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    Pliant Therapeutics Inc.

    Subscribe to $PLRX
    $PLRX
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Pliant Therapeutics, Inc., a clinical stage biopharmaceutical company, discovers, develops, and commercializes novel therapies for the treatment of fibrosis and related diseases in the United States. Its lead product candidate is PLN-74809, an oral small-molecule dual selective inhibitor of avß6 and avß1 integrins, which is in Phase II single ascending dose/multiple ascending dose trails and completed Phase Ib proof-of-mechanism trials for the treatment of idiopathic pulmonary fibrosis and primary sclerosing cholangitis. The company also develops PLN-1474, a small-molecule selective inhibitor of avß1, which completed Phase 1 clinical trial for the treatment of liver fibrosis associated with nonalcoholic steatohepatitis. In addition, it is developing two additional preclinical integrin-based programs, which include an oncology program, as well as a program for an allosteric agonistic monoclonal antibody against an undisclosed integrin receptor for treatment of muscular dystrophies, including duchenne muscular dystrophy. Pliant Therapeutics, Inc. was founded in 2015 and is based in South San Francisco, California.

    IPO Year: 2020

    Exchange: NASDAQ

    Website: pliantrx.com

    Recent Analyst Ratings for Pliant Therapeutics Inc.

    DatePrice TargetRatingAnalyst
    3/4/2025Buy → Hold
    Needham
    3/4/2025Neutral
    Cantor Fitzgerald
    3/3/2025Buy → Hold
    Stifel
    3/3/2025Outperform → Market Perform
    Leerink Partners
    2/10/2025Overweight → Neutral
    Analyst
    2/10/2025$43.00 → $4.00Buy → Hold
    Canaccord Genuity
    2/10/2025Outperform → Perform
    Oppenheimer
    2/10/2025$40.00 → $4.00Buy → Neutral
    Citigroup
    2/10/2025$41.00 → $4.00Overweight → Equal Weight
    Wells Fargo
    2/10/2025$5.00 → $4.00Outperform → Sector Perform
    RBC Capital Mkts
    See more ratings

    Pliant Therapeutics Inc. Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

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    • Chief Human Resource Officer Cheung Lily was granted 25,875 shares, increasing direct ownership by 105% to 50,425 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/27/25 6:14:06 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • General Counsel & Corp. Sec'y Ouimette Mike was granted 35,000 shares, increasing direct ownership by 50% to 105,544 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/27/25 6:10:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chief Business Officer Hull Hans was granted 40,150 shares, increasing direct ownership by 19% to 251,708 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/27/25 6:07:17 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chief Medical Officer Lefebvre Eric was granted 45,650 shares, increasing direct ownership by 23% to 240,224 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/27/25 6:04:15 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chief Financial Officer Cummings Keith Lamont was granted 56,650 shares, increasing direct ownership by 22% to 319,258 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/27/25 6:01:38 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • President and CEO Coulie Bernard was granted 162,500 shares, increasing direct ownership by 38% to 593,017 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/27/25 5:58:27 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • President and CEO Coulie Bernard sold $587,150 worth of shares (52,419 units at $11.20), decreasing direct ownership by 11% to 430,517 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/22/25 6:07:10 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chief Financial Officer Cummings Keith Lamont sold $225,680 worth of shares (20,148 units at $11.20), decreasing direct ownership by 7% to 262,608 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/22/25 6:05:28 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chief Business Officer Hull Hans sold $178,501 worth of shares (15,936 units at $11.20), decreasing direct ownership by 7% to 211,558 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/22/25 6:02:33 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chief Medical Officer Lefebvre Eric sold $206,974 worth of shares (18,478 units at $11.20), decreasing direct ownership by 9% to 194,574 units (SEC Form 4)

      4 - PLIANT THERAPEUTICS, INC. (0001746473) (Issuer)

      1/22/25 6:00:36 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Pliant Therapeutics Inc. Press Releases

    Fastest customizable press release news feed in the world

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    • Pliant Therapeutics Provides Corporate Update and Reports First Quarter 2025 Financial Results

      Activities supporting the close out of BEACON-IPF continue; topline data expected in the second quarter of 2025 Recently announced strategic realignment of workforce and operations will extend cash runway to support execution of late-stage clinical trials SOUTH SAN FRANCISCO, Calif., May 08, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a clinical-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today provided a corporate update and reported first quarter 2025 financial results. "During the first quarter and over recent weeks, our teams have been working diligently to close out the g

      5/8/25 4:05:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Announces Strategic Realignment of Workforce and Operations

      -  Implementation of cost reduction initiatives to position Pliant for execution of late-stage clinical trials -  Pliant will reduce its current workforce by approximately 45% -  Closing activities for BEACON-IPF trial ongoing; topline data expected in the second quarter of 2025 SOUTH SAN FRANCISCO, Calif., May 01, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced a strategic restructuring of its workforce and other cost saving actions to extend the cash runway to support execution of late-stage clinical trials. The restructuring aims to minimize costs and preserve cash reserves as the Company awaits topline data from the BEACON-IPF Phase 2b/3 trial of be

      5/1/25 4:05:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Announces Upcoming Presentations at the 2025 American Thoracic Society International Conference

      SOUTH SAN FRANCISCO, Calif., April 07, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced that the Company will present three scientific posters at the upcoming 2025 American Thoracic Society (ATS) International Conference, taking place in San Francisco, California from May 16-21, 2025. The following abstracts are posted on ATS 2025's online itinerary planner for registered users. Pliant was selected for a featured oral presentation as part of the ATS 2025 Mini Symposiums program. Title: Characterizing the Antifibrotic Activity of Bexotegrast on Distinct Fibroblast Populations in PCLS From Multiple ILD SubtypesPresenter: Johanna Schaub, Ph.D., Director of T

      4/7/25 4:05:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Announces Interim Phase 1 Data for PLN-101095 in Patients with Immune Checkpoint Inhibitor-Refractory Advanced Solid Tumors

      Antitumor activity observed with confirmed partial responses in 50% of patientsat highest dose tested to date, across multiple tumor types PLN-101095 was generally well tolerated across all doses SOUTH SAN FRANCISCO, Calif., March 17, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced data from the first three of five potential cohorts of its ongoing Phase 1 dose escalation clinical trial evaluating PLN-101095, an integrin αvβ8 and αvβ1 inhibitor, in combination with pembrolizumab, in patients with immune checkpoint inhibitor (ICI) -refractory advanced or metastatic solid tumors. Interim results demonstrated PLN-101095 anti-tumor activity in combination with

      3/17/25 8:00:00 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Adopts Limited Duration Stockholder Rights Agreement

      SOUTH SAN FRANCISCO, Calif., March 13, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced that its Board of Directors has unanimously adopted a limited duration stockholder rights agreement (the "Rights Agreement") to protect stockholder interests. The Board resolved to adopt the Rights Agreement in response to recent accumulations of the Company's common stock. The Rights Agreement is intended to reduce the likelihood that any entity, person or group is able to gain control of Pliant through open market accumulation without paying all stockholders an appropriate control premium or providing the Board sufficient opportunity to make informed judgments and take

      3/13/25 7:20:00 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2024 Financial Results

      Discontinuation of BEACON-IPF following DSMB and outside expert panel recommendation SOUTH SAN FRANCISCO, Calif., March 03, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a clinical-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today provided a corporate update and reported fourth quarter 2024 financial results. Fourth Quarter and Recent Highlights Bexotegrast Highlights BEACON-IPF discontinued following recommendation from expanded data safety monitoring board (DSMB). Following a prespecified data review and recommendation by the trial's independent DSMB, as well as a secondary r

      3/3/25 4:05:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Provides Update on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis

      SOUTH SAN FRANCISCO, Calif., March 03, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced that following a prespecified data review and recommendation by the trial's independent Data Safety Monitoring Board (DSMB), as well as a secondary review and recommendation by an outside expert panel, Pliant has discontinued the BEACON-IPF Phase 2b trial evaluating bexotegrast in patients with idiopathic pulmonary fibrosis (IPF). While an imbalance in unadjudicated IPF-related adverse events between the treatment and placebo groups led to the discontinuation of the trial, early evidence of efficacy on the forced vital capacity (FVC) endpoint was also observed. BEACON-IP

      3/3/25 9:27:03 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Announces Next Steps Following DSMB Recommendation on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis

      SOUTH SAN FRANCISCO, Calif., Feb. 13, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced that, per the charter of the trial's independent Data Safety Monitoring Board (DSMB), the Company has initiated the assembly of an outside expert panel to review unblinded data from the ongoing BEACON-IPF Phase 2b trial of bexotegrast in patients with idiopathic pulmonary fibrosis (IPF). The panel, consisting of world-renowned experts in pulmonary diseases and biostatistics, will provide an independent recommendation to Pliant regarding the BEACON-IPF trial. Subsequently, the panel will serve as part of an expanded DSMB with the goal to reach a consensus recommendation reg

      2/13/25 8:00:00 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Provides Update on BEACON-IPF, a Phase 2b/3 Trial in Patients with Idiopathic Pulmonary Fibrosis

      Following DSMB recommendation, the Company has voluntarily paused enrollment and dosing in the BEACON-IPF Phase 2b trial and will monitor current patients while data is reviewed SOUTH SAN FRANCISCO, Calif., Feb. 07, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced that following a prespecified data review and recommendations by the trial's independent Data Safety Monitoring Board (DSMB), the Company has voluntarily paused enrollment and dosing in the ongoing BEACON-IPF Phase 2b trial of bexotegrast in patients with idiopathic pulmonary fibrosis (IPF). Patients currently enrolled in BEACON-IPF will remain in the trial. Enrollment and dosing have been paused

      2/7/25 4:58:09 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

      SOUTH SAN FRANCISCO, Calif., Jan. 22, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), today announced that on January 21, 2025, it granted stock options to purchase an aggregate of 275,000 shares of common stock upon vesting to Delphine Imbert, Ph.D., the Company's newly appointed Chief Technical Officer, as a material inducement to her employment. The stock options that were granted are subject to an exercise price of $11.07 per share, which is equal to the closing price of the Company's common stock on January 21, 2025, and will vest over 4 years, with 25% of the shares underlying the employee's option vesting on the one-year anniversary of the grant date and the remai

      1/22/25 4:00:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Pliant Therapeutics Inc. SEC Filings

    See more
    • SEC Form 10-Q filed by Pliant Therapeutics Inc.

      10-Q - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      5/8/25 4:16:45 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Inc. filed SEC Form 8-K: Results of Operations and Financial Condition, Financial Statements and Exhibits

      8-K - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      5/8/25 4:11:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 8-K filed by Pliant Therapeutics Inc.

      8-K - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      5/1/25 4:13:37 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form DEFA14A filed by Pliant Therapeutics Inc.

      DEFA14A - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      4/23/25 4:19:20 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form DEF 14A filed by Pliant Therapeutics Inc.

      DEF 14A - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      4/23/25 4:17:27 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form PRE 14A filed by Pliant Therapeutics Inc.

      PRE 14A - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      4/10/25 4:30:13 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Inc. filed SEC Form 8-K: Material Modification to Rights of Security Holders, Entry into a Material Definitive Agreement, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year

      8-K - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      3/13/25 8:49:28 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 8-A12B filed by Pliant Therapeutics Inc.

      8-A12B - PLIANT THERAPEUTICS, INC. (0001746473) (Filer)

      3/13/25 8:05:33 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SCHEDULE 13D filed by Pliant Therapeutics Inc.

      SCHEDULE 13D - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      3/10/25 5:24:28 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SCHEDULE 13G/A filed by Pliant Therapeutics Inc.

      SCHEDULE 13G/A - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      3/7/25 10:01:30 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Pliant Therapeutics Inc. Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

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    • Pliant Therapeutics downgraded by Needham

      Needham downgraded Pliant Therapeutics from Buy to Hold

      3/4/25 8:19:24 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Cantor Fitzgerald resumed coverage on Pliant Therapeutics

      Cantor Fitzgerald resumed coverage of Pliant Therapeutics with a rating of Neutral

      3/4/25 7:42:23 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by Stifel

      Stifel downgraded Pliant Therapeutics from Buy to Hold

      3/3/25 3:36:54 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by Leerink Partners

      Leerink Partners downgraded Pliant Therapeutics from Outperform to Market Perform

      3/3/25 12:39:39 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by Analyst

      Analyst downgraded Pliant Therapeutics from Overweight to Neutral

      2/10/25 9:08:23 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by Canaccord Genuity with a new price target

      Canaccord Genuity downgraded Pliant Therapeutics from Buy to Hold and set a new price target of $4.00 from $43.00 previously

      2/10/25 8:21:56 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by Oppenheimer

      Oppenheimer downgraded Pliant Therapeutics from Outperform to Perform

      2/10/25 8:21:30 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by Citigroup with a new price target

      Citigroup downgraded Pliant Therapeutics from Buy to Neutral and set a new price target of $4.00 from $40.00 previously

      2/10/25 7:05:45 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by Wells Fargo with a new price target

      Wells Fargo downgraded Pliant Therapeutics from Overweight to Equal Weight and set a new price target of $4.00 from $41.00 previously

      2/10/25 7:04:22 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics downgraded by RBC Capital Mkts with a new price target

      RBC Capital Mkts downgraded Pliant Therapeutics from Outperform to Sector Perform and set a new price target of $4.00 from $5.00 previously

      2/10/25 7:04:01 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Pliant Therapeutics Inc. Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    • SEC Form SC 13G filed by Pliant Therapeutics Inc.

      SC 13G - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      11/14/24 9:00:58 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Pliant Therapeutics Inc.

      SC 13G/A - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      11/14/24 5:05:23 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Pliant Therapeutics Inc.

      SC 13G/A - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      11/14/24 4:47:50 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Pliant Therapeutics Inc.

      SC 13G/A - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      11/14/24 1:22:39 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Pliant Therapeutics Inc.

      SC 13G/A - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      11/12/24 11:53:39 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by Pliant Therapeutics Inc.

      SC 13G - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      10/4/24 5:34:36 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by Pliant Therapeutics Inc.

      SC 13G - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      2/14/24 8:55:33 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by Pliant Therapeutics Inc.

      SC 13G - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      2/14/24 5:10:45 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed by Pliant Therapeutics Inc. (Amendment)

      SC 13G/A - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      2/14/24 4:26:22 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed by Pliant Therapeutics Inc. (Amendment)

      SC 13G/A - PLIANT THERAPEUTICS, INC. (0001746473) (Subject)

      2/14/24 4:15:51 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Pliant Therapeutics Inc. Leadership Updates

    Live Leadership Updates

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    • Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter 2024 Financial Results

      Discontinuation of BEACON-IPF following DSMB and outside expert panel recommendation SOUTH SAN FRANCISCO, Calif., March 03, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a clinical-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today provided a corporate update and reported fourth quarter 2024 financial results. Fourth Quarter and Recent Highlights Bexotegrast Highlights BEACON-IPF discontinued following recommendation from expanded data safety monitoring board (DSMB). Following a prespecified data review and recommendation by the trial's independent DSMB, as well as a secondary r

      3/3/25 4:05:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Appoints Delphine Imbert, Ph.D. as Chief Technical Officer

      Dr. Imbert brings 25 years of strategic clinical to commercial-stage manufacturing and drug development experience SOUTH SAN FRANCISCO, Calif., Jan. 22, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a late-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today announced the appointment of Delphine Imbert, Ph.D. as Chief Technical Officer. Dr. Imbert brings 25 years of product development, process optimization and manufacturing experience across multiple drug modalities, including small molecules. In this role, Dr. Imbert will lead chemistry, manufacturing and control (CMC)-related acti

      1/22/25 8:00:00 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2024 Financial Results

      BEACON-IPF Phase 2b trial on track for full enrollment in the first quarter of 2025 with data anticipated in mid-2026 SOUTH SAN FRANCISCO, Calif., Nov. 07, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a late-stage clinical biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today provided a corporate update and reported third quarter 2024 financial results. "A highlight to this quarter's progress was the continued strong execution of our BEACON-IPF Phase 2b/3 trial which is enrolling well and on track to complete enrollment in the first quarter of 2025," said Bernard Coulie, M.D., Ph.D.

      11/7/24 4:05:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Pliant Therapeutics Appoints Gary Palmer, M.D. as Senior Vice President of Medical Affairs

      Former Bristol Myers Squibb Global Medical Affairs Lead brings over 25 years of experience to Pliant SOUTH SAN FRANCISCO, Calif., Oct. 01, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a late-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today announced the appointment of Gary Palmer, M.D., MBA as Senior Vice President of Medical Affairs. Dr. Palmer will lead the Company's global medical affairs activities including scientific communications and patient advocacy. "Gary brings deep global medical affairs leadership and strategic expertise in supporting successful and orphan disease

      10/1/24 4:35:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Aligos Therapeutics Strengthens Senior Leadership Team with the Appointment of Hardean Achneck, MD as Chief Medical Officer

      SOUTH SAN FRANCISCO, Calif., Sept. 24, 2024 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on improving patient outcomes through best-in-class therapies for liver and viral diseases, today announced the appointment of Dr. Hardean Achneck as Chief Medical Officer, effective immediately. Dr. Achneck will lead the Company's global clinical development efforts and serve as a member of Aligos' Senior Leadership Team. Dr. Hardean Achneck is a seasoned clinical development executive with extensive experience across multiple therapeutic areas, including hepatology and infectious diseases. "I am excited to welcome Hardean to Aligos a

      9/24/24 8:00:00 AM ET
      $ALGS
      $HAE
      $NVO
      $PLRX
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
      Medical/Dental Instruments
      Biotechnology: Pharmaceutical Preparations
    • Korro Announces Addition of Industry Veteran Katharine Knobil to and Resignation of David Lucchino From Its Board of Directors

      CAMBRIDGE, Mass., Aug. 28, 2024 (GLOBE NEWSWIRE) -- Korro Bio, Inc. (Korro) (NASDAQ:KRRO), a biopharmaceutical company focused on developing a new class of genetic medicines based on editing RNA for both rare and highly prevalent diseases, today announced that the Board of Directors has appointed Katharine Knobil, M.D. as an Independent Director, effective immediately. Korro also announced that David Lucchino has stepped down from the Board. Dr. Knobil brings a wealth of experience in clinical development and regulatory affairs to Korro. With over 25 years in the pharmaceutical and biotech industries, she has played a pivotal role in advancing numerous therapeutics from early-stage develo

      8/28/24 8:00:00 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2024 Financial Results

      Positive data from a 12-week Phase 2a PET imaging trial demonstrated reduced total lung collagen, improved FVC and reduced cough severity in IPF patients treated with bexotegrast Positive long-term data from INTEGRIS-PSC 320 mg dose group demonstrated bexotegrast was well tolerated with continued antifibrotic and anti-cholestatic activity observed at 24 weeks across multiple measures BEACON-IPF Phase 2b trial on track for full enrollment in the first quarter of 2025 with data anticipated in mid-2026 SOUTH SAN FRANCISCO, Calif., Aug. 07, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a late-stage clinical biotechnology company and leader in the discovery and

      8/7/24 4:05:00 PM ET
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    • Pliant Therapeutics Announces Appointment of Steve Krognes to Board of Directors

      SOUTH SAN FRANCISCO, June 13, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a late-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today announced the appointment of Steve Krognes to its Board of Directors. "Steve is a tremendous addition to our board, bringing extensive strategic leadership experience and a depth of financial expertise that will benefit Pliant's continued evolution as a late-stage clinical company," said Bernard Coulie, M.D., Ph.D., President and Chief Executive Officer of Pliant. "Steve's broad financial experience will be highly complimentary to the strong science

      6/13/24 4:05:00 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Nimbus Therapeutics Appoints Katharine Knobil, M.D., to Board of Directors

      Nimbus Therapeutics, LLC ("Nimbus Therapeutics" or "Nimbus"), a biotechnology company that designs and develops breakthrough medicines for patients through its powerful computational drug discovery engine, today announced that Katharine Knobil, M.D., has been appointed to the Company's Board of Directors. Dr. Knobil is a seasoned executive with more than 20 years of experience in pharmaceutical research and product development including global clinical research, medical affairs, and patient safety. "We are honored to welcome Dr. Knobil to our Board of Directors as we embark on the next exciting chapter at Nimbus with plans to accelerate and expand our development programs in multiple ther

      3/12/24 8:00:00 AM ET
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    • Pliant Therapeutics Provides Corporate Update and Reports Third Quarter 2023 Financial Results

      Positive interim 12-week safety and efficacy data reported from Phase 2a INTEGRIS-PSC trial in patients with PSC Positive DSMB safety review recommends INTEGRIS-PSC trial continue without modification Key Clinical Development and Regulatory appointments expand leadership team SOUTH SAN FRANCISCO, Calif., Nov. 09, 2023 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a clinical-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today provided a corporate update and reported third quarter 2023 financial results. "The third quarter was highlighted by positive interim data from th

      11/9/23 4:05:00 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    Pliant Therapeutics Inc. Financials

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    • Pliant Therapeutics Adopts Limited Duration Stockholder Rights Agreement

      SOUTH SAN FRANCISCO, Calif., March 13, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced that its Board of Directors has unanimously adopted a limited duration stockholder rights agreement (the "Rights Agreement") to protect stockholder interests. The Board resolved to adopt the Rights Agreement in response to recent accumulations of the Company's common stock. The Rights Agreement is intended to reduce the likelihood that any entity, person or group is able to gain control of Pliant through open market accumulation without paying all stockholders an appropriate control premium or providing the Board sufficient opportunity to make informed judgments and take

      3/13/25 7:20:00 AM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
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    • Pliant Therapeutics Announces Positive Safety and Exploratory Efficacy Data from the INTEGRIS-PSC Phase 2a Trial of Bexotegrast 320 mg in Patients with Primary Sclerosing Cholangitis and Suspected Liver Fibrosis

      Bexotegrast (PLN-74809) at 320 mg was well tolerated over 12 weeks of treatment with no drug-related severe or serious adverse events; No safety concerns identified across all dose cohorts Bexotegrast at 320 mg reduced liver fibrosis markers ELF and PRO-C3 and showed improvements in hepatocyte function and bile flow by contrast MRI imaging relative to placebo at Week 12 The 320 mg data continue to demonstrate antifibrotic effects of bexotegrast, consistent with previous findings Company to host webcast and conference call tomorrow, Monday, February 5 at 8:00 a.m. ET SOUTH SAN FRANCISCO, Calif., Feb. 04, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced

      2/4/24 3:29:07 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Pliant Therapeutics Announces Positive Safety and Exploratory Efficacy Data from Phase 2a INTEGRIS-PSC Clinical Trial of Bexotegrast in Patients with Primary Sclerosing Cholangitis and Suspected Liver Fibrosis

      Bexotegrast (PLN-74809) was well tolerated over 12 weeks of treatment with few discontinuations and no drug-related severe or serious adverse events Bexotegrast reduced both the Enhanced Liver Fibrosis (ELF) score and collagen synthesis biomarker PRO-C3 levels relative to placebo at all doses with statistical significance at the 160 mg dose Bexotegrast-treated patients showed improved liver biochemistry and imaging parameters relative to placebo at Week 12 Company to host webcast and conference call today, Tuesday, September 26 at 8:00 a.m. ET SOUTH SAN FRANCISCO, Calif., Sept. 26, 2023 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), today announced positive data f

      9/26/23 7:30:00 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Pliant Therapeutics to Host Investor Call and Webcast to Discuss Interim Results from INTEGRIS-PSC, a Phase 2a Trial in Patients with Primary Sclerosing Cholangitis

      SOUTH SAN FRANCISCO, Calif., Sept. 25, 2023 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced it will host a conference call and webcast on Tuesday, September 26, 2023 at 8:00 a.m. ET | 5:00 a.m. PT to discuss the interim results from the INTEGRIS-PSC Phase 2a trial. Members of Pliant's management will be joined by Gideon Hirschfield, FRCP, Ph.D., Lily and Terry Horner Chair in Autoimmune Liver Disease at the University of Toronto and a principal investigator in the INTEGRIS-PSC trial. The conference call will be simultaneously webcast online and will be accessible from the Events & Presentation section of Pliant's website. The live audio of the conference call c

      9/25/23 4:05:00 PM ET
      $PLRX
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    • Pliant Therapeutics Announces Positive Long-Term Data from the INTEGRIS-IPF Phase 2a Trial Demonstrating Bexotegrast was Well Tolerated at 320 mg with Durable Improvement Shown in FVC and Across Multiple Measures

      Bexotegrast was well tolerated up to 40 weeks of treatment with no drug-related serious adverse events Combination of bexotegrast with standard of care reduced FVC decline by 80% relative to standard of care alone at Week 24 89% of bexotegrast-treated patients with an increase in FVC from baseline at Week 12 maintained an increase at Week 24 Stabilization of fibrosis as measured by QLF imaging was observed in the bexotegrast group while the placebo group showed progression of fibrosis at Weeks 12 and 24 A reduction in patient-reported cough severity was reported in the bexotegrast group in contrast to worsening in the placebo group BEACON-IPF Phase 2b trial to be initiated in mid-2023

      4/30/23 2:10:28 PM ET
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      Health Care
    • Pliant Therapeutics Announces Positive Data from the INTEGRIS-IPF Phase 2a Trial Demonstrating Bexotegrast 320 mg was Well Tolerated and Achieved Statistically Significant FVC Increase in Patients with Idiopathic Pulmonary Fibrosis

      Bexotegrast demonstrated statistically significant increase in FVC at 4, 8 and 12 weeks of treatment, outperforming lower dose groups No bexotegrast-treated patients experienced disease progression as defined by FVCpp decline of greater than or equal to 10% Bexotegrast was well tolerated over 12 weeks of treatment with no drug-related severe or serious adverse events Company to host webcast and conference call tomorrow, Monday, January 23rd at 8:00 a.m. ET SOUTH SAN FRANCISCO, Calif., Jan. 22, 2023 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX) today announced 12-week interim data from the 320 mg dose group of INTEGRIS-IPF, a multinational, randomized, double-blind, pla

      1/22/23 2:00:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
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    • Pliant Therapeutics Announces Positive Safety and Efficacy Data from Phase 2a INTEGRIS-IPF Clinical Trial of PLN-74809 in Patients with Idiopathic Pulmonary Fibrosis

      PLN-74809 demonstrated a dose-dependent treatment effect on FVC and QLF versus placebo over 12 weeks of treatment PLN-74809 treatment effect was observed on top of standard of care therapy and as monotherapy PLN-74809 was well tolerated over 12 weeks of treatment with no drug related SAEs and no treatment discontinuations due to adverse events Company to host webcast and conference call tomorrow, Monday July 11 at 8:00 a.m. ET SOUTH SAN FRANCISCO, Calif., July 10, 2022 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), today announced positive data from INTEGRIS-IPF, a multinational, randomized, double-blind, placebo-controlled Phase 2a clinical trial of PLN-74809 in patient

      7/10/22 6:10:21 PM ET
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    • Pliant Therapeutics Reports Positive Interim Results from Phase 2a PET Imaging Clinical Trial in Patients with Idiopathic Pulmonary Fibrosis

      - Single dose administration of PLN-74809 achieved αvβ6 target engagement up to 98% in the lungs of IPF patients - All doses achieved target engagement above the threshold for predicted anti-fibrotic activity, with an observed dose-response relationship- PLN-74809 reached highly fibrotic regions of the lung and was bound to αvβ6 in IPF patients - Data provide insight into potential anti-fibrotic activity of PLN-74809 at the doses being evaluated in the ongoing Phase 2a INTEGRIS-IPF trial - Company to host conference call and webcast today at 8:00 a.m. ET SOUTH SAN FRANCISCO, Calif., Sept. 07, 2021 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a clinical stage biotechnolog

      9/7/21 7:00:00 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Pliant Therapeutics Announces Webcast to Present Interim Clinical Data from Ongoing Phase 2a PET Trial of PLN-74809 in Patients with Idiopathic Pulmonary Fibrosis

      SOUTH SAN FRANCISCO, Calif., Sept. 03, 2021 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today announced that the Company plans to issue a pre-market press release and conduct a conference call and webcast on Tuesday, September 7, 2021, to discuss interim clinical data from an ongoing Phase 2a positron emission tomography (PET) imaging trial of PLN-74809 in patients with idiopathic pulmonary fibrosis (IPF). The Company will host a conference call and webcast at 8:00 a.m. ET on Tuesday, September 7th to discuss this update. The link to the webcast o

      9/3/21 4:10:00 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Pliant Therapeutics Provides Corporate Update and Reports Fourth Quarter and Full Year 2020 Financial Results

      - PLN-74809 Phase 2a PET Imaging Trial Resumed, with Preliminary Data Expected First Half of 2021 - PLN-74809 Phase 2a 12-week trials in IPF and PSC Gained Momentum in the Fourth Quarter, Currently on Track to Complete Enrollment by the End of 2021 and First Half of 2022, Respectively SOUTH SAN FRANCISCO, Calif., March 16, 2021 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX) (the Company), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today provided a corporate update and reported fourth quarter and full year 2020 financial results. “We entered 2021 in a strong position resulting from our team’

      3/16/21 4:05:00 PM ET
      $PLRX
      Biotechnology: Pharmaceutical Preparations
      Health Care