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    SEC Form SCHEDULE 13G filed by Maze Therapeutics Inc.

    5/15/25 5:05:19 PM ET
    $MAZE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $MAZE alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    Maze Therapeutics, Inc.

    (Name of Issuer)


    Common Stock par value $0.0001 per share

    (Title of Class of Securities)


    578784100

    (CUSIP Number)


    03/31/2025

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox not checked   Rule 13d-1(c)
    Checkbox checked   Rule 13d-1(d)






    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    ARCH Venture Fund X, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    ARCH Venture Fund X Overage, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    ARCH Venture Partners X, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    ARCH Venture Partners X Overage, L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    PN


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    ARCH Venture Partners X, LLC
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    OO


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    Keith Crandell
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    Kristina Burow
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    Steven Gillis
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    CUSIP No.
    578784100


    1Names of Reporting Persons

    Robert Nelsen
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    4,120,053.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    4,120,053.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    4,120,053.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    9.4 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Maze Therapeutics, Inc.
    (b)Address of issuer's principal executive offices:

    171 Oyster Point Blvd., Suite 300, South San Francisco, CA 94080
    Item 2. 
    (a)Name of person filing:

    ARCH Venture Fund X, L.P. ("AVF X"); ARCH Venture Partners X, L.P. ("AVP X LP"); ARCH Venture Partners X, LLC ("AVP X LLC"); ARCH Venture Fund X Overage, L.P. ("AVF X Overage"); ARCH Venture Partners X Overage, L.P. ("AVP X Overage GP") (collectively, the "Reporting Entities" and individually, each a "Reporting Entity"); and Keith Crandell ("Crandell"), Robert Nelsen ("Nelsen"), Kristina Burow ("Burow") and Steven Gillis ("Gillis) (collectively, the "Investment Committee" and individually, each a "Committee Member"). The Reporting Entities and the Committee Members collectively are referred to as the "Reporting Persons".
    (b)Address or principal business office or, if none, residence:

    8755 W. Higgins Avenue, Suite 1025, Chicago, IL 60631
    (c)Citizenship:

    Each of AVF X, AVP X LP, AVF X Overage and AVP X Overage GP, are limited partnerships organized under the laws of the State of Delaware. AVP X LLC is a limited liability company organized under the laws of the State of Delaware. Each Committee Member is a US citizen.
    (d)Title of class of securities:

    Common Stock par value $0.0001 per share
    (e)CUSIP No.:

    578784100
    Item 3.If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
    (a)Checkbox not checked   Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
    (b)Checkbox not checked   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
    (c)Checkbox not checked   Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
    (d)Checkbox not checked   Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
    (e)Checkbox not checked   An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
    (f)Checkbox not checked   An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
    (g)Checkbox not checked   A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
    (h)Checkbox not checked   A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)Checkbox not checked   A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)Checkbox not checked   A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
           please specify the type of institution:
    (k)Checkbox not checked   Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
     
    Item 4.Ownership
    (a)Amount beneficially owned:

    AVF X is the record owner of 1,949,930 shares of Common Stock (the "AVF X Shares") as of March 31, 2025. AVP X LP, as the sole general partner of ARCH Venture Fund X, may be deemed to beneficially own the AVF X Shares. AVF X Overage is the record owner of 2,170,123 shares of Common Stock (the "AVF X Overage Shares"; combined with AVF X Shares, the "Record Shares") as of March 31, 2025. AVP X Overage GP, as the sole general partner of AVF X Overage, may be deemed to beneficially own the AVF X Overage Shares. AVP X LLC, as the sole general partner of AVP X LP and AVP X Overage LP, may be deemed to beneficially own the Record Shares. As Committee Members of AVP X LLC, each Committee Member may also be deemed to share the power to direct the disposition and vote of the Record Shares.
    (b)Percent of class:

    See line 11 of the cover sheets. The percentages set forth on the cover sheet for each Reporting Person is based upon 43,796,057 shares of common stock outstanding as of March 25, 2025 as reported on the Issuer's Form 10-K as filed with the Securities and Exchange Commission on March 31, 2025.
    (c)Number of shares as to which the person has:
     (i) Sole power to vote or to direct the vote:

    See line 5 of the cover sheets.

     (ii) Shared power to vote or to direct the vote:

    See line 6 of the cover sheets.

     (iii) Sole power to dispose or to direct the disposition of:

    See line 7 of the cover sheets.

     (iv) Shared power to dispose or to direct the disposition of:

    See line 8 of the cover sheets.

    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Item 6.Ownership of more than 5 Percent on Behalf of Another Person.
     
    Not Applicable
    Item 7.Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
     
    Not Applicable
    Item 8.Identification and Classification of Members of the Group.
     
    Not Applicable
    Item 9.Notice of Dissolution of Group.
     
    Not Applicable

    Item 10.Certifications:
     
    Not Applicable

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    ARCH Venture Fund X, L.P.
     
    Signature:ARCH Venture Partners X, L.P.
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:ARCH Venture Partners X, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Fund X Overage, L.P.
     
    Signature:ARCH Venture Partners X Overage, L.P.
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:ARCH Venture Partners X, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Partners X, L.P.
     
    Signature:ARCH Venture Partners X, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Partners X Overage, L.P.
     
    Signature:ARCH Venture Partners X, LLC
    Name/Title:its General Partner
    Date:05/15/2025
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    ARCH Venture Partners X, LLC
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director
    Date:05/15/2025
     
    Keith Crandell
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Keith Crandell
    Date:05/15/2025
     
    Kristina Burow
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Kristina Burow
    Date:05/15/2025
     
    Steven Gillis
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Steven Gillis
    Date:05/15/2025
     
    Robert Nelsen
     
    Signature:/s/ Mark McDonnell
    Name/Title:* Mark McDonnell, as Attorney-in-Fact for Robert Nelsen
    Date:05/15/2025

    Comments accompanying signature:  * This Schedule 13G was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24 and 24.1 to the Form 3 relating to the beneficial ownership of shares of Verve Therapeutics, Inc. by the Reporting Persons filed with the Securities Exchange Commission on June 16, 2021 and incorporated herein in its entirety by reference.
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    Maze Therapeutics Announces Positive First-in-Human Results from Phase 1 Trial of MZE782, Establishing Proof of Mechanism for a Potent, Oral SLC6A19 Inhibitor with Potential to Treat Phenylketonuria (PKU) and Chronic Kidney Disease (CKD)

    Phase 1 data in healthy volunteers exceed expectations and support best-in-class potential, enabling Phase 2 advancement for both intended indications of PKU and CKD Dose-dependent urinary amino acid excretion demonstrated across all SAD and MAD cohorts, including up to a 42-fold increase in urinary phenylalanine (Phe) excretion, a well-validated biomarker for PKU and predictive for CKD Dose-dependent initial eGFR dip similar to SGLT2 inhibitors observed, supporting a potential kidney protective effect in CKD Well tolerated across all doses with an excellent safety profile and no serious adverse events observed Phase 2 trials in both PKU and CKD expected to initiate in 2026 Maze to hos

    9/11/25 7:30:00 AM ET
    $MAZE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care