SEC Form SC 13G filed by Adagene Inc.

2/11/22 3:26:06 PM ET

$ADAG

Biotechnology: Pharmaceutical Preparations

Health Care

Get the next $ADAG alert in real time by email

SC 13G 1 eh220223350_13g-adagene.htm SCHEDULE 13G

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. )*

Adagene Inc.

(Name of Issuer)

Ordinary shares, par value US$0.0001 per share

(Title of Class of Securities)

005329107**

(CUSIP Number)

December 31, 2021

(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

	☐	Rule 13d-1(b)
	☐	Rule 13d-1(c)
	☒	Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

**This CUSIP applies to the American Depositary Shares, evidenced by American Depositary Receipts, each representing one and one quarter (1.25) ordinary shares. No CUSIP has been assigned to the ordinary shares.

CUSIP No. 005329107

SCHEDULE 13G

Page 2 of 25

1	NAME OF REPORTING PERSON General Atlantic Singapore Fund Pte. Ltd.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Singapore

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON CO

CUSIP No. 005329107

SCHEDULE 13G

Page 3 of 25

1	NAME OF REPORTING PERSON General Atlantic Singapore Interholdco Ltd.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Bermuda

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON CO

CUSIP No. 005329107

SCHEDULE 13G

Page 4 of 25

1	NAME OF REPORTING PERSON General Atlantic Partners (Bermuda) IV, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Bermuda

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 5 of 25

1	NAME OF REPORTING PERSON General Atlantic Partners (Bermuda) EU, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Bermuda

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 6 of 25

1	NAME OF REPORTING PERSON General Atlantic GenPar (Bermuda), L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Bermuda

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 7 of 25

1	NAME OF REPORTING PERSON GAP (Bermuda) L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Bermuda

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 8 of 25

1	NAME OF REPORTING PERSON General Atlantic, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 9 of 25

1	NAME OF REPORTING PERSON GAP Coinvestments III, LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON OO

CUSIP No. 005329107

SCHEDULE 13G

Page 10 of 25

1	NAME OF REPORTING PERSON GAP Coinvestments IV, LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON OO

CUSIP No. 005329107

SCHEDULE 13G

Page 11 of 25

1	NAME OF REPORTING PERSON GAP Coinvestments V, LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON OO

CUSIP No. 005329107

SCHEDULE 13G

Page 12 of 25

1	NAME OF REPORTING PERSON GAP Coinvestments CDA, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 13 of 25

1	NAME OF REPORTING PERSON General Atlantic Partners (Lux) SCSp
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Luxembourg

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 14 of 25

1	NAME OF REPORTING PERSON General Atlantic GenPar (Lux) SCSp
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Luxembourg

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON PN

CUSIP No. 005329107

SCHEDULE 13G

Page 15 of 25

1	NAME OF REPORTING PERSON General Atlantic (Lux) S.à r.l.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Luxembourg

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON CO

CUSIP No. 005329107

SCHEDULE 13G

Page 16 of 25

1	NAME OF REPORTING PERSON General Atlantic Singapore AI Pte. Ltd.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP	(a) ☐ (b) ☒
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Singapore

NUMBER OF

BENEFICIALLY OWNED

BY EACH REPORTING

PERSON

WITH

SOLE VOTING POWER

SHARED VOTING POWER

4,782,441

SOLE DISPOSITIVE POWER

SHARED DISPOSITIVE POWER

4,782,441

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,782,441
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES	☐
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.8%
12	TYPE OF REPORTING PERSON CO

CUSIP No. 005329107

SCHEDULE 13G

Page 17 of 25

ITEM 1.	(a)	Name of Issuer

	Adagene Inc.

	(b)	Address of Issuer’s Principal Executive Offices

	4F, Building C14, No. 218, Xinghu Street, Suzhou Industrial Park Suzhou, Jiangsu Province, 215123 People's Republic of China

ITEM 2.	(a)	Name of PersonS Filing

	This statement is being filed on behalf of each of the following persons (collectively, the “Reporting Persons”).

	(i)	General Atlantic Singapore Fund Pte. Ltd. (“GASF”);

	(ii)	General Atlantic Singapore Interholdco Ltd. (“GAS Interholdco”);

	(iii)	General Atlantic Partners (Bermuda) IV, L.P. (“GAP Bermuda IV”);

	(iv)	General Atlantic Partners (Bermuda) EU, L.P. (“GAP Bermuda EU”);

	(v)	General Atlantic GenPar (Bermuda), L.P. (“GenPar Bermuda”);

	(vi)	GAP (Bermuda) L.P. (“GAP (Bermuda) LP”);

	(vii)	General Atlantic, L.P. (“GA LP”);

	(viii)	GAP Coinvestments III, LLC (“GAPCO III”);

	(ix)	GAP Coinvestments IV, LLC (“GAPCO IV”);

	(x)	GAP Coinvestments V, LLC (“GAPCO V”);

	(xi)	GAP Coinvestments CDA, L.P. (“GAPCO CDA”);

	(xii)	General Atlantic Partners (Lux) SCSp (“GAP Lux”);

	(xiii)	General Atlantic GenPar, (Lux) SCSp (“GA GenPar Lux”);

	(xiv)	General Atlantic (Lux) S.à. r.l. (“GA Lux”); and

	(xv)	General Atlantic Singapore AI Pte. Ltd. (“GA AI”).

	GAP Bermuda IV, GAP Bermuda EU, GAP Lux, GAPCO III, GAPCO IV, GAPCO V and GAPCO CDA are collectively referred to as the “GA Funds.”

CUSIP No. 005329107

SCHEDULE 13G

Page 18 of 25

	(b)	Address of Principal Business Office, or if none, Residence

	The address of GA LP, GAPCO III, GAPCO IV, GAPCO V, and GAPCO CDA is c/o General Atlantic Service Company, L.P., 55 East 52nd Street, 33rd Floor, New York, NY 10055. The address of GAS Interholdco, GAP Bermuda IV, GAP Bermuda EU, GenPar Bermuda, and GAP (Bermuda) LP is C/O Conyers Client Services Limited, Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda. The address of GAP Lux, GA GenPar Lux and GA Lux Sarl is 412F, route d’Esch, L-2086 Luxembourg, Grand Duchy of Luxembourg. The address of GASF and GA AI is 80 Robinson Road #02-00, Singapore, 068898.

	(c)	Citizenship

	(i)	GASF - Singapore

	(ii)	GAS Interholdco - Bermuda

	(iii)	GAP Bermuda IV - Bermuda

	(iv)	GAP Bermuda EU - Bermuda

	(v)	GenPar Bermuda - Bermuda

	(vi)	GAP (Bermuda) LP - Bermuda

	(vii)	GA LLC - Delaware

	(viii)	GAPCO III - Delaware

	(ix)	GAPCO IV - Delaware

	(x)	GAPCO V - Delaware

	(xi)	GAPCO CDA - Delaware

	(xii)	GAP Lux - Luxembourg

	(xiii)	GA GenPar Lux - Luxembourg

	(xiv)	GA Lux - Luxembourg

	(xv)	GA AI - Singapore

CUSIP No. 005329107

SCHEDULE 13G

Page 19 of 25

	(d)	Title of Class of Securities

	Ordinary shares, par value US$0.0001 per share (“ordinary shares”). The Issuer’s American Depositary Shares (the “ADSs”), evidenced by American Depositary Receipts, each representing one and one quarter (1.25) ordinary shares, are listed on the Nasdaq Global Select Market under the symbol “ADAG.”

	(e)	CUSIP Number

	005329107* *This CUSIP applies to the ADSs, evidenced by American Depositary Receipts, each representing one and one quarter (1.25) ordinary shares. No CUSIP has been assigned to the ordinary shares.

ITEM 3.	IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b) OR 13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS:

	Not Applicable.

ITEM 4.	OWNERSHIP

	As of December 31, 2021, the Reporting Persons owned the following number of ordinary shares:

	(i)	GASF owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(ii)	GAS Interholdco owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(iii)	GAP Bermuda IV owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(iv)	GAP Bermuda EU owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(v)	GenPar Bermuda owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(vi)	GAP (Bermuda) LP owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(vii)	GA LP owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(viii)	GAPCO III owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

CUSIP No. 005329107

SCHEDULE 13G

Page 20 of 25

	(ix)	GAPCO IV owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(x)	GAPCO V owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(xi)	GAPCO CDA owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(xii)	GAP Lux owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(xiii)	GA GenPar Lux owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(xiv)	GA Lux owned of record no ordinary shares and no ADSs representing ordinary shares, or 0.0% of the issued and outstanding ordinary shares.

	(xv)	GA AI owned of record 4,452,441 ordinary shares and 264,000 ADSs representing 330,000 ordinary shares, or approximately 8.8% of the issued and outstanding ordinary shares.

GA AI is wholly owned by GASF. The majority shareholder of GASF is GAS Interholdco. The members of GAS Interholdco that share beneficial ownership of the ordinary shares and ADSs held of record by GA AI are the GA Funds. The general partner of GAP Lux is GA GenPar Lux and the general partner of GA GenPar Lux is GA Lux. The general partner of GAP Bermuda EU and GAP Bermuda IV and the sole shareholder of GA Lux is GenPar Bermuda. GAP (Bermuda) LP, which is controlled by the Management Committee of GASC MGP, LLC (the “GA Management Committee”), is the general partner of GenPar Bermuda. GA LP, which is also controlled by the GA Management Committee, is the managing member of GAPCO III, GAPCO IV and GAPCO V and the general partner of GAPCO CDA. There are nine members of the GA Management Committee as of the date hereof. Each of the members of the GA Management Committee disclaims ownership of the ordinary shares, the ADSs and the underlying ordinary shares except to the extent that he has a pecuniary interest therein. The name, the business address and the citizenship of each of the members of the GA Management Committee and the directors of GASF and GAS Interholdco, in each case as of the date hereof, is attached hereto as Schedule A and is hereby incorporated by reference.

Amount Beneficially Owned:

By virtue of the relationship described above, each of the Reporting Persons may be deemed to beneficially own 4,452,441 ordinary shares and 264,000 ADSs representing 330,000 ordinary shares.

Percentage Owned:

All calculations of percentage ownership herein are based on an aggregate of 54,397,383 ordinary shares of the Issuer reported to be outstanding as of March 31, 2021, as reflected in the Issuer’s Annual Report on Form 20-K, filed with the U.S. Securities and Exchange Commission on April 28, 2021.

CUSIP No. 005329107

SCHEDULE 13G

Page 21 of 25

	Number of Shares as to Which Such Person Has Sole/Shared Power to Vote or to Direct the Vote and Sole/Shared Power to Dispose or to Direct the Disposition of:
	(i)	Each of the Reporting Persons may be deemed to have the sole power to direct the voting and dispositions of the ordinary shares, the ADSs and underlying ordinary shares as indicated on such Reporting Person’s cover page included herein.

	(ii)	Each of the Reporting Persons may be deemed to share the power to direct the voting and dispositions of 4,452,441 ordinary shares and 264,000 ADSs representing 330,000 ordinary shares that may be deemed to be owned beneficially by each of them.

ITEM 5.	OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

	Not Applicable.

ITEM 6.	OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

	Not Applicable.

ITEM 7.	IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

	Not Applicable.

ITEM 8.	IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

	See Item 4, which states the identity of the members of the group filing this Schedule 13G.

ITEM 9.	NOTICE OF DISSOLUTION OF GROUP

	Not Applicable.

ITEM 10.	CERTIFICATION

	Not Applicable.

CUSIP No. 005329107

SCHEDULE 13G

Page 22 of 25

Exhibit Index

Exhibit 1:

Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended.

CUSIP No. 005329107

SCHEDULE 13G

Page 23 of 25

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 11, 2022

	GENERAL ATLANTIC SINGAPORE FUND PTE. LTD.

	By:	/s/ Ong Yu Huat
	Name:	Ong Yu Huat
	Title:	Director


	GENERAL ATLANTIC SINGAPORE INTERHOLDCO LTD.

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Director


	GENERAL ATLANTIC PARTNERS (BERMUDA) IV, L.P.

	By:	General Atlantic GenPar (Bermuda), L.P., its General Partner

	By:	GAP (Bermuda) L.P., its General Partner

	By:	GAP (Bermuda) GP Limited, its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GENERAL ATLANTIC PARTNERS (BERMUDA) EU, L.P.

	By:	General Atlantic GenPar (Bermuda), L.P., its General Partner

	By:	GAP (Bermuda) L.P., its General Partner

	By:	GAP (Bermuda) GP Limited, its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GENERAL ATLANTIC GENPAR (BERMUDA), L.P.

	By:	GAP (Bermuda) L.P., its General Partner

	By:	GAP (Bermuda) GP Limited, its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP (BERMUDA) L.P.

	By:	GAP (Bermuda) GP Limited, its general partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director

CUSIP No. 005329107

SCHEDULE 13G

Page 24 of 25

	GENERAL ATLANTIC, L.P.

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP COINVESTMENTS III, LLC

	By:	General Atlantic, L.P., its Managing Member

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP COINVESTMENTS IV, LLC

	By:	General Atlantic, L.P., its Managing Member

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP COINVESTMENTS V, LLC

	By:	General Atlantic, L.P., its Managing Member

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP COINVESTMENTS CDA, L.P.

	By:	General Atlantic, L.P., its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director

CUSIP No. 005329107

SCHEDULE 13G

Page 25 of 25

	GENERAL ATLANTIC PARTNERS (LUX) SCSP

	By:	General Atlantic GenPar (Lux) SCSp, its General Partner

	By:	General Atlantic (Lux) S.à r.l., its General Partner

	By:	/s/ Ingrid van der Hoorn
	Name:	Ingrid van der Hoorn
	Title:	Manager A

	By:	/s/ Gregor Dalrymple
	Name:	Gregor Dalrymple
	Title:	Manager B


	GENERAL ATLANTIC GENPAR, (LUX) SCSP

	By:	General Atlantic (Lux) S.à. r.l., its General Partner

	By:	/s/ Ingrid van der Hoorn
	Name:	Ingrid van der Hoorn
	Title:	Manager A

	By:	/s/ Gregor Dalrymple
	Name:	Gregor Dalrymple
	Title:	Manager B


	GENERAL ATLANTIC (LUX) S.À R.L.

	By:	/s/ Ingrid van der Hoorn
	Name:	Ingrid van der Hoorn
	Title:	Manager A

	By:	/s/ Gregor Dalrymple
	Name:	Gregor Dalrymple
	Title:	Manager B


	GENERAL ATLANTIC SINGAPORE AI PTE. LTD.

	By:	/s/ Ong Yu Huat
	Name:	Ong Yu Huat
	Title:	Director

SCHEDULE A

Members of the GA Management Committee (as of the date hereof)

Name	Address	Citizenship
William E. Ford (Chief Executive Officer)	55 East 52nd Street 33rd Floor New York, New York 10055	United States
Gabriel Caillaux	23 Savile Row London W1S 2ET United Kingdom	France
Andrew Crawford	55 East 52nd Street 33rd Floor New York, New York 10055	United States
Martin Escobari	55 East 52nd Street 33rd Floor New York, New York 10055	Bolivia and Brazil
Anton J. Levy	55 East 52nd Street 33rd Floor New York, New York 10055	United States
Sandeep Naik	Asia Square Tower 1 8 Marina View, #41-04 Singapore 018960	United States
Graves Tompkins	55 East 52nd Street 33rd Floor New York, New York 10055	United States
N. Robbert Vorhoff	55 East 52nd Street 33rd Floor New York, New York 10055	United States
Eric Zhang	Suite 5704-5706, 57F Two IFC, 8 Finance Street Central, Hong Kong, China	Hong Kong SAR

Directors of General Atlantic Singapore Fund Pte. Ltd.

(as of the date hereof)

Name

Address

Citizenship

Ong Yu Huat

Asia Square Tower 1

8 Marina View, #41-04

Singapore 018960

Singapore

Izkander Edward Heylett

Asia Square Tower 1

8 Marina View, #41-04

Singapore 018960

Malaysia

Directors of General Atlantic Singapore Interholdco Ltd.

(as of the date hereof)

Name

Address

Citizenship

Michael Gosk

55 East 52nd Street

33rd Floor

New York, New York 10055

United States

Christopher G. Lanning

55 East 52nd Street

33rd Floor

New York, New York 10055

United States

EXHIBIT 1

JOINT ACQUISITION STATEMENT

PURSUANT TO RULE 13D-1(k)(1)

The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is accurate.

February 11, 2022

	GENERAL ATLANTIC SINGAPORE FUND PTE. LTD.

	By:	/s/ Ong Yu Huat
	Name:	Ong Yu Huat
	Title:	Director


	GENERAL ATLANTIC SINGAPORE INTERHOLDCO LTD.

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Director


	GENERAL ATLANTIC PARTNERS (BERMUDA) IV, L.P.

	By:	General Atlantic GenPar (Bermuda), L.P., its General Partner

	By:	GAP (Bermuda) L.P., its General Partner

	By:	GAP (Bermuda) GP Limited, its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director

	GENERAL ATLANTIC PARTNERS (BERMUDA) EU, L.P.

	By:	General Atlantic GenPar (Bermuda), L.P., its General Partner

	By:	GAP (Bermuda) L.P., its General Partner

	By:	GAP (Bermuda) GP Limited, its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GENERAL ATLANTIC GENPAR (BERMUDA), L.P.

	By:	GAP (Bermuda) L.P., its General Partner

	By:	GAP (Bermuda) GP Limited, its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP (BERMUDA) L.P.

	By:	GAP (Bermuda) GP Limited, its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GENERAL ATLANTIC, L.P.

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director

	GAP COINVESTMENTS III, LLC

	By:	General Atlantic L.P., its Managing Member

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP COINVESTMENTS IV, LLC

	By:	General Atlantic, L.P., its Managing Member

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP COINVESTMENTS V, LLC

	By:	General Atlantic, L.P., its Managing Member

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director


	GAP COINVESTMENTS CDA, L.P.

	By:	General Atlantic, L.P., its General Partner

	By:	/s/ Michael Gosk
	Name:	Michael Gosk
	Title:	Managing Director

	GENERAL ATLANTIC PARTNERS (LUX) SCSP

	By:	General Atlantic GenPar (Lux) SCSp, its General Partner

	By:	General Atlantic (Lux) S.à r.l., its General Partner

	By:	/s/ Ingrid van der Hoorn
	Name:	Ingrid van der Hoorn
	Title:	Manager A

	By:	/s/ Gregor Dalrymple
	Name:	Gregor Dalrymple
	Title:	Manager B


	GENERAL ATLANTIC GENPAR, (LUX) SCSP

	By:	General Atlantic (Lux) S.à. r.l., its General Partner

	By:	/s/ Ingrid van der Hoorn
	Name:	Ingrid van der Hoorn
	Title:	Manager A

	By:	/s/ Gregor Dalrymple
	Name:	Gregor Dalrymple
	Title:	Manager B


	GENERAL ATLANTIC (LUX) S.À R.L.

	By:	/s/ Ingrid van der Hoorn
	Name:	Ingrid van der Hoorn
	Title:	Manager A

	By:	/s/ Gregor Dalrymple
	Name:	Gregor Dalrymple
	Title:	Manager B


	GENERAL ATLANTIC SINGAPORE AI PTE. LTD.

	By:	/s/ Ong Yu Huat
	Name:	Ong Yu Huat
	Title:	Director

Get the next $ADAG alert in real time by email

Date	Price Target	Rating	Analyst
1/31/2025		Overweight → Equal-Weight	Morgan Stanley
2/1/2022	$27.00 → $15.00	Overweight	Morgan Stanley

SEC Form SC 13G filed by Adagene Inc.

Chat with this insight

Recent Analyst Ratings for
$ADAG

$ADAG
Large Ownership Changes

This live feed shows all institutional transactions in real time.

Amendment: SEC Form SC 13G/A filed by Adagene Inc.

SEC Form SC 13D/A filed by Adagene Inc. (Amendment)

SEC Form SC 13G/A filed by Adagene Inc. (Amendment)

$ADAG
Press Releases

Fastest customizable press release news feed in the world

Adagene Appoints John Maraganore, Ph.D. as Executive Advisor

Adagene Announces Upcoming Poster Presentation on Masked Anti-CTLA-4 SAFEbody® ADG126 (Muzastotug) at American Society of Clinical Oncology (ASCO) Annual Meeting

Adagene to Present at Stifel's 2025 Virtual Targeted Oncology Forum

$ADAG
Financials

Live finance-specific insights

Adagene Reports Financial Results for the Six Months Ended June 30, 2022 and Provides Corporate Updates

$ADAG
Analyst Ratings

Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

$ADAG
SEC Filings

$ADAG
Leadership Updates

Live Leadership Updates

Adagene downgraded by Morgan Stanley

Morgan Stanley reiterated coverage on Adagene with a new price target

SEC Form 20-F filed by Adagene Inc.

SEC Form 6-K filed by Adagene Inc.

Amendment: SEC Form SCHEDULE 13G/A filed by Adagene Inc.

Adagene Appoints John Maraganore, Ph.D. as Executive Advisor

Adagene Appoints Heinz-Josef Lenz, M.D., FACP to Scientific and Strategic Advisory Board

Adagene Appoints Professor Aurélien Marabelle to Scientific and Strategic Advisory Board

SEC Form SC 13G filed by Adagene Inc.

Chat with this insight

Recent Analyst Ratings for $ADAG

$ADAG Large Ownership Changes

This live feed shows all institutional transactions in real time.

Amendment: SEC Form SC 13G/A filed by Adagene Inc.

SEC Form SC 13D/A filed by Adagene Inc. (Amendment)

SEC Form SC 13G/A filed by Adagene Inc. (Amendment)

$ADAG Press Releases

Fastest customizable press release news feed in the world

Adagene Appoints John Maraganore, Ph.D. as Executive Advisor

Adagene Announces Upcoming Poster Presentation on Masked Anti-CTLA-4 SAFEbody® ADG126 (Muzastotug) at American Society of Clinical Oncology (ASCO) Annual Meeting

Adagene to Present at Stifel's 2025 Virtual Targeted Oncology Forum

$ADAG Financials

Live finance-specific insights

Adagene Reports Financial Results for the Six Months Ended June 30, 2022 and Provides Corporate Updates

$ADAG Analyst Ratings

Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

$ADAG SEC Filings

$ADAG Leadership Updates

Live Leadership Updates

Adagene downgraded by Morgan Stanley

Morgan Stanley reiterated coverage on Adagene with a new price target

SEC Form 20-F filed by Adagene Inc.

SEC Form 6-K filed by Adagene Inc.

Amendment: SEC Form SCHEDULE 13G/A filed by Adagene Inc.

Adagene Appoints John Maraganore, Ph.D. as Executive Advisor

Adagene Appoints Heinz-Josef Lenz, M.D., FACP to Scientific and Strategic Advisory Board

Adagene Appoints Professor Aurélien Marabelle to Scientific and Strategic Advisory Board

Recent Analyst Ratings for
$ADAG

$ADAG
Large Ownership Changes

$ADAG
Press Releases

$ADAG
Financials

$ADAG
Analyst Ratings

$ADAG
SEC Filings

$ADAG
Leadership Updates