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    SEC Form SCHEDULE 13G filed by Sarepta Therapeutics Inc.

    7/25/25 4:08:08 PM ET
    $SRPT
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $SRPT alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13G


    UNDER THE SECURITIES EXCHANGE ACT OF 1934
    Sarepta Therapeutics, Inc.

    (Name of Issuer)


    Common Stock, $0.0001 par value per share

    (Title of Class of Securities)


    803607100

    (CUSIP Number)


    07/18/2025

    (Date of Event Which Requires Filing of this Statement)


    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
    Checkbox not checked   Rule 13d-1(b)
    Checkbox checked   Rule 13d-1(c)
    Checkbox not checked   Rule 13d-1(d)






    SCHEDULE 13G

    CUSIP No.
    803607100


    1Names of Reporting Persons

    D. E. Shaw & Co., L.P.
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    5,000,212.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    5,059,912.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    5,059,912.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    5.1 %
    12Type of Reporting Person (See Instructions)

    IA, PN


    SCHEDULE 13G

    CUSIP No.
    803607100


    1Names of Reporting Persons

    David E. Shaw
    2Check the appropriate box if a member of a Group (see instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3Sec Use Only
    4Citizenship or Place of Organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    5Sole Voting Power

    0.00
    6Shared Voting Power

    5,000,212.00
    7Sole Dispositive Power

    0.00
    8Shared Dispositive Power

    5,059,912.00
    9Aggregate Amount Beneficially Owned by Each Reporting Person

    5,059,912.00
    10Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

    Checkbox not checked
    11Percent of class represented by amount in row (9)

    5.1 %
    12Type of Reporting Person (See Instructions)

    IN


    SCHEDULE 13G

    Item 1. 
    (a)Name of issuer:

    Sarepta Therapeutics, Inc.
    (b)Address of issuer's principal executive offices:

    215 First Street, Suite 415, Cambridge, MA 02142
    Item 2. 
    (a)Name of person filing:

    D. E. Shaw & Co., L.P. David E. Shaw
    (b)Address or principal business office or, if none, residence:

    The business address for each reporting person is: Two Manhattan West 375 Ninth Avenue, 52nd Floor New York, NY 10001
    (c)Citizenship:

    D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America.
    (d)Title of class of securities:

    Common Stock, $0.0001 par value per share
    (e)CUSIP No.:

    803607100
    Item 3.If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
    (a)Checkbox not checked   Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
    (b)Checkbox not checked   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
    (c)Checkbox not checked   Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
    (d)Checkbox not checked   Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
    (e)Checkbox not checked   An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
    (f)Checkbox not checked   An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
    (g)Checkbox not checked   A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
    (h)Checkbox not checked   A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
    (i)Checkbox not checked   A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
    (j)Checkbox not checked   A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
           please specify the type of institution:
    (k)Checkbox not checked   Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
     
    Item 4.Ownership
    (a)Amount beneficially owned:

    D. E. Shaw & Co., L.P.: 5,059,912 shares This is composed of (i) 2,781,337 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,391,459 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 887,116 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw: 5,059,912 shares This is composed of (i) 2,781,337 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,391,459 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 887,116 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw does not own any shares directly. By virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Valence Portfolios, L.L.C. and D. E. Shaw Oculus Portfolios, L.L.C. and the managing member of D. E. Shaw Investment Management, L.L.C., and by virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the manager of D. E. Shaw Valence Portfolios, L.L.C. and D. E. Shaw Oculus Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of 5,000,212 shares, and the shared power to dispose or direct the disposition of 5,059,912 shares, the 5,059,912 shares as described above constituting 5.1% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 5,059,912 shares.
    (b)Percent of class:

    D. E. Shaw & Co., L.P.: 5.1% David E. Shaw: 5.1%
    (c)Number of shares as to which the person has:
     (i) Sole power to vote or to direct the vote:

    D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares

     (ii) Shared power to vote or to direct the vote:

    D. E. Shaw & Co., L.P.: 5,000,212 shares David E. Shaw: 5,000,212 shares

     (iii) Sole power to dispose or to direct the disposition of:

    D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares

     (iv) Shared power to dispose or to direct the disposition of:

    D. E. Shaw & Co., L.P.: 5,059,912 shares David E. Shaw: 5,059,912 shares

    Item 5.Ownership of 5 Percent or Less of a Class.
     
    Item 6.Ownership of more than 5 Percent on Behalf of Another Person.
     
    Not Applicable
    Item 7.Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
     
    Not Applicable
    Item 8.Identification and Classification of Members of the Group.
     
    Not Applicable
    Item 9.Notice of Dissolution of Group.
     
    Not Applicable

    Item 10.Certifications:
     
    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    D. E. Shaw & Co., L.P.
     
    Signature:/s/ Daniel R. Marcus
    Name/Title:Daniel R. Marcus / Chief Compliance Officer
    Date:07/25/2025
     
    David E. Shaw
     
    Signature:/s/ Daniel R. Marcus
    Name/Title:Daniel R. Marcus / Attorney-in-Fact for David E. Shaw
    Date:07/25/2025

    Comments accompanying signature:  Exhibit 1: Power of Attorney, granted by David E. Shaw relating to D. E. Shaw & Co., Inc., in favor of the signatories hereto, among others, dated August 1, 2024.
    Exhibit Information

    Exhibit 2: Joint Filing Agreement, by and among the Reporting Persons, dated July 25, 2025.

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