Ambrx Biopharma Inc., a clinical-stage biologics company, discovers and develops engineered precision biologics using its proprietary expanded genetic code technology platform. Its lead product candidate is ARX788, an anti-HER2 antibody-drug conjugate (ADC), which is investigated in various clinical trials for the treatment of breast cancer, gastric/gastroesophageal junction cancer, and other solid tumors, including ongoing Phase 2/3 clinical trials for the treatment of HER2-positive metastatic breast cancer and gastric cancer. The company is also developing two earlier-stage product candidates, including ARX517, an anti-PSMA ADC, which is in a Phase 1 clinical trial for the treatment of prostate cancer and other solid tumors; and ARX305, an anti-CD70 ADC in investigational new drug-enabling studies for the treatment of renal cell carcinoma and other cancers. In addition, it is developing other multiple product candidates targeting immuno-oncology applications, which include ARX822, a fab-small molecule bispecific that is in preclinical development for cancers; and ARX102, an immuno-oncology IL-2 pathway agonist to stimulate the patient's own immune system by targeting the ß and gamma receptors on the cytotoxic T cell. Ambrx Biopharma Inc. has collaborations with Bristol Myers Squibb Company; AbbVie Inc.; BeiGene; Sino Biopharmaceutical Co., Ltd.; NovoCodex; and Elanco Animal Health. The company was incorporated in 2003 and is headquartered in La Jolla, California.
IPO Year:
Exchange: NYSE
Website: https://ambrx.com
| Date | Price Target | Rating | Analyst |
|---|---|---|---|
| 9/25/2023 | $15.00 | Mkt Outperform | JMP Securities |
| 9/12/2023 | $26.00 | Buy | BTIG Research |
| 7/31/2023 | $29.00 | Outperform | RBC Capital Mkts |
| 6/14/2023 | $26.00 | Buy | B. Riley Securities |
| 6/2/2023 | $30.00 | Outperform | Oppenheimer |
| 5/19/2023 | $25.00 | Overweight | Cantor Fitzgerald |
| 4/7/2022 | $16.00 | Outperform | Robert W. Baird |
| 2/28/2022 | $6.00 | Neutral | Goldman Sachs |
4 - Ambrx Biopharma Inc. (0001836056) (Issuer)
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Company to Transfer Stock Exchange Listing from NYSE to Nasdaq Ticker symbol will remain "AMAM" Ambrx Biopharma Inc. (NYSE: AMAM) ("Ambrx" or "the Company") today announced that it will voluntarily transfer its stock exchange listing to the Nasdaq Stock Market from the New York Stock Exchange, effective March 16, 2023 after market close. Ambrx's American Depositary Shares are expected to begin trading as a Nasdaq-listed security on March 17, 2023. The Company will retain its current ticker symbol "AMAM". "The listing of our stock on the Nasdaq represents a significant milestone in our growth as a publicly-traded company and is an important step that will help facilitate our mission to di
- Company now focused on earlier stage engineered antibody drugs for cancer therapies, including new lead asset ARX517 – - Revised focus and projected cost-reductions expected to extend cash runway into 2025 – - Ambrx to host a conference call today at 5:00 p.m. EST / 2:00 p.m. PST - SAN DIEGO, Oct. 18, 2022 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc., or Ambrx, (NYSE:AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today announced a strategic reprioritization of its pipeline and provided a corporate update. The strategic assessment considered the company's cash runway, pipeline near term v
SAN DIEGO, Oct. 11, 2022 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc., or Ambrx, (NYSE:AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today announced the company will host a corporate update conference call and live webcast on October 18, 2022 at 2:00 p.m. Pacific Time / 5:00 p.m. Eastern Time, to discuss the company's strategic review of its development pipeline. Individuals interested in listening to the conference call may do so by registering via the webcast link in the investor relations section of the company's website at: www.ambrx.com. To access the call by phone, please use the reg
- Conference Call Scheduled for Tuesday, April 26, 2022 at 4:30 p.m. ET - Ambrx Biopharma Inc., or Ambrx, (NYSE:AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics, today announced that the company will release full year 2021 financial results on Tuesday April 26, 2022 after the close of market. Ambrx will host a corresponding conference call and a live webcast at 1:30 p.m. PT / 4:30 p.m. ET on the same day to discuss the results and provide a corporate update. Individuals interested in listening to the conference call may do so by dialing (844) 200-6205 for domestic callers, or (929) 526-1599 for in
JMP Securities initiated coverage of Ambrx Biopharma with a rating of Mkt Outperform and set a new price target of $15.00
BTIG Research initiated coverage of Ambrx Biopharma with a rating of Buy and set a new price target of $26.00
RBC Capital Mkts initiated coverage of Ambrx Biopharma with a rating of Outperform and set a new price target of $29.00
B. Riley Securities initiated coverage of Ambrx Biopharma with a rating of Buy and set a new price target of $26.00
Oppenheimer initiated coverage of Ambrx Biopharma with a rating of Outperform and set a new price target of $30.00
Cantor Fitzgerald initiated coverage of Ambrx Biopharma with a rating of Overweight and set a new price target of $25.00
Robert W. Baird initiated coverage of Ambrx Biopharma with a rating of Outperform and set a new price target of $16.00
Goldman Sachs initiated coverage of Ambrx Biopharma with a rating of Neutral and set a new price target of $6.00
– Industry veteran to serve as independent director, strengthening the board and bringing extensive leadership, executive and governance experience to Cartography as it builds out its oncology platform and pipeline - Cartography Biosciences, Inc., an oncology company advancing a pipeline of antibody therapeutics that more precisely target tumors, today announced the appointment of Troy E. Wilson, Ph.D., J.D., as an independent director. Dr. Wilson, a 25-year veteran of the biopharma industry, is President, CEO and co-founder of Kura Oncology (NASDAQ:KURA) and has served as chairman of its Board of Directors since it was founded in 2014. "We are delighted to have attracted a true industry
SAN DIEGO, March 06, 2024 (GLOBE NEWSWIRE) -- Ambrx Biopharma, Inc., ("Ambrx" or the "Company") (NASDAQ:AMAM), today announced that its shareholders approved a proposal to adopt the merger agreement entered into between the Company and Johnson & Johnson at its Special Meeting of Shareholders. As previously announced, under the terms of the transaction, Ambrx shareholders will receive $28.00 per share in cash in connection with the closing of the transaction. Daniel J. O'Connor, Chief Executive Officer of Ambrx, said, "We want to thank our shareholders for their strong support of this transaction. With a steadfast focus on protein engineering innovation and some of the best ADC talent in t
SAN DIEGO, Jan. 08, 2024 (GLOBE NEWSWIRE) -- Ambrx Biopharma, Inc., or Ambrx (NASDAQ:AMAM), today announced that it has entered into a definitive agreement pursuant to which Johnson & Johnson will acquire all of the outstanding shares of Ambrx for $28.00 per share in cash, representing an approximately 105% premium to Ambrx's closing stock price on January 5, 2024, for a total equity value of approximately $2.0 billion. "We are excited to reach this agreement with Johnson & Johnson for advancing scientific research to treat cancers with high unmet needs," said Daniel J. O'Connor, Chief Executive Officer of Ambrx. "With our deep and unique knowledge of precision engineering of protein ther
Portfolio of Clinical and Preclinical Programs, Including Lead Product Candidate ARX517, a Prostate-Specific Membrane Antigen (PSMA)-Targeting Antibody Drug Conjugate (ADC), Strengthens Johnson & Johnson's Commitment to Oncology Innovation Novel Technology Platform Sets Stage for the Development of Next Generation ADCs and Targeted Oncologic Therapeutics Johnson & Johnson (NYSE:JNJ) announced today it has entered into a definitive agreement to acquire Ambrx Biopharma, Inc., or Ambrx (NASDAQ:AMAM), a clinical-stage biopharmaceutical company with a proprietary synthetic biology technology platform to design and develop next-generation antibody drug conjugates (ADCs), in an all-cash merger
SAN DIEGO, Dec. 14, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma, Inc., or Ambrx, (NASDAQ:AMAM), today announced that the Company will be added to the NASDAQ Biotechnology Index (NASDAQ:NBI), effective prior to the market open on Monday, December 18, 2023. "2023 has been a transformational year for Ambrx, especially for our publicly held securities. We voluntarily transferred to Nasdaq from the New York Stock Exchange, we changed our parent company domicile to Delaware from the Cayman Islands and we terminated our ADS program, resulting in our common stock being listed on Nasdaq," said Daniel J. O'Connor, Chief Executive Officer of Ambrx. "Now, at the end of the year and due to these actions
Cohort 9 Following completion of the 21-day observation period at 3.4 mg/kg (Cohort 9), no dose limiting toxicities (DLTs) or serious adverse events (SAEs) were observed Two patients in Cohort 9 experienced rapid PSA reduction at three weeks post-treatment following the first ARX517 dose Cohort 8 The cohort (2.88 mg/kg) is now fully enrolled with 20 patients Recommended phase 2 dose expected by early next year SAN DIEGO, Nov. 28, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma, Inc., or Ambrx (NASDAQ:AMAM), today announced a clinical update regarding its proprietary anti-PSMA antibody drug conjugate (ADC) ARX517 in the ongoing APEX-01 Phase 1 / 2 dose escalation and dose expansion clinical
Newly published data from the Phase 1 portion of the on-goingPhase 1 / 2 APEX-01 trial provide the following key points: Multiple efficacy endpoints demonstrate consistent and promising anti-cancer activity at therapeutic doses of 2.0 – 2.88 mg/kg (Cohorts 6-8) in heavily pretreated patients (median of 4 and maximum of 13 prior lines of therapy): 52% (12/23) of patients experienced a ≥50% PSA reduction81% (17/21) of patients experienced ≥50% circulating tumor DNA reduction50% (3/6) of patients with prior PSMA-targeted radionuclide therapy (TRT) experienced a ≥50% PSA reduction50% (2/4) experienced a >30% reduction in target lesion(s) A strong and highly differentiated safety profile obs
Newly published abstract regarding dose escalation patients provides key updates including: ≥50% PSA reduction observed across putative therapeutic dose levels ≥2.0 mg/kg – 3 of 3 in Cohort 6 (2.0 mg/kg), 2 of 3 in Cohort 7 (2.4 mg/kg) and 2 of 3 in Cohort 8 (2.88 mg/kg)No drug-related severe adverse events (SAEs) and no dose limiting toxicities (DLTs) observed in any cohortPharmacokinetic (PK) data indicated strong ADC stability preventing premature release of anticancer payload Ambrx to host a live event / webcast to discuss additional data presented at ESMO on Sunday, October 22, 2023, at 8 p.m. CEST / 2 p.m. ET SAN DIEGO, Oct. 16, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma, Inc., o
SAN DIEGO, Sept. 26, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc., Ambrx (or the "Company") (NASDAQ:AMAM), today announced that it will host an in-person key opinion leader (KOL) event during the European Society for Medical Oncology (ESMO) Congress 2023. The event will take place on Sunday, October 22, 2023 from 8:00pm – 10:00pm CEST (2:00pm – 4:00pm ET) at the Santo Mauro Hotel in Madrid, Spain. Discussions will feature preliminary safety, efficacy, and pharmacokinetic (PK) data from APEX-01 (NCT04662580), a first-in-human study evaluating ARX517 in prostate cancer patients, which will be presented for the first time at ESMO 2023. The event will showcase presentations from prostate can
Morgan Stanley Fireside Chat Replay Now Available SAN DIEGO, Sept. 18, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc., Ambrx (or the "Company") (NASDAQ:AMAM), today announced that Daniel J. O'Connor, Chief Executive Officer and President of Ambrx, will participate in a fireside chat and one-on-one meetings at the Cantor Fitzgerald Global Healthcare conference, being held in New York, NY. Presentation details are below: Cantor Fitzgerald Global Healthcare Conference: Date: Wednesday, September 27, 2023Time: 10:20 AM ET A replay of Daniel J. O'Connor's Fireside Chat at the Morgan Stanley Annual Global Healthcare Conference is now available on the Events and Presentations section of the Am
4 - Ambrx Biopharma, Inc. (0001990550) (Issuer)
4 - Ambrx Biopharma, Inc. (0001990550) (Issuer)
4 - Ambrx Biopharma, Inc. (0001990550) (Issuer)
4 - Ambrx Biopharma, Inc. (0001990550) (Issuer)
4 - Ambrx Biopharma, Inc. (0001990550) (Issuer)
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– Industry veteran to serve as independent director, strengthening the board and bringing extensive leadership, executive and governance experience to Cartography as it builds out its oncology platform and pipeline - Cartography Biosciences, Inc., an oncology company advancing a pipeline of antibody therapeutics that more precisely target tumors, today announced the appointment of Troy E. Wilson, Ph.D., J.D., as an independent director. Dr. Wilson, a 25-year veteran of the biopharma industry, is President, CEO and co-founder of Kura Oncology (NASDAQ:KURA) and has served as chairman of its Board of Directors since it was founded in 2014. "We are delighted to have attracted a true industry
SAN DIEGO, Aug. 01, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc. ("Ambrx" or the "Company") (NASDAQ:AMAM), today announced the appointment of Renu Vaish, M.Sc., as Chief Regulatory Officer. Ms. Vaish will be responsible for overseeing and designing the Company's global regulatory strategy and will report to the Company's President and Chief Executive Officer, Daniel J. O'Connor. Ms. Vaish is an experienced leader in U.S. and global regulatory affairs with extensive experience in oncology drug development ranging from pre-clinical to commercial products in many fields, including prostate and breast cancer. She has held senior regulatory leadership positions at Celgene, Merck and Kite Phar
SAN DIEGO, June 05, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc., or Ambrx (NASDAQ:AMAM), today announced the appointment of Jared Kelly as Senior Vice President, General Counsel and Corporate Secretary. After practicing for more than ten years at large corporate law firms, Mr. Kelly brings his extensive experience advising public companies on corporate governance, financing transactions and mergers and acquisitions to Ambrx. He will be responsible for developing and overseeing the legal strategy of the Company and for providing legal guidance to the Company's board of directors, executive management team and other business units. Mr. Kelly is an experienced public company lawyer who
SAN DIEGO, May 18, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc., or Ambrx (NASDAQ:AMAM), today announced that Stephen Glover has joined the Company's Board of Directors as Chairman. Mr. Glover has extensive experience building successful biopharmaceutical companies, with a focus on pharmaceutical business strategy, corporate development, product development, commercialization, and business optimization. The Company's former Chair, Katrin Rupalla, Ph.D., has resigned from Ambrx's Board of Directors to pursue another opportunity, which precludes her ability to serve on any boards of directors. Stephen Glover's experience spans Fortune 100, start-up and entrepreneurial environments and hi
SAN DIEGO, May 04, 2023 (GLOBE NEWSWIRE) -- Ambrx Biopharma Inc., or Ambrx (NASDAQ:AMAM), today announced the appointment of Andrew P. Aromando as Chief Operating Officer. Mr. Aromando brings over 30 years of experience across numerous functional areas in the biopharmaceutical industry, serving in senior executive roles focused on corporate development, clinical operations, and commercial strategy. He will be responsible for leading certain operational functions, as well as the Company's business development activities. Mr. Aromando has served in C-level roles for 15 years across multiple oncology-focused biopharmaceutical companies. He has also held senior executive positions at IQVIA,
Ambrx Biopharma, Inc., or Ambrx (NYSE:AMAM), a clinical stage biopharmaceutical company using its proprietary Engineered Precision Biologics (EPBs) platform to create antibody-drug conjugates (ADCs), has appointed Sandra Aung, Ph.D., as Executive Vice President, Head of Clinical Development. Dr. Aung will assume all clinical development leadership responsibilities of Ambrx's proprietary pipeline of several ADC product candidates. Dr. Aung brings over 20 years of experience in the pharmaceutical and biotechnology industry having led oncology-focused clinical development teams and projects in companies of different sizes. Dr. Aung has a versatile background in autoimmunity, immune-oncology,
Ambrx Biopharma Inc., or Ambrx, (NYSE:AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today announced the appointment of Daniel O'Connor as Chief Executive Officer. "On behalf of the board of directors and management team, I would like to welcome Dan to Ambrx. I very much look forward to working with him to execute on Ambrx's new strategic direction," said Katrin Rupalla, Chair of Ambrx's Board of Directors. "Dan is the ideal candidate for the role of CEO, given his extensive leadership experience in oncology drug development, strategic partnership formation, and streamlining operations w
- Appointed Kate Hermans as Interim Chief Executive Officer – Ambrx Biopharma Inc., or Ambrx, (NYSE:AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today provided a corporate update and reported financial results for the first half of 2022. "I am very grateful for all that Tian accomplished during his tenure leading Ambrx, from spearheading the development of the company's research and development programs to the transition to a public company last year," said Kate Hermans, Interim Chief Executive Officer of Ambrx. "While the Board conducts a search for a permanent CEO, we will review th
- Katrin Rupalla, Ph.D., appointed Chair of Ambrx's Board of Directors - - Ambrx to conduct strategic pipeline review with focus on commercial opportunity and cash runway extension - - Dr. Tian will continue to be available to Ambrx in an advisory capacity - Ambrx Biopharma Inc., or Ambrx, (NYSE:AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today announced the appointment of Kate Hermans as interim Chief Executive Officer, replacing Feng Tian, Ph.D., effective immediately. Dr. Tian has agreed to remain available to the company in an advisory capacity. Ambrx's Board of Directors has com
Ambrx Biopharma Inc., or Ambrx, (NYSE:AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today announced the appointments of Edward Hu and Kate Hermans to its Board of Directors. "I am delighted to welcome both Edward and Kate to Ambrx's Board," said Feng Tian, Ph. D., Chairman of the Board, President, and CEO of Ambrx. "Together, they have decades of experience in business strategy and operations in the pharmaceutical industry on a global scale. I look forward to working closely with Edward and Kate and utilizing their invaluable insight as we continue to progress ARX788 and the rest of our
As previously announced, under the terms of the transaction, Ambrx shareholders will receive $28.00 per share in cash in connection with the closing of the transaction.
Ambrx Biopharma's (NYSE:AMAM) short percent of float has fallen 67.62% since its last report. The company recently reported that it has 1.74 million shares sold short, which is 2.93% of all regular shares that are available for trading. Based on its trading volume, it would take traders 1.0 days to cover their short positions on average. Why Short Interest Matters Short interest is the number of shares that have been sold short but have not yet been covered or closed out. Short selling is when a trader sells shares of a company they do not own, with the hope that the price will fall. Traders make money from short selling if the price of the stock falls and they lose if it rises. Short intere
Friday afternoon, the FDA approved Johnson & Johnson’s (NYSE:JNJ) supplemental New Drug Application (sNDA) for Balversa (erdafitinib) for adult patients with locally advanced or metastatic urothelial carcinoma (mUC) with susceptible fibroblast growth factor receptor 3 (FGFR3) genetic alterations whose disease has progressed on or after at least one line of prior systemic therapy. Balversa is not recommended for patients who are eligible for and have not received prior PD-1 or PD-L1 inhibitor therapy. Balversa is the first oral FGFR kinase inhibitor to be approved and the first and only targeted treatment for patients with mUC and FGFR alterations. This FDA action converts the Apri
Johnson & Johnson (NYSE:JNJ), will be reporting its fourth-quarter earnings on Tuesday. Wall Street is expecting the company to report $2.28 in EPS and $20.99 billion in revenue, as it reports before market hours. With a market cap of over $389 billion, Johnson & Johnson is one of the world’s most valuable companies. It is one of only two U.S.-based companies that has a prime credit rating of AAA. The other is Microsoft (NASDAQ:MSFT). The company is exclusively focused on developing and producing pharmaceutical prescription drugs and medical device technologies. As a 130-year-old surgical dressing and baby products company, its most popular products include Band-Aids, Tylenol and Johnson
Baird analyst Joel Beatty downgrades Ambrx Biopharma (NASDAQ:AMAM) from Outperform to Neutral and announces $28 price target.
JMP Securities analyst Reni Benjamin downgrades Ambrx Biopharma (NASDAQ:AMAM) from Market Outperform to Market Perform.
Providing a diverse range of perspectives from bullish to bearish, 7 analysts have published ratings on Ambrx Biopharma (NASDAQ:AMAM) in the last three months. The following table summarizes their recent ratings, shedding light on the changing sentiments within the past 30 days and comparing them to the preceding months. Bullish Somewhat Bullish Indifferent Somewhat Bearish Bearish Total Ratings 0 5 2 0 0 Last 30D 0 0 1 0 0 1M Ago 0 0 0 0 0 2M Ago 0 3 1 0 0 3M Ago 0 2 0 0 0 Insights from analysts' 12-month price targets are revealed, presenting an average target of $22.43, a high estimate of $33.00, and a low estimate of $9.00. This current average has decreased by 8.45%
B. Riley Securities analyst Yuan Zhi downgrades Ambrx Biopharma (NASDAQ:AMAM) from Buy to Neutral and raises the price target from $26 to $28.
U.S. stocks traded higher toward the end of trading, with the Dow Jones index gaining more than 100 points on Monday. The Dow traded up 0.35% to 37,596.43 while the NASDAQ rose 1.89% to 14,799.21. The S&P 500 also rose, gaining, 1.11% to 4,749.41. Check This Out: Don't Miss These 3 Consumer Stocks With Over 3% Dividend Yields From Wall Street's Most Accurate Analysts Leading and Lagging Sectors Information technology shares jumped by 2.1% on Monday. In trading on Monday, energy shares fell by 2.1%. Top Headline Commercial Metals Company (NYSE:CMC) posted upbeat earnings for its first quarter on Monday. Commercial Metals posted adjusted earnings of $1.63 per share, beatin
Shares of RxSight, Inc. (NASDAQ:RXST) rose sharply during Monday’s session after the company issued preliminary FY23 and FY24 revenue guidance above estimates. Also, Needham maintained a Buy rating on the stock and raised its price target from $35 to $41. RxSight shares jumped 20% to $44.31 on Monday. Here are some other stocks moving in today's mid-day session. Gainers Harpoon Therapeutics, Inc. (NASDAQ:HARP) shares jumped 111.2% to $22.28 after Merck announced it will acquire the company for $23 per share in cash. Ambrx Biopharma Inc. (NASDAQ:AMAM) jumped 98.1% to $27.00 after Johnson & Johnson announced it will acquire the company in an all-cash merger for a total equity value