• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
PublishDashboard
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlertsPublish with Us
    Company
    AboutQuantisnow PlusContactJobsAI employees
    Legal
    Terms of usePrivacy policyCookie policy

    SEC Form SC TO-T filed by Inozyme Pharma Inc.

    6/2/25 6:25:02 AM ET
    $INZY
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $INZY alert in real time by email
    SC TO-T 1 d942767dsctot.htm SC TO-T SC TO-T
     
     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE TO

    TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1)

    OF THE SECURITIES EXCHANGE ACT OF 1934

     

     

    INOZYME PHARMA, INC.

    (Name of Subject Company (Issuer))

    INCLINE MERGER SUB, INC.

    (Offeror)

    A Wholly-Owned Subsidiary of

    BIOMARIN PHARMACEUTICAL INC.

    (Parent of Offeror)

    (Names of Filing Persons (identifying status as offeror, issuer or other person))

    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

    45790W108

    (CUSIP Number of Class of Securities)

    Alexander Hardy

    President and Chief Executive Officer

    G. Eric Davis

    Executive Vice President & Chief Legal Officer

    BioMarin Pharmaceutical Inc.

    770 Lindaro Street

    San Rafael, California 94901

    (415) 506-6700

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications on Behalf of Filing Persons)

     

     

    Copies to:

    Jamie Leigh, Esq.

    Ben Beerle, Esq.

    Chadwick Mills, Esq.

    Siana Lowrey, Esq.

    Cooley LLP

    3 Embarcadero Center

    20th Floor

    San Francisco, CA 94111

    (415) 693-2000

     

     

     

    ☐ 

    Check the box if the filing relates solely to preliminary communications made before the commencement of a tender offer. Check the appropriate boxes below to designate any transactions to which the statement relates:

     

      ☒ 

    Third-party offer subject to Rule 14d-1.

      ☐ 

    Issuer tender offer subject to Rule 13e-4.

      ☐ 

    Going-private transaction subject to Rule 13e-3.

      ☐ 

    Amendment to Schedule 13D under Rule 13d-2.

    Check the following box if the filing is a final amendment reporting the results of the tender offer: E

    If applicable, check the appropriate box(es) below to designate the appropriate rule provision(s) relied upon:

     

      ☐ 

    Rule 13e-4(i) (Cross-Border Issuer Tender Offer)

      ☐ 

    Rule 14d-1(d) (Cross-Border Third Party Tender Offer)

     

     
     


    Items 1 through 9 and Item 11.

    This Tender Offer Statement on Schedule TO (the “Schedule TO”) relates to the offer by Incline Merger Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of BioMarin Pharmaceutical Inc., a Delaware corporation, to acquire all of the outstanding shares of common stock, par value $0.0001 per share (the “Shares”) of Inozyme Pharma, Inc., a Delaware corporation, for $4.00 per Share, in cash, without interest, subject to any applicable withholding of taxes, upon the terms and subject to the conditions set forth in the Offer to Purchase, dated June 2, 2025 (as it may be amended or supplemented from time to time, the “Offer to Purchase”), and the related Letter of Transmittal (as it may be amended or supplemented from time to time, the “Letter of Transmittal”), copies of which are attached hereto as Exhibits (a)(1)(i) and (a)(1)(ii), respectively.

    The information set forth in the Offer to Purchase, including all schedules thereto, is hereby expressly incorporated herein by reference in response to all of the items of this Schedule TO, except as otherwise set forth below.

     

    Item 10.

    Financial Statements.

    Not applicable.


    Item 12.

    Exhibits.

     

    Exhibit No.   Description
    (a)(1)(i)*   Offer to Purchase, dated as of June 2, 2025.
    (a)(1)(ii)*   Form of Letter of Transmittal (including Guidelines for Certification of Taxpayer Identification Number on IRS Form W-9).
    (a)(1)(iii)*   Form of Letter to Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees.
    (a)(1)(iv)*   Form of Letter to Clients for use by Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees.
    (a)(1)(v)*   Form of Notice of Guaranteed Delivery.
    (a)(1)(vi)*   Summary Advertisement, as published in The Wall Street Journal on June 2, 2025.
    (a)(5)(i)   Joint Press Release issued by BioMarin Pharmaceutical Inc. and Inozyme Pharma, Inc. dated May  16, 2025 (incorporated by reference to (i) Exhibit 99.1 of the BioMarin Pharmaceutical Inc. Current Report on Form 8-K (File No.  000-26727) filed with the Securities and Exchange Commission on May 16, 2025 and (ii)  Exhibit 99.1 of the Inozyme Pharma, Inc. Current Report on Form 8-K (File No. 001-39397) filed with the Securities and Exchange Commission on May 16, 2025).
    (a)(5)(ii)   Letter to BioMarin Employees dated May  16, 2025 (incorporated by reference to Exhibit 99.1 of the second BioMarin Pharmaceutical Inc. Pre-Commencement Communication on Schedule TO filed with the Securities and Exchange Commission on May  16, 2025).
    (a)(5)(iii)   Letter to Inozyme Employees dated May 16, 2025 (incorporated by reference to Exhibit 99.2 of the second BioMarin Pharmaceutical Inc. Pre-Commencement Communication on Schedule TO filed with the Securities and Exchange Commission on May 16, 2025).
    (a)(5)(iv)   BioMarin Social Media Content dated May  16, 2025 (incorporated by reference to Exhibit 99.3 of the second BioMarin Pharmaceutical Inc. Pre-Commencement Communication on Schedule TO filed with the Securities and Exchange Commission on May  16, 2025).
    (a)(5)(v)   Email from Douglas A. Treco, Chief Executive Officer and Chairman of Inozyme Pharma, Inc., to employees on May  16, 2025 (incorporated by reference to Exhibit 99.1 of the Inozyme Pharma, Inc. Solicitation/Recommendation Statement on Schedule 14D-9-C filed with the Securities and Exchange Commission on May 16, 2025).
    (a)(5)(vi)   Transcript from BioMarin Business Update Call dated May  16, 2025 (incorporated by reference to Exhibit 99.1 of the BioMarin Pharmaceutical Inc. Pre-Commencement Communication on Schedule TO filed with the Securities and Exchange Commission on May 19, 2025).
    (a)(5)(vii)   Presentation to BioMarin Employees dated May  19, 2025 (incorporated by reference to Exhibit 99.1 of the second BioMarin Pharmaceutical Inc. Pre-Commencement Communication on Schedule TO filed with the Securities and Exchange Commission on May  19, 2025).
    (a)(5)(viii)   Presentation to Inozyme Employees dated May  19, 2025 (incorporated by reference to Exhibit 99.2 of the second BioMarin Pharmaceutical Inc. Pre-Commencement Communication on Schedule TO filed with the Securities and Exchange Commission on May  19, 2025).
    (b)   Not Applicable.
    (d)(1)+   Agreement and Plan of Merger, dated as of May  16, 2025, by and among Inozyme Pharma, Inc., BioMarin Pharmaceutical Inc., and Incline Merger Sub, Inc. (incorporated by reference to Exhibit 2.1 of the BioMarin Pharmaceutical Inc. Current Report on Form 8-K (File No. 000-26727) filed with the Securities and Exchange Commission on May 16, 2025).
    (d)(2)   Form of Tender and Support Agreement (incorporated by reference to Exhibit 10.1 of the BioMarin Pharmaceutical Inc. Current Report on Form 8-K (File No. 000-26727) filed with the Securities and Exchange Commission on May 16, 2025).


    Exhibit No.   Description
    (d)(3)*   Mutual Non-Disclosure Agreement, dated May 8, 2024, by and between BioMarin Pharmaceutical Inc. and Inozyme Pharma, Inc.
    (d)(4)*   Exclusivity Agreement, dated May 10, 2025, by and between BioMarin Pharmaceutical Inc. and Inozyme Pharma, Inc.
    (g)   Not Applicable.
    (h)   Not Applicable.
    107*   Filing Fee Table.

     

    *

    Filed herewith

    +

    Certain exhibits and schedules have been omitted pursuant to Item 601(a)(5) of Regulation S-K. BioMarin agrees to furnish supplementally a copy of any omitted exhibit or schedule to the Securities and Exchange Commission upon request; provided, however, that BioMarin may request confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended, for any schedule so furnished.


    SIGNATURES

    After due inquiry and to the best knowledge and belief of the undersigned, each of the undersigned certify that the information set forth in this statement is true, complete and correct.

     

    Date: June 2, 2025       Incline Merger Sub, Inc.,
    a Delaware corporation
        By:  

    /s/ G. Eric Davis

          G. Eric Davis
          President
          BioMarin Pharmaceutical Inc.,
    a Delaware corporation
        By:  

    /s/ G. Eric Davis

          G. Eric Davis
          Executive Vice President, Chief Legal Officer
    Get the next $INZY alert in real time by email

    Chat with this insight

    Save time and jump to the most important pieces.

    Recent Analyst Ratings for
    $INZY

    DatePrice TargetRatingAnalyst
    12/12/2024$26.00Outperform
    Raymond James
    9/12/2024$16.00Buy
    Stifel
    8/13/2024$16.00 → $17.00Buy
    Jefferies
    5/30/2024$14.00Overweight
    Wells Fargo
    3/23/2023$4.50 → $6.00Hold → Buy
    Jefferies
    5/26/2022$5.00Hold
    Jefferies
    2/7/2022$33.00Buy
    HC Wainwright & Co.
    11/29/2021$23.00Buy
    Needham
    More analyst ratings

    $INZY
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • Director Bolte Axel exercised 157,230 shares at a strike of $0.98, increasing direct ownership by 59% to 423,926 units (SEC Form 4)

      4 - Inozyme Pharma, Inc. (0001693011) (Issuer)

      5/20/25 4:00:06 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • CEO & Chairman Treco Douglas A converted options into 25,000 shares and sold $7,849 worth of shares (8,819 units at $0.89), increasing direct ownership by 65% to 41,046 units (SEC Form 4)

      4 - Inozyme Pharma, Inc. (0001693011) (Issuer)

      4/3/25 4:27:09 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • COO Winton Matthew was granted 2,490 shares, increasing direct ownership by 51% to 7,388 units (SEC Form 4)

      4 - Inozyme Pharma, Inc. (0001693011) (Issuer)

      4/2/25 4:29:22 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $INZY
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • BioMarin Strengthens Enzyme Therapy Business with Acquisition of Inozyme Pharma

      Acquisition is Strong Strategic Fit for BioMarin, Adding INZ-701, a Phase 3 Enzyme Replacement Therapy Being Developed for Treatment of ENPP1 Deficiency First Pivotal Data Readout in Children Expected in Early 2026 with Potential Launch in 2027; Additional Clinical Programs to Expand to Patients of all Ages  Potential First-in-Disease Treatment for ENPP1 Deficiency Conference Call and Webcast Scheduled Today at 8:45 a.m. ET SAN RAFAEL, Calif. and BOSTON, May 16, 2025 /PRNewswire/ -- BioMarin Pharmaceutical Inc. (NASDAQ:BMRN) and Inozyme Pharma, Inc. (NASDAQ:INZY) announced today that BioMarin has entered into a definitive agreement to acquire Inozyme for $4.00 per share in an all-cash transa

      5/16/25 7:30:00 AM ET
      $BMRN
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Inozyme Pharma Reports First Quarter 2025 Financial Results and Provides Business Highlights

      - Interim data from ENERGY 3 trial highlight INZ-701's potential to modify disease course in ENPP1 Deficiency, with sustained phosphate increases and favorable safety and immunogenicity profile to date - - ENERGY 3 trial on track for topline data in first quarter of 2026; no patient dropouts, dose adjustments or discontinuations, and no new safety signals - - Petra Duda, M.D., Ph.D. appointed Chief Medical Officer - BOSTON, May 14, 2025 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (NASDAQ:INZY) ("the Company" or "Inozyme"), a clinical-stage biopharmaceutical company developing innovative therapeutics for rare diseases that affect bone health and blood vessel function, today reported financi

      5/14/25 7:30:00 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Inozyme Pharma Announces JBMR Plus Publication Demonstrating Real-World Impact of ENPP1 Deficiency

      - Data from the largest retrospective analysis of ENPP1 Deficiency provides insights into the evolution of the disease's serious cardiovascular and musculoskeletal complications - - Findings highlight the urgent need for early and improved diagnosis, care and treatments that address the long-term systemic effects of ENPP1 Deficiency - BOSTON, April 10, 2025 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (NASDAQ:INZY) ("the Company" or "Inozyme"), a clinical-stage biopharmaceutical company developing innovative therapeutics for rare diseases that affect bone health and blood vessel function, today announced the publication of a paper titled, "Phenotypic characterization of ENPP1 deficiency: gen

      4/10/25 8:30:00 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $INZY
    Leadership Updates

    Live Leadership Updates

    See more
    • Inozyme Pharma Reports First Quarter 2025 Financial Results and Provides Business Highlights

      - Interim data from ENERGY 3 trial highlight INZ-701's potential to modify disease course in ENPP1 Deficiency, with sustained phosphate increases and favorable safety and immunogenicity profile to date - - ENERGY 3 trial on track for topline data in first quarter of 2026; no patient dropouts, dose adjustments or discontinuations, and no new safety signals - - Petra Duda, M.D., Ph.D. appointed Chief Medical Officer - BOSTON, May 14, 2025 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (NASDAQ:INZY) ("the Company" or "Inozyme"), a clinical-stage biopharmaceutical company developing innovative therapeutics for rare diseases that affect bone health and blood vessel function, today reported financi

      5/14/25 7:30:00 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Inozyme Pharma Reports Third Quarter 2024 Financial Results and Provides Business Highlights

      - Interim data from ENERGY 1, a Phase 1b trial of INZ-701 in infants with ENPP1 Deficiency, on track for fourth quarter of 2024 – - Topline data from ENERGY 3, a pivotal trial of INZ-701 in pediatric patients with ENPP1 Deficiency, expected in early 2026 - - Company plans to initiate registrational trials in calciphylaxis and ABCC6 Deficiency in 2025 subject to regulatory alignment and sufficient funding - - Cash, cash equivalents, and short-term investments as of September 30, 2024, expected to fund operations into the fourth quarter of 2025 – BOSTON, Nov. 05, 2024 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (NASDAQ:INZY) ("the Company" or "Inozyme"), a clinical-stage biopharmaceutical c

      11/5/24 8:30:00 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Inozyme Pharma Announces Appointment of Biopharmaceutical Commercial Leader Erik Harris to its Board of Directors

      BOSTON, Oct. 07, 2024 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (NASDAQ:INZY) ("the Company" or "Inozyme"), a clinical-stage biopharmaceutical company developing innovative therapeutics for rare diseases that affect bone health and blood vessel function, today announced the appointment of Erik Harris to its Board of Directors, effective October 3, 2024. Mr. Harris, who currently serves as Chief Commercial Officer and Executive Vice President at Ultragenyx, brings to Inozyme over 20 years of commercial expertise within the biopharma industry. "It is a privilege to welcome Erik to the Inozyme Board of Directors at this exciting juncture for Inozyme as we continue to lay the groundwork for ou

      10/7/24 8:30:17 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $INZY
    SEC Filings

    See more
    • SEC Form SCHEDULE 13G filed by Inozyme Pharma Inc.

      SCHEDULE 13G - Inozyme Pharma, Inc. (0001693011) (Subject)

      6/4/25 5:09:30 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 14D9/A filed by Inozyme Pharma Inc.

      SC 14D9/A - Inozyme Pharma, Inc. (0001693011) (Subject)

      6/4/25 4:51:51 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC TO-T/A filed by Inozyme Pharma Inc.

      SC TO-T/A - Inozyme Pharma, Inc. (0001693011) (Subject)

      6/4/25 4:32:35 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $INZY
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • SEC Form SC 13G filed by Inozyme Pharma Inc.

      SC 13G - Inozyme Pharma, Inc. (0001693011) (Subject)

      12/9/24 4:14:49 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Inozyme Pharma Inc.

      SC 13G/A - Inozyme Pharma, Inc. (0001693011) (Subject)

      11/14/24 12:19:37 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by Inozyme Pharma Inc.

      SC 13G - Inozyme Pharma, Inc. (0001693011) (Subject)

      10/24/24 2:02:10 PM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $INZY
    Financials

    Live finance-specific insights

    See more
    • BioMarin Strengthens Enzyme Therapy Business with Acquisition of Inozyme Pharma

      Acquisition is Strong Strategic Fit for BioMarin, Adding INZ-701, a Phase 3 Enzyme Replacement Therapy Being Developed for Treatment of ENPP1 Deficiency First Pivotal Data Readout in Children Expected in Early 2026 with Potential Launch in 2027; Additional Clinical Programs to Expand to Patients of all Ages  Potential First-in-Disease Treatment for ENPP1 Deficiency Conference Call and Webcast Scheduled Today at 8:45 a.m. ET SAN RAFAEL, Calif. and BOSTON, May 16, 2025 /PRNewswire/ -- BioMarin Pharmaceutical Inc. (NASDAQ:BMRN) and Inozyme Pharma, Inc. (NASDAQ:INZY) announced today that BioMarin has entered into a definitive agreement to acquire Inozyme for $4.00 per share in an all-cash transa

      5/16/25 7:30:00 AM ET
      $BMRN
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Inozyme Pharma Announces Positive Topline Data from Ongoing Phase 1/2 Trials of INZ-701 in Adults with ABCC6 Deficiency (PXE) and ENPP1 Deficiency

      - Favorable safety and immunogenicity profile in ABCC6 Deficiency, with clinical improvements in vascular pathology, visual function and patient reported outcomes (PROs) - - Natural history study highlights stroke as common feature among patients with early-onset ABCC6 Deficiency - - Favorable safety, immunogenicity and clinical outcome data were maintained through 48 weeks in Cohorts 1-3 in ENPP1 Deficiency; Data from Cohort 4 support once weekly dosing in ongoing and future clinical trials - - Company to host conference call and webcast today at 8:00 a.m. ET - BOSTON, April 08, 2024 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (NASDAQ:INZY) ("the Company" or "Inozyme"), a clinical-stage

      4/8/24 6:30:35 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Inozyme Pharma to Report Topline Data from Ongoing Phase 1/2 Trials of INZ-701 in Adults with ABCC6 Deficiency and ENPP1 Deficiency on April 8, 2024

      - Company to host conference call and webcast featuring key opinion leaders on Monday, April 8, 2024 at 8:00 a.m. ET - BOSTON, March 26, 2024 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (NASDAQ:INZY) ("the Company" or "Inozyme"), a clinical-stage rare disease biopharmaceutical company developing novel therapeutics for the treatment of pathologic mineralization and intimal proliferation, today announced that it will host a conference call and webcast on Monday, April 8, 2024 at 8:00 a.m. Eastern Time. During the conference call and webcast, the Company will discuss topline data from its ongoing Phase 1/2 trial of INZ-701 in adults with ABCC6 Deficiency (pseudoxanthoma elasticum or PXE), and

      3/26/24 8:30:42 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $INZY
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • Raymond James initiated coverage on Inozyme Pharma with a new price target

      Raymond James initiated coverage of Inozyme Pharma with a rating of Outperform and set a new price target of $26.00

      12/12/24 8:10:19 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Stifel initiated coverage on Inozyme Pharma with a new price target

      Stifel initiated coverage of Inozyme Pharma with a rating of Buy and set a new price target of $16.00

      9/12/24 7:42:17 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Jefferies resumed coverage on Inozyme Pharma with a new price target

      Jefferies resumed coverage of Inozyme Pharma with a rating of Buy and set a new price target of $17.00 from $16.00 previously

      8/13/24 7:33:31 AM ET
      $INZY
      Biotechnology: Pharmaceutical Preparations
      Health Care