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    Amendment: SEC Form SC 13G/A filed by Dianthus Therapeutics Inc.

    11/14/24 5:48:32 PM ET
    $DNTH
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $DNTH alert in real time by email
    SC 13G/A 1 tm2427620d23_sc13ga.htm SC 13G/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

    SCHEDULE 13G/A

     

    Under the Securities Exchange Act of 1934

    (Amendment No. 2)*

     

    Dianthus Therapeutics, Inc.

    (Name of Issuer)

     

    Common stock, $0.001 par value per share

    (Title of Class of Securities)

     

    252828108

    (CUSIP Number)

     

    September 30, 2024

    (Date of Event Which Requires Filing of this Statement)

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

    ¨ 

    x 

    ¨

    Rule 13d-1(b) 

    Rule 13d-1(c) 

    Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

     

    The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

    CUSIP No.   252828108
    1.

    Names of Reporting Persons

    5AM Ventures VII, L.P.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨             (b) x (1)

    3.

    SEC Use Only

     

    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    1,027,711 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    1,027,711 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    1,027,711 (2)

    10.

    Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨

     

    11.

    Percent of Class Represented by Amount in Row (9)

    3.5% (3)

    12.

    Type of Reporting Person (See Instructions)

    PN

           

    (1)This Schedule 13G is filed by 5AM Ventures VII, L.P. (“Ventures VII”), 5AM Partners VII, LLC (“Partners VII”), 5AM Opportunities II, L.P. (“Opps II”), 5AM Opportunities II (GP), LLC (“Opps II GP”), Andrew J. Schwab (“Schwab”) and Dr. Kush Parmar (“Parmar” and, with Ventures VII, Partners VII, Opps II, Opps II GP and Schwab collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Consists of 1,027,711 shares of Common Stock held by Ventures VII. Partners VII is the sole general partner of Ventures VII and Schwab and Parmar are the managing members of Partners VII. Each of Partners VII, Schwab and Parmar shares voting and dispositive power over the shares held by Ventures VII.

     

    (3)This percentage is calculated based upon 29,596,965 shares of common stock outstanding as of November 5, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 7, 2024.

     

    2

     

     

    CUSIP No.   252828108
    1.

    Names of Reporting Persons

    5AM Partners VII, LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨             (b) x (1)

    3.

    SEC Use Only

     

    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    1,027,711 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    1,027,711 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    1,027,711 (2)

    10.

    Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨

     

    11.

    Percent of Class Represented by Amount in Row (9)

    3.5% (3)

    12.

    Type of Reporting Person (See Instructions)

    OO       

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Consists of 1,027,711 shares of Common Stock held by Ventures VII. Partners VII is the sole general partner of Ventures VII and Schwab and Parmar are the managing members of Partners VII. Each of Partners VII, Schwab and Parmar shares voting and dispositive power over the shares held by Ventures VII.

     

    (3)This percentage is calculated based upon 29,596,965 shares of common stock outstanding as of November 5, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 7, 2024.

     

    3

     

     

    CUSIP No.   252828108
    1.

    Names of Reporting Persons

    5AM Opportunities II, L.P.

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨             (b) x (1)

    3.

    SEC Use Only

     

    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    0

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    0

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    0

    10.

    Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨

     

    11.

    Percent of Class Represented by Amount in Row (9)

    0.0%

    12.

    Type of Reporting Person (See Instructions)

    PN

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    4

     

     

    CUSIP No.   252828108
    1.

    Names of Reporting Persons

    5AM Opportunities II (GP), LLC

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨             (b) x (1)

    3.

    SEC Use Only

     

    4.

    Citizenship or Place of Organization

    Delaware

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    0

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    0

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    0

    10.

    Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨

     

    11.

    Percent of Class Represented by Amount in Row (9)

    0.0%

    12.

    Type of Reporting Person (See Instructions)

    OO

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    5

     

     

    CUSIP No.   252828108
    1.

    Names of Reporting Persons

    Andrew J. Schwab

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨             (b) x (1)

    3.

    SEC Use Only

     

    4.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    1,027,711 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    1,027,711 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    1,027,711 (2)

    10.

    Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨

     

    11.

    Percent of Class Represented by Amount in Row (9)

    3.5% (3)

    12.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Consists of 1,027,711 shares of Common Stock held by Ventures VII. Partners VII is the sole general partner of Ventures VII and Schwab and Parmar are the managing members of Partners VII. Each of Partners VII, Schwab and Parmar shares voting and dispositive power over the shares held by Ventures VII.

     

    (3)This percentage is calculated based upon 29,596,965 shares of common stock outstanding as of November 5, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 7, 2024.

     

    6

     

     

    CUSIP No.   252828108
    1.

    Names of Reporting Persons

    Kush Parmar

    2.

    Check the Appropriate Box if a Member of a Group (See Instructions)

    (a) ¨             (b) x (1)

    3.

    SEC Use Only

     

    4.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    5.

    Sole Voting Power

    0

    6.

    Shared Voting Power

    1,027,711 (2)

    7.

    Sole Dispositive Power

    0

    8.

    Shared Dispositive Power

    1,027,711 (2)

    9.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    1,027,711 (2)

    10.

    Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)    ¨

     

    11.

    Percent of Class Represented by Amount in Row (9)

    3.5% (3)

    12.

    Type of Reporting Person (See Instructions)

    IN

           

    (1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

     

    (2)Consists of 1,027,711 shares of Common Stock held by Ventures VII. Partners VII is the sole general partner of Ventures VII and Schwab and Parmar are the managing members of Partners VII. Each of Partners VII, Schwab and Parmar shares voting and dispositive power over the shares held by Ventures VII.

     

    (3)This percentage is calculated based upon 29,596,965 shares of common stock outstanding as of November 5, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 7, 2024.

     

    7

     

     

    Item 1.
      (a)

    Name of Issuer

    Dianthus Therapeutics, Inc.

      (b)

    Address of Issuer’s Principal Executive Offices

    7 Times Square, 43rd Floor

    New York, NY 10036

     
    Item 2.
      (a)

    Name of Person Filing

    5AM Ventures VII, L.P. (“Ventures VII”)

    5AM Partners VII, LLC (“Partners VII”)

    5AM Opportunities II, L.P. (“Opps II”)

    5AM Opportunities II (GP), LLC (“Opps II GP”)

    Andrew J. Schwab (“Schwab”)

    Dr. Kush Parmar (“Parmar”)

      (b)

    Address of Principal Business Office or, if none, Residence

    c/o 5AM Ventures

    4 Embarcadero Center, Suite 3110
    San Francisco, CA 94111

      (c) Citizenship    
        Entities: Ventures VII -  Delaware
          Partners VII -  Delaware
          Opps II -  Delaware
          Opps II GP -  Delaware
               
        Individuals: Schwab -  United States
          Parmar - United States

      (d)

    Title of Class of Securities

    Common Stock, $0.001 par value (“Common Stock”)

      (e)

    CUSIP Number

    252828108

     
    Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
       
      Not applicable

     

    8

     

     

    Item 4.Ownership

       

    The following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1 is provided as of November 14, 2024:

     

    Reporting
    Persons
     

    Shares Held
    Directly

      

    Sole
    Voting
    Power

      

    Shared
    Voting
    Power

      

    Sole
    Dispositive
    Power

      

    Shared
    Dispositive
    Power

      

    Beneficial
    Ownership

      

    Percentage
    of Class (2)

     
    Ventures VII (1)   1,027,711    0    1,027,711    0    1,027,711    1,027,711    3.5%
    Partners VII (1)   0    0    1,027,711    0    1,027,711    1,027,711    3.5%
    Opps II   0    0    0    0    0    0    0.0%
    Opps II GP   0    0    0    0    0    0    0.0%
    Schwab (1)   0    0    1,027,711    0    1,027,711    1,027,711    3.5%
    Parmar (1)   0    0    1,027,711    0    1,027,711    1,027,711    3.5%

                   

    (1)     Consists of 1,027,711 shares of Common Stock held by Ventures VII. Partners VII is the sole general partner of Ventures VII and Schwab and Parmar are the managing members of Partners VII. Each of Partners VII, Schwab and Parmar shares voting and dispositive power over the shares held by Ventures VII.

    (2)     This percentage is calculated based upon 29,596,965 shares of common stock outstanding as of November 5, 2024, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 7, 2024..

     
    Item 5. Ownership of Five Percent or Less of a Class
       
      If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   x
     
    Item 6. Ownership of More than Five Percent on Behalf of Another Person
       
      Not applicable
     
    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
       
      Not applicable
       
    Item 8. Identification and Classification of Members of the Group
       
      Not applicable
     
    Item 9. Notice of Dissolution of Group
       
      Not applicable
     
    Item 10. Certification
       
      By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.
                       

    9

     

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: November 14, 2024

     

    5AM Ventures VII, L.P.   5AM Partners VII, LLC
             
    By: 5AM Partners VII, LLC   By: /s/ Andrew J. Schwab
    its General Partner     Name: Andrew J. Schwab
            Title: Managing Member
             
    By: /s/ Andrew J. Schwab      
      Name: Andrew J. Schwab      
      Title: Managing Member      

     

    5AM Opportunities II, L.P.   5AM Opportunities II (GP), LLC
             
    By: 5AM Opportunities II (GP), LLC   By: /s/ Andrew J. Schwab
    its General Partner     Name: Andrew J. Schwab
            Title: Managing Member
             
    By: /s/ Andrew J. Schwab      
      Name: Andrew J. Schwab      
      Title: Managing Member      
             
    /s/ Andrew J. Schwab      
    Andrew J. Schwab      
           
    /s/ Dr. Kush Parmar      
    Dr. Kush Parmar      

     

      ATTENTION  
    Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).

     

    10

     

     

    Exhibit(s):

     

    AJoint Filing Agreement

     

    11

     

     

    EXHIBIT A

     

    JOINT FILING AGREEMENT

     

    We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the Common Stock of Dianthus Therapeutics, Inc. is filed on behalf of each of us.

     

    Dated: November 14, 2024

     

    5AM Ventures VII, L.P.   5AM Partners VII, LLC
             
    By: 5AM Partners VII, LLC   By: /s/ Andrew J. Schwab
    its General Partner     Name: Andrew J. Schwab
            Title: Managing Member
             
    By: /s/ Andrew J. Schwab      
      Name: Andrew J. Schwab      
      Title: Managing Member      

     

    5AM Opportunities II, L.P.   5AM Opportunities II (GP), LLC
             
    By: 5AM Opportunities II (GP), LLC   By: /s/ Andrew J. Schwab
    its General Partner     Name: Andrew J. Schwab
            Title: Managing Member
             
    By: /s/ Andrew J. Schwab      
      Name: Andrew J. Schwab      
      Title: Managing Member      
             
    /s/ Andrew J. Schwab      
    Andrew J. Schwab      
           
    /s/ Dr. Kush Parmar      
    Dr. Kush Parmar      

     

     

     

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    Dr. Read brings >30 years of leadership and scientific expertise in the biopharmaceutical industry Previously served as CEO and Founder of Mariana Oncology until its acquisition by Novartis in 2024 and CSO of Ra Pharma until its acquisition by UCB in 2020 NEW YORK and WALTHAM, Mass., May 22, 2025 (GLOBE NEWSWIRE) -- Dianthus Therapeutics, Inc. (NASDAQ:DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the appointment of Simon Read, Ph.D., to the Company's Board of Directors. Dr. Read is a serial entrepreneur with more than 30 years of biopharmaceutical experi

    5/22/25 4:10:00 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    Dianthus Therapeutics Strengthens Strategic Commercial Leadership With Appointment of John C. King as Chief Commercial Officer and Welcomes Sujay Kango, A Seasoned Commercial Leader, to Board of Directors

    Mr. King launched the first approved biologic and C5 complement inhibitor into the Myasthenia Gravis market and helped set the foundation for the multi-billion dollar C5 franchise of Alexion Mr. King also led the commercial strategy behind the first FDA-approved, self-administered, subcutaneous biologic for gMG as the Chief Commercial Officer of Ra Pharma, acquired by UCB for $2.5 billion Mr. Kango has >26 years of industry experience spanning senior executive, commercial and business development roles in the pharmaceutical and biotechnology sector NEW YORK and WALTHAM, Mass., March 05, 2025 (GLOBE NEWSWIRE) -- Dianthus Therapeutics, Inc. (NASDAQ:DNTH), a clinical-stage biotechnology co

    3/5/25 7:00:00 AM ET
    $DNTH
    Biotechnology: Pharmaceutical Preparations
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    Dianthus Therapeutics Enhances Leadership Team with Appointment of Jeffrey Stavenhagen, Ph.D., as Chief Scientific Officer

    Dr. Stavenhagen brings over 20 years of experience in leading drug discovery initiatives, with a focus on monoclonal antibodies targeting neuro diseases Jennifer Davis Ruff also named Vice President, Head of Investor Relations & Corporate Affairs with over 20 years of experience at leading public biopharmaceutical companies NEW YORK and WALTHAM, Mass., Nov. 29, 2023 (GLOBE NEWSWIRE) -- Dianthus Therapeutics, Inc. (NASDAQ:DNTH), a clinical-stage biotechnology company dedicated to advancing the next generation of antibody complement therapeutics to treat severe autoimmune diseases, today announced the appointment of Jeffrey Stavenhagen, Ph.D., as Chief Scientific Officer. In this role, Dr.

    11/29/23 4:05:00 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    $DNTH
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    Dianthus Therapeutics Highlights Recent Business Achievements, Including GO Decision for Phase 3 CAPTIVATE CIDP Trial, and Reports Q4 and FY 2025 Financial Results

    Early GO decision reached in CAPTIVATE ahead of Q2'26 guidance based on GO criteria of 20 confirmed responders achieved with less than 40 planned participants completing open-label Part A  Phase 3 registrational trial of claseprubart evaluating 300mg/2mL Q2W and 300mg/2mL Q4W in generalized Myasthenia Gravis (gMG) expected to initiate in mid-2026; top-line results anticipated in 2H'28 Phase 2 MoMeNtum trial of claseprubart in Multifocal Motor Neuropathy (MMN) ongoing; top-line results on track for 2H'26 Phase 1 healthy volunteer data for DNTH212 anticipated in 2H'26; update on indication prioritization planned for 1H'26 $514.4 million of cash as of December 31, 2025 provides runway into

    3/9/26 7:09:07 AM ET
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    Dianthus Therapeutics Announces Early GO Decision Following Interim Responder Analysis in Phase 3 CAPTIVATE Trial of Claseprubart in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    Early GO decision reached ahead of Q2'26 guidance based on GO criteria of 20 confirmed responders achieved with less than 40 planned participants completing open-label Part A  Key objectives achieved: Company will maintain the Part A dose of 300mg/2mL S.C. Q2W, plans to engage with regulators to remove the 600mg/4mL S.C. Q2W dose arm from Part B, and expects to enroll up to 256 patients in Part A to randomize 128 patients in Part B Independent DSMB review confirmed GO decision; no related serious infections, no clinical symptoms of autoimmune activation, and no related serious adverse events or discontinuations GO decision supports continued development of claseprubart 300mg/2mL Q2W S.C.

    3/9/26 7:00:00 AM ET
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    Dianthus Therapeutics to Host Conference Call and Webcast to Discuss the Interim Responder Analysis Results of the Phase 3 Captivate Trial of Claseprubart in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    NEW YORK and WALTHAM, Mass., March 08, 2026 (GLOBE NEWSWIRE) -- Dianthus Therapeutics, Inc. (NASDAQ:DNTH), a clinical-stage biotechnology company dedicated to developing next-generation therapies to transform the treatment of severe autoimmune diseases, today announced a conference call and webcast to discuss the interim responder analysis results from Part A of the Phase 3 CAPTIVATE trial of claseprubart in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) scheduled for tomorrow, Monday, March 9, 2026 at 8:00 a.m. ET. Investor Conference Call & Webcast InformationTo access the live conference call by phone, please register here. Conference call participants in the question and ans

    3/8/26 5:00:00 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    Amendment: SEC Form SC 13D/A filed by Dianthus Therapeutics Inc.

    SC 13D/A - Dianthus Therapeutics, Inc. /DE/ (0001690585) (Subject)

    12/3/24 9:19:18 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    SEC Form SC 13G filed by Dianthus Therapeutics Inc.

    SC 13G - Dianthus Therapeutics, Inc. /DE/ (0001690585) (Subject)

    11/22/24 4:41:50 PM ET
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    Amendment: SEC Form SC 13G/A filed by Dianthus Therapeutics Inc.

    SC 13G/A - Dianthus Therapeutics, Inc. /DE/ (0001690585) (Subject)

    11/14/24 5:48:32 PM ET
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    Biotechnology: Pharmaceutical Preparations
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