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    Amendment: SEC Form SCHEDULE 13D/A filed by Apogee Therapeutics Inc.

    3/27/26 5:30:11 PM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $APGE alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 5)


    Apogee Therapeutics, Inc.

    (Name of Issuer)


    Common Stock, $0.00001 par value

    (Title of Class of Securities)




    03770N101

    (CUSIP Number)
    Ms. Erin O'Connor
    Fairmount Funds Management LLC, 200 Barr Harbor Drive, Suite 400
    West Conshohocken, PA, 19428
    (267) 262-5300

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    03/26/2026

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).




    schemaVersion:


    SCHEDULE 13D

    CUSIP Number(s):
    03770N101


    1 Name of reporting person

    Fairmount Funds Management LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    6,666,332.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    6,666,332.00
    11Aggregate amount beneficially owned by each reporting person

    6,666,332.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.84 %
    14Type of Reporting Person (See Instructions)

    IA

    Comment for Type of Reporting Person:
    The securities include (i) 298,647 shares of common stock, $0.00001 par value per share (the "Common Stock") and (ii) 6,367,685 shares of Common Stock issuable upon conversion of 6,367,685 shares of Non-Voting Common Stock, par value $0.00001 per share (the "Non-Voting Common Stock"), the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock, both directly held by Fairmount Healthcare Fund II L.P., a Delaware limited partnership ("Fund II"). The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock held by Fund II in excess of the beneficial ownership limitation. Row 13 is based on 67,754,402 shares of Common Stock outstanding as of March 26, 2026, consisting of (i) 61,302,301 shares of Common Stock outstanding as of March 26, 2026, as reported in the Company's final prospectus supplement filed pursuant to Rule 424(b)(5) dated March 24, 2026, (ii) 84,416 shares underlying vested stock options owned by the Reporting Persons and (iii) 6,367,685 shares of Common Stock underlying the 6,367,685 shares of Non-Voting Common Stock owned by Fund II, applying the beneficial ownership limitation.


    SCHEDULE 13D

    CUSIP Number(s):
    03770N101


    1 Name of reporting person

    Fairmount Healthcare Fund II L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    6,666,332.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    6,666,332.00
    11Aggregate amount beneficially owned by each reporting person

    6,666,332.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.84 %
    14Type of Reporting Person (See Instructions)

    PN

    Comment for Type of Reporting Person:
    The securities include (i) 298,647 shares of Common Stock and (ii) 6,367,685 shares of Common Stock issuable upon conversion of 6,367,685 shares of Non-Voting Common Stock, the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock, both directly held by Fund II. The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock held by Fund II in excess of the beneficial ownership limitation. Row 13 is based on 67,754,402 shares of Common Stock outstanding as of March 26, 2026, consisting of (i) 61,302,301 shares of Common Stock outstanding as of March 26, 2026, as reported in the Company's final prospectus supplement filed pursuant to Rule 424(b)(5) dated March 24, 2026, (ii) 84,416 shares underlying vested stock options owned by the Reporting Persons and (iii) 6,367,685 shares of Common Stock underlying the 6,367,685 shares of Non-Voting Common Stock owned by Fund II, applying the beneficial ownership limitation.


    SCHEDULE 13D

    CUSIP Number(s):
    03770N101


    1 Name of reporting person

    Peter Evan Harwin
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    93,374.00
    8Shared Voting Power

    6,671,600.00
    9Sole Dispositive Power

    93,374.00
    10Shared Dispositive Power

    6,671,600.00
    11Aggregate amount beneficially owned by each reporting person

    6,764,974.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.99 %
    14Type of Reporting Person (See Instructions)

    IN, HC

    Comment for Type of Reporting Person:
    The securities include (a) 51,166 shares of Common Stock held directly by Mr. Harwin, (b) 42,208 shares of Common Stock underlying vested options held by Mr. Harwin* and (c) Fund II's direct holdings of (i) 298,647 shares of Common Stock and (ii) 6,372,953 shares of Common Stock issuable upon conversion of 6,372,953 shares of Non-Voting Common Stock, the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock. The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock in excess of the beneficial ownership limitation. Row 13 is based on 67,717,462 shares of Common Stock outstanding as of March 26, 2026, consisting of (i) 61,302,301 shares of Common Stock outstanding as of March 26, 2026, as reported in the Company's final prospectus supplement filed pursuant to Rule 424(b)(5) dated March 24, 2026, (ii) 42,208 shares of Common Stock underlying vested options held by Mr. Harwin and (iii) 6,372,953 shares of Common Stock underlying the 6,372,953 shares of Non-Voting Common Stock owned by Fund II, subject to the beneficial ownership limitation. * Under Mr. Harwin's arrangement with Fairmount, Mr. Harwin holds the options for one or more investment vehicles managed by Fairmount (each, a "Fairmount Fund"). Mr. Harwin is obligated to turn over to Fairmount any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Harwin therefore disclaims beneficial ownership of the option and underlying common stock.


    SCHEDULE 13D

    CUSIP Number(s):
    03770N101


    1 Name of reporting person

    Tomas Kiselak
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    SLOVAKIA
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    93,374.00
    8Shared Voting Power

    6,671,600.00
    9Sole Dispositive Power

    93,374.00
    10Shared Dispositive Power

    6,671,600.00
    11Aggregate amount beneficially owned by each reporting person

    6,764,974.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.99 %
    14Type of Reporting Person (See Instructions)

    IN, HC

    Comment for Type of Reporting Person:
    The securities include (a) 51,166 shares of Common Stock held directly by Mr. Kiselak, (b) 42,208 shares of Common Stock underlying vested options held by Mr. Kiselak* and (c) Fund II's direct holdings of (i) 298,647 shares of Common Stock and (ii) 6,372,953 shares of Common Stock issuable upon conversion of 6,372,953 shares of Non-Voting Common Stock, the conversion of which is subject to a beneficial ownership limitation of 9.99% of the outstanding Common Stock. The securities exclude shares of Common Stock issuable upon conversion of shares of Non-Voting Common Stock in excess of the beneficial ownership limitation. Row 13 is based on 67,717,462 shares of Common Stock outstanding as of March 26, 2026, consisting of (i) 61,302,301 shares of Common Stock outstanding as of March 26, 2026, as reported in the Company's final prospectus supplement filed pursuant to Rule 424(b)(5) dated March 24, 2026, (ii) 42,208 shares of Common Stock underlying vested options held by Mr. Kiselak and (iii) 6,372,953 shares of Common Stock underlying the 6,372,953 shares of Non-Voting Common Stock owned by Fund II, subject to the beneficial ownership limitation. * Under Mr. Kiselak's arrangement with Fairmount, Mr. Kiselak holds the options for one or more investment vehicles managed by Fairmount (each, a "Fairmount Fund"). Mr. Kiselak is obligated to turn over to Fairmount any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Kiselak therefore disclaims beneficial ownership of the option and underlying common stock.


    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, $0.00001 par value
    (b)Name of Issuer:

    Apogee Therapeutics, Inc.
    (c)Address of Issuer's Principal Executive Offices:

    221 Crescent Street, Building 17, Suite 102b, Waltham, MASSACHUSETTS , 02453.
    Item 1 Comment:
    This Amendment No. 5 amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the "SEC") on July 21, 2023, Amendment No. 1 filed on January 31, 2024, Amendment No. 2 filed on April 1, 2024, Amendment No. 3 filed on October 14, 2025, and Amendment No. 4 filed on January 22, 2026 (as amended, the "Statement" or the "Schedule 13D") by the Reporting Persons with respect to the Common Stock of the Company. Unless otherwise defined herein, capitalized terms used in this Amendment No. 4 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged.
    Item 5.Interest in Securities of the Issuer
    (a)
    The information in rows 11 and 13 of each of the cover pages (including the explanatory note in the "Comments") of this Amendment No. 5 is incorporated by reference herein.
    (b)
    The information in rows 7 through 10 of each of the cover pages of this Amendment No. 5 is incorporated by reference herein. In the aggregate, the Reporting Persons have voting and dispositive power over 6,264,531 shares of Common Stock, which is comprised of the following: (i) 298,647 shares of Common Stock held by Fund II; (ii) 6,264,531 shares of Common Stock issuable upon conversion of 6,264,531 shares of Non-Voting Common Stock, held by Fund II, reflecting the beneficial ownership limitation of 9.99% of the outstanding Common Stock; (iii) 51,166 shares of Common Stock held by Mr. Harwin; (iv) 42,208 shares of Common Stock underlying vested options held by Mr. Harwin; (v) 51,166 shares of Common Stock held by Mr. Kiselak; and (vi) 42,208 shares of Common Stock underlying vested options held by Mr. Kiselak. In total, Fund II currently owns 6,743,321 shares of Non-Voting Common Stock.
    (c)
    None
    Item 6.Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
     
    Lock-Up Agreement In connection with the Company's underwritten public offering of common stock that closed on March 26, 2026, Fund II entered into a customary lock-up letter agreement (the "Lock-Up Agreement") with Jefferies LLC, TD Securities (USA) LLC, Stifel, Nicolaus & Company, Incorporated and Guggenheim Securities, LLC, as representatives of the several underwriters party to an underwriting agreement with the Company. Pursuant to the Lock-Up Agreement, Fund II agreed to refrain from selling shares of the Company's securities without the consent of Jefferies LLC, and other customary lock-up conditions, for a period of 60 days from the date of the Company's final prospectus supplement related to the offering. The Reporting Persons did not purchase any securities of the Company or otherwise participate in the offering. The foregoing description of the Lock-Up Agreement does not purport to be complete and is qualified in its entirety by reference to the form of the Lock-Up Agreement, which is filed as Exhibit 99.2 to this Schedule 13D and incorporated herein by reference.
    Item 7.Material to be Filed as Exhibits.
     
    99.1 Joint Filing Agreement (incorporated by reference to Exhibit 99.1 to the Schedule 13D filed with the SEC on October 14, 2025) 99.2 Lock-Up Agreement (incorporated by reference to Exhibit A to the Underwriting Agreement filed as Exhibit 1.1 of the Company's Form 8-K filed with the SEC on March 25, 2026)

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Fairmount Funds Management LLC
     
    Signature:/s/ Peter Harwin
    Name/Title:Peter Harwin, Managing Member
    Date:03/27/2026
     
    Signature:/s/ Tomas Kiselak
    Name/Title:Tomas Kiselak, Managing Member
    Date:03/27/2026
     
    Fairmount Healthcare Fund II L.P.
     
    Signature:/s/ Peter Harwin
    Name/Title:Peter Harwin, Managing Member
    Date:03/27/2026
     
    Signature:/s/ Tomas Kiselak
    Name/Title:Tomas Kiselak, Managing Member
    Date:03/27/2026
     
    Peter Evan Harwin
     
    Signature:/s/ Peter Harwin
    Name/Title:Peter Harwin
    Date:03/27/2026
     
    Tomas Kiselak
     
    Signature:/s/ Tomas Kiselak
    Name/Title:Tomas Kiselak
    Date:03/27/2026
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    Phase 1b interim results of zumilokibart (APG777) in asthma demonstrated rapid and durable suppression of FeNO (key biomarker of Type 2 inflammation) through 16 weeks for all patients - Suppression of FeNO through 32 weeks for patients with available follow up - Results reinforce continued development in asthma testing every 3- or 6-month dosing Successful expansion of zumilokibart beyond dermatology confirms its pipeline-in-a-product potential across I&I indications Zumilokibart in atopic dermatitis (AD) advancing in Phase 2 APEX trials with goal of Phase 3 initiation by end of 2026:- Part A maintenance (52-week) data readout expected in Q1 2026 with potential to establish best-in-class e

    1/6/26 6:00:00 AM ET
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    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

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    Large Ownership Changes

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    Amendment: SEC Form SC 13G/A filed by Apogee Therapeutics Inc.

    SC 13G/A - Apogee Therapeutics, Inc. (0001974640) (Subject)

    11/14/24 5:46:11 PM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    SEC Form SC 13G filed by Apogee Therapeutics Inc.

    SC 13G - Apogee Therapeutics, Inc. (0001974640) (Subject)

    11/14/24 11:16:12 AM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Apogee Therapeutics Inc.

    SC 13G/A - Apogee Therapeutics, Inc. (0001974640) (Subject)

    11/14/24 10:18:32 AM ET
    $APGE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care