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    SEC Form SC 13D/A filed by Tempest Therapeutics Inc. (Amendment)

    2/8/24 5:41:56 PM ET
    $TPST
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $TPST alert in real time by email
    SC 13D/A 1 d768185dsc13da.htm SC 13D/A SC 13D/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13D

    (Rule 13d-102)

    INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT

    TO RULE 13d-l(a) AND AMENDMENTS THERETO FILED PURSUANT

    TO RULE 13d-2(a)

    (Amendment No. 2)*

     

     

    Tempest Therapeutics, Inc.

    (Name of Issuer)

    Common Stock, par value $0.001 per share

    (Title of Class of Securities)

    87978U108

    (CUSIP Number)

    Versant Venture Capital VI, L.P.

    Max Eisenberg

    One Sansome Street, Suite 1650

    San Francisco, CA 94104

    415-801-8100

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

    November 8, 2023

    (Date of Event Which Requires Filing of this Statement)

     

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

     

     

     


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Venture Capital VI, L.P.

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b)  ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    WC

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With

       7.   

    Sole Voting Power

     

    997,940 shares of Common Stock (2)

       8.   

    Shared Voting Power

     

    0

       9.   

    Sole Dispositive Power

     

    997,940 shares of Common Stock (2)

       10.   

    Shared Dispositive Power

     

    0

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    997,940 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    5.2% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    PN

     

    (1)

    This Schedule 13D is filed by Versant Venture Capital IV, L.P. (“Versant IV”), Versant Side Fund IV, L.P. (“Side Fund IV”), Versant Ventures IV, LLC (“LLC IV”), Versant Venture Capital VI, L.P. (“Versant VI”), Versant Ventures VI GP, L.P. (“GP VI”), Versant Ventures VI GP-GP, LLC (“LLC VI”), Versant Vantage II, L.P. (“Vantage II LP”), Versant Vantage II GP, L.P. (“Vantage II GP”), Versant Vantage II GP-GP, LLC (“Vantage II LLC” and, with Versant IV, Side Fund IV, LLC IV, Versant VI, GP VI, LLC VI, Vantage II LP and Vantage II GP, collectively, the “Reporting Persons”). LLC IV is the general partner of Versant IV and Side Fund IV, and LLC IV has voting and dispositive power over the shares held by Versant IV and Side Fund IV. LLC VI is the general partner of GP VI, which is the general partner of Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI. Vantage II LLC is the general partner of Vantage II GP, which is the general partner of Vantage II LP. Each of Vantage II LLC and Vantage II GP share voting and dispositive power over the shares held by Vantage II LP. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Versant VI. LLC VI is the general partner of GP VI, which is the general partner of Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Issuer’s quarterly report on Form 10-Q for the quarter ended September 30, 2023, filed with the United States Securities and Exchange Commission (the “Commission”) on November 8, 2023 (the “Form 10-Q”).


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Ventures VI GP, L.P.

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b)  ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    AF

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With

       7.   

    Sole Voting Power

     

    0

       8.   

    Shared Voting Power

     

    997,940 shares of Common Stock (2)

       9.   

    Sole Dispositive Power

     

    0

       10.   

    Shared Dispositive Power

     

    997,940 shares of Common Stock (2)

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    997,940 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    5.2% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    PN

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Versant VI. LLC VI is the general partner of GP VI, which is the general partner of Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Ventures VI GP-GP, LLC

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b)  ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    AF

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With

       7.   

    Sole Voting Power

     

    0

       8.   

    Shared Voting Power

     

    997,940 shares of Common Stock (2)

       9.   

    Sole Dispositive Power

     

    0

       10.   

    Shared Dispositive Power

     

    997,940 shares of Common Stock (2)

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    997,940 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    5.2% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    OO

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Versant VI. LLC VI is the general partner of GP VI, which is the general partner of Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Vantage II, L.P.

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b) ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    WC

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With

       7.   

    Sole Voting Power

     

    2,118,644 shares of Common Stock (2)

       8.   

    Shared Voting Power

     

    0

       9.   

    Sole Dispositive Power

     

    2,118,644 shares of Common Stock (2)

       10.   

    Shared Dispositive Power

     

    0

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    2,118,644 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    11.0% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    PN

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Vantage II LP. Vantage II LLC is the general partner of Vantage II GP, which is the general partner of Vantage II LP. Each of Vantage II LLC and Vantage II GP share voting and dispositive power over the shares held by Vantage II LP and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Vantage II GP, L.P.

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b) ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    AF

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With

       7.   

    Sole Voting Power

     

    0

       8.   

    Shared Voting Power

     

    2,118,644 shares of Common Stock (2)

       9.   

    Sole Dispositive Power

     

    0

       10.   

    Shared Dispositive Power

     

    2,118,644 shares of Common Stock (2)

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    2,118,644 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    11.0% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    PN

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Vantage II LP. Vantage II LLC is the general partner of Vantage II GP, which is the general partner of Vantage II LP. Each of Vantage II LLC and Vantage II GP share voting and dispositive power over the shares held by Vantage II LP and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Vantage II GP-GP, LLC

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b) ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    AF

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With:

       7.   

    Sole Voting Power

     

    0

       8.   

    Shared Voting Power

     

    2,118,644 shares of Common Stock (2)

       9.   

    Sole Dispositive Power

     

    0

       10.   

    Shared Dispositive Power

     

    2,118,644 shares of Common Stock (2)

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    2,118,644 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    11.0% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    OO

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Vantage II LP. Vantage II LLC is the general partner of Vantage II GP, which is the general partner of Vantage II LP. Each of Vantage II LLC and Vantage II GP share voting and dispositive power over the shares held by Vantage II LP and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Venture Capital IV, L.P.

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b) ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    WC

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With:

       7.   

    Sole Voting Power

     

    1,171,094 shares of Common Stock (2)

       8.   

    Shared Voting Power

     

    0

       9.   

    Sole Dispositive Power

     

    1,171,094 shares of Common Stock (2)

       10.   

    Shared Dispositive Power

     

    0

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    1,171,094 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    6.1% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    PN

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Versant IV. LLC IV is the general partner of Versant IV and has voting and dispositive power over the shares held by Versant IV and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Side Fund IV, L.P.

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b) ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    WC

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With

       7.   

    Sole Voting Power

     

    7,377 shares of Common Stock (2)

       8.   

    Shared Voting Power

     

    0

       9.   

    Sole Dispositive Power

     

    7,377 shares of Common Stock (2)

       10.   

    Shared Dispositive Power

     

    0

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    7,377 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    0.0% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    PN

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    These shares are held by Side Fund IV. LLC IV is the general partner of Side Fund IV and has voting and dispositive power over the shares held by Side Fund IV and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    1.   

    Name of Reporting Persons

     

    Versant Ventures IV, LLC

    2.   

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ☐  (b) ☒(1)

     

    3.   

    SEC Use Only

     

    4.   

    Source of Funds (See Instructions)

     

    AF

    5.   

    Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)

     

    ☐

    6.   

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially  

    Owned by

    Each

    Reporting

    Person

    With

       7.   

    Sole Voting Power

     

    0

       8.   

    Shared Voting Power

     

    1,178,471 shares of Common Stock (2)

       9.   

    Sole Dispositive Power

     

    0

       10.   

    Shared Dispositive Power

     

    1,178,471 shares of Common Stock (2)

    11.   

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    1,178,471 shares of Common Stock (2)

    12.   

    Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

     

    ☐

    13.   

    Percent of Class Represented by Amount in Row 11

     

    6.1% (3)

    14.   

    Type of Reporting Person (See Instructions)

     

    OO

     

    (1)

    This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

    (2)

    Includes (i) 1,171,094 shares held by Versant IV; and (ii) 7,377 shares held by Side Fund IV. LLC IV is the general partner of Versant IV and Side Fund IV, and LLC IV has voting and dispositive power over the shares held by each of Versant IV and Side Fund IV and as a result may be deemed to have beneficial ownership over such securities.

    (3)

    Based on 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as set forth in the Form 10-Q.


    CUSIP No. 87978U108       13D

     

    Explanatory Note:

    This Amendment No. 2 (this “Amendment”) amends and supplements the Schedule 13D originally filed by the Reporting Persons with the Commission on May 9, 2022, as amended by Amendment No. 1 filed with the Commission on November 9, 2023 (the “Original Schedule 13D”). Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13D remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original Schedule 13D.

    Item 5. Interest in Securities of the Issuer

    This information reported below is based on a total of 19,247,495 shares of the Issuer’s Common Stock outstanding as of November 7, 2023, as reported on the Issuer’s Form 10-Q filed with the Commission on November 8, 2023. This Amendment is being filed to update the aggregate percentage of the Issuer’s Common Stock owned by the Reporting Persons due to dilution caused by the Issuer’s sales of additional shares of its Common Stock from time to time since the date of the filing of the Original Schedule 13D. Such transactions resulted in a decrease of over one percent (1%) in the aggregate percentage ownership reported by the Reporting Persons in the Original Schedule 13D.

    (a) and (b) See Items 7-11 of the cover pages of this Statement and Item 2 above.


    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

    February 8, 2024

     

    Versant Venture Capital VI, L.P.
    By:   Versant Ventures VI GP, L.P.
    Its:   General Partner
    By:   Versant Ventures VI GP-GP, LLC
    Its:   General Partner
    By:   /s/ Max Eisenberg, Chief Operating Officer
    Versant Ventures VI GP, L.P.
    By:   Versant Ventures VI GP-GP, LLC
    Its:   General Partner
    By:   /s/ Max Eisenberg, Chief Operating Officer
    Versant Ventures VI GP-GP, LLC
    By:   /s/ Max Eisenberg, Chief Operating Officer
    Versant Vantage II, L.P.
    By:   Versant Vantage II GP, L.P.
    Its:   General Partner
    By:   Versant Vantage II GP-GP, LLC
    Its:   General Partner
    By:   /s/ Max Eisenberg, Chief Operating Officer
    Versant Vantage II GP, L.P.
    By:   Versant Vantage II GP-GP, LLC
    Its:   General Partner
    By:   /s/ Max Eisenberg, Chief Operating Officer
    Versant Vantage II GP-GP, LLC
    By:   /s/ Max Eisenberg, Chief Operating Officer
    Versant Venture Capital IV, L.P.
    By:   Versant Vantage IV, LLC
    Its:   General Partner
    By:   /s/ Max Eisenberg, Chief Operating Officer


    Versant Side Fund IV, L.P.
    By:   Versant Ventures IV, LLC
    Its:   General Partner
    By:   /s/ Max Eisenberg, Chief Operating Officer
    Versant Ventures IV, LLC
    By:   /s/ Max Eisenberg, Chief Operating Officer
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    • Tempest Presents New Amezalpat MOA Data Reinforcing Its Potential as Novel Cancer Treatment at the 2025 AACR Annual Meeting

      BRISBANE, Calif., April 28, 2025 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST), a clinical-stage biotechnology company developing first-in-classi targeted and immune-mediated therapeutics to fight cancer, today announced that a presentation of new data supporting the immune component of amezalpat's purported dual mechanism of action that reinforces its potential as a novel cancer treatment at the 2025 American Association for Cancer Research (AACR) Annual Meeting. "The data presented at the AACR Annual Meeting show that amezalpat reduced tumor promoting immunosuppression by M2 macrophages and T regulatory cells resulting in immune activation. These data support the immune

      4/28/25 4:05:00 PM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Tempest Receives Orphan Drug Designation from the FDA for TPST-1495 to Treat Patients with FAP

      BRISBANE, Calif., April 21, 2025 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST), a clinical-stage biotechnology company developing first-in-class1 targeted and immune-mediated therapeutics to fight cancer, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) to TPST-1495, the company's novel dual receptor inhibitor of prostaglandin (PGE2) signaling, for the treatment of patients with Familial Adenomatous Polyposis (FAP). "Receiving orphan drug designation for TPST-1495, our second clinical program, is a significant milestone in our mission to bring innovative therapies to patients with unmet medical need," said Stephen Br

      4/21/25 8:00:00 AM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Tempest Announces Plan to Explore Strategic Alternatives to Advance Promising Pipeline of Clinical Oncology Assets and Maximize Stockholder Value

      Amezalpat (TPST-1120) is Phase 3-ready: completed FDA and EMA interactions for first-line pivotal study in hepatocellular carcinoma (HCC); global investigator support in placeAwarded both Orphan Drug & Fast Track designations for amezalpat based on positive randomized Phase 2 data in first-line HCC Received FDA "Study May Proceed" letter for TPST-1495 in a Phase 2 trial for the treatment of familial adenomatous polyposis (FAP); data expected 2026 BRISBANE, Calif., April 09, 2025 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST), a clinical-stage biotechnology company developing first-in-classi targeted and immune-mediated therapeutics to fight cancer, today announced that the c

      4/9/25 4:30:00 PM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    $TPST
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    • SEC Form 4 filed by President and CEO Brady Stephen R

      4 - Tempest Therapeutics, Inc. (0001544227) (Issuer)

      1/6/25 5:00:25 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    • SEC Form 4 filed by Chief Financial Officer Maestas Nicholas

      4 - Tempest Therapeutics, Inc. (0001544227) (Issuer)

      1/6/25 5:00:20 PM ET
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    • SEC Form 4 filed by Corporate Controller Trojanowski Justin

      4 - Tempest Therapeutics, Inc. (0001544227) (Issuer)

      1/6/25 5:00:22 PM ET
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    • President and CEO Brady Stephen R bought $73,850 worth of shares (35,000 units at $2.11), increasing direct ownership by 308% to 46,376 units (SEC Form 4)

      4 - Tempest Therapeutics, Inc. (0001544227) (Issuer)

      7/8/24 4:15:11 PM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Chief Medical Officer Whiting Samuel bought $9,951 worth of shares (4,672 units at $2.13), increasing direct ownership by 95% to 9,573 units (SEC Form 4)

      4 - Tempest Therapeutics, Inc. (0001544227) (Issuer)

      7/3/24 7:35:42 PM ET
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    • Corporate Controller Trojanowski Justin bought $16,200 worth of shares (7,500 units at $2.16), increasing direct ownership by 51% to 22,168 units (SEC Form 4)

      4 - Tempest Therapeutics, Inc. (0001544227) (Issuer)

      7/2/24 4:15:14 PM ET
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    • Tempest Extends Limited Duration Stockholder Rights Plan

      BRISBANE, Calif., Oct. 10, 2024 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST) ("Tempest" or the "Company"), a clinical-stage biotechnology company developing first-in-classi targeted and immune-mediated therapeutics to fight cancer, today announced that its Board of Directors (the "Board") has adopted an amendment to its existing limited duration stockholder rights plan (as amended, the "Rights Plan") to extend the duration of the Rights Plan until the Annual Meeting of Stockholders. "Given the significant milestones reached this year in the amezalpat program – the positive survival data compared to standard of care and broad agreement with FDA on the Phase 3 path – coupled

      10/10/24 7:00:00 AM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Tempest Unveils New Survival Data for Amezalpat (TPST-1120) in Randomized First-Line HCC Study Demonstrating a Six-Month Improvement over Control Arm

      21 months median OS in amezalpat arm vs. 15 in control arm 50% (20/40) of patients on amezalpat arm remain in survival follow up 0.65 hazard ratio, maintained since 0.59 observed in primary analysis 10 months earlier Early and persistent separation of survival curves OS is the primary regulatory endpoint for first-line HCCCompany to host webcast conference call today at 8:30am ET BRISBANE, Calif., June 20, 2024 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST), a clinical-stage oncology company developing first-in-class1 therapeutics that combine both targeted and immune-mediated mechanisms, today announced new positive data from the ongoing global randomized Phase 1b/2 clinica

      6/20/24 8:00:00 AM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Tempest to Report New Data from Global Randomized Combination Study of Amezalpat (TPST-1120) in First-Line Hepatocellular Carcinoma

      BRISBANE, Calif., June 18, 2024 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST), a clinical-stage biotechnology company developing first-in-classi targeted and immune-mediated therapeutics to fight cancer, today announced the company plans to report new data from the global randomized Phase 1b/2 combination study of amezalpat (TPST-1120) with atezolizumab and bevacizumab in first-line treatment of hepatocellular carcinoma (HCC) in a premarket press release followed by a webcasted conference call with associated slide presentation on Thursday, June 20, 2024 at 8:30 a.m. ET. To join the conference call via phone and participate in the live Q&A session, please pre-register onlin

      6/18/24 6:22:51 PM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Amendment: SEC Form SC 13D/A filed by Tempest Therapeutics Inc.

      SC 13D/A - Tempest Therapeutics, Inc. (0001544227) (Subject)

      8/12/24 8:59:00 PM ET
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    • SEC Form SC 13D/A filed by Tempest Therapeutics Inc. (Amendment)

      SC 13D/A - Tempest Therapeutics, Inc. (0001544227) (Subject)

      5/13/24 4:54:01 PM ET
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    • SEC Form SC 13G/A filed by Tempest Therapeutics Inc. (Amendment)

      SC 13G/A - Tempest Therapeutics, Inc. (0001544227) (Subject)

      2/14/24 6:49:42 PM ET
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    • Amendment: SEC Form 10-K/A filed by Tempest Therapeutics Inc.

      10-K/A - Tempest Therapeutics, Inc. (0001544227) (Filer)

      4/30/25 4:05:19 PM ET
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    • SEC Form 8-K filed by Tempest Therapeutics Inc.

      8-K - Tempest Therapeutics, Inc. (0001544227) (Filer)

      4/28/25 9:49:42 AM ET
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    • SEC Form 8-K filed by Tempest Therapeutics Inc.

      8-K - Tempest Therapeutics, Inc. (0001544227) (Filer)

      4/18/25 4:16:40 PM ET
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    • Tempest Further Strengthens Leadership Team with Appointment of Sheldon Mullins as Vice President, Regulatory Affairs

      BRISBANE, Calif., Sept. 18, 2024 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST), a clinical-stage biotechnology company developing first-in-classi targeted and immune-mediated therapeutics to fight cancer, today announced the appointment of Sheldon Mullins as Vice President, Regulatory Affairs. Mr. Mullins' presence on the team builds upon the recent addition of Troy Wagner as Vice President of Quality Assurance, who brought additional late-stage experience to the company. Additionally, in connection with the plan to advance amezalpat into a pivotal study in first-line HCC patients and to reflect their roles in late-stage development, the titles of Darrin Bomba and Henry John

      9/18/24 8:00:00 AM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Tempest Announces the Appointment of Troy M. Wagner as Vice President of Quality Assurance

      BRISBANE, Calif., Aug. 21, 2024 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (NASDAQ:TPST), a clinical-stage biotechnology company developing first-in-classi targeted and immune-mediated therapeutics to fight cancer, today announced the appointment of Troy M. Wagner as Vice President of Quality Assurance. "Troy brings a wealth of experience in late-stage product development, including managing quality systems across a range of global clinical studies and assisting with global regulatory filings. We look forward to her contributions as we move towards Phase 3 development of amezalpat to treat hepatocellular carcinoma and are thrilled to have her join the Tempest leadership team,"

      8/21/24 8:00:00 AM ET
      $TPST
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    • Actym Therapeutics Appoints Chan Whiting as Chief Development Officer

      BERKELEY, Calif., Nov. 11, 2021 /PRNewswire/ -- Actym Therapeutics, Inc. today announced the appointment of Chan Whiting, Ph.D. as Chief Development Officer. Chan brings over 20 years of drug development experience within the biotechnology industry. As CDO, Chan will play a key leadership role in advancing Actym's pipeline of first-in-class, systemically administered therapeutics that re-program the immunosuppressive microenvironment in solid tumors.   Actym Therapeutics hires Dr. Chan Whiting as Chief Development Officer."Chan has significant experience advancing novel cancer

      11/11/21 9:00:00 AM ET
      $QGEN
      $TPST
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    • Tempest Therapeutics downgraded by Scotiabank

      Scotiabank downgraded Tempest Therapeutics from Sector Outperform to Sector Perform

      4/10/25 8:50:49 AM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Tempest Therapeutics downgraded by H.C. Wainwright

      H.C. Wainwright downgraded Tempest Therapeutics from Buy to Neutral

      4/10/25 8:03:29 AM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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    • Scotiabank initiated coverage on Tempest Therapeutics with a new price target

      Scotiabank initiated coverage of Tempest Therapeutics with a rating of Sector Outperform and set a new price target of $13.00

      3/14/24 8:21:09 AM ET
      $TPST
      Biotechnology: Pharmaceutical Preparations
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