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    SEC Form SC 13G/A filed by Aprea Therapeutics Inc. (Amendment)

    2/10/22 8:44:54 PM ET
    $APRE
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $APRE alert in real time by email
    SC 13G/A 1 d258346dsc13ga.htm SC 13G/A SC 13G/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13G

    (Rule 13d-102)

    INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)

    (Amendment No. 2)

     

     

    Aprea Therapeutics, Inc.

    (Name of Issuer)

    Common Stock, par value $0.001 per share

    (Title of Class of Securities)

    03836J102

    (CUSIP Number)

    December 31, 2021

    (Date of Event Which Requires Filing of this Statement)

     

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

    ☐    Rule 13d-1(b)

    ☒    Rule 13d-1(c)

    ☐    Rule 13d-1(d)

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     


    CUSIP No. 03836J102   13G   

     

      1.    

      Name of Reporting Persons

     

      Versant Ventures V, LLC

      2.  

      Check the Appropriate Box if a Member of a Group (See Instructions)

      (a)  ☐        (b)  ☒(1)

     

      3.  

      SEC Use Only

     

      4.  

      Citizenship or Place of Organization

     

      Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5.    

      Sole Voting Power

     

      0

       6.  

      Shared Voting Power

     

      0

       7.  

      Sole Dispositive Power

     

          0

       8.  

      Shared Dispositive Power

     

      0

      9.    

      Aggregate Amount Beneficially Owned by Each Reporting Person

     

      0

    10.  

      Check if the Aggregate Amount in Row 9 Excludes Certain Shares (See Instructions)

     

      ☐

    11.  

      Percent of Class Represented by Amount in Row 9

     

      0.0%

    12.  

      Type of Reporting Person (See Instructions)

     

      OO

     

    (1)

    This Schedule 13G is filed by Versant Venture Capital V, L.P. (“VVC V”), Versant Affiliates Fund V, L.P. (“VAF V”), Versant Ophthalmic Affiliates Fund I, L.P. (“VOA”), Versant Ventures V, LLC (“VV V”), Versant Ventures V (Canada), L.P. (“VV CAN GP”), Versant Venture Capital V (Canada) LP (“VVC CAN”),Versant Ventures V GP-GP (Canada), Inc. (“VV CAN GP-GP”, and together with VVC V, VAF V, VOA, VV V, VV CAN, VVC CAN and VV CAN GP, the “Reporting Persons”). VV V is the sole general partner of each of VVC V, VAF V and VOA and VV CAN GP-GP is the sole general partner of VV CAN GP which is the sole general partner of VVC CAN. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.


    CUSIP No. 03836J102   13G   

     

      1.    

      Name of Reporting Persons

     

      Versant Ventures V GP-GP (Canada), Inc.

      2.  

      Check the Appropriate Box if a Member of a Group (See Instructions)

      (a)  ☐        (b)  ☒(1)

     

      3.  

      SEC Use Only

     

      4.  

      Citizenship or Place of Organization

     

      Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5.    

      Sole Voting Power

     

      0

       6.  

      Shared Voting Power

     

      0

       7.  

      Sole Dispositive Power

     

          0

       8.  

      Shared Dispositive Power

     

      0

      9.    

      Aggregate Amount Beneficially Owned by Each Reporting Person

     

      0

    10.  

      Check if the Aggregate Amount in Row 9 Excludes Certain Shares (See Instructions)

     

      ☐

    11.  

      Percent of Class Represented by Amount in Row 9

     

      0.0%

    12.  

      Type of Reporting Person (See Instructions)

     

      CO

     

    (1)

    This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.


    CUSIP No. 03836J102   13G   

     

      1.    

      Name of Reporting Persons

     

      Versant Ventures V (Canada), L.P.

      2.  

      Check the Appropriate Box if a Member of a Group (See Instructions)

      (a)  ☐        (b)  ☒(1)

     

      3.  

      SEC Use Only

     

      4.  

      Citizenship or Place of Organization

     

      Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5.    

      Sole Voting Power

     

      0

       6.  

      Shared Voting Power

     

      0

       7.  

      Sole Dispositive Power

     

          0

       8.  

      Shared Dispositive Power

     

      0

      9.    

      Aggregate Amount Beneficially Owned by Each Reporting Person

     

      0

    10.  

      Check if the Aggregate Amount in Row 9 Excludes Certain Shares (See Instructions)

     

      ☐

    11.  

      Percent of Class Represented by Amount in Row 9

     

      0.0%

    12.  

      Type of Reporting Person (See Instructions)

     

      PN

     

    (1)

    This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.


    CUSIP No. 03836J102   13G   

     

      1.    

      Name of Reporting Persons

     

      Versant Venture Capital V (Canada) LP

      2.  

      Check the Appropriate Box if a Member of a Group (See Instructions)

      (a)  ☐        (b)  ☒(1)

     

      3.  

      SEC Use Only

     

      4.  

      Citizenship or Place of Organization

     

      Ontario, Canada

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5.    

      Sole Voting Power

     

      0

       6.  

      Shared Voting Power

     

      0

       7.  

      Sole Dispositive Power

     

          0

       8.  

      Shared Dispositive Power

     

      0

      9.    

      Aggregate Amount Beneficially Owned by Each Reporting Person

     

      0

    10.  

      Check if the Aggregate Amount in Row 9 Excludes Certain Shares (See Instructions)

     

      ☐

    11.  

      Percent of Class Represented by Amount in Row 9

     

      0.0%

    12.  

      Type of Reporting Person (See Instructions)

     

      PN

     

    (1)

    This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.


    CUSIP No. 03836J102   13G   

     

      1.    

      Name of Reporting Persons

     

      Versant Affiliates Fund V, L.P.

      2.  

      Check the Appropriate Box if a Member of a Group (See Instructions)

      (a)  ☐        (b)  ☒(1)

     

      3.  

      SEC Use Only

     

      4.  

      Citizenship or Place of Organization

     

      Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5.    

      Sole Voting Power

     

      0

       6.  

      Shared Voting Power

     

      0

       7.  

      Sole Dispositive Power

     

          0

       8.  

      Shared Dispositive Power

     

      0

      9.    

      Aggregate Amount Beneficially Owned by Each Reporting Person

     

      0

    10.  

      Check if the Aggregate Amount in Row 9 Excludes Certain Shares (See Instructions)

     

      ☐

    11.  

      Percent of Class Represented by Amount in Row 9

     

      0.0%

    12.  

      Type of Reporting Person (See Instructions)

     

      PN

     

    (1)

    This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.


    CUSIP No. 03836J102   13G   

     

      1.    

      Name of Reporting Persons

     

      Versant Ophthalmic Affiliates Fund I, L.P.

      2.  

      Check the Appropriate Box if a Member of a Group (See Instructions)

      (a)  ☐        (b)  ☒(1)

     

      3.  

      SEC Use Only

     

      4.  

      Citizenship or Place of Organization

     

      Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5.    

      Sole Voting Power

     

      0

       6.  

      Shared Voting Power

     

      0

       7.  

      Sole Dispositive Power

     

          0

       8.  

      Shared Dispositive Power

     

      0

      9.    

      Aggregate Amount Beneficially Owned by Each Reporting Person

     

      0

    10.  

      Check if the Aggregate Amount in Row 9 Excludes Certain Shares (See Instructions)

     

      ☐

    11.  

      Percent of Class Represented by Amount in Row 9

     

      0.0%

    12.  

      Type of Reporting Person (See Instructions)

     

      PN

     

    (1)

    This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.


    CUSIP No. 03836J102   13G   

     

      1.    

      Name of Reporting Persons

     

      Versant Venture Capital V, L.P.

      2.  

      Check the Appropriate Box if a Member of a Group (See Instructions)

      (a)  ☐        (b)  ☒(1)

     

      3.  

      SEC Use Only

     

      4.  

      Citizenship or Place of Organization

     

      Delaware

    Number of

    Shares

     Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5.    

      Sole Voting Power

     

      0

       6.  

      Shared Voting Power

     

      0

       7.  

      Sole Dispositive Power

     

          0

       8.  

      Shared Dispositive Power

     

      0

      9.    

      Aggregate Amount Beneficially Owned by Each Reporting Person

     

      0

    10.  

      Check if the Aggregate Amount in Row 9 Excludes Certain Shares (See Instructions)

     

      ☐

    11.  

      Percent of Class Represented by Amount in Row 9

     

      0.0%

    12.  

      Type of Reporting Person (See Instructions)

     

      PN

     

    (1)

    This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.


    Introductory Note: This Amendment No. 2 (this “Amendment”) amends and supplements the Schedule 13G originally filed by the Reporting Persons with the United States Securities and Exchange Commission (the “Commission”) on October 17, 2019, as amended by Amendment No. 1 filed with the Commission on February 16, 2021 (collectively, the “Original Schedule 13G”). Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13G remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original Schedule 13G.

     

    Item 2(a)

    Name of Persons Filing

     

      (a)

    Name of Person(s) Filing:

    Versant Vantage I, L.P., Versant Vantage I GP, L.P. and Versant Vantage I GP-GP, LLC, each a reporting person on the Original Schedule 13G, reported the disposition of all of their holdings and beneficial ownership in the Original Schedule 13G, and accordingly, are no longer Reporting Persons.

     

    Item 4

    Ownership

    The following information with respect to the ownership of the Issuer’s Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of the date of the filing of this Amendment:

     

      (a)

    Amount beneficially owned:

    See line 9 of each cover sheet.

     

      (b)

    Percent of class:

    See line 11 of each cover sheet.

     

      (c)

    Number of shares as to which the person has:

     

      i.

    Sole power to vote or to direct the vote: see line 5 of cover sheets.*

     

      ii.

    Shared power to vote or to direct the vote: see line 6 of cover sheets.*

     

      iii.

    Sole power to dispose or to direct the disposition of: see line 7 of cover sheets.*

     

      iv.

    Shared power to dispose or to direct the disposition of: see line 8 of cover sheets.*

     

    *

    Each Reporting Person disclaims beneficial ownership of such shares of Common Stock, except for the shares, if any, such Reporting Person holds of record and to the extent of its pecuniary interest therein.

     

    Item 5

    Ownership of Five Percent or Less of a Class

    If this statement is being filed to report the fact that as of the date hereof, the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities, check the following:  ☒


    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

    February 11, 2022

     

    Versant Ventures V, LLC
    By:  

    /s/ Robin L. Praeger

      Robin L. Praeger, Managing Director
    Versant Ventures V GP-GP (Canada), Inc.
    By:  

    /s/ Robin L. Praeger

      Robin L. Praeger, Director
    Versant Ventures V (Canada), L.P.
    By: Versant Ventures V GP-GP (Canada), Inc.
    Its: General Partner
    By:  

    /s/ Robin L. Praeger

      Robin L. Praeger, Director
    Versant Venture Capital V (Canada) LP
    By: Versant Ventures V (Canada), L.P.
    Its: General Partner
    By: Versant Ventures V GP-GP (Canada), Inc.
    Its: General Partner
    By:  

    /s/ Robin L. Praeger

      Robin L. Praeger, Director
    Versant Affiliates Fund V, L.P.
    By: Versant Ventures V, LLC
    Its: General Partner
    By:  

    /s/ Robin L. Praeger

      Robin L. Praeger, Managing Director
    Versant Ophthalmic Affiliates Fund I, L.P.
    By: Versant Ventures V, LLC
    Its: General Partner
    By:  

    /s/ Robin L. Praeger

      Robin L. Praeger, Managing Director
    Versant Venture Capital V, L.P.
    By: Versant Ventures V, LLC
    Its: General Partner
    By:  

    /s/ Robin L. Praeger

      Robin L. Praeger, Managing Director
    Get the next $APRE alert in real time by email

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      BOSTON, May 16, 2022 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (NASDAQ:APRE), a biopharmaceutical company focused on developing and commercializing novel cancer therapeutics targeting DNA damage response pathways today announced that it has acquired Atrin Pharmaceuticals Inc. ("Atrin") and reported financial results for the three months ended March 31, 2022. Business Operations Update:  On May 16, 2022 Aprea completed the acquisition of Atrin, a privately held biotechnology company focused on the discovery and development of novel therapeutics targeting proteins in the DNA damage response, or DDR, pathway in oncology through synthetic lethality. The Company believes its cash and cash

      5/16/22 9:21:33 AM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Aprea Therapeutics Announces a Partial Clinical Hold on Myeloid Malignancy Programs

      BOSTON, Aug. 05, 2021 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (NASDAQ:APRE), a biopharmaceutical company focused on developing and commercializing novel cancer therapeutics that reactivate mutant tumor suppressor protein, p53, today announced that the U.S. Food and Drug Administration (FDA) has placed a partial clinical hold on its clinical trials of eprenetapopt in combination with azacitidine in its myeloid malignancy programs. The partial clinical hold does not apply to the Company's ongoing clinical trials in lymphoid malignancies and solid tumors, or the APR-548 clinical trial. There are approximately 20 patients currently receiving eprenetapopt in combination with azacitidine i

      8/5/21 5:00:00 PM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $APRE
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

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    • President/CEO Gilad Oren bought $10,110 worth of shares (5,500 units at $1.84), increasing direct ownership by 2% to 345,620 units (SEC Form 4)

      4 - Aprea Therapeutics, Inc. (0001781983) (Issuer)

      4/4/25 7:30:11 AM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • President/CEO Gilad Oren bought $1,958 worth of shares (500 units at $3.92), increasing direct ownership by 0.15% to 333,395 units (SEC Form 4)

      4 - Aprea Therapeutics, Inc. (0001781983) (Issuer)

      10/24/24 8:30:13 AM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Director Duey Marc bought $131,700 worth of shares (30,000 units at $4.39), increasing direct ownership by 14% to 240,113 units (SEC Form 4)

      4 - Aprea Therapeutics, Inc. (0001781983) (Issuer)

      10/17/24 8:30:55 AM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $APRE
    SEC Filings

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    • SEC Form DEFA14A filed by Aprea Therapeutics Inc.

      DEFA14A - Aprea Therapeutics, Inc. (0001781983) (Filer)

      4/22/25 4:15:12 PM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form DEF 14A filed by Aprea Therapeutics Inc.

      DEF 14A - Aprea Therapeutics, Inc. (0001781983) (Filer)

      4/22/25 4:05:14 PM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SCHEDULE 13G/A filed by Aprea Therapeutics Inc.

      SCHEDULE 13G/A - Aprea Therapeutics, Inc. (0001781983) (Subject)

      4/8/25 3:14:41 PM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $APRE
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    • SEC Form SC 13G filed by Aprea Therapeutics Inc.

      SC 13G - Aprea Therapeutics, Inc. (0001781983) (Subject)

      10/10/24 4:07:13 PM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by Aprea Therapeutics Inc.

      SC 13G - Aprea Therapeutics, Inc. (0001781983) (Subject)

      2/14/24 8:00:11 AM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed by Aprea Therapeutics Inc. (Amendment)

      SC 13G/A - Aprea Therapeutics, Inc. (0001781983) (Subject)

      2/7/24 6:55:18 PM ET
      $APRE
      Biotechnology: Pharmaceutical Preparations
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