Bicycle Therapeutics plc, a clinical-stage biopharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics. Its lead product candidate is BT1718, a bicycle toxin conjugate (BTC), which is in Phase I/IIa clinical trials targeting tumors that express Membrane Type 1 matrix metalloprotease. The company's oncology product candidates also comprise BT5528, a BTC that is in a Phase I/IIa clinical trial targeting EphA2; BT8009, which is in preclinical studies targeting Nectin-4; and CD137, an immune cell co-stimulatory molecule that is in preclinical stage. In addition, it is developing THR-149, a plasma kallikrein inhibitor that completed Phase I clinical trials for the treatment of diabetic macular edema. Further, the company collaborates with biopharmaceutical companies and organizations to develop programs in therapeutic areas, such as anti-infective, cardiovascular, ophthalmology, and respiratory indications. It has a clinical trial and license agreement with the Cancer Research Technology Limited and CRUK; research collaboration agreements with AstraZeneca, Sanofi, Oxurion, and the Dementia Discovery Fund; and discovery collaboration and license agreement with Genentech for the discovery and development of Bicycle peptides for multiple immuno-oncology targets. Bicycle Therapeutics plc was incorporated in 2009 and is headquartered in Cambridge, the United Kingdom.
IPO Year: 2019
Exchange: NASDAQ
Website: bicycletherapeutics.com
| Date | Price Target | Rating | Analyst |
|---|---|---|---|
| 11/8/2024 | $25.00 | Equal-Weight | Stephens |
| 9/6/2024 | $35.00 | Outperform | RBC Capital Mkts |
| 8/7/2024 | $33.00 → $28.00 | Buy → Neutral | B. Riley Securities |
| 9/11/2023 | Neutral → Buy | B. Riley Securities | |
| 8/31/2022 | Outperform | Cowen | |
| 7/28/2022 | $30.00 | Overweight | Barclays |
| 7/6/2022 | $60.00 | Buy | Canaccord Genuity |
| 4/13/2022 | $62.00 → $33.00 | Buy → Neutral | B. Riley Securities |
| 4/7/2022 | $100.00 → $80.00 | Overweight | Cantor Fitzgerald |
| 3/3/2022 | $85.00 → $70.00 | Market Outperform | JMP Securities |
4 - BICYCLE THERAPEUTICS PLC (0001761612) (Issuer)