficiencies. Erica has been forging new ground as a leader in patient recruitment for nearly 20 years, most notably with IQVIA where she was Global Head of Recruitment and Retention for more than three years and led the company's direct-to-patient recruitment and retention efforts. Prior to IQVIA, Erica spent 11 years with Acurian through the acquisition by PPD where she was Head of Enrollment Opera

      4/25/23 7:59:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • Science 37 Adds New Head of Quality, Irena Lambridis

      RESEARCH TRIANGLE PARK, N.C., April 18, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (NASDAQ:SNCE), the industry-leading Metasite™, today announced the appointment of Irena Lambridis as its Global Head of Quality Assurance & Compliance. Irena will be responsible for overseeing quality and compliance across all functions, including the Company's newly announced global Centers of Excellence in India, Pakistan, and Slovakia. This key appointment reflects Science 37's commitment to quality as it expands operations globally. Irena brings nearly two decades of experience in clinical research quality assurance, having held senior leadership positions at KCR and Novella Clinical (now IQVIA

      4/18/23 7:59:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology

    $SNCE
    Financials

    Live finance-specific insights

    See more
    • Science 37 Reports Third Quarter 2023 Financial Results

      RESEARCH TRIANGLE PARK, N.C., Nov. 07, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (NASDAQ:SNCE), ("Science 37"), the industry-leading Metasite™, today reported its financial results for the quarter ended September 30, 2023. "Our third quarter results were highlighted by continued quarterly improvements in our key profitability metrics and cash burn rate," stated David Coman, Chief Executive Officer of Science 37. "We look forward to a strong finish to the year and positive momentum headed into 2024." Quarterly Financial Highlights Gross bookings were $17.9 million for the quarter ended September 30, 2023, a 50.6%

      11/7/23 6:00:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • Science 37 to Report Third Quarter 2023 Financial Results on November 7, 2023

      RESEARCH TRIANGLE PARK, N.C., Oct. 24, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (NASDAQ:SNCE), the industry-leading Metasite™ today announced it will report third quarter 2023 financial results prior to the market open on Tuesday, November 7, 2023. The Science 37 management team will host a conference call to discuss these results on November 7, 2023, at 8:30 a.m. Eastern Time. The call can be accessed by dialing 1-877-269-7751 (toll-free domestic) or 1-201-389-0908 (international) and using the Conference ID 13741458 or by utilizing the Call me™ feature using this link to request a return call for instant telephone access to the event. The live webcast may be accessed via the i

      10/24/23 6:00:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • Science 37 Reports Second Quarter 2023 Financial Results

      RESEARCH TRIANGLE PARK, N.C., Aug. 08, 2023 (GLOBE NEWSWIRE) -- Science 37 Holdings, Inc. (NASDAQ:SNCE), ("Science 37"), the industry-leading Metasite™, today reported its financial results for the quarter ended June 30, 2023. "The actions we have taken over the past nine months are leading to meaningful improvements as evidenced by our sequential quarterly results including growth in gross bookings and gross profit margins along with a reduction in cash burn," stated David Coman, Chief Executive Officer of Science 37. "We look forward to finishing the year strong and continuing to position the company for sustainable financial growth and shareholder value creation." Quarterly Financial

      8/8/23 6:00:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology

    $SNCE
    SEC Filings

    See more
    • SEC Form 15-12G filed by Science 37 Holdings Inc.

      15-12G - Science 37 Holdings, Inc. (0001819113) (Filer)

      3/22/24 6:50:27 PM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • SEC Form EFFECT filed by Science 37 Holdings Inc.

      EFFECT - Science 37 Holdings, Inc. (0001819113) (Filer)

      3/15/24 12:15:04 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • SEC Form EFFECT filed by Science 37 Holdings Inc.

      EFFECT - Science 37 Holdings, Inc. (0001819113) (Filer)

      3/15/24 12:15:11 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology

    $SNCE
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • Lake Street initiated coverage on Science 37 with a new price target

      Lake Street initiated coverage of Science 37 with a rating of Buy and set a new price target of $15.00

      11/1/21 9:12:40 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • Robert W. Baird initiated coverage on Science 37 with a new price target

      Robert W. Baird initiated coverage of Science 37 with a rating of Outperform and set a new price target of $15.00

      11/1/21 7:43:34 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • William Blair initiated coverage on Science 37 Hldgs

      William Blair initiated coverage of Science 37 Hldgs with a rating of Outperform

      11/1/21 5:42:17 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology

    $SNCE
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • SEC Form SC 13D/A filed by Science 37 Holdings Inc. (Amendment)

      SC 13D/A - Science 37 Holdings, Inc. (0001819113) (Subject)

      3/14/24 4:17:56 PM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • SEC Form SC 13D/A filed by Science 37 Holdings Inc. (Amendment)

      SC 13D/A - Science 37 Holdings, Inc. (0001819113) (Subject)

      3/13/24 5:15:52 PM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • SEC Form SC 13D/A filed by Science 37 Holdings Inc. (Amendment)

      SC 13D/A - Science 37 Holdings, Inc. (0001819113) (Subject)

      1/31/24 5:15:22 PM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology

    $SNCE
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • Science 37 Completes Second FDA Inspection as Enrollment Leader in Phase 3 Asthma Trial

      MORRISVILLE, N.C., April 08, 2025 (GLOBE NEWSWIRE) -- Science 37, a leader in enhancing patient access to clinical trials, today announced the successful completion of its second FDA inspection, reaffirming the quality of its Direct-to-Patient Site for clinical research. The inspection resulted in a No Action Indicated (NAI) categorization, with no objectionable conditions noted and no Form 483 issued. Led by Science 37's internal Quality Assurance & Compliance team, the inspection focused on the company's role in a registrational Phase 3 asthma study, which Science 37 contributed 28% of the total patient enrollment. The FDA evaluated internal processes, technology, data integrity, patien

      4/8/25 8:00:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • Science 37 Appoints Tyler Van Horn as CEO to Lead Next Era of Patient-Access Innovation

      MORRISVILLE, N.C., Jan. 14, 2025 (GLOBE NEWSWIRE) -- Science 37, a leader in enhancing patient access to clinical trials, announces the appointment of Tyler Van Horn as Chief Executive Officer. Formerly the company's Chief Commercial Officer, Van Horn's appointment follows his pivotal role in driving operational excellence and shaping the company's strategic direction to better prioritize client success – initiatives credited with driving growth for the company. Since joining Science 37 in 2021, Van Horn has been a chief architect in assembling and empowering a team capable of matching or surpassing the testing standards and data quality of traditional clinical trial sites. By emphasizing

      1/14/25 8:00:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • Science 37 Nearly Doubles U.S. Enrollment for GSK Phase 3 Rare Disease Trial

      MORRISVILLE, N.C., Nov. 21, 2024 (GLOBE NEWSWIRE) -- Science 37, a leader in enhancing patient access to clinical trials, was a key enrolling site for the primary completion of a Phase 3 rare disease trial sponsored by global biopharmaceutical company, GSK. The hepatology study of an investigational medicine for cholestatic pruritus in primary biliary cholangitis (PBC) required 230 global participants, of which Science 37 was able to contribute almost half (17 - 47%) of the U.S. enrollment for the study. Recognizing that the available participant population for rare disease studies is often extremely limited and dispersed globally, GSK welcomed an innovative approach to expanding trial

      11/21/24 8:00:00 AM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology

    $SNCE
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • SEC Form 4 filed by Thermo Fisher Scientific Inc.

      4 - Science 37 Holdings, Inc. (0001819113) (Issuer)

      3/14/24 4:26:37 PM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • SEC Form 4 filed by Thermo Fisher Scientific Inc.

      4 - Science 37 Holdings, Inc. (0001819113) (Issuer)

      3/14/24 4:25:33 PM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology
    • New insider Thermo Fisher Scientific Inc. claimed ownership of 17,379,797 shares (SEC Form 3) (Amendment)

      3/A - Science 37 Holdings, Inc. (0001819113) (Issuer)

      3/14/24 4:20:09 PM ET
      $SNCE
      Computer Software: Prepackaged Software
      Technology