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    SEC Form SC 13G/A filed by Caribou Biosciences Inc. (Amendment)

    2/14/24 4:06:37 PM ET
    $CRBU
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $CRBU alert in real time by email
    SC 13G/A 1 tm245198d3_sc13ga.htm SC 13G/A

     

     

    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C.  20549
     
    SCHEDULE 13G
    (Rule 13d-102)
     
    Information Statement Pursuant to Rules 13d-1 and 13d-2
    Under the Securities Exchange Act of 1934
    (Amendment No. 3)*
     
      Caribou Biosciences, Inc.  
    (Name of Issuer)
     
      Common stock, $0.0001 par value per share  
    (Title of Class of Securities)
     
      142038108  
      (CUSIP Number)  
         
      December 31, 2023  
      (Date of Event Which Requires Filing of the Statement)  

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

    ¨
    x
    ¨
    Rule 13d-1(b)
    Rule 13d-1(c)
    Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

     

    CUSIP NO. 142038108 13G Page 2 of 11 Pages

     

     

    1.

     

    NAME OF REPORTING PERSON

     

     PFM Health Sciences, LP

     

    2.

     

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

    (a)       ¨

     

    (b)       x

     

    3.

     

    SEC USE ONLY

     

     

    4.

     

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

     

     

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

     

    5.

     

    SOLE VOTING POWER

    0

     

    6.

     

    SHARED VOTING POWER

     

    6,480,764 shares

     

    7.

     

    SOLE DISPOSITIVE POWER

    0

     

    8.

     

    SHARED DISPOSITIVE POWER

    See Row 6 above

     

    9.

     

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    See Row 6 above

     

    10.

     

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                                           ¨

     

     

    11.

     

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     

    7.3% 1

     

    12.

     

    TYPE OF REPORTING PERSON

    IA; PN

               

     
    1The percentages reported in this Schedule 13G are based upon 88,431,136 shares of common stock outstanding as of November 2, 2023 (as set forth in the issuer’s Form 10-Q filed with the Securities and Exchange Commission on November 7, 2023).

     

     

     

     

    CUSIP NO. 142038108 13G Page 3 of 11 Pages

     

     

    1.

     

    NAME OF REPORTING PERSON

     

    PFM Health Sciences GP, LLC

     

    2.

     

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

    (a)       ¨

     

    (b)       x

     

    3.

     

    SEC USE ONLY

     

     

    4.

     

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

     

     

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

     

    5.

     

    SOLE VOTING POWER

    0

     

    6.

     

    SHARED VOTING POWER

     

    6,480,764 shares

     

    7.

     

    SOLE DISPOSITIVE POWER

    0

     

    8.

     

    SHARED DISPOSITIVE POWER

    See Row 6 above

     

    9.

     

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    See Row 6 above

     

    10.

     

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                                           ¨

     

     

    11.

     

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     

    7.3%

     

    12.

     

    TYPE OF REPORTING PERSON

    OO

               

     

     

     

    CUSIP NO. 142038108 13G Page 4 of 11 Pages

     

     

    1.

     

    NAME OF REPORTING PERSON

     

    PFM Healthcare Growth Equity I GP, LLC

     

    2.

     

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

    (a)       ¨ 

     

    (b)       x

     

    3.

     

    SEC USE ONLY

     

     

    4.

     

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

     

     

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

     

    5.

     

    SOLE VOTING POWER

    0

     

    6.

     

    SHARED VOTING POWER

     

    1,253,484 shares

     

    7.

     

    SOLE DISPOSITIVE POWER

    0

     

    8.

     

    SHARED DISPOSITIVE POWER

    See Row 6 above

     

    9.

     

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    See Row 6 above

     

    10.

     

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                                           ¨

     

     

    11.

     

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     

    1.4%

     

    12.

     

    TYPE OF REPORTING PERSON

    OO

               

     

     

     

    CUSIP NO. 142038108 13G Page 5 of 11 Pages

     

     

    1.

     

    NAME OF REPORTING PERSON

     

    Partner Asset Management, LLC

     

    2.

     

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

    (a)       ¨

     

    (b)       x

     

    3.

     

    SEC USE ONLY

     

     

    4.

     

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

     

     

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

     

    5.

     

    SOLE VOTING POWER

    0

     

    6.

     

    SHARED VOTING POWER

     

    6,480,764 shares

     

    7.

     

    SOLE DISPOSITIVE POWER

    0

     

    8.

     

    SHARED DISPOSITIVE POWER

    See Row 6 above

     

    9.

     

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    See Row 6 above

     

    10.

     

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                                           ¨

     

     

    11.

     

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     

    7.3%

     

    12.

     

    TYPE OF REPORTING PERSON

    OO

               

     

     

     

    CUSIP NO. 142038108 13G Page 6 of 11 Pages

     

     

    1.

     

    NAME OF REPORTING PERSON

     

    Brian D. Grossman

     

    2.

     

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

    (a)       ¨

     

    (b)       x

     

    3.

     

    SEC USE ONLY

     

     

    4.

     

    CITIZENSHIP OR PLACE OF ORGANIZATION

    U.S. Citizen

     

     

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

     

    5.

     

    SOLE VOTING POWER

    0

     

    6.

     

    SHARED VOTING POWER

     

    6,480,764 shares

     

    7.

     

    SOLE DISPOSITIVE POWER

    0

     

    8.

     

    SHARED DISPOSITIVE POWER

    See Row 6 above

     

    9.

     

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    See Row 6 above

     

    10.

     

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES                                           ¨

     

     

    11.

     

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     

    7.3%

     

    12.

     

    TYPE OF REPORTING PERSON

    IN

               

     

     

     

    CUSIP NO. 142038108 13G Page 7 of 11 Pages

     

    Item 1(a)Name of Issuer

    Caribou Biosciences, Inc.

     

    Item 1(b) Address of Issuer’s Principal Executive Offices
    2929 7th Street, Suite 105, Berkeley, California 94710

     

    Item 2(a)Name of Person Filing
    This Schedule 13G is being jointly filed by PFM Health Sciences, LP (“PFM”), PFM Health Sciences GP, LLC (“PFM-GP”), PFM Healthcare Growth Equity I GP, LLC (“HCG-GP”), Partner Asset Management, LLC (“PAM”), and Brian D. Grossman (“Grossman” and, collectively with PFM, PFM-GP, HCG-GP, and PAM, the “Reporting Persons”) with respect to shares of common stock of the above-named issuer owned by PFM Biotech Opportunities Fund, L.P., a Cayman Islands limited partnership (“BO”), PFM Healthcare Master Fund, L.P., a Cayman Islands limited partnership (“HCM”), PFM Healthcare Growth Equity Fund I, LP, a Delaware limited partnership (“HCG”), and Partner Investments, L.P., a Delaware limited partnership (“PI” and, collectively with BO, HCM and HCG, the “Funds”).

     

    PFM is the investment advisor for the Funds. HCG-GP is the general partner of HCG. PAM is the general partner of BO, HCM and PI and the member manager of HCG-GP. PFM-GP is the general partner of PFM and the manager of PAM. Grossman is the sole member of PFM-GP.

     

    The filing of this statement shall not be construed as an admission that any of the Reporting Persons is the beneficial owner of any securities covered by the statement other than the securities actually owned by such person (if any).

     

    Item 2(b)Address or Principal Business Office or, if none, Residence
    The address of the principal business office of each of the Reporting Persons is c/o PFM Health Sciences, LP, 475 Sansome Street, Suite 1720, San Francisco, California 94111.

     

    Item 2(c)Citizenship
    PFM is organized as a limited partnership under the laws of the State of Delaware. Each of PFM-GP, HCG-GP and PAM is organized as a limited liability company under the laws of the State of Delaware. Grossman is a U.S. citizen.

     

    Item 2(d) Title of Class of Securities
    Common stock, $0.0001 par value per share

     

    Item 2(e) CUSIP Number
    142038108

     

     

     

     

    CUSIP No. 142038108 13G Page 8 of 11 Pages

     

    Item 3If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:

     

    (a)¨ Broker or dealer registered under Section 15 of the Exchange Act;

     

    (b)¨ Bank as defined in Section 3(a)(6) of the Exchange Act;

     

    (c)¨ Insurance company as defined in Section 3(a)(19) of the Exchange Act;

     

    (d)¨ Investment company registered under Section 8 of the Investment Company Act;

     

    (e)¨ An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

     

    (f)¨ An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);

     

    (g)¨ A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);

     

    (h)¨ A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;

     

    (i)¨ A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;

     

      (j) ¨ A non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J);

     

      (k) ¨ Group, in accordance with Rule 13d-1(b)(1)(ii)(K).

     

    If filing as a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution: ____________.

     

     

     

     

    CUSIP No. 142038108 13G Page  9 of 11 Pages

     

    Item 4 Ownership

     

    A.PFM Health Sciences, LP, PFM Health Sciences GP, LLC and Partner Asset Management, LLC

     

    (a)PFM, PFM-GP and PAM may be deemed to beneficially own 6,480,764 shares of Common Stock.

     

    (b)The number of shares PFM, PFM-GP and PAM may be deemed to beneficially own constitutes approximately 7.3% of the Common Stock outstanding.

     

    (c)Number of shares as to which such person has:

     

    (i)sole power to vote or to direct the vote: 0

     

    (ii)shared power to vote or to direct the vote: 6,480,764

     

    (iii)sole power to dispose or to direct the disposition of: 0

     

    (iv)shared power to dispose or to direct the disposition of: 6,480,764

     

    B.PFM Healthcare Growth Equity I GP, LLC

     

    (a)HCG-GP may be deemed to beneficially own 1,253,484 shares of Common Stock.

     

    (b)The number of shares HCG-GP may be deemed to beneficially own constitutes approximately 1.4% of the Common Stock outstanding.

     

    (c)Number of shares as to which such person has:

     

    (i)sole power to vote or to direct the vote: 0

     

    (ii)shared power to vote or to direct the vote: 1,253,484

     

    (iii)sole power to dispose or to direct the disposition of: 0

     

    (iv)shared power to dispose or to direct the disposition of: 1,253,484

     

     

     

     

    CUSIP No. 142038108 13G Page  10 of 11 Pages

     

    C.Brian D. Grossman

     

    (a)Grossman may be deemed to beneficially own 6,480,764 shares of Common Stock.

     

    (b)The number of shares Grossman may be deemed to beneficially own constitutes approximately 7.3% of the Common Stock outstanding.

     

    (c)Number of shares as to which such person has:

     

    (i)sole power to vote or to direct the vote: 0

     

    (ii)shared power to vote or to direct the vote: 6,480,764

     

    (iii)sole power to dispose or to direct the disposition of: 0

     

    (iv)shared power to dispose or to direct the disposition of: 6,480,764

     

    Item 5Ownership of Five Percent or Less of a Class
    If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ¨.

     

    Item 6Ownership of More than Five Percent on Behalf of Another Person

    Not Applicable

     

    Item 7Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company

    See Item 2 above

     

    Item 8Identification and Classification of Members of the Group

    Not Applicable

     

    Item 9Notice of Dissolution of Group

    Not Applicable

     

    Item 10Certification
    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

     

     

     

     

    After reasonable inquiry and to the best of its knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.

     

    Dated this 14th day of February, 2024.

     

    PFM Health Sciences, LP  PFM Health Sciences GP, LLC

     

    By: PFM Health Sciences GP, LLC,   By: /s/ Darren Mooney
      its general partner     Darren Mooney, Authorized Signatory
             
    By: /s/ Darren Mooney      
      Darren Mooney, Authorized Signatory      

     

    PFM Healthcare Growth Equity I GP, LLC  PARTNER Asset MANAGEMENT, LLC

     

        By: PFM Health Sciences GP, LLC,
    By: Partner Asset Management, LLC,   its general partner
      its member manager    
          By: /s/ Darren Mooney
    By: /s/ Darren Mooney     Darren Mooney, Authorized Signatory
      Darren Mooney, Authorized Signatory      

     

    BRIAN D. GROSSMAN

           
    By: /s/ Darren Mooney    
      Darren Mooney, attorney-in-fact*    

     

     

    *        Darren Mooney is signing on behalf of Brian Grossman as attorney-in-fact pursuant to a power of attorney dated February 1, 2024, and incorporated by reference herein. The power of attorney was filed as an attachment to a filing by certain of the Reporting Persons on Schedule 13G/A for Praxis Precision Medicines, Inc. on February 14, 2024.

     

     

     

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      -- CB-010 allogeneic CAR-T cell therapy with partial HLA matching has potential to rival efficacy and safety profile of approved autologous CAR-T cell therapies -- -- 14.4 months median PFS in ANTLER patients with partial HLA matching (≥4 alleles) -- -- Plan to enroll ~20 additional 2L LBCL patients in ANTLER to confirm that partial HLA matching improves patient outcomes; initial data expected in H1 2025 -- -- Caribou expects to initiate a pivotal trial for CB-010 in H2 2025, upon confirmation of improved outcomes in partially HLA matched cohort -- -- Off-the-shelf CB-010 is partially HLA matched to patient within current screening timelines -- -- KOL webcast discussion of data from 46

      6/2/24 7:00:00 PM ET
      $CRBU
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Caribou Biosciences Expands Clinical Development of CB-010 with FDA Clearance of IND in Lupus

      -- FDA has cleared Caribou's IND application for CB-010 in lupus nephritis and extrarenal lupus; GALLOP Phase 1 clinical trial expected to initiate by YE 2024 -- -- Driven by encouraging initial safety and efficacy in the ongoing ANTLER trial for r/r B-NHL, CB-010 clinical development has expanded to include autoimmune diseases -- -- Advancing ANTLER Phase 1 trial for 2L LBCL; initial dose expansion data to be shared at a medical congress in Q2 2024 -- -- Conference call and webcast scheduled for today at 5:00 pm ET -- BERKELEY, Calif., April 04, 2024 (GLOBE NEWSWIRE) -- Caribou Biosciences, Inc. (NASDAQ:CRBU), a leading clinical-stage CRISPR genome-editing biopharmaceutical company, t

      4/4/24 4:00:00 PM ET
      $CRBU
      Biotechnology: Biological Products (No Diagnostic Substances)
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    • Caribou Biosciences Reports Positive Clinical Data from Dose Escalation of CB-010 ANTLER Phase 1 Trial in r/r B-NHL

      -- CB-010 allogeneic CAR-T cell therapy data rival response rates and safety profile of approved autologous CAR-T cell therapies -- -- 94% overall response rate (ORR), 69% complete response (CR) rate, and 44% CR rate at ≥6 months following a single dose of CB-010; 24 months is the longest CR maintained to date -- -- LBCL patient subgroup had a 50% CR rate at ≥6 months; 18 months is the longest LBCL subgroup CR maintained to date -- -- Actively enrolling second-line LBCL patients in ANTLER dose expansion -- -- Conference call and webcast scheduled for today at 4:30 pm ET -- BERKELEY, Calif., July 13, 2023 (GLOBE NEWSWIRE) -- Caribou Biosciences, Inc. (NASDAQ:CRBU), a leading clinical-s

      7/13/23 4:01:00 PM ET
      $CRBU
      Biotechnology: Biological Products (No Diagnostic Substances)
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    $CRBU
    Leadership Updates

    Live Leadership Updates

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    • Caribou Biosciences Appoints Sri Ryali as Chief Financial Officer

      BERKELEY, Calif., Jan. 02, 2025 (GLOBE NEWSWIRE) -- Caribou Biosciences, Inc. (NASDAQ:CRBU), a leading clinical-stage CRISPR genome-editing biopharmaceutical company, today announced the appointment of Sri Ryali as chief financial officer, effective immediately. Mr. Ryali brings 20 years of finance and commercial experience in the biopharmaceutical industry to his role, and he will be responsible for the strategic leadership of the corporate finance, investor relations, and corporate communications functions. He will report to Rachel Haurwitz, PhD, Caribou's president and chief executive officer. "I am excited to welcome Sri to Caribou at the beginning of this pivotal year for our organiz

      1/2/25 8:00:00 AM ET
      $CRBU
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Caribou Biosciences Appoints Tina Albertson, MD, PhD, as Chief Medical Officer

      -- Highly-experienced hematologist and oncologist with proven track record successfully driving global clinical development of CAR-T cell therapies -- BERKELEY, Calif., Aug. 12, 2024 (GLOBE NEWSWIRE) -- Caribou Biosciences, Inc. (NASDAQ:CRBU), a leading clinical-stage CRISPR genome-editing biopharmaceutical company, today announced the appointment of Tina Albertson, MD, PhD, as chief medical officer. Dr. Albertson brings 15 years of experience leading clinical drug development of cellular therapies and biologics. She will be responsible for strategic leadership of the clinical, regulatory, and medical affairs functions, and provide medical and operational leadership of Caribou's four clin

      8/12/24 8:00:00 AM ET
      $CRBU
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Caribou Biosciences Announces Appointment of Terri Laufer, MD, to its Scientific Advisory Board

      -- Dr. Laufer is an immunologist advancing the scientific understanding and treatment of autoimmune diseases -- BERKELEY, Calif., July 09, 2024 (GLOBE NEWSWIRE) -- Caribou Biosciences, Inc. (NASDAQ:CRBU), a leading clinical-stage CRISPR genome-editing biopharmaceutical company, today announced the appointment of Terri Laufer, MD, to its scientific advisory board. Dr. Laufer is a leading rheumatologist known for her extensive research into immune cell regulation and dysfunction that leads to autoimmune diseases. She is an emeritus associate professor of medicine at the Perelman School of Medicine at the University of Pennsylvania and an attending rheumatologist at the Penn Presbyterian Med

      7/9/24 8:00:00 AM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    $CRBU
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    • Amendment: SEC Form SC 13D/A filed by Caribou Biosciences Inc.

      SC 13D/A - Caribou Biosciences, Inc. (0001619856) (Subject)

      12/6/24 4:06:56 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Caribou Biosciences Inc.

      SC 13G/A - Caribou Biosciences, Inc. (0001619856) (Subject)

      11/14/24 7:53:54 PM ET
      $CRBU
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Caribou Biosciences Inc.

      SC 13G/A - Caribou Biosciences, Inc. (0001619856) (Subject)

      11/14/24 6:08:51 PM ET
      $CRBU
      Biotechnology: Biological Products (No Diagnostic Substances)
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