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    SEC Form SC 13G/A filed by Connect Biopharma Holdings Limited (Amendment)

    10/4/23 5:26:27 PM ET
    $CNTB
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $CNTB alert in real time by email
    SC 13G/A 1 d454741dsc13ga.htm SC 13G/A SC 13G/A

     

     

    Securities and Exchange Commission

    Washington, D.C. 20549

     

     

    Schedule 13G

    (Rule 13d-102)

    Information to be Included in Statements Filed Pursuant

    to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed

    Pursuant to § 240.13d-2

    UNDER THE SECURITIES EXCHANGE ACT OF 1934

    (Amendment No. 1)*

     

     

    Connect Biopharma Holdings Limited

    (Name of Issuer)

    Ordinary Shares

    (Title of Class of Securities)

    207523101**

    (CUSIP Number)

    October 2, 2023

    (Date of Event Which Requires Filing of this Statement)

     

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

    ☐

    Rule 13d-1(b)

     

    ☒

    Rule 13d-1(c)

     

    ☐

    Rule 13d-1(d)

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

     

    **

    There is no CUSIP number assigned to the Ordinary Shares of the Issuer (“Ordinary Shares”). CUSIP number 207523101 has been assigned to the American Depositary Shares of the Issuer (“ADSs”). Each ADS represents one Ordinary Share.

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     


    CUSIP No. 207523101    Schedule 13G    Page 1 of 12

     

     

     1   

     Names of Reporting Persons

     

     Panacea Opportunity Fund I, L.P.

     2  

     Check the Appropriate Box if a Member of a Group

     (a) ☐  (b) ☐

     

     3  

     SEC Use Only

     

     4  

     Citizenship or Place of Organization

     

     Cayman Islands

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5   

     Sole Voting Power

     

     0

       6  

     Shared Voting Power

     

     0

       7  

     Sole Dispositive Power

     

     0

       8  

     Shared Dispositive Power

     

     0

     9   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     0

    10  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     Not Applicable

    11  

     Percent of Class Represented by Amount in Row 9

     

     0%

    12  

     Type of Reporting Person

     

     PN


    CUSIP No. 207523101    Schedule 13G    Page 2 of 12

     

     1   

     Names of Reporting Persons

     

     Panacea Opportunity Fund I GP Company, Ltd.

     2  

     Check the Appropriate Box if a Member of a Group

     (a) ☐  (b) ☐

     

     3  

     SEC Use Only

     

     4  

     Citizenship or Place of Organization

     

     Cayman Islands

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5   

     Sole Voting Power

     

     0

       6  

     Shared Voting Power

     

     0

       7  

     Sole Dispositive Power

     

     0

       8  

     Shared Dispositive Power

     

     0

     9   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     0

    10  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     Not Applicable

    11  

     Percent of Class Represented by Amount in Row 9

     

     0%

    12  

     Type of Reporting Person

     

     CO


    CUSIP No. 207523101    Schedule 13G    Page 3 of 12

     

     1   

     Names of Reporting Persons

     

     Panacea Innovation Limited

     2  

     Check the Appropriate Box if a Member of a Group

     (a) ☐  (b) ☐

     

     3  

     SEC Use Only

     

     4  

     Citizenship or Place of Organization

     

     Cayman Islands

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5   

     Sole Voting Power

     

     0

       6  

     Shared Voting Power

     

     5,995,000

       7  

     Sole Dispositive Power

     

     0

       8  

     Shared Dispositive Power

     

     5,995,000

     9   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     5,995,000

    10  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     Not Applicable

    11  

     Percent of Class Represented by Amount in Row 9

     

     10.9%

    12  

     Type of Reporting Person

     

     CO


    CUSIP No. 207523101    Schedule 13G    Page 4 of 12

     

     1   

     Names of Reporting Persons

     

     Panacea Venture Healthcare Fund II, L.P.

     2  

     Check the Appropriate Box if a Member of a Group

     (a) ☐  (b) ☐

     

     3  

     SEC Use Only

     

     4  

     Citizenship or Place of Organization

     

     Cayman Islands

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5   

     Sole Voting Power

     

     0

       6  

     Shared Voting Power

     

     5,995,000

       7  

     Sole Dispositive Power

     

     0

       8  

     Shared Dispositive Power

     

     5,995,000

     9   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     5,995,000

    10  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     Not Applicable

    11  

     Percent of Class Represented by Amount in Row 9

     

     10.9%

    12  

     Type of Reporting Person

     

     PN


    CUSIP No. 207523101    Schedule 13G    Page 5 of 12

     

     1   

     Names of Reporting Persons

     

     Panacea Venture Healthcare Fund II GP Company, Ltd.

     2  

     Check the Appropriate Box if a Member of a Group

     (a) ☐  (b) ☐

     

     3  

     SEC Use Only

     

     4  

     Citizenship or Place of Organization

     

     Cayman Islands

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5   

     Sole Voting Power

     

     0

       6  

     Shared Voting Power

     

     5,995,000

       7  

     Sole Dispositive Power

     

     0

       8  

     Shared Dispositive Power

     

     5,995,000

     9   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     5,995,000

    10  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     Not Applicable

    11  

     Percent of Class Represented by Amount in Row 9

     

     10.9%

    12  

     Type of Reporting Person

     

     CO


    CUSIP No. 207523101    Schedule 13G    Page 6 of 12

     

     1   

     Names of Reporting Persons

     

     James Huang

     2  

     Check the Appropriate Box if a Member of a Group

     (a) ☐  (b) ☐

     

     3  

     SEC Use Only

     

     4  

     Citizenship or Place of Organization

     

     Republic of China

    Number of

    Shares

    Beneficially 

    Owned by

    Each

    Reporting

    Person

    With

       5   

     Sole Voting Power

     

     0

       6  

     Shared Voting Power

     

     5,995,000

       7  

     Sole Dispositive Power

     

     0

       8  

     Shared Dispositive Power

     

     5,995,000

     9   

     Aggregate Amount Beneficially Owned by Each Reporting Person

     

     5,995,000

    10  

     Check if the Aggregate Amount in Row (9) Excludes Certain Shares

     

     Not Applicable

    11  

     Percent of Class Represented by Amount in Row 9

     

     10.9%

    12  

     Type of Reporting Person

     

     IN


    CUSIP No. 207523101    Schedule 13G    Page 7 of 12

     

    ITEM 1.    (a)    Name of Issuer:
         

    Connect Biopharma Holdings Limited (the “Issuer”).

       (b)    Address of Issuer’s Principal Executive Offices:
         

    12265 El Camino Real, Suite 350, San Diego, CA 92130.

    ITEM 2.    (a)    Name of Person Filing:
         

    Each of the following is hereinafter individually referred to as a “Reporting Person” and collectively as the “Reporting Persons.” This statement is filed on behalf of:

         

    Panacea Opportunity Fund I, L.P.

         

    Panacea Opportunity Fund I GP Company, Ltd.

         

    Panacea Innovation Limited

         

    Panacea Venture Healthcare Fund II, L.P.

         

    Panacea Venture Healthcare Fund II GP Company, Ltd.

         

    James Huang

       (b)    Address of Principal Business Office:
         

    The business address of each of the Reporting Persons is c/o Maples Corporate Services Limited, Ugland House, Grand Cayman KY1-1104, Cayman Islands.

       (c)    Citizenship of each Reporting Person is:
         

    Mr. Huang is a citizen of the Republic of China. The remaining Reporting Persons are organized under the laws of the Cayman Islands.

       (d)    Title of Class of Securities:
         

    Ordinary Shares, par value $0.000174 per share (the “Ordinary Shares”). The Ordinary Shares are sold on the U.S. market as ADSs, each of which represents one Ordinary Share.

       (e)    CUSIP Number:
         

    207523101

     

    ITEM 3.

    Not applicable.


    CUSIP No. 207523101    Schedule 13G    Page 8 of 12

     

    ITEM 4.

    Ownership.

    (a-c)

    The ownership information presented below represents beneficial ownership of Ordinary Shares as of the date of this filing, based upon 55,064,947 Ordinary Shares outstanding as of June 30, 2023, as disclosed in the Issuer’s Report on Form 6-K, furnished with the Securities and Exchange Commission on September 12, 2023.

     

    Reporting Person   

    Amount

    beneficially

    owned

        

    Percent

    of class:

        Sole
    power
    to vote
    or to
    direct
    the
    vote:
         Shared
    power to
    vote or to
    direct the
    vote:
        

    Sole
    power to
    dispose or
    to direct
    the
    disposition

    of:

        

    Shared

    power to

    dispose or

    to direct

    the

    disposition

    of:

     

    Panacea Opportunity Fund I, L.P.

         0        0 %      0        0        0        0  

    Panacea Opportunity Fund I GP Company, Ltd.

         0        0 %      0        0        0        0  

    Panacea Innovation Limited

         5,995,000        10.9 %      0        5,995,000        0        5,995,000  

    Panacea Venture Healthcare Fund II, L.P.

         5,995,000        10.9 %      0        5,995,000        0        5,995,000  

    Panacea Venture Healthcare Fund II GP Company, Ltd.

         5,995,000        10.9 %      0        5,995,000        0        5,995,000  

    James Huang

         5,995,000        10.9 %      0        5,995,000        0        5,995,000  

    Panacea Venture Healthcare Fund II, L.P. is the record holder of the Ordinary Shares reported herein.

    James Huang is the sole owner of Panacea Innovation Limited, which is the sole owner of Panacea Venture Healthcare Fund II GP Company, Ltd., which is the general partner of Panacea Venture Healthcare Fund II, L.P. As a result, each of the Reporting Persons may be deemed to share beneficial ownership of the Ordinary Shares directly reported herein, but each disclaims such beneficial ownership.

     

    ITEM 5.

    Ownership of Five Percent or Less of a Class.

    This statement is being filed to report that, as of the date hereof, each of Panacea Opportunity Fund I, L.P. and Panacea Opportunity Fund I GP Company, Ltd. no longer beneficially own any Ordinary Shares.

     

    ITEM 6.

    Ownership of More than Five Percent on Behalf of Another Person.

    Not applicable.

     

    ITEM 7.

    Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.

    Not applicable.


    CUSIP No. 207523101    Schedule 13G    Page 9 of 12

     

    ITEM 8.

    Identification and Classification of Members of the Group.

    Not applicable.

     

    ITEM 9.

    Notice of Dissolution of Group.

    Not applicable.

     

    ITEM 10.

    Certification.

    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a-11.


    CUSIP No. 207523101    Schedule 13G    Page 10 of 12

     

    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

    Date: October 4, 2023

     

    Panacea Opportunity Fund I, L.P.
    By: Panacea Opportunity Fund I GP Company, Ltd., its general partner
    By: Panacea Innovation Limited, its sole owner
    By:   /s/ James Huang
    Name:   James Huang
    Title:   Founding Managing Partner
    Panacea Opportunity Fund I GP Company, Ltd.
    By: Panacea Innovation Limited, its sole owner
    By:   /s/ James Huang
    Name:   James Huang
    Title:   Founding Managing Partner
    Panacea Innovation Limited
    By:   /s/ James Huang
    Name:   James Huang
    Title:   Founding Managing Partner
    Panacea Venture Healthcare Fund II, L.P.
    By: Panacea Venture Healthcare Fund II GP Company, Ltd., its general partner
    By: Panacea Innovation Limited, its sole owner
    By:   /s/ James Huang
    Name:   James Huang
    Title:   Founding Managing Partner
    Panacea Venture Healthcare Fund II GP Company, Ltd.
    By: Panacea Innovation Limited, its sole owner
    By:   /s/ James Huang
    Name:   James Huang
    Title:   Founding Managing Partner


    CUSIP No. 207523101    Schedule 13G    Page 11 of 12

     

    James Huang

    /s/ James Huang


    CUSIP No. 207523101    Schedule 13G    Page 12 of 12

     

    LIST OF EXHIBITS

     

    Exhibit No.   

    Description

    99    Joint Filing Agreement.

     

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    • Connect Biopharma Announces Positive Long-Term Data from the China Pivotal Trial of Rademikibart in Patients with Moderate-to-Severe Atopic Dermatitis

      Clinical response (IGA 0/1 and EASI-75) achieved at Week 16 with rademikibart treatment was maintained through Week 52 with both every two weeks (Q2W) and every four weeks (Q4W) dosing regimens Approximately 90% of patients on Q4W dose maintained both IGA 0/1 and EASI-75 through Week 52 Over 36 weeks of treatment in Stage 2 of the study, the percentage of patients achieving IGA 0/1 and EASI-75 continued to increaseRademikibart continued to be well tolerated over 52 weeks of treatmentA conference call and webcast presentation to discuss the data will be held today at 8:30 a.m. ET, details below SAN DIEGO, CA and TAICANG, China, Nov. 21, 2023 (GLOBE NEWSWIRE) -- Connect Biopharma Holdings L

      11/21/23 6:00:00 AM ET
      $CNTB
      Biotechnology: Pharmaceutical Preparations
      Health Care