Telomir Pharmaceuticals Inc. filed SEC Form 8-K: Other Events
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Item 8.01 Other Events
Telomir Pharmaceuticals Announces In Vitro Data Showing Telomir-1 Inhibits Key Epigenetic Enzymes Driving Tumor Growth, Autoimmune Disease, Neurodegeneration, and Metabolic Dysfunction
New data from Eurofins Discovery show that Telomir-1 blocks enzymes that drive disease by turning off critical genes—highlighting its potential to treat cancer, autoimmune conditions, neurodegeneration, and metabolic disorders through epigenetic modulation.
On August 7, 2025, Telomir Pharmaceuticals, Inc. (NASDAQ:TELO), a preclinical-stage biotechnology company developing therapies that target the underlying mechanisms of aging and age-related diseases, today announced new in vitro data supporting the mechanism of action of its lead drug candidate, Telomir-1.
In a preclinical study conducted in collaboration with Eurofins Discovery, Telomir-1 was shown to inhibit three key histone demethylase enzymes—JMJD3, FBXL10, and FBXL11—that regulate gene expression through epigenetic mechanisms. These enzymes function by removing methyl groups from histones, effectively switching genes on or off. When overactive, they silence tumor suppressor genes and activate pro-inflammatory or metabolic genes that contribute to disease.
Overactivation of these enzymes can result from genetic amplification, chronic inflammation, and stress signals from the tumor microenvironment. These factors can trigger persistent gene silencing or inappropriate activation of disease-promoting pathways, reinforcing their role in cancer, immune disorders, and metabolic dysfunction.
Specifically:
| ● | JMJD3 is associated with inflammation, metastasis, and immune signaling dysregulation. It is overexpressed in several cancers and chronic inflammatory diseases. | |
| ● | FBXL10 is known to drive aggressive cancers and promote resistance to therapy by maintaining cancer cell stemness and suppressing tumor suppressors. | |
| ● | FBXL11 contributes to tumor proliferation and immune evasion and has been linked to both metabolic dysfunction and neurodevelopmental disorders. |
By inhibiting all three enzymes, Telomir-1 may help restore normal gene expression patterns in diseases characterized by epigenetic silencing, making it a promising candidate across multiple high-burden indications.
Telomir-1’s inhibition of these enzymes represents a potential breakthrough in the company’s effort to target upstream regulators of disease-related gene silencing. The findings build upon previously disclosed results showing Telomir-1’s ability to reverse epigenetic silencing of tumor suppressor genes such as STAT1 and TMS1 in PC3 xenograft prostate cancer models. In head-to-head comparisons, Telomir-1 demonstrated more complete reactivation of STAT1 than either Paclitaxel or Rapamycin.
These results provide important insight into Telomir-1’s mechanism of action and support its continued development across oncology and other age-related therapeutic areas. The company is currently preparing to advance Telomir-1 into IND-enabling studies.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
| TELOMIR PHARMACEUTICALS, INC. | ||
| Dated: August 7, 2025 | By: | /s/ Erez Aminov |
| Name: | Erez Aminov | |
| Title: | Chief Executive Officer | |