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    SEC Form SC 13G/A filed by scPharmaceuticals Inc. (Amendment)

    2/14/24 4:25:22 PM ET
    $SCPH
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $SCPH alert in real time by email
    SC 13G/A 1 tm245429d4_sc13ga.htm SC 13G/A

     

     

         
      UNITED STATES  
      SECURITIES AND EXCHANGE COMMISSION  
      Washington, D.C. 20549  

     

    SCHEDULE 13G

     

    Under the Securities Exchange Act of 1934
    (Amendment No. 3)*

     

    scPharmaceuticals Inc.

    (Name of Issuer)

     

    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

     

    810648 105

    (CUSIP Number)

     

    December 31, 2023

    (Date of Event Which Requires Filing of this Statement)

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

    ¨ Rule 13d-1(b)
    x Rule 13d-1(c)
    ¨ Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

     

    The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    5AM Ventures IV, L.P.
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    Delaware
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     980,963 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    980,963 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    980,963 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    2.7% (3)
     
      12. Type of Reporting Person (See Instructions)
    PN
               

    (1)This Schedule 13G is filed by 5AM Ventures IV, L.P., a Delaware limited partnership (“Ventures IV”), 5AM Co-Investors IV, L.P., a Delaware limited partnership (“Co-Investors IV”), 5AM Partners IV, LLC, a Delaware limited liability company (“Partners IV”), 5AM Opportunities I, L.P., a Delaware limited partnership (“Opportunities”), 5AM Opportunities I (GP), LLC, a Delaware limited liability company (“Opportunities GP”), Dr. John D. Diekman (“Diekman”), Andrew J. Schwab (“Schwab”), Dr. Kush Parmar (“Parmar”) and Dr. Scott M. Rocklage (“Rocklage”) and together with Ventures IV, Co-Investors IV, Partners IV, Opportunities, Opportunities GP, Diekman, Schwab and Parmar, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Shares are held by Ventures IV. Partners IV serves as the sole general partner of Ventures IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the “SEC”) on November 8, 2023.

     

    2

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    5AM Co-Investors IV, L.P.
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    Delaware
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     40,873 shares  (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    40,873 shares  (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    40,873 of Common Stock (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    0.1% (3)
     
      12. Type of Reporting Person (See Instructions)
    PN
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Shares are held by Co-Investors IV. Partners IV serves as the sole general partner of Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Co-Investors IV.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    3

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    5AM Partners IV, LLC
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x   (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    Delaware
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     1,021,836 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    1,021,836 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    1,021,836 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    2.8% (3)
     
      12. Type of Reporting Person (See Instructions)
    OO
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Includes (i) 980,963 shares of Common Stock held by Ventures IV; and (ii) 40,873 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    4

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    5AM Opportunities I, L.P.
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    Delaware
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     178,811 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    178,811 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    178,811 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    0.5% (3)
     
      12. Type of Reporting Person (See Instructions)
    PN
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Shares are held by Opportunities. Opportunities GP serves as the sole general partner of Opportunities.  Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    5

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    5AM Opportunities I (GP), LLC
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    Delaware
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     178,811 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    178,811 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    178,811 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    0.5% (3)
     
      12. Type of Reporting Person (See Instructions)
    OO
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Includes 178,811 shares of Common Stock held by Opportunities. Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    6

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    Dr. John D. Diekman
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    United States
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     1,021,836 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    1,021,836 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    1,021,836 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    2.8% (3)
     
      12. Type of Reporting Person (See Instructions)
    IN
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Includes (i) 980,963 shares of Common Stock held by Ventures IV; and (ii) 40,873 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    7

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    Andrew J. Schwab
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    United States
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     1,200,647 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    1,200,647 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    1,200,647 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    3.3% (3)
     
      12. Type of Reporting Person (See Instructions)
    IN
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Includes (i) 980,963 shares of Common Stock held by Ventures IV; (ii) 40,873 shares of Common Stock held by Co-Investors IV; and (iii) 178,811 shares of Common Stock held by Opportunities. Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.  Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    8

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    Dr. Kush Parmar
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    United States
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     178,811 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    178,811 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    178,811 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    0.5% (3)
     
      12. Type of Reporting Person (See Instructions)
    IN
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Includes 178,811 shares of Common Stock held by Opportunities.  Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    9

     

     

    CUSIP No. 810648 105
     
      1. Names of Reporting Persons
    Dr. Scott M. Rocklage
     
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) ¨
        (b) x (1)
     
      3. SEC Use Only
     
      4. Citizenship or Place of Organization
    United States
         
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    5. Sole Voting Power
    0 shares
     
    6. Shared Voting Power
     1,021,836 shares (2)
     
    7. Sole Dispositive Power
     0 shares
     
    8. Shared Dispositive Power
    1,021,836 shares (2)
     
      9. Aggregate Amount Beneficially Owned by Each Reporting Person
    1,021,836 shares (2)
     
      10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
     
      11. Percent of Class Represented by Amount in Row (9)
    2.8% (3)
     
      12. Type of Reporting Person (See Instructions)
    IN
               

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Includes (i) 980,963 shares of Common Stock held by Ventures IV; and (ii) 40,873 shares of Common Stock held by Co-Investors IV. Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.

     

    (3)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    10

     

     

    Item 1.
      (a) Name of Issuer
    scPharmaceuticals Inc.
      (b)

    Address of Issuer’s Principal Executive Offices
    25 Burlington Mall Road, Suite 203

    Burlington, Massachusetts 01803

     
    Item 2.
      (a)

    Name of Person Filing
    5AM Ventures IV, L.P. (“Ventures IV”)

    5AM Co-Investors IV, L.P. (“Co-Investors IV”)

    5AM Partners IV, LLC (“Partners IV”)

    5AM Opportunities I, L.P. (“Opportunities”)

    5AM Opportunities I (GP), LLC (“Opportunities GP”)

    Dr. John D. Diekman (“Diekman”)

    Andrew J. Schwab (“Schwab”)

    Dr. Kush Parmar (“Parmar”)

    Dr. Scott M. Rocklage (“Rocklage”)

      (b)

    Address of Principal Business Office or, if none, Residence
    c/o 5AM Ventures

    501 Second Street, Suite 350

    San Francisco, CA 94107

     

     

    (c)

    Citizenship

        Entities: 5AM Ventures IV, L.P. - Delaware
          5AM Co-Investors IV, L.P. - Delaware
          5AM Partners IV, LLC - Delaware
          5AM Opportunities I, L.P. - Delaware
          5AM Opportunities I (GP), LLC - Delaware
               
        Individuals: Diekman - United States
          Schwab - United States
          Parmar - United States
          Rocklage - United States

    (d) Title of Class of Securities
    Common stock, par value $0.0001 per share
      (e) CUSIP Number
    810648 105
     
    Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
      Not applicable.

     

    11

     

     

    Item 4. Ownership

     

    Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1 is provided as of December 31, 2023.

     

    Reporting Persons 

    Shares Held

    Directly

      

    Sole
    Voting
    Power

      

    Shared
    Voting
    Power

      

    Sole
    Dispositive
    Power

      

    Shared
    Dispositive
    Power

      

    Beneficial
    Ownership

      

    Percentage
    of Class (6)

     
    Ventures IV (1) (3)   980,963        980,963        980,963    980,963    2.7%
                                        
    Co-Investors IV (2) (3)   40,873         40,873         40,873    40,873    0.1%
                                        
    Partners IV (1) (2) (3)             1,021,836         1,021,836    1,021,836    2.8%
                                        
    Opportunities (4) (5)   178,811         178,811         178,811    178,811    0.5%
                                        
    Opportunities GP  (4) (5)             178,811         178,811    178,811    0.5%
                                        
    Diekman (1) (2) (3)             1,021,836         1,021,836    1,021,836    2.8%
                                        
    Schwab (1) (2) (3) (4) (5)             1,200,647         1,200,647    1,200,647    3.3%
                                        
    Parmar (4) (5)             178,811         178,811    178,811    0.5%
                                        
    Rocklage (1) (2) (3) (4) (5)             1,021,836         1,021,836    1,021,836    2.8%

     

    (1)Includes 980,963 shares of Common Stock held by Ventures IV.
    (2)Includes 40,873 shares of Common Stock held by Co-Investors IV.
    (3)Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.
    (4)Includes 178,811 shares of Common Stock held by Opportunities.
    (5)Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities.
    (6)This percentage is calculated based upon 35,860,497 shares of Common Stock outstanding as of November 7, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 8, 2023.

     

    Item 5. Ownership of Five Percent or Less of a Class

     

    If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   x.

     

    Item 6. Ownership of More than Five Percent on Behalf of Another Person
       
      Not applicable.
       

    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
       
      Not applicable.

     
    Item 8. Identification and Classification of Members of the Group
       
      Not applicable.

     

    Item 9. Notice of Dissolution of Group
       
      Not applicable.

     

    Item 10. Certification

     

    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.  

     

    12

     

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: February 14, 2024

     

    5AM Ventures IV, L.P.   5AM Co-Investors IV, L.P.
         
    By: 5AM Partners IV, LLC   By: 5AM Partners IV, LLC
    its General Partner   its General Partner
         
    By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
      Name: Andrew J. Schwab     Name: Andrew J. Schwab
      Title: Managing Member     Title: Managing Member
         
    5AM Partners IV, LLC    
         
    By: /s/ Andrew J. Schwab    
      Name: Andrew J. Schwab    
      Title: Managing Member    
         
    5AM Opportunities I, L.P.   5AM Opportunities I (GP), LLC
         
    By: 5AM Opportunities I (GP), LLC    
    its General Partner    
         
    By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
      Name: Andrew J. Schwab     Name: Andrew J. Schwab
      Title: Managing Member     Title: Managing Member
         
      /s/ Dr. John D. Diekman     /s/ Andrew J. Schwab
      Dr. John D. Diekman     Andrew J. Schwab
         
      /s/ Dr. Kush Parmar     /s/ Dr. Scott M. Rocklage
      Dr. Dr. Kush Parmar     Dr. Scott M. Rocklage

     

      ATTENTION  
    Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).

     

    13

     

     

    Exhibit(s):

     

    A - Joint Filing Statement

     

    14

     

     

    EXHIBIT A

     

    JOINT FILING STATEMENT

     

    We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the Common Stock of scPharmaceuticals Inc. is filed on behalf of each of us.

     

    Dated: February 14, 2024

     

    5AM Ventures IV, L.P.   5AM Co-Investors IV, L.P.
         
    By: 5AM Partners IV, LLC   By: 5AM Partners IV, LLC
    its General Partner   its General Partner
         
    By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
      Name: Andrew J. Schwab     Name: Andrew J. Schwab
      Title: Managing Member     Title: Managing Member
         
    5AM Partners IV, LLC    
         
    By: /s/ Andrew J. Schwab    
      Name: Andrew J. Schwab    
      Title: Managing Member    
         
    5AM Opportunities I, L.P.   5AM Opportunities I (GP), LLC
         
    By: 5AM Opportunities I (GP), LLC    
    its General Partner    
         
    By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
      Name: Andrew J. Schwab     Name: Andrew J. Schwab
      Title: Managing Member     Title: Managing Member
         
      /s/ Dr. John D. Diekman     /s/ Andrew J. Schwab
      Dr. John D. Diekman     Andrew J. Schwab
         
      /s/ Dr. Kush Parmar     /s/ Dr. Scott M. Rocklage
      Dr. Dr. Kush Parmar     Dr. Scott M. Rocklage

     

    15

     

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