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    SEC Form SCHEDULE 13G filed by Entera Bio Ltd.

    4/2/25 6:51:11 PM ET
    $ENTX
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $ENTX alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    Entera Bio Ltd.

    (Name of Issuer)


    Ordinary Shares Nominal value of NIS 0.0000769 per share

    (Title of Class of Securities)


    M40527109

    (CUSIP Number)


    03/16/2025

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox checked   Rule 13d-1(c)
    Checkbox not checked   Rule 13d-1(d)






    SCHEDULE 13G

    CUSIP No.
    M40527109


    1Names of Reporting Persons

    OPKO HEALTH, INC.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    3,685,226.00
    6Shared Voting Power

    0.00
    7Sole Dispositive Power

    3,685,226.00
    8Shared Dispositive Power

    0.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    3,685,226.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    8.1 %
    12Type of Reporting Person (See Instructions)

    CO

    Comment for Type of Reporting Person:  Based on 45,420,676 shares of ordinary shares of the Issuer outstanding on March 20, 2025, as set forth in the Issuer's Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 28, 2025.


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Entera Bio Ltd.
    (b)Address of issuer's principal executive offices:

    KIRYAT HADASSAH, MINRAV BUILDING, FIFTH FLOOR, JERUSALEM, ISRAEL, 9112002.
    Item 2. 
    (a)Name of person filing:

    OPKO Health, Inc. (the "Reporting Person")
    (b)Address or principal business office or, if none, residence:

    4400 Biscayne Blvd., Miami, FL 33137
    (c)Citizenship:

    State of Delaware
    (d)Title of class of securities:

    Ordinary Shares Nominal value of NIS 0.0000769 per share
    (e)CUSIP No.:

    M40527109
    Item 3.If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
    (a)Checkbox not checked   Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
    (b)Checkbox not checked   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
    (c)Checkbox not checked   Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
    (d)Checkbox not checked   Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
    (e)Checkbox not checked   An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
    (f)Checkbox not checked   An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
    (g)Checkbox not checked   A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
    (h)Checkbox not checked   A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)Checkbox not checked   A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)Checkbox not checked   A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
           please specify the type of institution:
    (k)Checkbox not checked   Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
     
    Item 4.Ownership
    (a)Amount beneficially owned:

    The information required by Items 4(a) - (c) is set forth in Rows 5 - 11 of the cover page for the Reporting Person and is incorporated herein by reference. The percentage set forth in Row (11) of the cover page for each of the Reporting Persons is based on the 45,420,676 shares of ordinary shares of the Issuer outstanding on March 20, 2025, as set forth in the Issuer's Form 10-K filed with the SEC on March 28, 2025.
    (b)Percent of class:

    8.1% The percentage set forth in Row (11) of the cover page for each of the Reporting Persons is based on the 45,420,676 shares of ordinary shares of the Issuer outstanding on March 20, 2025, as set forth in the Issuer's Form 10-K filed with the SEC on March 28, 2025.
    (c)Number of shares as to which the person has:
     (i) Sole power to vote or to direct the vote:

    3,685,226 Shares

     (ii) Shared power to vote or to direct the vote:

    -

     (iii) Sole power to dispose or to direct the disposition of:

    3,685,226

     (iv) Shared power to dispose or to direct the disposition of:

    -

    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Item 6.Ownership of more than 5 Percent on Behalf of Another Person.
     
    Not Applicable
    Item 7.Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
     
    Not Applicable
    Item 8.Identification and Classification of Members of the Group.
     
    Not Applicable
    Item 9.Notice of Dissolution of Group.
     
    Not Applicable

    Item 10.Certifications:
     
    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    OPKO HEALTH, INC.
     
    Signature:/s/ Steven D. Rubin
    Name/Title:Executive Vice President - Administration
    Date:04/02/2025
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