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    Amendment: SEC Form SCHEDULE 13D/A filed by Monte Rosa Therapeutics Inc.

    3/19/26 4:05:18 PM ET
    $GLUE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $GLUE alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 3)


    Monte Rosa Therapeutics, Inc.

    (Name of Issuer)


    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)




    61225M102

    (CUSIP Number)
    Stephanie Brecher
    New Enterprise Associates, 1954 Greenspring Drive, Suite 600
    Timonium, MD, 21093
    (410)842-4000

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    03/17/2026

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).




    schemaVersion:


    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    New Enterprise Associates 17, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    NEA Partners 17, L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    NEA 17 GP, LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    OO



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Forest Baskett
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Ali Behbahani
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    104,732.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    104,732.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,797,030.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.7 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Carmen Chang
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Anthony A. Florence, Jr.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Mohamad H. Makhzoumi
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Edward T. Mathers
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Scott D. Sandell
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Paul Walker
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    CUSIP Number(s):
    61225M102


    1 Name of reporting person

    Rick Yang
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    AF
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED STATES
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    7,692,298.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    7,692,298.00
    11Aggregate amount beneficially owned by each reporting person

    7,692,298.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    9.6 %
    14Type of Reporting Person (See Instructions)

    IN



    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common Stock, par value $0.0001 per share
    (b)Name of Issuer:

    Monte Rosa Therapeutics, Inc.
    (c)Address of Issuer's Principal Executive Offices:

    321 Harrison Avenue, Suite 900, Boston, MASSACHUSETTS , 02118.
    Item 1 Comment:
    This Amendment No. 3 ("Amendment No. 3") to Schedule 13D amends and supplements the Schedule 13D originally filed on July 12, 2021 (the "Schedule 13D"), Amendment No. 1 thereto filed on May 13, 2024 ("Amendment No. 1") and Amendment No. 2 thereto filed on August 12, 2024 ("Amendment No. 2") relating to the Common Stock of the Issuer. Certain terms used but not defined in this Amendment No. 3 have the meanings assigned thereto in the Schedule 13D (and Amendment No. 1 and Amendment No. 2 thereto). Except as specifically provided herein, this Amendment No. 3 does not modify any of the information previously reported on the Schedule 13D (and Amendment No. 1 and Amendment No. 2 thereto). This Amendment No. 3 is being filed to report that the beneficial ownership of Common Stock by the Reporting Persons (as defined below) has decreased by more than 1% as a result of an increase in the number of Common Stock outstanding.
    Item 2.Identity and Background
    (a)
    New Enterprise Associates 17, L.P. ("NEA 17"); NEA Partners 17, L.P. ("NEA Partners 17"), which is the sole general partner of NEA 17; and NEA 17 GP, LLC ("NEA 17 LLC" and, together with NEA Partners 17, the "Control Entities"), which is the sole general partner of NEA Partners 17; and Forest Baskett ("Baskett"), Ali Behbahani ("Behbahani"), Carmen Chang ("Chang"), Anthony A. Florence, Jr. ("Florence"), Mohamad H. Makhzoumi ("Makhzoumi"), Edward T. Mathers ("Mathers"), Scott D. Sandell ("Sandell"), Paul Walker ("Walker"), and Rick Yang ("Yang") (together, the "Managers"). The Managers are the managers of NEA 17 LLC. The persons named in this Item 2 are referred to individually herein as "Reporting Person" and collectively as the "Reporting Persons."
    (b)
    The address of the principal business office of NEA 17, each Control Entity and Sandell is New Enterprise Associates, 1954 Greenspring Drive, Suite 600, Timonium, MD 21093. The address of the principal business office of Baskett, Behbahani, Chang, Makhzoumi, Walker and Yang is New Enterprise Associates, 2855 Sand Hill Road, Menlo Park, CA 94025. The address of the principal business office of Florence and Mathers is New Enterprise Associates, 104 5th Avenue, 19th Floor, New York, NY 10011.
    (c)
    The principal business of NEA 17 is to invest in and assist growth-oriented businesses located principally in the United States. The principal business of NEA Partners 17 is to act as the sole general partner of NEA 17. The principal business of NEA 17 LLC is to act as the sole general partner of NEA Partners 17. The principal business of each of the Managers is to manage the Control Entities, NEA 17 and a number of affiliated partnerships with similar businesses.
    (d)
    During the five years prior to the date hereof, none of the Reporting Persons has been convicted in a criminal proceeding or has been a party to a civil proceeding ending in a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.
    (e)
    During the five years prior to the date hereof, none of the Reporting Persons has been convicted in a criminal proceeding or has been a party to a civil proceeding ending in a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.
    (f)
    NEA 17 LLC is a limited liability company organized under the laws of the State of Delaware. NEA 17 and NEA Partners 17 are limited partnerships organized under the laws of the State of Delaware. Each of the Managers is a United States citizen.
    Item 3.Source and Amount of Funds or Other Consideration
     
    Not applicable.
    Item 4.Purpose of Transaction
     
    NEA 17 acquired the NEA 17 Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, NEA 17 and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board; (e) Any material change in the present capitalization or dividend policy of the Issuer; (f) Any other material change in the Issuer's business or corporate structure; (g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person; (h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association; (i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or (j) Any action similar to any of those enumerated above.
    Item 5.Interest in Securities of the Issuer
    (a)
    NEA 17 is the record owner of the NEA 17 Shares. As the general partner of NEA 17, NEA Partners 17 may be deemed to own beneficially the NEA 17 Shares. As the sole general partner of NEA Partners 17, NEA 17 LLC may be deemed to beneficially own the NEA 17 Shares. As members of NEA 17 LLC each of the Managers may be deemed to own beneficially the NEA 17 Shares. Each Reporting Person disclaims beneficial ownership of the NEA 17 Shares other than those shares which such person owns of record. As of March 19, 2026, Behbahani is the record owner of options to purchase 104,732 shares of Common Stock exercisable within 60 days (the "Behbahani Option Shares"). The percentage of outstanding Common Stock of the Issuer which may be deemed to be beneficially owned by each Reporting Person is set forth on Line 13 of such Reporting Person's cover sheet. Such percentage was calculated based on the 80,015,667 shares of Common Stock reported by the Issuer to be outstanding as of March 2, 2026, as reported on the Issuer's Form 10-K filed with the Securities and Exchange Commission on March 17, 2026. The percentage set forth on the cover sheet for Behbahani is calculated based on the shares described in the preceding sentence plus the Behbahani Option Shares.
    (b)
    Regarding the number of shares as to which such person has: (i) sole power to vote or to direct the vote: See line 7 of cover sheets (ii) shared power to vote or to direct the vote: See line 8 of cover sheets (iii) sole power to dispose or to direct the disposition: See line 9 of cover sheets (iv) shared power to dispose or to direct the disposition: See line 10 of cover sheets.
    (c)
    None of the Reporting Persons has effected any transaction in the last 60 days.
    (d)
    No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, Common Stock beneficially owned by any of the Reporting Persons.
    (e)
    Not applicable.
    Item 6.Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
     
    Not applicable.
    Item 7.Material to be Filed as Exhibits.
     
    Exhibit 1 - Agreement regarding filing of joint Schedule 13D. Exhibit 2 - Power of Attorney regarding filings under the Securities Exchange Act of 1934, as amended.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    New Enterprise Associates 17, L.P.
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Anthony A. Florence Jr., Managing Partner and Co-Chief Executive Officer
    Date:03/19/2026
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Mohamad H. Makhzoumi, Managing Partner and Co-Chief Executive Officer
    Date:03/19/2026
     
    NEA Partners 17, L.P.
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Anthony A. Florence Jr., Managing Partner and Co-Chief Executive Officer
    Date:03/19/2026
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Mohamad H. Makhzoumi, Managing Partner and Co-Chief Executive Officer
    Date:03/19/2026
     
    NEA 17 GP, LLC
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Anthony A. Florence Jr., Managing Partner and Co-Chief Executive Officer
    Date:03/19/2026
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Mohamad H. Makhzoumi, Managing Partner and Co-Chief Executive Officer
    Date:03/19/2026
     
    Forest Baskett
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Forest Baskett
    Date:03/19/2026
     
    Ali Behbahani
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Ali Behbahani
    Date:03/19/2026
     
    Carmen Chang
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Carmen Chang
    Date:03/19/2026
     
    Anthony A. Florence, Jr.
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Anthony A. Florence, Jr.
    Date:03/19/2026
     
    Mohamad H. Makhzoumi
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Mohamad H. Makhzoumi
    Date:03/19/2026
     
    Edward T. Mathers
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Edward T. Mathers
    Date:03/19/2026
     
    Scott D. Sandell
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Scott D. Sandell
    Date:03/19/2026
     
    Paul Walker
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Paul Walker
    Date:03/19/2026
     
    Rick Yang
     
    Signature:/s/ Zachary Bambach
    Name/Title:Zachary Bambach as attorney-in-fact for Rick Yang
    Date:03/19/2026
    Comments accompanying signature:
    This Amendment No. 3 to Schedule 13D was executed by Zachary Bambach on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which is attached as Exhibit 2.
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    Amendment: SEC Form SCHEDULE 13D/A filed by Monte Rosa Therapeutics Inc.

    SCHEDULE 13D/A - Monte Rosa Therapeutics, Inc. (0001826457) (Subject)

    3/19/26 4:05:18 PM ET
    $GLUE
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    SEC Form S-8 filed by Monte Rosa Therapeutics Inc.

    S-8 - Monte Rosa Therapeutics, Inc. (0001826457) (Filer)

    3/18/26 11:37:59 AM ET
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    SEC Form 10-K filed by Monte Rosa Therapeutics Inc.

    10-K - Monte Rosa Therapeutics, Inc. (0001826457) (Filer)

    3/17/26 7:14:47 AM ET
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    Director Leo Chandra P. bought $58,383 worth of shares (10,000 units at $5.84) (SEC Form 4)

    4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

    3/25/25 6:32:00 PM ET
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    Monte Rosa Therapeutics Announces Fourth Quarter and Full-Year 2025 Financial Results and Business Updates

    Positive interim Phase 1 data of NEK7-directed MGD MRT-8102 demonstrated profound CRP reductions in elevated CVD-risk subjects; readout of expanded part 3 CRP PoC trial (now called GFORCE-1) anticipated in H2 2026 Newly announced unblinded safety data from MRT-8102 SAD/MAD cohorts continue to support favorable safety/tolerability profile and wide therapeutic window Company plans to initiate multiple Phase 2 studies of MRT-8102, including in patients with elevated CVD-risk in H2 2026, in patients with gout flares in Q4 2026/Q1 2027, and in patients with moderate to severe hidradenitis suppurativa in H1 2027 Presented positive interim data from the Phase 1/2 clinical study of MRT-2359 in co

    3/17/26 7:00:00 AM ET
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    Monte Rosa Therapeutics Announces Clinical Supply Agreement to Support Phase 2 Trial Evaluating MRT-2359 in Combination with Apalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

    MRT-2359 is an investigational, orally bioavailable, GSPT1-directed molecular glue degrader that has shown compelling clinical activity in combination with androgen receptor (AR) inhibition in heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) patients with AR mutations in an ongoing Phase 1/2 clinical study  Monte Rosa plans to initiate a new, signal-confirming Phase 2 study of MRT-2359 in combination with apalutamide targeting AR mutant patients in Q3 2026 BOSTON, March 16, 2026 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (NASDAQ:GLUE), a clinical-stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced th

    3/16/26 7:00:00 AM ET
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    Monte Rosa Therapeutics Presents Updated Clinical Data from Phase 1/2 Study of MRT-2359 in Combination with Enzalutamide in Heavily Pretreated Metastatic Castration-Resistant Prostate Cancer Patients at ASCO Genitourinary Cancers Symposium (ASCO GU)

    In mCRPC patients with androgen receptor (AR) mutations, treatment with MRT-2359 in combination with enzalutamide led to a 100% PSA response rate (5 of 5 patients) and a 100% disease control rate, including 2 patients with RECIST partial responses and 3 with stable disease, all showing reduction in size of target lesions Across all 15 evaluable patients, the overall RECIST disease control rate was 67%, and 10 of 15 patients showed tumor size reductions of target lesions Combination of MRT-2359 and enzalutamide was generally well-tolerated with primarily Grade 1-2 adverse events (AEs); no treatment discontinuations due to AEs Company plans to initiate a new, signal-confirming Phase 2 stud

    2/24/26 7:00:00 AM ET
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    Principal Accounting Officer Dunn Edmund sold $2,496 worth of shares (139 units at $17.96), decreasing direct ownership by 0.61% to 22,554 units (SEC Form 4)

    4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

    3/5/26 5:24:23 PM ET
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    President & CEO Warmuth Markus sold $97,974 worth of shares (5,466 units at $17.92), decreasing direct ownership by 0.88% to 613,471 units (SEC Form 4)

    4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

    3/4/26 4:50:05 PM ET
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    Principal Accounting Officer Dunn Edmund exercised 25,700 shares at a strike of $13.41 and sold $464,886 worth of shares (25,700 units at $18.09) (SEC Form 4)

    4 - Monte Rosa Therapeutics, Inc. (0001826457) (Issuer)

    3/2/26 5:02:46 PM ET
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    Monte Rosa Therapeutics downgraded by Wells Fargo with a new price target

    Wells Fargo downgraded Monte Rosa Therapeutics from Overweight to Equal Weight and set a new price target of $11.00 from $14.00 previously

    12/19/24 7:39:47 AM ET
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    Wedbush initiated coverage on Monte Rosa Therapeutics with a new price target

    Wedbush initiated coverage of Monte Rosa Therapeutics with a rating of Outperform and set a new price target of $11.00

    2/15/24 6:27:11 AM ET
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    Monte Rosa Therapeutics upgraded by Wells Fargo with a new price target

    Wells Fargo upgraded Monte Rosa Therapeutics from Equal Weight to Overweight and set a new price target of $18.00

    1/3/23 8:03:46 AM ET
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    Monte Rosa Therapeutics Appoints Dr. Eric A. Hughes to Board of Directors

    BOSTON, Dec. 13, 2024 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (NASDAQ:GLUE), a clinical-stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced the appointment of Eric A. Hughes, M.D, Ph.D., to its Board of Directors. Dr. Hughes is currently Executive Vice President, Global R&D and Chief Medical Officer of Teva Pharmaceuticals and brings decades of biopharmaceutical industry leadership experience to Monte Rosa. "I am very excited to welcome Dr. Eric Hughes to the Monte Rosa Board of Directors," said Markus Warmuth, M.D., Chief Executive Officer of Monte Rosa Therapeutics. "Eric brings extensive experience building and lea

    12/13/24 7:00:00 AM ET
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    Monte Rosa Therapeutics Appoints Dr. Anthony M. Manning to Board of Directors

    BOSTON, July 26, 2023 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (NASDAQ:GLUE), a clinical stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced the appointment of Anthony M. Manning, Ph.D., to its Board of Directors. Dr. Manning is a highly accomplished drug discovery leader in the field of autoimmune and inflammatory diseases. "Dr. Manning brings extensive knowledge and experience in the field of immunology and inflammation to our Board of Directors, and we're delighted to have him on our team," said Markus Warmuth, M.D., CEO of Monte Rosa. "Tony's experience developing multiple first-in-class therapeutics for the treatment of

    7/26/23 7:30:00 AM ET
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    Monte Rosa Therapeutics Appoints Dr. Jan Skvarka to Board of Directors

    BOSTON, March 23, 2023 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (NASDAQ:GLUE), a clinical stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced the appointment of Jan Skvarka, Ph.D., MBA to its Board of Directors. Dr. Skvarka is an accomplished biopharmaceutical executive bringing over three decades of extensive operational, strategic and financial expertise to the Board. "We are delighted to have Dr. Skvarka join our Board of Directors, bringing his extensive experience as a life sciences leader to the team," said Markus Warmuth, M.D., CEO of Monte Rosa. "Having served as the CEO of two clinical-stage companies, Jan has demon

    3/23/23 7:30:00 AM ET
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    Monte Rosa Therapeutics Announces Positive Interim Phase 1 Data of MRT-8102 Demonstrating Profound CRP Reductions in Elevated CVD-risk Subjects

    In subjects with elevated cardiovascular disease (CVD) risk, MRT-8102, a NEK7-directed molecular glue degrader in development for the treatment of NLRP3/IL-1/IL-6 driven inflammatory diseases, demonstrated rapid and durable reductions in systemic inflammation  After four weeks of MRT-8102 treatment, C-reactive protein (CRP) levels were reduced by 85%, and 94% of study participants achieved CRP values below 2 mg/L, a threshold associated with reduced cardiovascular disease (CVD) risk Single ascending dose (SAD) and multiple ascending dose (MAD) cohorts demonstrated deep and sustained NEK7 degradation at doses from 5 mg to 400 mg Favorable safety profile observed with mild to moderate adve

    1/7/26 7:00:00 AM ET
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    Monte Rosa Therapeutics to Present Interim MRT-8102 Phase 1 Study Results

    BOSTON, Jan. 06, 2026 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (NASDAQ:GLUE), a clinical-stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced that management will host a live conference call and webcast on Wednesday, January 7, at 8:00 a.m. ET. The webcast presentation will highlight interim clinical results from the ongoing Phase 1 study of the NEK7-directed MGD MRT-8102, including interim data from the ongoing Part 3 CRP proof-of-concept cohort in subjects with elevated cardiovascular disease risk. A webcast of the presentation will be accessible via the "Events & Presentations" section of Monte Rosa's website at ir.montero

    1/6/26 4:05:00 PM ET
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    Monte Rosa Therapeutics Announces Compelling Clinical Activity of MRT-2359 in Combination with Enzalutamide in Heavily Pretreated Metastatic Castration-Resistant Prostate Cancer Patients with Androgen Receptor Mutations

    In mCRPC patients with androgen receptor (AR) mutations, treatment with MRT-2359 in combination with enzalutamide led to a 100% PSA response rate (4 of 4 patients) and a 100% disease control rate, including 2 patients with RECIST responses and 2 with stable disease  Combination of MRT-2359 and enzalutamide was generally well-tolerated with primarily Grade 1-2 adverse events Company plans to initiate a new, signal-confirming Phase 2 study of MRT-2359 targeting AR mutant and AR signaling-dependent patients in 2026 Updated MRT-2359 data expected to be presented at ASCO Genitourinary Cancers Symposium in February 2026 Conference call and webcast planned for today at 8 a.m. ET BOSTON, Dec

    12/16/25 7:00:00 AM ET
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    Amendment: SEC Form SC 13G/A filed by Monte Rosa Therapeutics Inc.

    SC 13G/A - Monte Rosa Therapeutics, Inc. (0001826457) (Subject)

    11/14/24 1:22:39 PM ET
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    Amendment: SEC Form SC 13G/A filed by Monte Rosa Therapeutics Inc.

    SC 13G/A - Monte Rosa Therapeutics, Inc. (0001826457) (Subject)

    11/12/24 10:32:12 AM ET
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    Amendment: SEC Form SC 13D/A filed by Monte Rosa Therapeutics Inc.

    SC 13D/A - Monte Rosa Therapeutics, Inc. (0001826457) (Subject)

    10/30/24 5:10:55 PM ET
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