• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Dashboard
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlerts
    Company
    AboutQuantisnow PlusContactJobs
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form SC 13G/A filed by Autolus Therapeutics plc (Amendment)

    2/14/24 4:08:06 PM ET
    $AUTL
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $AUTL alert in real time by email
    SC 13G/A 1 tm245955d3_sc13ga.htm SC 13G/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13G

    Under the Securities Exchange Act of 1934

    (Amendment No. 1)*

     

     

    Autolus Therapeutics plc

    (Name of Issuer)

     

    Ordinary Shares, nominal value $0.000042 per share**

    (Title of Class of Securities)

     

    05280R100***

    (CUSIP Number)

     

    December 31, 2023

    (Date of Event Which Requires Filing of this statement)

     

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

    ¨Rule 13d-1(b)

     

    xRule 13d-1(c)

     

    ¨Rule 13d-1(d)

     

    * The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

     

    ** The Reporting Persons own ordinary shares through the Issuer’ s American Depositary Shares, each representing one ordinary share.

     

    *** The ordinary shares have no CUSIP number. The CUSIP number for the Issuer’ s American Depositary Shares, each representing one ordinary share, is 05280R100.

     

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

    Page 1 of 9 Pages

     

     

    CUSIP No. 05280R100

     

    1.Names of Reporting Persons

     

    Paradigm BioCapital Advisors LP

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a)¨
    (b)x

     

    3.SEC Use Only

     

    4.Citizenship or Place of Organization

     

    Delaware

     

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH:
    5.  SOLE VOTING POWER 12,611,335  
    6.  SHARED VOTING POWER 0  
    7.  SOLE DISPOSITIVE POWER 12,611,335  
    8.  SHARED DISPOSITIVE POWER 0  

     

    9.Aggregate Amount Beneficially Owned by Each Reporting Person

     

    12,611,335

     

    10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

     

    11.Percent of Class Represented by Amount in Row (9)

     

    7.2%

     

    12.Type of Reporting Person (See Instructions)

     

    PN

     

    Page 2 of 9 Pages

     

    CUSIP No. 05280R100

     

    1.Names of Reporting Persons

     

    Paradigm BioCapital Advisors GP LLC

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a)¨
    (b)x

     

    3.SEC Use Only

     

    4.Citizenship or Place of Organization

     

    Delaware

     

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH:
    5.  SOLE VOTING POWER 12,611,335  
    6.  SHARED VOTING POWER 0  
    7.  SOLE DISPOSITIVE POWER 12,611,335  
    8.  SHARED DISPOSITIVE POWER 0  

     

    9.Aggregate Amount Beneficially Owned by Each Reporting Person

     

    12,611,335

     

    10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

     

    11.Percent of Class Represented by Amount in Row (9)

     

    7.2%

     

    12.Type of Reporting Person (See Instructions)

     

    OO

     

    Page 3 of 9 Pages

     

     

    CUSIP No. 05280R100

     

    1.Names of Reporting Persons

     

    Senai Asefaw, M.D.

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a)¨
    (b)x

     

    3.SEC Use Only

     

    4.Citizenship or Place of Organization

     

    United States of America

     

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH:
    5.  SOLE VOTING POWER 12,611,335  
    6.  SHARED VOTING POWER 0  
    7.  SOLE DISPOSITIVE POWER 12,611,335  
    8.  SHARED DISPOSITIVE POWER 0  

     

    9.Aggregate Amount Beneficially Owned by Each Reporting Person

     

    12,611,335

     

    10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

     

    11.Percent of Class Represented by Amount in Row (9)

     

    7.2%

     

    12.Type of Reporting Person (See Instructions)

     

    IN

     

    Page 4 of 9 Pages

     

     

    CUSIP No. 05280R100

     

    1.Names of Reporting Persons

     

    Paradigm BioCapital International Fund Ltd.

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a)¨
    (b)x

     

    3.SEC Use Only

     

    4.Citizenship or Place of Organization

     

    Cayman Islands

     

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH:
    5.  SOLE VOTING POWER 10,754,846  
    6.  SHARED VOTING POWER 0  
    7.  SOLE DISPOSITIVE POWER 10,754,846  
    8.  SHARED DISPOSITIVE POWER 0  

     

    9.Aggregate Amount Beneficially Owned by Each Reporting Person

     

    10,754,846

     

    10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

     

    11.Percent of Class Represented by Amount in Row (9)

     

    6.2%

     

    12.Type of Reporting Person (See Instructions)

     

    CO

     

    Page 5 of 9 Pages

     

     

    Item 1.

     

    (a)The name of the issuer is Autolus Therapeutics plc (the “Issuer”).

     

    (b)The principal executive offices of the Issuer are located at The Mediaworks, 191 Wood Lane, London W12 7FP, United Kingdom.

     

    Item 2.

     

    (a)This Schedule 13G/A1 is filed by the following (the “Reporting Persons”): (1) Paradigm BioCapital Advisors LP (the “Adviser”); (2) Paradigm BioCapital Advisors GP LLC (the “GP”); (3) Senai Asefaw, M.D. (“Senai Asefaw”); and (4) Paradigm BioCapital International Fund Ltd. (the “Fund”). The Fund is a private investment vehicle. The Fund and a separately managed account managed by the Adviser (the “Account”) directly beneficially own the Ordinary Shares (as defined below) reported in this Statement. The Adviser is the investment manager of the Fund and the Account. The GP is the general partner of the Adviser. Senai Asefaw is the managing member of the GP. The Adviser, the GP and Senai Asefaw may be deemed to beneficially own the Ordinary Shares directly beneficially owned by the Fund and the Account. Each Reporting Person disclaims beneficial ownership with respect to any Ordinary Shares other than the Ordinary Shares directly beneficially owned by such Reporting Person.

     

    (b)The principal business office of the Reporting Persons is 767 Third Avenue, 17th Floor, New York, NY 10017.

     

    (c)For citizenship information see Item 4 of the cover page of each Reporting Person.

     

    (d)This statement relates to the Ordinary shares, nominal value $0.000042 per share, of the Issuer (the “Ordinary Shares”).

     

    (e)The Ordinary Shares have no CUSIP number. The CUSIP number for the Issuer’s American Depositary Shares, each representing one Ordinary Share, is 05280R100.

     

    Item 3. If this statement is filed pursuant to 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

     

    (a)¨ Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
    (b)¨ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
    (c)¨ Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
    (d)¨ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
    (e)¨ An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);
    (f)¨ An employee benefit plan or endowment fund in accordance with 240.13d-1(b)(1)(ii)(F);

     

    Page 6 of 9 Pages

     

     

    (g)¨ A parent holding company or control person in accordance with 240.13d-1(b)(1)(ii)(G);

    (h)¨ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)¨ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)¨ A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);
    (k)¨ Group, in accordance with §240.13d-1(b)(1)(ii)(K).

     

    If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution:__________________________

     

    Item 4. Ownership.

     

    See Items 5-9 and 11 on the cover page for each Reporting Person, and Item 2, which information is given as of the Event Date of this Schedule 13G/A1.

     

    The percentages of beneficial ownership contained herein are based on 173,989,157 Ordinary Shares outstanding as of November 9, 2023, as disclosed in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 9, 2023.

     

    Item 5. Ownership of Five Percent or Less of a Class.

     

    If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: ¨

     

    Item 6. Ownership of More than Five Percent on Behalf of Another Person.

     

    Not applicable.

     

    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.

     

    Not applicable.

     

    Item 8. Identification and Classification of Members of the Group.

     

    Not applicable. 

     

    Item 9. Notice of Dissolution of Group.

     

    Not applicable.

     

    Page 7 of 9 Pages

     

     

    Item 10. Certification.

     

    (a)Not applicable.

     

    (b)Not applicable.

     

    (c)By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a-11.

     

     

     

    Page 8 of 9 Pages

     

     

    SIGNATURE

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: February 14, 2024

     

    Paradigm BioCapital Advisors LP

    Paradigm BioCapital Advisors GP LLC

    Paradigm BioCapital International Fund Ltd.

     

     

    By: /s/ David K. Kim  
    Name: David K. Kim  
    Title: Authorized Signatory  
       
       
    /s/ Senai Asefaw, M.D.  
    Senai Asefaw, M.D.  

     

    Page 9 of 9 Pages

     

    Get the next $AUTL alert in real time by email

    Chat with this insight

    Save time and jump to the most important pieces.

    Recent Analyst Ratings for
    $AUTL

    DatePrice TargetRatingAnalyst
    11/18/2024$7.00 → $7.60Neutral → Buy
    Goldman
    11/15/2024$13.00Neutral → Buy
    Redburn Atlantic
    11/9/2023$10.00Buy
    Deutsche Bank
    3/27/2023$8.00Overweight
    Wells Fargo
    3/17/2023$5.00Buy
    Bryan Garnier
    More analyst ratings

    $AUTL
    Financials

    Live finance-specific insights

    See more
    • Autolus Therapeutics Reports First Quarter 2025 Financial Results and Business Updates

      Company reports Q1 2025 AUCATZYL® net product revenue of $9.0 millionU.K. Medicines and Healthcare products Regulatory Agency (MHRA) granted conditional marketing authorization for AUCATZYL® for the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (r/r B-ALL)Encouraging preliminary data reported in Phase 1 CARLYSLE trial in systemic lupus erythematosus (SLE); planned Phase 2 pivotal clinical trial in lupus nephritis (LN) and Phase 1 clinical trial in progressive forms of multiple sclerosis (MS) initiating before year-end 2025Conference call to be held today at 08:30 am EDT/13:30 pm GMT: conference call participants should pre-register usin

      5/8/25 7:00:00 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Autolus Therapeutics Highlights Advancing Autoimmune Pipeline at R&D Investor Event

      Company outlined potential for value creation driven by obe-cel across multiple B cell driven malignancies and autoimmune diseases, including acute lymphoblastic leukemia (ALL), lupus nephritis (LN) and multiple sclerosis (MS)Preliminary data in initial six patient cohort treated in Phase 1 trial in systemic lupus erythematosus (SLE) support progressing obe-cel into a planned Phase 2 pivotal study in lupus nephritis; first patient expected to be dosed in Phase 2 trial by year-end 2025Company plans to advance obe-cel in progressive forms of multiple sclerosis (MS); first patient expected to be dosed in Phase 1 trial by year-end 2025 LONDON, April 23, 2025 (GLOBE NEWSWIRE) -- Autolus Therap

      4/23/25 4:05:00 PM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Autolus Therapeutics to Report First Quarter 2025 Financial Results and Host Conference Call on May 8, 2025

      LONDON, April 22, 2025 (GLOBE NEWSWIRE) -- Autolus Therapeutics plc (NASDAQ:AUTL), an early commercial stage biopharmaceutical company developing, manufacturing and delivering next-generation programmed T cell therapies, today announces that it will release its first quarter 2025 financial results and operational highlights before open of US markets on Thursday, May 8, 2025. Management will host a conference call and webcast at 8:30 am EDT/13:30 pm BST to discuss the company's financial results and provide a general business update. Conference call participants should pre-register using this link to receive the dial-in numbers and a personal PIN, which are required to access the conferenc

      4/22/25 7:00:00 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $AUTL
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • Amendment: SEC Form SC 13G/A filed by Autolus Therapeutics plc

      SC 13G/A - Autolus Therapeutics plc (0001730463) (Subject)

      11/14/24 4:32:31 PM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Autolus Therapeutics plc

      SC 13G/A - Autolus Therapeutics plc (0001730463) (Subject)

      11/14/24 1:44:27 PM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Autolus Therapeutics plc

      SC 13G/A - Autolus Therapeutics plc (0001730463) (Subject)

      11/14/24 9:12:16 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $AUTL
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • Autolus Therapeutics Presents Clinical Data Updates at the 2025 European Hematology Association (EHA) Congress

      LONDON, May 14, 2025 (GLOBE NEWSWIRE) -- Autolus Therapeutics plc (NASDAQ:AUTL), an early commercial-stage biopharmaceutical company developing, manufacturing and delivering next-generation programmed T cell therapies, announces the online publication of three abstracts submitted to the European Hematology Association (EHA) Congress, to be held June 12-15, 2025, Milan, Italy. Autolus will have two oral and one poster presentation, which includes updated follow up from the FELIX study of obecabtagene autoleucel (obe-cel) in adult patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). Oral S113: Title: Can CAR T-cell therapy be a definitive treatment for ad

      5/14/25 9:30:00 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Autolus Therapeutics Reports First Quarter 2025 Financial Results and Business Updates

      Company reports Q1 2025 AUCATZYL® net product revenue of $9.0 millionU.K. Medicines and Healthcare products Regulatory Agency (MHRA) granted conditional marketing authorization for AUCATZYL® for the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (r/r B-ALL)Encouraging preliminary data reported in Phase 1 CARLYSLE trial in systemic lupus erythematosus (SLE); planned Phase 2 pivotal clinical trial in lupus nephritis (LN) and Phase 1 clinical trial in progressive forms of multiple sclerosis (MS) initiating before year-end 2025Conference call to be held today at 08:30 am EDT/13:30 pm GMT: conference call participants should pre-register usin

      5/8/25 7:00:00 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Autolus Therapeutics Announces License of AUCATZYL® (obecabtagene autoleucel) Issued by UK MHRA for Adult Patients (≥ 18 years) with Relapsed or Refractory B-Cell Precursor Acute Lymphoblastic Leukemia (R/R B-ALL)(1)

      UK Medicines and Healthcare products Regulatory Agency (MHRA) authorisation based on FELIX clinical trial of obecabtagene autoleucel in adult patients with r/r B-ALL1AUCATZYL® licensed from MHRA under ‘conditional marketing authorisation', meaning that the MHRA will review new efficacy and safety information at least once every year1 Investors, US and UK National, Medical and Industry media only LONDON, April 25, 2025 (GLOBE NEWSWIRE) -- Autolus Therapeutics plc (NASDAQ:AUTL), an early commercial-stage biopharmaceutical company developing, manufacturing and delivering next-generation programmed T cell therapies and candidates, announces today that the UK Medicines and Healthcare products

      4/25/25 12:06:39 PM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $AUTL
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • Autolus Therapeutics upgraded by Goldman with a new price target

      Goldman upgraded Autolus Therapeutics from Neutral to Buy and set a new price target of $7.60 from $7.00 previously

      11/18/24 7:38:09 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Autolus Therapeutics upgraded by Redburn Atlantic with a new price target

      Redburn Atlantic upgraded Autolus Therapeutics from Neutral to Buy and set a new price target of $13.00

      11/15/24 7:30:20 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Deutsche Bank initiated coverage on Autolus Therapeutics with a new price target

      Deutsche Bank initiated coverage of Autolus Therapeutics with a rating of Buy and set a new price target of $10.00

      11/9/23 6:38:44 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $AUTL
    SEC Filings

    See more
    • SEC Form EFFECT filed by Autolus Therapeutics plc

      EFFECT - Autolus Therapeutics plc (0001730463) (Filer)

      5/16/25 12:15:27 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form 424B3 filed by Autolus Therapeutics plc

      424B3 - Autolus Therapeutics plc (0001730463) (Filer)

      5/15/25 4:13:24 PM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SCHEDULE 13G/A filed by Autolus Therapeutics plc

      SCHEDULE 13G/A - Autolus Therapeutics plc (0001730463) (Subject)

      5/12/25 10:24:40 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $AUTL
    Leadership Updates

    Live Leadership Updates

    See more
    • Innate Pharma Proposes to Its Shareholders to Transform Its Corporate Governance Structure Into a Board of Directors and to Change Its Composition

      Innate to propose to its Annual General Meeting taking place on May 22, 2025, to move from an executive board/supervisory board corporate governance structure to a CEO/board of directors Irina Staatz-Granzer, current Chairwoman of the Supervisory board would be appointed Chairwoman of the board of Directors Jonathan Dickinson, current Chairman of the Executive board would be appointed Chief Executive Officer and named to the board of Directors Two new members would join the board of Directors Regulatory News: Innate Pharma SA (PARIS:IPH, NASDAQ:IPHA) ("Innate" or the "Company") today announced it will propose to its Annual General Meeting taking place on May 22, 2025, to move from

      4/16/25 1:00:00 AM ET
      $AUTL
      $IPHA
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Autolus Therapeutics announces appointment of Matthias Will, M.D. as Chief Development Officer

      LONDON, Sept. 19, 2024 (GLOBE NEWSWIRE) -- Autolus Therapeutics plc (NASDAQ:AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, announced the appointment of Matthias Will, M.D., as Chief Development Officer. Dr. Will is joining Autolus' executive team and will lead the company's development organization effective September 30, 2024. "Matthias has a proven track record of success in pharmaceutical product development, achieving many key regulatory milestones and marketing approvals across several cancer indications," said Dr. Christian Itin, Chief Executive Officer of Autolus. "His in-depth development experience and leadership skil

      9/19/24 7:00:00 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Autolus Therapeutics Announces Changes to its Board of Directors

      LONDON, April 01, 2024 (GLOBE NEWSWIRE) -- Autolus Therapeutics plc (NASDAQ:AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, today announces the appointment of Mike Bonney as Chairman of the Board, and Ravi Rao M.D., as Non-Executive Director. John H. Johnson advised the Board of his decision to step down from his role as Chairman of the Board and Non-Executive Director. These changes are effective as of today, April 1, 2024. "On behalf of the Board and Management team, we would like to thank John for his leadership during a transformational period for the Company, which included conducting the pivotal Phase 2 FELIX study and th

      4/1/24 7:00:00 AM ET
      $AUTL
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care