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    Amendment: SEC Form SC 13D/A filed by Design Therapeutics Inc.

    8/13/24 6:53:06 PM ET
    $DSGN
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $DSGN alert in real time by email
    SC 13D/A 1 dsgn13d.htm

    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

    SCHEDULE 13D

    Under the Securities Exchange Act of 1934
    (Amendment No. 1)

     

    Design Therapeutics, Inc.

    (Name of Issuer)

     

    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

     

    25056L103

    (CUSIP Number)

     

    Derek Gould
    Logos Global Management LP
    One Letterman Drive, Building C, Suite C3-350
    San Francisco, CA 94129
    Telephone: (415) 801-4660

    (Name, Address and Telephone Number of Person
    Authorized to Receive Notices and Communications)

     

    August 9, 2024

    (Date of Event Which Requires Filing of this Statement)

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of sections 240.13d-1(e), 240.13d-1(f) or 140.13d-1(g), check the following box. [ ]

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See section 240.13d-7 for other parties to whom copies are to be sent.

    * The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

    Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

     1 
    CUSIP No. 25056L103

     

     

    1.Names of Reporting Persons.

    Logos Global Management LP

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ______
    (b) ______

     

    3.SEC Use Only

     

     

    4.Source of Funds (See Instructions) AF

     

    5.Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____

     

    6.Citizenship or Place of Organization Delaware

     

    Number of

    Shares

    Beneficially

    Owned by

    Each Reporting

    Person With

    7. Sole Voting Power 0

     

    8. Shared Voting Power 4,217,627

     

    9. Sole Dispositive Power 0
    10. Shared Dispositive Power 4,217,627

     

    11.Aggregate Amount Beneficially Owned by Each Reporting Person 4,217,627

     

    12.Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
    Instructions) ______

     

    13.Percent of Class Represented by Amount in Row (11) 7.4%

     

    14.Type of Reporting Person (See Instructions) IA, PN

     

     2 
    CUSIP No. 25056L103

     

     

    1.Names of Reporting Persons.

    Logos Global Management GP LLC

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ______
    (b) ______

     

    3.SEC Use Only

     

     

    4.Source of Funds (See Instructions) AF

     

    5.Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____

     

    6.Citizenship or Place of Organization Delaware

     

    Number of

    Shares

    Beneficially

    Owned by

    Each Reporting

    Person With

    7. Sole Voting Power 0

     

    8. Shared Voting Power 4,217,627

     

    9. Sole Dispositive Power 0
    10. Shared Dispositive Power 4,217,627

     

    11.Aggregate Amount Beneficially Owned by Each Reporting Person 4,217,627

     

    12.Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
    Instructions) ______

     

    13.Percent of Class Represented by Amount in Row (11) 7.4%

     

    14.Type of Reporting Person (See Instructions) HC, OO

     

     3 
    CUSIP No. 25056L103

     

     

    1.Names of Reporting Persons.

    Arsani William

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ______
    (b) ______

     

    3.SEC Use Only

     

     

    4.Source of Funds (See Instructions) AF

     

    5.Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____

     

    6.Citizenship or Place of Organization U.S.A.

     

    Number of

    Shares

    Beneficially

    Owned by

    Each Reporting

    Person With

    7. Sole Voting Power 15,000

     

    8. Shared Voting Power 4,217,627

     

    9. Sole Dispositive Power 15,000
    10. Shared Dispositive Power 4,217,627

     

    11.Aggregate Amount Beneficially Owned by Each Reporting Person 4,232,627

     

    12.Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
    Instructions) ______

     

    13.Percent of Class Represented by Amount in Row (11) 7.5%

     

    14.Type of Reporting Person (See Instructions) HC, IN

     

     4 
    CUSIP No. 25056L103

     

     

    1.Names of Reporting Persons.

    Logos Global Master Fund LP

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ______
    (b) ______

     

    3.SEC Use Only

     

     

    4.Source of Funds (See Instructions) WC

     

    5.Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____

     

    6.Citizenship or Place of Organization Cayman Islands

     

    Number of

    Shares

    Beneficially

    Owned by

    Each Reporting

    Person With

    7. Sole Voting Power 0

     

    8. Shared Voting Power 3,000,000

     

    9. Sole Dispositive Power 0
    10. Shared Dispositive Power 3,000,000

     

    11.Aggregate Amount Beneficially Owned by Each Reporting Person 3,000,000

     

    12.Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
    Instructions) ______

     

    13.Percent of Class Represented by Amount in Row (11) 5.3%

     

    14.Type of Reporting Person (See Instructions) PN

     

     5 
    CUSIP No. 25056L103

     

     

    1.Names of Reporting Persons.

    Logos GP LLC

     

    2.Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ______
    (b) ______

     

    3.SEC Use Only

     

     

    4.Source of Funds (See Instructions) AF

     

    5.Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ____

     

    6.Citizenship or Place of Organization Delaware

     

    Number of

    Shares

    Beneficially

    Owned by

    Each Reporting

    Person With

    7. Sole Voting Power 0

     

    8. Shared Voting Power 3,000,000

     

    9. Sole Dispositive Power 0
    10. Shared Dispositive Power 3,000,000

     

    11.Aggregate Amount Beneficially Owned by Each Reporting Person 3,000,000

     

    12.Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
    Instructions) ______

     

    13.Percent of Class Represented by Amount in Row (11) 5.3%

     

    14.Type of Reporting Person (See Instructions) OO

     

     6 
    CUSIP No. 25056L103

     

    Item 1.Security and Issuer

    This statement relates to shares of Common Stock, par value $0.0001 per share (the “Stock”), of Design Therapeutics, Inc. (the “Issuer”). The principal executive office of the Issuer is located at 6005 Hidden Valley Road, Suite 110, Carlsbad, California 92011.

     

    Item 2. Identity and Background

    The persons filing this statement and the persons enumerated in Instruction C of Schedule 13D and, where applicable, their respective places of organization, general partners, directors, executive officers and controlling persons, and the information regarding them, are as follows:

    (a)Logos Global Management LP (“Logos Global”), Logos Global Management GP LLC (“Logos Global GP”), Logos Global Master Fund LP (“Global Fund”), Logos GP LLC (“Logos GP”) and Dr. Arsani William (collectively, the “Filers”).

     

    Each Filer disclaims beneficial ownership of the Stock except to the extent of that person’s pecuniary interest therein.

     

    (b)The business address of the Filers is
    One Letterman Drive, Building C, Suite C3-350, San Francisco, California 94129

     

    (c)Present principal occupation or employment of the Filers and the name, principal business and address of any corporation or other organization in which such employment is conducted:


    Logos Global is an investment adviser to several private investment funds, including Global Fund (collectively, the “Funds”). Logos GP is the general partner of Global Fund. Logos Global GP is the general partner of Logos Global. Dr. William is the controlling person of Logos Global.

     

    (d)During the last five years, none of the Filers has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).
    (e)During the last five years, none of the Filers was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

     

    (f)For citizenship of the Filers, see Item 6 of each Filer’s cover page.

     

     7 
    CUSIP No. 25056L103
    Item 3.Source and Amount of Funds or Other Consideration

    Certain of the Funds acquired 1,217,627 shares of the Stock as a result of the automatic conversion of shares of Preferred Stock of the Issuer immediately prior to the completion of the Issuer’s initial public offering on March 30, 2021. No additional consideration was paid for those shares of Stock.

    Dr. William was granted options to acquire 15,000 shares of the Stock for his services as a director.

    The other shares of Stock were acquired by certain of the Funds for a total purchase price of $20,519,558.90. The Funds paid for such shares from working capital.

    Item 4.Purpose of Transaction

    The Filers are filing this Schedule 13D because Dr. William is on the Issuer’s board of directors. The Filers acquired the Stock for investment purposes. The Filers will routinely monitor the Issuer regarding a wide variety of factors that affect their investment considerations, including, current and anticipated future trading prices of the Stock and other securities, the Issuer’s operations, assets, prospects, financial position, and business development, Issuer’s management, Issuer-related competitive and strategic matters, general economic, financial market and industry conditions, and other investment considerations. Depending on their evaluation of various factors, the Filers may take such actions regarding their holdings of the Issuer’s securities as they deem appropriate in light of circumstances existing from time to time. Such actions may include purchasing additional Stock in the open market, through privately negotiated transactions with third parties or otherwise, and selling at any time, in the open market, through privately negotiated transactions with third parties or otherwise, all or part of the Stock now owned or hereafter acquired by any of them. The Filers also may from time to time enter into or unwind hedging or other derivative transactions with respect to the Stock or pledge their interests in the Stock to obtain liquidity. In addition, from time to time the Filers and their representatives and advisers may communicate with other stockholders, industry participants and other interested parties about the Issuer.

    The Filers have no present plan or proposal that relates to or would result in any of the actions specified in clauses (a) through (j) of Item 4 of Schedule 13D of the Act. However, the Filers may recommend action to the Issuer’s management, board of directors and stockholders. Any such actions could involve one or more of the events referred to in clauses (a) through (j) of Item 4 of Schedule 13D, including, potentially, one or more mergers, consolidations, sales or acquisitions of assets, change in control, issuances, purchases, dispositions or pledges of securities or other changes in capitalization.

    Item 5.Interest in Securities of the Issuer

    The beneficial ownership of the Stock by each Filer on the date hereof is reflected on that Filer’s cover page. The Filers engaged in the following transactions in the Issuer’s Common Stock in the 60 days preceding the date of this Schedule 13D:

    Name

    Purchase or Sale

     

    Date Manner Effected Number of Shares Price Per Share
    Logos SPV 1 LP Sale 8/9/2024 Public Market 814,874 $4.25

     

    Item 6.Contracts, Arrangement, Understandings or Relationships with Respect to Securities of the Issuer

     

    Logos Global is the investment adviser to its clients pursuant to investment management agreements or limited partnership agreements providing to Logos Global the authority, among other things, to invest the funds of such clients in Stock, to vote and dispose of Stock and to file this statement on behalf of such clients. Pursuant to such limited partnership agreements, Logos Global and its affiliates are entitled to allocations based on assets under management and realized and unrealized gains. Pursuant to such investment management agreements, Logos Global is entitled to fees based on assets under management and realized and unrealized gains.

    Certain of the Funds and other stockholders of the Issuer entered into an Amended and Restated Investors’ Rights Agreement with the Issuer (the “Investors’ Rights Agreement”), dated as of January 25, 2021. Pursuant to the Investors’ Rights Agreement and subject to the terms and conditions therein, such persons have certain registration rights as set forth below.

    The demand, piggyback and Form S-3 registration rights described below will expire upon the earliest to occur of (i) the closing of the Issuer’s first registered public offering of its common stock, with respect to any holder who then holds an amount of shares equal to less than one percent of the Issuer’s outstanding securities and may sell all such shares under Rule 144 during any three-month period; (ii) the fifth anniversary of the date of the Investors’ Rights Agreement; or (iii) with respect to any particular holder, at such time that such holder can sell its shares under Rule 144 of the Securities Act of 1933, as amended (the “Securities Act”), or another similar exemption during any three-month period.

    Demand Registration Rights

    The holders of the Issuer’s registrable securities will be entitled to certain demand registration rights. Beginning 180 days following the effectiveness of the registration statement for the Issuer’s initial public offering, certain investors holding, collectively, at least 50% of registrable securities then outstanding may, on not more than two occasions, request that the Issuer register all or a portion of their shares, subject to certain specified exceptions. If any of these holders exercises its demand registration rights, then holders of all registrable securities will be entitled to register their shares, subject to specified conditions and limitations, in the corresponding offering. Such request for registration must cover shares with an anticipated aggregate offering price of at least $10.0 million.

    Piggyback Registration Rights

    In the event that the Issuer proposes to register any of its securities under the Securities Act in an offering after its initial public offering, either for the Issuer’s own account or for the account of other security holders, the holders of the Issuer’s registrable securities will be entitled to certain “piggyback” registration rights allowing them to include their shares in such registration, subject to specified conditions and limitations.

    S-3 Registration Rights

    Upon the closing of the Issuer’s initial public offering, the holders of the Issuer’s registrable securities will initially be entitled to certain Form S-3 registration rights. Certain investors may, on not more than two registrations on Form S-3 within any 12-month period, request that the Issuer register all or a portion of their shares on Form S-3 if the Issuer is qualified to file a registration statement on Form S-3, subject to specified exceptions. Such request for registration on Form S-3 must cover securities with an aggregate offering price which equals at least $3.0 million, net of selling expenses. The right to have such shares registered on Form S-3 is further subject to other specified conditions and limitations.

    The foregoing description of the Investors’ Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of such agreement, which is incorporated herein by reference.

     8 
    CUSIP No. 25056L103
    Item 7.Material to Be Filed as Exhibits

    Exhibit A Agreement Regarding Joint Filing of Statement on Schedule 13D or 13G.

    Exhibit B Amended and Restated Investor Rights Agreement, attached as Exhibit 4.2 to the Issuer’s Form S-1 Registration Statement (No. 333-253954), filed on March 5, 2021, and incorporated herein by reference.

    SIGNATURES

     

    After reasonable inquiry and to the best of my knowledge, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: August 13, 2024

     

     

     

    /s/ Arsani William
    Arsani William

     

     

     

     

    Logos Global Management LP


    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Partner

     

    Logos Global Management GP LLC


    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Member

     

     

    Logos Global Master Fund LP

     

    By Logos Global Management LP, its investment manager and attorney-in-fact

     

    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Member

     

    Logos GP LLC


    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Member

     

     

     9 
    CUSIP No. 25056L103

    EXHIBIT A

     

    AGREEMENT REGARDING JOINT FILING

    OF STATEMENT ON SCHEDULE 13D OR 13G

     

    The undersigned agree to file jointly with the Securities and Exchange Commission (the “SEC”) any and all statements on Schedule 13D, Schedule 13G or forms 3, 4 or 5 (and any amendments or supplements thereto) required under section 13(d) or 16(a) of the Securities Exchange Act of 1934, as amended, in connection with purchases by the undersigned of the securities of any issuer. For that purpose, the undersigned hereby constitute and appoint Logos Global Management LP, a Delaware limited partnership, as their true and lawful agent and attorney-in-fact, with full power and authority for and on behalf of the undersigned to prepare or cause to be prepared, sign, file with the SEC and furnish to any other person all certificates, instruments, agreements and documents necessary to comply with section 13(d) and section 16(a) of the Act, in connection with said purchases, and to do and perform every act necessary and proper to be done incident to the exercise of the foregoing power, as fully as the undersigned might or could do if personally present.

     

     

    Dated: August 13, 2024

     

     

     

    /s/ Arsani William
    Arsani William

     

     

     

     

    Logos Global Management LP


    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Partner

     

    Logos Global Management GP LLC


    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Member

     

     

    Logos Global Master Fund LP

     

    By Logos Global Management LP, its investment manager and attorney-in-fact

     

    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Member

     

    Logos GP LLC


    By: /s/ Arsani William
    Name: Arsani William
    Title: Managing Member

     

     

     

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      5/7/25 4:01:00 PM ET
      $DSGN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Design Therapeutics Announces Favorable Phase 1 Data for DT-168 Supporting Advancement into Phase 2 Biomarker Trial for Patients with Fuchs Endothelial Corneal Dystrophy

      CARLSBAD, Calif., May 01, 2025 (GLOBE NEWSWIRE) -- Design Therapeutics, Inc. (NASDAQ:DSGN), a clinical-stage biotechnology company developing treatments for serious degenerative genetic diseases, today announced favorable data from a Phase 1 single- and multiple-ascending dose (SAD/MAD) trial of DT-168 in healthy volunteers, which will be presented on May 2, 2025 at Eyecelerator @ Park City 2025, an event backed by the American Academy of Ophthalmology highlighting industry advancements and innovative new products disrupting eye care. DT-168 is a novel GeneTAC® small molecule, formulated as an eye drop, that is designed to selectively target and reduce the expression of the mutant TCF4 ge

      5/1/25 8:00:00 AM ET
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      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Design Therapeutics to Present Phase 1 Data for Fuchs Endothelial Corneal Dystrophy Program at Eyecelerator @ Park City 2025

      CARLSBAD, Calif., April 21, 2025 (GLOBE NEWSWIRE) -- Design Therapeutics, Inc. (NASDAQ:DSGN), a clinical-stage biotechnology company developing treatments for serious degenerative genetic diseases, today announced that it will present an update on the progress of its DT-168 program for Fuchs endothelial corneal dystrophy (FECD) at Eyecelerator @ Park City 2025 on Friday, May 2, 2025, at 1:30 p.m. MT in Park City, UT. The presentation will include safety findings from the Phase 1 single- and multiple-ascending dose trial of DT-168 in healthy adult volunteers and plans for Phase 2 clinical development in FECD patients. DT-168 is a GeneTAC® small molecule, formulated as an eye drop, that is

      4/21/25 4:01:00 PM ET
      $DSGN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 3 filed by new insider Dunham Trust Co

      3 - Design Therapeutics, Inc. (0001807120) (Issuer)

      2/7/25 4:17:28 PM ET
      $DSGN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4 filed by Director Lappe Rodney W

      4 - Design Therapeutics, Inc. (0001807120) (Issuer)

      1/6/25 7:00:35 PM ET
      $DSGN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4 filed by President, CEO and Chairperson Shah Pratik

      4 - Design Therapeutics, Inc. (0001807120) (Issuer)

      1/6/25 7:00:31 PM ET
      $DSGN
      Biotechnology: Pharmaceutical Preparations
      Health Care

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    Leadership Updates

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    • Design Therapeutics Appoints Veteran Industry Executive Chris Storgard, M.D., as Chief Medical Officer

      CARLSBAD, Calif., April 17, 2025 (GLOBE NEWSWIRE) -- Design Therapeutics, Inc. (NASDAQ:DSGN), a clinical-stage biotechnology company developing treatments for serious degenerative genetic diseases, today announced the appointment of Chris M. Storgard, M.D., as Chief Medical Officer (CMO). Dr. Storgard brings over two decades of leadership and hands-on drug development experience, having successfully advanced multiple assets from preclinical stages through global regulatory approvals. "We are thrilled to welcome Chris to our team at this exciting time for Design, as we advance our portfolio of GeneTAC® small molecules toward key clinical milestones," said Pratik Shah, Ph.D., chairperson an

      4/17/25 8:00:00 AM ET
      $DSGN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Bright Peak Therapeutics Appoints John Schmid to its Board of Directors

      SAN DIEGO and BASEL, Switzerland , April 17, 2025 (GLOBE NEWSWIRE) -- Bright Peak Therapeutics, a clinical-stage biotechnology company focused on discovering and developing multifunctional immunotherapies for cancer, today announced the appointment of John Schmid, a seasoned biotechnology executive, to its Board of Directors. "It is a pleasure to welcome John to our Board," said Fredrik Wiklund, Chief Executive Officer of Bright Peak Therapeutics. "John brings decades of experience and an extensive track record of success in the biotech sector. His strategic insights and financial expertise will be instrumental as we advance our clinical pipeline and scale Bright Peak for long-term succ

      4/17/25 7:00:00 AM ET
      $ANAB
      $DSGN
      $PSTX
      $XERS
      Biotechnology: Pharmaceutical Preparations
      Health Care
      Biotechnology: Biological Products (No Diagnostic Substances)
      Business Services
    • Design Therapeutics Reports Pipeline and Business Progress and Fourth Quarter and Full Year 2021 Financial Results

      Phase 1 Trial of DT-216, a Novel FA GeneTAC™ Molecule, in Patients with Friedreich Ataxia On Track to Begin Soon Preclinical Data Supporting Development of Novel GeneTAC™ Small Molecules for the Treatment of Fuchs Endothelial Corneal Dystrophy (FECD) to be Presented at ARVO 2022 Well-Capitalized with $384.1 Million in Cash and Investments at the End of 2021 to Support Upcoming Milestones CARLSBAD, Calif., March 10, 2022 (GLOBE NEWSWIRE) -- Design Therapeutics, Inc. (NASDAQ:DSGN), a biotechnology company developing treatments for degenerative genetic disorders, today announced pipeline and business progress and reported fourth quarter and full year 2021 financial results. "This is an e

      3/10/22 4:02:00 PM ET
      $DSGN
      Biotechnology: Pharmaceutical Preparations
      Health Care