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    Amendment: SEC Form SC 13G/A filed by Astria Therapeutics Inc.

    11/14/24 5:45:56 PM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ATXS alert in real time by email
    SC 13G/A 1 tm2428137d1_sc13ga.htm SC 13G/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

    SCHEDULE 13G/A

     

    Under the Securities Exchange Act of 1934

    (Amendment No. 1)*

     

    Astria Therapeutics, Inc.

    (Name of Issuer)

     

    Common stock, $0.001 par value per share

    (Title of Class of Securities)

     

    04635X 10 2

    (CUSIP Number)

     

    September 30, 2024

    (Date of Event Which Requires Filing of this Statement)

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

    ¨ Rule 13d-1(b)
       
    x Rule 13d-1(c)
       
    ¨ Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

     

    The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

    CUSIP No. 04635X 10 2 Page 2 of 14

     

    1.

    Names of Reporting Persons

     

    Venrock Healthcare Capital Partners III, L.P.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a) x (1) (b) ¨

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

     

    0

    6.

    Shared Voting Power

     

    3,458,645 (2)

    7.

    Sole Dispositive Power

     

    0

    8.

    Shared Dispositive Power

     

    3,458,645 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    3,458,645 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

     

    6.1% (3)

    12.

    Type of Reporting Person (See Instructions)

     

    PN

           
    (1)Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.
      
    (2)Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P.
      
    (3)This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the “SEC”) on August 12, 2024.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 3 of 14

     

    1.

    Names of Reporting Persons

     

    VHCP Co-Investment Holdings III, LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a) x (1) (b) ¨

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

     

    0

    6.

    Shared Voting Power

     

    3,458,645 (2)

    7.

    Sole Dispositive Power

     

    0

    8.

    Shared Dispositive Power

     

    3,458,645 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    3,458,645 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

     

    6.1% (3)

    12.

    Type of Reporting Person (See Instructions)

     

    OO

           
    (1)Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.
      
    (2)Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P.
      
    (3)This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 4 of 14

     

    1.

    Names of Reporting Persons

     

    Venrock Healthcare Capital Partners EG, L.P.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a) x (1) (b) ¨

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

     

    0

    6.

    Shared Voting Power

     

    3,458,645 (2)

    7.

    Sole Dispositive Power

     

    0

    8.

    Shared Dispositive Power

     

    3,458,645 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    3,458,645 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

     

    6.1% (3)

    12.

    Type of Reporting Person (See Instructions)

     

    PN

           
    (1)Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.
      
    (2)Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P.
      
    (3)This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 5 of 14

     

    1.

    Names of Reporting Persons

     

    VHCP Management III, LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a) x (1) (b) ¨

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

     

    0

    6.

    Shared Voting Power

     

    3,458,645 (2)

    7.

    Sole Dispositive Power

     

    0

    8.

    Shared Dispositive Power

     

    3,458,645 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    3,458,645 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

     

    6.1% (3)

    12.

    Type of Reporting Person (See Instructions)

     

    OO

           
    (1)Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.
      
    (2)Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P.
      
    (3)This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 6 of 14

     

    1.

    Names of Reporting Persons

     

    VHCP Management EG, LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a) x (1) (b) ¨

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

     

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

     

    0

    6.

    Shared Voting Power

     

    3,458,645 (2)

    7.

    Sole Dispositive Power

     

    0

    8.

    Shared Dispositive Power

     

    3,458,645 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    3,458,645 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

     

    6.1% (3)

    12.

    Type of Reporting Person (See Instructions)

     

    OO

           
    (1)Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.
      
    (2)Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P.
      
    (3)This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 7 of 14

     

    1.

    Names of Reporting Persons

     

    Shah, Nimish

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a) x (1) (b) ¨

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

     

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

     

    0

    6.

    Shared Voting Power

     

    3,458,645 (2)

    7.

    Sole Dispositive Power

     

    0

    8.

    Shared Dispositive Power

     

    3,458,645 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    3,458,645 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

     

    6.1% (3)

    12.

    Type of Reporting Person (See Instructions)

     

    IN

           
    (1)Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.
      
    (2)Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P.
      
    (3)This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 8 of 14

     

    1.

    Names of Reporting Persons

     

    Koh, Bong

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

     

    (a) x (1) (b) ¨

    3. SEC Use Only
    4.

    Citizenship or Place of Organization

     

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

     

    0

    6.

    Shared Voting Power

     

    3,458,645 (2)

    7.

    Sole Dispositive Power

     

    0

    8.

    Shared Dispositive Power

     

    3,458,645 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

     

    3,458,645 (2)

    10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨
    11.

    Percent of Class Represented by Amount in Row (9)

     

    6.1% (3)

    12.

    Type of Reporting Person (See Instructions)

     

    IN

           
    (1)Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.
      
    (2)Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P.
      
    (3)This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 9 of 14

     

    Introductory Note:  This Schedule 13G/A is filed on behalf of Venrock Healthcare Capital Partners III, L.P., a limited partnership organized under the laws of the State of Delaware (“VHCP III LP”), VHCP Co-Investment Holdings III, LLC, a limited liability company organized under the laws of the State of Delaware (“VHCP Co-Investment III”), Venrock Healthcare Capital Partners EG, L.P., a limited partnership organized under the laws of the State of Delaware (“VHCP EG”), VHCP Management III, LLC, a limited liability company organized under the laws of the State of Delaware (“VHCP Management III”), VHCP Management EG, LLC, a limited liability company organized under the laws of the State of Delaware (“VHCP Management EG” and collectively with VHCP III LP, VHCP Co-Investment III, VHCP EG and VHCP Management III, the “Venrock Entities”), Nimish Shah (“Shah”) and Bong Koh (“Koh”) in respect of the Common Stock of Astria Therapeutics, Inc.
     
    Item 1.
      (a)

    Name of Issuer

     

    Astria Therapeutics, Inc.

     
      (b)

    Address of Issuer’s Principal Executive Offices

     

    22 Boston Wharf Road, 10th Floor

    Boston, MA 02210

     
    Item 2.
      (a)

    Name of Person Filing

     

    Venrock Healthcare Capital Partners III, L.P.

    VHCP Co-Investment Holdings III, LLC

    Venrock Healthcare Capital Partners EG, L.P.

    VHCP Management III, LLC

    VHCP Management EG, LLC

    Nimish Shah

    Bong Koh

     
      (b)

    Address of Principal Business Office or, if none, Residence

     

    New York Office:

     

    7 Bryant Park

    23rd Floor

    New York, NY 10018

     

     

    Palo Alto Office:

     

    3340 Hillview Avenue

    Palo Alto, CA 94304

     
      (c)

    Citizenship

     

    All of the Venrock Entities were organized in Delaware. The individuals are both United States citizens.

     
      (d)

    Title of Class of Securities

     

    Common Stock, $0.001 par value

     
      (e)

    CUSIP Number

     

    04635X 10 2

     

     

     

     

    CUSIP No. 04635X 10 2 Page 10 of 14

     

    Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
      Not applicable
     
    Item 4. Ownership
      (a) Amount beneficially owned as of September 30, 2024:
           
          Venrock Healthcare Capital Partners III, L.P. 3,458,645 (1)
          VHCP Co-Investment Holdings III, LLC 3,458,645 (1)
          Venrock Healthcare Capital Partners EG, L.P. 3,458,645 (1)
          VHCP Management III, LLC 3,458,645 (1)
          VHCP Management EG, LLC 3,458,645 (1)
          Nimish Shah 3,458,645 (1)
          Bong Koh 3,458,645 (1)
     
      (b) Percent of class as of September 30, 2024:
         
          Venrock Healthcare Capital Partners III, L.P. 6.1% (2)
          VHCP Co-Investment Holdings III, LLC 6.1% (2)
          Venrock Healthcare Capital Partners EG, L.P. 6.1% (2)
          VHCP Management III, LLC 6.1% (2)
          VHCP Management EG, LLC 6.1% (2)
          Nimish Shah 6.1% (2)
          Bong Koh 6.1% (2)
     
      (c) Number of shares as to which the person has, as of September 30, 2024:
         
        (i)      Sole power to vote or to direct the vote:
           
          Venrock Healthcare Capital Partners III, L.P. 0
          VHCP Co-Investment Holdings III, LLC 0
          Venrock Healthcare Capital Partners EG, L.P. 0
          VHCP Management III, LLC 0
          VHCP Management EG, LLC 0
          Nimish Shah 0
          Bong Koh 0
             

     

     

     

     

    CUSIP No. 04635X 10 2 Page 11 of 14

     

       (ii) Shared power to vote or to direct the vote:
           
          Venrock Healthcare Capital Partners III, L.P. 3,458,645 (1)
          VHCP Co-Investment Holdings III, LLC 3,458,645 (1)
          Venrock Healthcare Capital Partners EG, L.P. 3,458,645 (1)
          VHCP Management III, LLC 3,458,645 (1)
          VHCP Management EG, LLC 3,458,645 (1)
          Nimish Shah 3,458,645 (1)
          Bong Koh 3,458,645 (1)
     
       (iii) Sole power to dispose or to direct the disposition of:
           
          Venrock Healthcare Capital Partners III, L.P. 0
          VHCP Co-Investment Holdings III, LLC 0
          Venrock Healthcare Capital Partners EG, L.P. 0
          VHCP Management III, LLC 0
          VHCP Management EG, LLC 0
          Nimish Shah 0
          Bong Koh 0
     
       (iv) Shared power to dispose or to direct the disposition of:
           
          Venrock Healthcare Capital Partners III, L.P. 3,458,645 (1)
          VHCP Co-Investment Holdings III, LLC 3,458,645 (1)
          Venrock Healthcare Capital Partners EG, L.P. 3,458,645 (1)
          VHCP Management III, LLC 3,458,645 (1)
          VHCP Management EG, LLC 3,458,645 (1)
          Nimish Shah 3,458,645 (1)
          Bong Koh 3,458,645 (1)
             
      (1) Consists of (i) 612,982 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 61,310 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 2,784,353 shares held by Venrock Healthcare Capital Partners EG, L.P. VHCP Management III, LLC is the general partner of Venrock Healthcare Capital Partners III, L.P. and the manager of VHCP Co-Investment Holdings III, LLC. VHCP Management EG, LLC is the general partner of Venrock Healthcare Capital Partners EG, L.P. Messrs. Shah and Koh are the voting members of VHCP Management III, LLC and VHCP Management EG, LLC.
         
      (2) This percentage is calculated based upon 56,425,282 shares of Common Stock outstanding as of July 31, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

      

    Item 5. Ownership of Five Percent or Less of a Class
      If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   ¨

     

     

     

     

    CUSIP No. 04635X 10 2 Page 12 of 14

     

    Item 6. Ownership of More than Five Percent on Behalf of Another Person
       
      Not applicable
     
    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
       
      Not applicable
     
    Item 8. Identification and Classification of Members of the Group
       
      Not applicable
     
    Item 9. Notice of Dissolution of Group
       
      Not applicable
     
    Item 10. Certification
       
      By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.

     

     

     

     

    CUSIP No. 04635X 10 2 Page 13 of 14

     

    SIGNATURE

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: November 14, 2024

     

    Venrock Healthcare Capital Partners III, L.P.   Venrock Healthcare Capital Partners EG, L.P.
         
    By: VHCP Management III, LLC   By: VHCP Management EG, LLC
    Its: General Partner   Its: General Partner
         
    By: /s/ Sherman G. Souther   By: /s/ Sherman G. Souther
      Name: Sherman G. Souther     Name: Sherman G. Souther
      Its: Authorized Signatory     Its: Authorized Signatory
         
    VHCP Co-Investment Holdings III, LLC    
         
    By: VHCP Management III, LLC    
    Its: Manager    
         
    By: /s/ Sherman G. Souther    
      Name: Sherman G. Souther    
      Its: Authorized Signatory    
         
    VHCP Management III, LLC   VHCP Management EG, LLC
         
    By: /s/ Sherman G. Souther   By: /s/ Sherman G. Souther
      Name: Sherman G. Souther     Name: Sherman G. Souther
      Its: Authorized Signatory     Its: Authorized Signatory
         
    Nimish Shah    
         
    /s/ Sherman G. Souther    
    Sherman G. Souther, Attorney-in-fact    
         
    Bong Koh    
         
    /s/ Sherman G. Souther    
    Sherman G. Souther, Attorney-in-fact    

     

     

     

     

    CUSIP No. 04635X 10 2 Page 14 of 14

     

    EXHIBITS

     

    A:Joint Filing Agreement (incorporated by reference to Exhibit A to Schedule 13G filed on January 2, 2024)

     

    B:Power of Attorney for Nimish Shah (incorporated by reference to Exhibit B to Schedule 13G filed January 2, 2024)

     

    C:Power of Attorney for Bong Koh (incorporated by reference to Exhibit C to Schedule 13G filed on January 2, 2024)

     

     

     

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    Cantor Fitzgerald
    1/31/2025$26.00Mkt Outperform
    JMP Securities
    7/29/2024$35.00Buy
    TD Cowen
    3/28/2023$18.00Outperform
    Evercore ISI
    9/29/2021$20.00Buy
    Jefferies
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    SEC Filings

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    Amendment: SEC Form SCHEDULE 13G/A filed by Astria Therapeutics Inc.

    SCHEDULE 13G/A - Astria Therapeutics, Inc. (0001454789) (Subject)

    8/14/25 5:56:05 PM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    SEC Form S-8 filed by Astria Therapeutics Inc.

    S-8 - Astria Therapeutics, Inc. (0001454789) (Filer)

    8/12/25 4:34:26 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    SEC Form 10-Q filed by Astria Therapeutics Inc.

    10-Q - Astria Therapeutics, Inc. (0001454789) (Filer)

    8/12/25 4:02:25 PM ET
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    Astria Therapeutics Announces Positive Initial Results from the Phase 1a Healthy Subject Trial of STAR-0310 at the European Academy of Dermatology and Venereology

    -- Results Support Potential for STAR-0310 to be Best-in-Class OX40 Antagonist -- -- STAR-0310 Exhibits Longest-in-Class Half-Life of 68 Days and Cytokine Suppression Lasting At Least 20 Weeks After a Single 300 mg SC Injection, Supporting Potential Every-Six-Month Administration -- -- STAR-0310 Was Well-Tolerated, with no ADCC-Related Treatment-Emergent Adverse Events, Supporting a Wider Therapeutic Window with the Potential to Drive Greater Efficacy than First-Generation OX40 Antibodies -- -- Results to be Presented by Dr. Stephan Weidinger, M.D., Ph.D. on September 18, at 4:00pm CEST -- Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company focused on developing lif

    9/17/25 8:00:00 AM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    Astria Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

    Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company focused on developing life-changing therapies for allergic and immunologic diseases, granted stock options to purchase 128,000 shares of Astria's common stock on September 2, 2025 under Astria's 2022 Inducement Stock Incentive Plan. The 2022 Inducement Stock Incentive Plan is used exclusively for the grant of equity awards to individuals who were not previously an employee of Astria. The options were granted as an inducement material to three employees entering into employment with Astria in accordance with Nasdaq Listing Rule 5635(c)(4). The options have an exercise price of $6.59, which is equal to the closing price of

    9/3/25 4:10:00 PM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    Astria Therapeutics to Present Initial Data from Phase 1a Trial of STAR-0310 at Upcoming European Academy of Dermatology & Venereology Congress 2025

    Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company focused on developing life-changing therapies for allergic and immunologic diseases, today announced that it will present initial data from the Phase 1a trial of STAR-0310 at the European Academy of Dermatology & Venereology (EADV) Congress 2025, taking place September 17-20, 2025 in Paris, France. Stephan Weidinger, M.D., Ph.D., Director and Chair of the Department of Dermatology and Allergy at the University Medical Center Kiel, Schleswig-Holstein, will present initial results from the Phase 1a trial of STAR-0310 in healthy participants in a late-breaking oral presentation titled, "Demonstration of Early Proof-of-Conce

    9/3/25 8:00:00 AM ET
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    $ATXS
    Analyst Ratings

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    H.C. Wainwright reiterated coverage on Astria Therapeutics with a new price target

    H.C. Wainwright reiterated coverage of Astria Therapeutics with a rating of Buy and set a new price target of $20.00 from $16.00 previously

    9/17/25 11:36:24 AM ET
    $ATXS
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    Cantor Fitzgerald initiated coverage on Astria Therapeutics with a new price target

    Cantor Fitzgerald initiated coverage of Astria Therapeutics with a rating of Overweight and set a new price target of $47.00

    4/29/25 8:10:45 AM ET
    $ATXS
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    JMP Securities initiated coverage on Astria Therapeutics with a new price target

    JMP Securities initiated coverage of Astria Therapeutics with a rating of Mkt Outperform and set a new price target of $26.00

    1/31/25 6:57:00 AM ET
    $ATXS
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    $ATXS
    Insider Trading

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    SEC Form 4 filed by Director Agarwal Sunil

    4 - Astria Therapeutics, Inc. (0001454789) (Issuer)

    6/12/25 7:16:46 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    SEC Form 4 filed by Director Bate Kenneth

    4 - Astria Therapeutics, Inc. (0001454789) (Issuer)

    6/12/25 7:15:46 PM ET
    $ATXS
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    SEC Form 4 filed by Director Cole Hugh M

    4 - Astria Therapeutics, Inc. (0001454789) (Issuer)

    6/12/25 7:14:39 PM ET
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    $ATXS
    Insider Purchases

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    Perceptive Advisors Llc bought $29,999,522 worth of shares (2,481,350 units at $12.09) (SEC Form 4)

    4 - Astria Therapeutics, Inc. (0001454789) (Issuer)

    2/5/24 5:02:33 PM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    Perceptive Advisors Llc bought $4,588,000 worth of shares (740,000 units at $6.20) (SEC Form 4)

    4 - Astria Therapeutics, Inc. (0001454789) (Issuer)

    12/22/23 2:51:57 PM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    Perceptive Advisors Llc bought $6,999,997 worth of shares (1,074,608 units at $6.51) (SEC Form 4)

    4 - Astria Therapeutics, Inc. (0001454789) (Issuer)

    10/18/23 4:11:36 PM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    $ATXS
    Leadership Updates

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    Astria Therapeutics Appoints Sunil Agarwal to Its Board of Directors

    Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company focused on developing life-changing therapies for allergic and immunological diseases, today announced the appointment of Sunil Agarwal, M.D., to its Board of Directors. Dr. Agarwal has more than 20 years of biotechnology research, development, and commercialization experience. "It is a pleasure to welcome Sunil to our Board of Directors," said Jill C. Milne, Ph.D., Chief Executive Officer at Astria Therapeutics. "His extensive drug development and clinical expertise strongly complements our Board's skills and experiences, and we look forward to his contributions as we continue to advance our programs into later-stage cl

    4/9/24 8:00:00 AM ET
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    Amendment: SEC Form SC 13G/A filed by Astria Therapeutics Inc.

    SC 13G/A - Astria Therapeutics, Inc. (0001454789) (Subject)

    11/14/24 5:46:12 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    Amendment: SEC Form SC 13G/A filed by Astria Therapeutics Inc.

    SC 13G/A - Astria Therapeutics, Inc. (0001454789) (Subject)

    11/14/24 5:45:56 PM ET
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    Amendment: SEC Form SC 13D/A filed by Astria Therapeutics Inc.

    SC 13D/A - Astria Therapeutics, Inc. (0001454789) (Subject)

    11/14/24 4:41:28 PM ET
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    Financials

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    Astria Therapeutics Announces Positive Initial Proof-of-Concept Results from the ALPHA-STAR Phase 1b/2 Trial of STAR-0215 for HAE

    -- STAR-0215 Dosed Once or Twice Over 6 Months Reduced Monthly Attack Rates by 90-96%, Supporting Chronic Dosing 2 or 4 Times Per Year -- -- 92-100% Decrease in Moderate or Severe Attacks and 91-95% Reduction in Attacks Requiring Rescue Medications with STAR-0215 -- -- Very Well-Tolerated with No Serious Adverse Events and No Discontinuations -- -- Phase 3 Initiation on Track for Q1 2025, with Top-Line Results Expected by Year End 2026 -- -- Current Cash Expected to Fund Company into Mid-2027 -- -- Conference Call Today at 8:30am ET – Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company focused on developing life-changing therapies for allergic and immunological

    3/25/24 7:30:00 AM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    Astria Therapeutics to Report Third Quarter 2023 Financial Results and Provide a Corporate Update on Monday, November 13th

    Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company focused on developing life-changing therapies for allergic and immunological diseases, will report third quarter 2023 financial results before the Nasdaq Global Market open on Monday, November 13, 2023. Jill C. Milne, Ph.D., Chief Executive Officer, will host a conference call and webcast at 8:30am ET to provide an update on corporate developments and to discuss third quarter financial results. Webcast Information: Interested parties may join the webcast via the Investors section of the Astria website, www.astriatx.com, or with the following link: https://lifescievents.com/event/astria-2/. Please connect to the webca

    10/30/23 8:00:00 AM ET
    $ATXS
    Biotechnology: Pharmaceutical Preparations
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    Astria Therapeutics Announces Exclusive Worldwide License Agreement with Ichnos Sciences for OX40 Portfolio

    -- Differentiated Preclinical Lead Candidate STAR-0310 to be Developed as a Potential Best-in-Class Long-Acting Treatment for Atopic Dermatitis – -- Conference Call and Webcast to be Held on October 12, 2023 at 8:30am ET -- Astria Therapeutics, Inc. (NASDAQ:ATXS), a biopharmaceutical company focused on developing life-changing therapies for allergic and immunological diseases, today announced that it has entered into a worldwide exclusive license agreement with Ichnos Sciences for an OX40 portfolio to be developed for the potential treatment of atopic dermatitis (AD) and potentially for other allergic and immunological diseases. Astria plans to develop the lead candidate, called STAR-03

    10/11/23 5:10:00 PM ET
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    Biotechnology: Pharmaceutical Preparations
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