SC 13G

NAMES OF REPORTING PERSONS

  I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (entities only)

  Eli Lilly and Company

  35-0470950

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)

(a) ☐ (b) ☐

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

Indiana

SC 13G 1 d181708dsc13g.htm SC 13G SC 13G

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

ProQR Therapeutics N.V.

(Name of Issuer)

Ordinary Shares, nominal value 0.04 EUR per share

(Title of Class of Securities)

N71542109

(CUSIP Number)

September 3, 2021

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13G

CUSIP No. N71542109

SCHEDULE 13G


*Item 1 (a)*		*Name of issuer:* ProQR Therapeutics N.V.

*Item 1 (b)*		*Address of issuer’s principal executive offices:* Darwinweg 24 Leiden P7 2333CR

*Item 2 (a)*		*Name of person filing:* This Statement is filed on behalf of Eli Lilly and Company, an Indiana corporation

*Item 2 (b)*		*Address or principal business office or, if none, residence:* Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285

*Item 2 (c)*		*Citizenship:* Eli Lilly and Company is an Indiana corporation.

*Item 2 (d)*		*Title of class of securities:* Ordinary Shares, nominal value 0.04 EUR per share

*Item 2 (e)*		*CUSIP No.:* N71542109

*Item 3.*		*If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:* Not Applicable

*Item 4.*		*Ownership:* Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

*(a)*		*Amount beneficially owned:* 3,989,976

*(b)*		*Percent of class:* 5.6%

*(c)*		*Number of shares as to which the person has:*

		*(i) Sole power to vote or to direct the vote* 3,989,976

		*(ii) Shared power to vote or to direct the vote* N/A

		*(iii) Sole power to dispose or to direct the disposition of* 3,989,976

		*(iv) Shared power to dispose or to direct the disposition of* N/A

*Item 5.*		*Ownership of 5 Percent or Less of a Class.* Not Applicable


*Item 6.*		*Ownership of More than 5 Percent on Behalf of Another Person.* Not Applicable

*Item 7.*		*Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.* Not Applicable

*Item 8.*		*Identification and Classification of Members of the Group.* Not Applicable

*Item 9.*		*Notice of Dissolution of Group.* Not Applicable

*Item 10.*		*Certifications* By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect other than activities solely in connection with a nomination under §240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: September 10, 2021


ELI LILLY AND COMPANY

By:		*
		Authorized Signatory

/s/ Erin Conway

*By:

Erin Conway

Attorney–in-Fact

This Schedule 13G was executed pursuant to a power of attorney previously filed with the Securities and Exchange Commission, and hereby incorporated by reference herein. The power of attorney for Eli Lilly and Company was filed as an attachment to a filing by Eli Lilly and Company on Schedule 13G for Sigilon Therapeutics, Inc. on February 12, 2021.

SEC Form SC 13G filed by ProQR Therapeutics N.V.