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    Purple Biotech Ltd.

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    $PPBT
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Purple Biotech Ltd., a clinical-stage pharmaceutical company, focuses on the development and commercialization of various pharmaceutical drugs in the United States. It operates through two segments, Oncology, and Pain and Hypertension. The company's marketed products include Consensi, a fixed-dose combination of celecoxib and amlodipine besylate for the simultaneous treatment of osteoarthritis pain and hypertension. Its oncology pipeline includes NT219, a small molecule that targets insulin receptor substrate 1 and 2, and signal transducer and activator of transcription, which is in Phase 1/2 clinical trials for the treatment of recurrent and/or metastatic solid tumors and squamous cell carcinoma of the head and neck cancer; and CM-24, a monoclonal antibody blocking CEACAM1 that is being developed as a combination therapy with anti-PD-1 checkpoint inhibitors, which is in Phase 1/2 clinical trials for the treatment of non-small cell lung cancer and pancreatic cancer. The company was formerly known as Kitov Pharma Ltd and changed its name to Purple Biotech Ltd. in December 2020. Purple Biotech Ltd. was founded in 2010 and is headquartered in Rehovot, Israel.

    IPO Year: 2015

    Exchange: NASDAQ

    Website: purple-biotech.com

    Recent Analyst Ratings for Purple Biotech Ltd.

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    Purple Biotech Ltd. Press Releases

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    • Purple Biotech Reports Final Data from Phase 2 Study of CM24 in Pancreatic Cancer Patients at AACR 2025 Annual Meeting: Improved Outcomes and Significant Efficacy in Biomarker-Enriched Subgroups

      Statistically significant efficacy in biomarker subgroup analyses was observed: 78% reduction in risk of death and 81% reduction in risk of progression or death in defined pretreatment ranges of serum or tumor CEACAM1 subgroup 61% reduction is risk of death and 72% reduction in risk of progression or death in defined pretreatment ranges of serum CEACAM1 or myeloperoxidase (MPO) subgroup90% reduction is risk of death and 81% reduction in risk of progression or death in high tumor CEACAM1 and low PD-L1 combined positive score (CPS) subgroup The biomarkers identified in the Phase 2 study are planned to be used for patient selection in the next Phase 2b study REHOVOT, Israel, April

      4/30/25 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Reports Positive NT219 Data at AACR for Colorectal and Head and Neck Cancers

      Activated b-catenin or loss of its negative regulator adenomatous polyposis coli (APC) is a potential biomarker for NT219 in the treatment of colorectal cancerNT219's mechanism of action informs how it can restore efficacy of immunotherapies and expand the patient population that can benefit from immunotherapies REHOVOT, Israel, April 28, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance, announced today that two posters reporting new NT219 data being presented at the American Association for Cancer Research (AACR

      4/28/25 8:28:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Announces Publication in the Neuro Oncology Journal Demonstrating the Potential of NT219 to Suppress Brain Metastasis of Colorectal Cancer

      Findings show combination therapy of NT219 and 5-flourouracil (5-FU) inhibits colorectal cancer brain metastasis through the IRS2 pathway IRS2, a novel target of NT219, is identified as a driver of brain metastasis in colorectal cancer, by comprehensive research conducted by Prof. Wolf and Dr. Rubinek team at Tel Aviv University and Sourasky Medical Center REHOVOT, Israel, April 16, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that overcome tumor immune evasion and drug resistance, announced today the publication of an independent study titled "IRS2 as a driver of brain

      4/16/25 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech to Participate in Panel Discussion at Canaccord Genuity Horizons in Oncology Virtual Conference on April 7, 2025

      REHOVOT, Israel, April 01, 2025 (GLOBE NEWSWIRE) --  Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance, announced today that the Company's CEO, Gil Efron will participate in a panel discussion at the Canaccord  Genuity Horizons in Oncology Virtual Conference on Monday, April 7, 2025. The panel titled "New Radiotherapy and Targeted Therapy Approaches" will take place from 2:00 PM to 2:50 PM ET.  Management will also participate in 1x1 meetings.   About Purple Biotech Purple Biotech Ltd. (NASDAQ/TASE: PPBT) is a clinical-stage company develo

      4/1/25 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Announces Three Posters Accepted for Presentation at the 2025 American Association for Cancer Research Meeting

      REHOVOT, Israel, March 28, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance, today announced upcoming poster presentations including one for CM24 in the treatment of pancreatic cancer, and two for NT219 in the treatment of colorectal and head and neck cancers, at the 2025 American Association for Cancer Research Meeting (2025 AACR), scheduled to take place from April 25th to April 30th in Chicago. Presentation details are below: Abstract Title: Final analysis of the randomized Phase 2 cohort of CM24 with nivolumab

      3/28/25 7:45:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Reports Fourth Quarter and Full-Year 2024 Financial Results

      Completed successful clinical trials for CM24 and NT219 oncology assets, demonstrating clinical benefits and identifying potential biomarkers CM24 is well positioned for personalized treatment, with planned biomarker-driven Phase 2b study based on serum biomarkers CEACAM1 and myeloperoxidase NT219 headed into Phase 2 head and neck cancer study in combination with pembrolizumab (anti-PD1) and in combination with cetuximab (anti-EGFR) CAPTN-3 tri-specific platform yields promising preclinical data, supporting its differentiated benefit and well positioning it in the multi-specific/engagers antibody space REHOVOT, Israel, March 10, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Bio

      3/10/25 8:57:02 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Granted New U.S. Patent for NT219 in Combination with EGFR Antibody Therapy, Enhancing Global IP Protection in Major Markets

      NT219 in combination with EGFR antibody cetuximab (Erbitux) is currently entering a Phase 2 study for head and neck cancer REHOVOT, Israel, March 05, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance, announced today that the U.S. Patent and Trademark Office has issued a patent for NT219 used in combination with epidermal growth factor receptor (EGFR) antibodies for treating cancer patients who have acquired resistance to EGFR therapies. The patent, titled "Combinations of IRS/STAT3 dual modulators and anti-cancer

      3/5/25 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Advances NT219 into Phase 2 Head and Neck Cancer Trial

      NT219, a novel agent designed to overcome tumor resistance to drug therapy, will be evaluated in combination with the standard-of-care head and neck cancer drugs pembrolizumab (Keytruda) or cetuximab (Erbitux) The study is conducted in collaboration with the University of Colorado Anschutz Medical Campus and is led by Dr. Antonio Jimeno, Professor and Director of the Head and Neck Cancer Program REHOVOT, Israel, Feb. 18, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that overcome tumor immune evasion and drug resistance, announced today it is advancing into a Phase 2 st

      2/18/25 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Announces Research Collaboration with the Icahn School of Medicine at Mount Sinai for CAPTN-3 Tri-Specific Antibody Platform

      Collaboration to explore the immunoregulation of NK and T cells within the tumor microenvironment (TME) by CAPTN-3, with the goal of enhancing tumor-specific immunity against multiple cancer types.CAPTN-3 antibodies are designed to promote innate-like antitumor functions by NK and CD8 T cells, through conditional activation of the anti-CD3 arm at the TME, blockade of NKG2A, and targeting tumor-specific antigens, potentially leading to improved responses in resistant cancer patients and overcoming the limitations of current therapies. REHOVOT, Israel, Feb. 03, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company dev

      2/3/25 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Announces Closing of $2.8 Million Registered Direct Offering of American Depositary Shares

      REHOVOT, Israel, Dec. 05, 2024 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or the "Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that overcome tumor immune evasion and drug resistance, today announced the closing of its previously announced registered direct offering of 472,668 of the Company's American Depositary Shares ("ADSs"), each ADS representing 200 ordinary shares, at a purchase price of $6.00 per ADS. H.C. Wainwright & Co. acted as the exclusive placement agent for the offering. The gross proceeds to the Company from the offering are approximately $2.8 million, before deducting the placement agent's fees and other offe

      12/5/24 7:13:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Purple Biotech Ltd. Financials

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    • Purple Biotech Reports Fourth Quarter and Full-Year 2022 Financial Results

      Expands pipeline with acquisition of new tri-specific antibodies Data readouts for two lead clinical programs expected in 2023 REHOVOT, Israel, Feb. 08, 2023 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies that harness the power of the tumor microenvironment to overcome tumor immune evasion and drug resistance, today announced financial results for the year and the three months ended December 31, 2022. "We are reporting our 2022 financial results which are in line with our plans," said Gil Efron, Chief Executive Officer of Purple Biotech. "Our end-of-y

      2/8/23 7:12:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Purple Biotech Ltd. SEC Filings

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    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      5/6/25 4:00:47 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      4/30/25 7:02:02 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      4/28/25 9:26:34 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      4/22/25 4:30:17 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      4/16/25 7:02:20 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      4/15/25 4:00:43 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      4/1/25 7:02:02 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      3/28/25 7:50:33 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 6-K filed by Purple Biotech Ltd.

      6-K - PURPLE BIOTECH LTD. (0001614744) (Filer)

      3/18/25 4:01:30 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 20-F filed by Purple Biotech Ltd.

      20-F - PURPLE BIOTECH LTD. (0001614744) (Filer)

      3/10/25 4:06:58 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Purple Biotech Ltd. Large Ownership Changes

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    • Amendment: SEC Form SC 13G/A filed by Purple Biotech Ltd.

      SC 13G/A - PURPLE BIOTECH LTD. (0001614744) (Subject)

      11/14/24 5:21:29 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed by Purple Biotech Ltd.

      SC 13G - PURPLE BIOTECH LTD. (0001614744) (Subject)

      2/14/24 3:49:16 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed by Purple Biotech Ltd. (Amendment)

      SC 13G/A - PURPLE BIOTECH LTD. (0001614744) (Subject)

      4/9/21 4:34:41 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed

      SC 13G/A - PURPLE BIOTECH LTD. (0001614744) (Subject)

      2/16/21 10:04:35 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G/A filed

      SC 13G/A - PURPLE BIOTECH LTD. (0001614744) (Subject)

      2/5/21 10:12:31 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13G filed

      SC 13G - PURPLE BIOTECH LTD. (0001614744) (Subject)

      2/4/21 4:29:30 PM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care

    Purple Biotech Ltd. Leadership Updates

    Live Leadership Updates

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    • Purple Biotech Appoints Dr. Yael Margolin to its Board of Directors

      Dr. Margolin brings 35 years of expertise in biotechnology, pharma, and venture capital Purple Biotech also announces the resignation of Mr. Fabien Sebille, who served as the Company's Chief Business Officer REHOVOT, Israel, Dec. 20, 2023 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that harness the power of the tumor microenvironment to overcome tumor immune evasion and drug resistance, today announced the appointment of Dr. Yael Margolin as an independent member of the Company's Board of Directors. Dr. Yael Margolin has more than 35 years of experience as senior manager, c

      12/20/23 8:05:00 AM ET
      $GMDA
      $PNT
      $PPBT
      $SCNI
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
      Biotechnology: Pharmaceutical Preparations
    • Purple Biotech Reports Temporary Medical Leave of CEO Gil Efron

      Board of Directors appoints Isaac Israel, Board member and former CEO, as acting CEOCompany's business plan and clinical development programs continue as planned REHOVOT, Israel, March 24, 2023 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech", or the "Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies that harness the power of the tumor microenvironment (TME) to overcome tumor immune evasion and drug resistance, today announced that the CEO, Gil Efron, has been hospitalized following an accident and will be on medical leave that is expected to last several months while he undergoes rehabilitation to recover from h

      3/24/23 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Appoints Lior Fhima as Chief Financial Officer

      Seasoned financial executive strengthens management team  REHOVOT, Israel, Nov. 02, 2022 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech", or the "Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies by harnessing the power of the tumor microenvironment to overcome tumor immune evasion and drug resistance, today announced the appointment of Lior Fhima, CPA, MBA, as Chief Financial Officer of the Company.  Mr. Fhima brings deep expertise in financial management in the pharmaceutical industry and strong managerial capabilities. "We are honored to welcome Lior Fhima to the executive management team," said Gil Efron, Ch

      11/2/22 7:37:26 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Appoints Life Sciences Industry Investor Ori Hershkovitz to its Board of Directors

      REHOVOT, Israel, Jan. 06, 2022 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech", or the "Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies by overcoming tumor immune evasion and drug resistance, today announced the appointment of Ori Hershkovitz, a long-time life sciences industry investor, to its Board of Directors. "We are thrilled to welcome Ori to the Purple Biotech Board of Directors," said Dr. Eric Rowinsky, Chairman of the Board of Purple Biotech. "Ori has spent many years investing in and advising development-stage life sciences companies.   We look forward to leveraging his industry and finan

      1/6/22 7:30:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Appoints Senior Business Development Executive Fabien Sebille as Chief Business Officer

      REHOVOT, Israel, Dec. 09, 2021 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech", or the "Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies by overcoming tumor immune evasion and drug resistance, today announced the appointment of Fabien Sebille, Ph.D., a senior business development executive with more than 15 years of professional experience in the biotechnology industry, as its Chief Business Officer. Dr. Sebille, who has led a series of licensing deals in oncology over the last four years, will be primarily responsible for business development, including strategic partnering opportunities. Previously, Dr. Sebil

      12/9/21 7:30:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Purple Biotech Appoints Seasoned Biopharmaceutical Industry Executive Suzana Nahum-Zilberberg to Board of Directors

      REHOVOT, Israel, May 19, 2021 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. ("Purple Biotech" ", or the "Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies by overcoming tumor immune evasion and drug resistance, today announced the appointment of Suzana Nahum-Zilberberg, a seasoned biopharmaceutical Industry executive, to its Board of Directors. "We are excited to welcome Suzana to our Board of Directors," said Dr. Eric Rowinsky, Chairman of the Board of Purple Biotech. "Ms. Nahum-Zilberberg has extensive experience in senior leadership positions at several leading biopharmaceutical companies.  As we continue to expeditiously adva

      5/19/21 7:00:00 AM ET
      $PPBT
      Biotechnology: Pharmaceutical Preparations
      Health Care