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    SEC Form SC 13G filed by Kyverna Therapeutics Inc.

    2/22/24 4:29:57 PM ET
    $KYTX
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $KYTX alert in real time by email
    SC 13G 1 tm246946d1_sc13g.htm SC 13G

     

     

    UNITED STATES 

    SECURITIES AND EXCHANGE COMMISSION 

    Washington, D.C. 20549

     

    SCHEDULE 13G

     

    Under the Securities Exchange Act of 1934 

    (Amendment No. )*

     

    Kyverna Therapeutics, Inc. 

    (Name of Issuer)

     

    Common stock, $0.00001 par value per share 

    (Title of Class of Securities)

     

    501976104 

    (CUSIP Number)

     

    February 12, 2024 

    (Date of Event Which Requires Filing of this Statement)

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

    ¨

     

    x

     

    ¨

    Rule 13d-1(b)

     

    Rule 13d-1(c)

     

    Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

     

    The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

    CUSIP No.   501976104
    1.

    Names of Reporting Persons

    Northpond Ventures, LP

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨ (b) x (1) 

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    450,000 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    450,000 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    450,000 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

    1.0% (3)

    12.

    Type of Reporting Person (See Instructions)

    PN

           

    (1)This Schedule 13G is filed by Northpond Ventures, LP (“Northpond”), Northpond Ventures GP, LLC (“Northpond GP”), Northpond Ventures III, LP (“Northpond III”), Northpond Ventures III GP, LLC (“Northpond III GP”) and Michael P. Rubin (“Rubin” and, with Northpond, Northpond GP, Northpond III and Northpond III GP, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)The shares are held by Northpond. Northpond GP is the general partner of Northpond and Rubin is the managing member of Northpond GP. As such, Northpond GP and Rubin have shared dispositive and voting power over the shares held by Northpond and may be deemed to have indirect beneficial ownership of the shares held by Northpond.

     

    (3)This percentage is calculated based on 42,997,525 shares of Common Stock outstanding as of February 12, 2024 upon the closing of the Issuer’s initial public offering, as reported in the prospectus dated February 7, 2024 filed by the Issuer with the SEC on February 8, 2024.

     

    2 

     

     

    CUSIP No.   501976104
    1.

    Names of Reporting Persons

    Northpond Ventures GP, LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨ (b) x (1) 

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    450,000 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    450,000 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    450,000 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

    1.0% (3)

    12.

    Type of Reporting Person (See Instructions)

    OO

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)The shares are held by Northpond. Northpond GP is the general partner of Northpond and Rubin is the managing member of Northpond GP. As such, Northpond GP and Rubin have shared dispositive and voting power over the shares held by Northpond and may be deemed to have indirect beneficial ownership of the shares held by Northpond.

     

    (3)This percentage is calculated based on 42,997,525 shares of Common Stock outstanding as of February 12, 2024 upon the closing of the Issuer’s initial public offering, as reported in the prospectus dated February 7, 2024 filed by the Issuer with the SEC on February 8, 2024.

     

    3 

     

     

    CUSIP No.   501976104
    1.

    Names of Reporting Persons

    Northpond Ventures III, LP

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨ (b) x (1) 

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    2,805,426 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    2,805,426 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    2,805,426 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

    6.5% (3)

    12.

    Type of Reporting Person (See Instructions)

    PN

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)The shares are held by Northpond III. Northpond III GP is the general partner of Northpond III and Rubin is the managing member of Northpond III GP. As such, Northpond III GP and Rubin have shared dispositive and voting power over the shares held by Northpond III and may be deemed to have indirect beneficial ownership of the shares held by Northpond III.

     

    (3)This percentage is calculated based on 42,997,525 shares of Common Stock outstanding as of February 12, 2024 upon the closing of the Issuer’s initial public offering, as reported in the prospectus dated February 7, 2024 filed by the Issuer with the SEC on February 8, 2024.

     

    4 

     

     

    CUSIP No.   501976104
    1.

    Names of Reporting Persons

    Northpond Ventures III GP, LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨ (b) x (1) 

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    2,805,426 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    2,805,426 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    2,805,426 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

    6.5% (3)

    12.

    Type of Reporting Person (See Instructions)

    OO

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)The shares are held by Northpond III. Northpond III GP is the general partner of Northpond III and Rubin is the managing member of Northpond III GP. As such, Northpond III GP and Rubin have shared dispositive and voting power over the shares held by Northpond III and may be deemed to have indirect beneficial ownership of the shares held by Northpond III.

     

    (3)This percentage is calculated based on 42,997,525 shares of Common Stock outstanding as of February 12, 2024 upon the closing of the Issuer’s initial public offering, as reported in the prospectus dated February 7, 2024 filed by the Issuer with the SEC on February 8, 2024.

     

    5 

     

     

    CUSIP No.   501976104
    1.

    Names of Reporting Persons

    Michael P. Rubin

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨ (b) x (1) 

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    3,255,426 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    3,255,426 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    3,255,426 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

    7.6% (3)

    12.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Consists of (i) 450,000 shares held by Northpond and (ii) 2,805,426 shares held by Northpond III. Northpond GP is the general partner of Northpond and Northpond III GP is the general partner of Northpond III. Rubin is the managing member of each of Northpond GP and Northpond III GP and shares voting and investment authority over these shares.

     

    (3)This percentage is calculated based on 42,997,525 shares of Common Stock outstanding as of February 12, 2024 upon the closing of the Issuer’s initial public offering, as reported in the prospectus dated February 7, 2024 filed by the Issuer with the SEC on February 8, 2024.

     

    6 

     

     

    Item 1.
      (a)

    Name of Issuer

    Kyverna Therapeutics, Inc.

      (b)

    Address of Issuer’s Principal Executive Offices

    5980 Horton St., Ste. 550

    Emeryville, CA 94608

     
    Item 2.
      (a)

    Name of Person Filing

    Northpond Ventures, LP (“Northpond”)

    Northpond Ventures GP, LLC (“Northpond GP”)

    Northpond Ventures III, LP (“Northpond III”)

    Northpond Ventures III GP, LLC (“Northpond III GP”)

    Michael P. Rubin (“Rubin”)

      (b)

    Address of Principal Business Office or, if none, Residence

    7500 Old Georgetown Road, Suite 800

    Bethesda , MD 20814

      (c)

    Citizenship

        Entities: Northpond - Delaware
          Northpond GP - Delaware
          Northpond III - Delaware
          Northpond III GP - Delaware
        Individuals: Rubin - United States
      (d)

    Title of Class of Securities

    Common Stock, $0.00001 par value (“Common Stock”)

      (e)

    CUSIP Number

    501976104

     

    Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
      Not applicable

     

    7 

     

     

    Item 4. Ownership
    The following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1 is provided as of February 22, 2024:

     

    Reporting Persons  Shares
    Held
    Directly
       Sole
    Voting
    Power
       Shared
    Voting
    Power
       Sole
    Dispositive
    Power
       Shared
    Dispositive
    Power
       Beneficial
    Ownership
       Percentage
    of Class (3)
     
    Northpond (1)   450,000         450,000        450,000    450,000    1.0%
    Northpond GP (1)            450,000         450,000    450,000    1.0%
    Northpond III (2)   2,805,426        2,805,426        2,805,426    2,805,426    6.5%
    Northpond III GP (2)             2,805,426         2,805,426    2,805,426    6.5%
    Rubin (1) (2)            3,255,426        3,255,426    3,255,426    7.6%

     

    (1)    Includes 450,000 shares held by Northpond. Northpond GP is the general partner of Northpond and Rubin is the managing member of Northpond GP. As such, Northpond GP and Rubin have shared dispositive and voting power over the shares held by Northpond and may be deemed to have indirect beneficial ownership of the shares held by Northpond.

    (2)    Includes 2,805,426 shares held by Northpond III. Northpond III GP is the general partner of Northpond III and Rubin is the managing member of Northpond III GP. As such, Northpond III GP and Rubin have shared dispositive and voting power over the shares held by Northpond III and may be deemed to have indirect beneficial ownership of the shares held by Northpond III.

    (3)    This percentage is calculated based on 42,997,525 shares of Common Stock outstanding as of February 12, 2024 upon the closing of the Issuer’s initial public offering, as reported in the prospectus dated February 7, 2024 filed by the Issuer with the SEC on February 8, 2024.

     
    Item 5. Ownership of Five Percent or Less of a Class
      If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   ¨
     
    Item 6. Ownership of More than Five Percent on Behalf of Another Person
      Not applicable
     
    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
      Not applicable
     
    Item 8. Identification and Classification of Members of the Group
      Not applicable
     
    Item 9. Notice of Dissolution of Group
      Not applicable

     

    Item 10. Certification
      By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.

     

    8 

     

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: February 22, 2024

     

    Northpond Ventures, LP  
         
    By: Northpond Ventures GP, LLC  
    its General Partner  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    Northpond Ventures GP, LLC  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    Northpond Ventures III, LP  
         
    By: Northpond Ventures III GP, LLC  
    its General Partner  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    Northpond Ventures III GP, LLC  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    /s/ Michael P. Rubin  
    Michael P. Rubin  

     

      ATTENTION  
    Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).

     

    9 

     

     

    Exhibit(s):

     

    AJoint Filing Agreement

     

    10 

     

     

    EXHIBIT A

     

    JOINT FILING AGREEMENT

     

    We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the Common Stock of Kyverna Therapeutics, Inc. is filed on behalf of each of us.

     

    Dated: February 22, 2024

     

    Northpond Ventures, LP  
         
    By: Northpond Ventures GP, LLC  
    its General Partner  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    Northpond Ventures GP, LLC  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    Northpond Ventures III, LP  
         
    By: Northpond Ventures III GP, LLC  
    its General Partner  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    Northpond Ventures III GP, LLC  
         
    By: /s/ Patrick Smerkers  
      Name: Patrick Smerkers  
      Title: Chief Financial Officer  
         
    /s/ Michael P. Rubin  
    Michael P. Rubin  

     

     

     

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    SC 13G - Kyverna Therapeutics, Inc. (0001994702) (Subject)

    10/10/24 12:36:27 PM ET
    $KYTX
    Biotechnology: Biological Products (No Diagnostic Substances)
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    SEC Form SC 13D filed by Kyverna Therapeutics Inc.

    SC 13D - Kyverna Therapeutics, Inc. (0001994702) (Subject)

    5/3/24 5:57:02 PM ET
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    Biotechnology: Biological Products (No Diagnostic Substances)
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    $KYTX
    Leadership Updates

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    Kyverna Therapeutics Appoints Mayo Pujols as Chief Technology Officer

    EMERYVILLE, Calif., Feb. 03, 2026 (GLOBE NEWSWIRE) -- Kyverna Therapeutics, Inc. (NASDAQ:KYTX), a clinical stage biopharmaceutical company developing cell therapies for patients with autoimmune diseases, today announced the appointment of Mayo Pujols as its Chief Technology Officer (CTO), effective February 9, 2026. Mr. Pujols brings more than 30 years of technical operations experience to the role with a deep background in leading late-stage and commercial manufacturing for cell and gene therapies. His work spans both large-scale and smaller biopharmaceutical companies with a proven track record of successfully advancing programs across their lifecycles. He succeeds Karen Walker, who is

    2/3/26 8:00:00 AM ET
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    Biotechnology: Biological Products (No Diagnostic Substances)
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    Kyverna Therapeutics Provides Business Update and Reports Second Quarter 2025 Financial Results

    Topline data for registrational Phase 2 trial of KYV-101 in stiff person syndrome (SPS) andBLA submission anticipated in 1H 2026 Registrational Phase 3 KYV-101 trial in myasthenia gravis (MG) to include ~60 patients with enrollment to initiate by year-end 2025; interim Phase 2 data expected in Q4 2025 Strong cash position to support upcoming milestones EMERYVILLE, Calif., Aug. 12, 2025 (GLOBE NEWSWIRE) -- Kyverna Therapeutics, Inc. (NASDAQ:KYTX), a clinical-stage biopharmaceutical company focused on developing cell therapies for patients with autoimmune diseases, today reported its business highlights and financial results for the quarter ended June 30, 2025.   "The second quarter was

    8/12/25 4:02:00 PM ET
    $KYTX
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Kyverna Therapeutics to Host Virtual KOL Event to Highlight Neuroimmunology CAR T Franchise

    Webcast to be held August 28, 2025, 11:00am ET EMERYVILLE, Calif., July 29, 2025 /PRNewswire/ -- Kyverna Therapeutics, Inc. ((Kyverna, NASDAQ:KYTX), a clinical-stage biopharmaceutical company focused on developing cell therapies for patients with autoimmune diseases, today announced that the Company will host a webcast event with Key Opinion Leaders (KOLs) to discuss its neuroimmunology franchise. The event will take place on Thursday, August 28, 2025, from 11:00am to 1:30pm ET. Presentations will feature members of the Company's management team and the following renowned KOLs: Srikanth Muppidi, M.D., Stanford MedicineRicardo Grieshaber-Bouyer, M.D., Ph.D., FAU Erlangen-NümbergAiden Haghiki

    7/29/25 8:30:00 AM ET
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    Biotechnology: Biological Products (No Diagnostic Substances)
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    $KYTX
    Financials

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    Kyverna Therapeutics Announces Positive Topline Data from Registrational KYSA-8 Trial of Miv-cel (KYV-101) in Stiff Person Syndrome

    Landmark results could pave the way for miv-cel to become the first FDA-approved CAR T-cell therapy for autoimmune disease; Company on track to submit BLA for stiff person syndrome in 1H 2026  Miv-cel achieved statistically significant clinical benefit across all primary and secondary endpoints, reversing disability and eliminating immunotherapies after a single dose Miv-cel was generally well-tolerated with no high-grade CRS or ICANS observed SPS is a debilitating, progressive autoimmune disease with no FDA-approved therapies Company to host webcast today, December 15, 2025 at 8 am ET EMERYVILLE, Calif., Dec. 15, 2025 (GLOBE NEWSWIRE) -- Kyverna Therapeutics, Inc. (NASDAQ:KYTX), a c

    12/15/25 6:30:00 AM ET
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    Biotechnology: Biological Products (No Diagnostic Substances)
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    Kyverna Therapeutics to Report Topline Results from Registrational Phase 2 KYSA-8 Trial of KYV-101 in Stiff Person Syndrome

    EMERYVILLE, Calif., Dec. 14, 2025 (GLOBE NEWSWIRE) -- Kyverna Therapeutics, Inc. (NASDAQ:KYTX), a clinical-stage biopharmaceutical company focused on developing cell therapies for patients with autoimmune diseases, announced it will host a live webcast and conference call on Monday, December 15, 2025 at 8:00 am ET to review topline results from the registrational Phase 2 KYSA-8 clinical trial evaluating KYV-101 in stiff person syndrome (SPS). Conference Call Details Participants will need to register at the below-noted URL in order to listen and participate in the call. Once registered, participants will receive a dial-in phone number and unique PIN number which will be needed to join th

    12/14/25 2:30:00 PM ET
    $KYTX
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Kyverna Therapeutics Announces Positive Interim Phase 2 Data from KYSA-6 Study of KYV-101 in Generalized Myasthenia Gravis at AANEM 2025

    Compelling results set new clinical standard in generalized myasthenia gravis (gMG), increasing confidence in the Company's registrational KYSA-6 Phase 3 MG trial 100% of patients achieved clinically meaningful responses in MG-ADL and QMG -- the co-primary endpoints of the Phase 3 trial -- with mean reductions of -8.0 pts and -7.7 points at 24 weeks KYV-101 was well-tolerated with no high-grade CRS and no ICANS observed, further supporting the consistent and manageable safety profile of KYV-101 Unprecedented results further reinforce KYV-101's potential to deliver durable, drug-free, disease-free remission with a single dose Company to host conference call today, October 29, 2025, at 8:0

    10/29/25 6:30:00 AM ET
    $KYTX
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care