Amendment: SEC Form SCHEDULE 13D/A filed by Vor Biopharma Inc.

The address of the principal business office of each of the Reporting Persons is 200 Berkeley Street, 18th Floor, Boston, MA 02116.

The Fund is a private investment vehicle. RA Capital provides investment management services to the Fund and the Nexus Fund. The principal occupation of each of Dr. Kolchinsky and Mr. Shah is investment management.

During the last five years, none of the Reporting Persons has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

During the last five years, none of the Reporting Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree of final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

See Item 6 of the cover pages.

Item 3 of the Statement is hereby amended and supplemented as follows: June 2025 Securities Purchase Agreement On June 25, 2025, the Issuer entered into a securities purchase agreement (the "June 2025 Securities Purchase Agreement") with certain accredited investors (the "June 2025 PIPE Investors"), including the Fund, pursuant to which the Issuer agreed to issue and sell to the June 2025 PIPE Investors in a private placement (the "June 2025 Private Placement") Pre-Funded Warrants to purchase up to 700,000,000 shares of common stock at a price of $0.25 per share (the "Pre-Funded Warrant Shares"). The Pre-Funded Warrants have an exercise price of $0.0001 per share and will become exercisable upon approval by the Issuer's stockholders of the issuance of the shares of common stock underlying the Pre-Funded Warrants and a charter amendment that has the effect of increasing the Issuer's authorized shares of common stock (the "Stockholder Approval"). The June 2025 Private Placement closed on June 27, 2025. The Fund purchased Pre-Funded Warrants exercisable for up to 200,000,000 Pre-Funded Warrant Shares in the June 2025 Private Placement, for total consideration of $50,000,000, which was funded by the working capital of the Fund. The foregoing description of the June 2025 Securities Purchase Agreement does not purport to be complete and is qualified in its entirety by reference to the June 2025 Securities Purchase Agreement, a copy of which is filed as Exhibit 99.5 hereto and incorporated by reference herein.

Rows 11 and 13 of each Reporting Person's cover page to this Schedule 13D/A set forth the aggregate number of shares of common stock and percentages of the shares of common stock beneficially owned by such Reporting Person and are incorporated by reference. The percentage set forth in each row 13 is based upon 124,959,520 shares of common stock outstanding as of May 8, 2025 as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on May 14, 2025, and giving effect to stock options, to the extent exercisable within 60 days hereof, as referenced herein.

Rows 7 through 10 of each Reporting Person's cover page to this Schedule 13D/A set forth the number of shares of common stock as to which such Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition and are incorporated by reference.

Except as set forth herein and below, none of the Reporting Persons has effected any transactions with respect to the securities of the Issuer during the past sixty days. No. Price Per Transaction Purchaser Date Shares Share Vest Stock Option (Right to Buy) RA Capital 05/22/2025 30,000 (1) (1) This option represents a right to purchase a total of 30,000 shares of the Issuer's common stock, which vested in full on May 22, 2025. This option has an exercise price of $1.61 per share.

No person (other than the Reporting Persons) is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities subject to this Schedule 13D/A.

Not applicable.

Item 6 of the Statement is hereby amended and supplemented as follows: June 2025 Registration Rights Agreement On June 25, 2025, the Issuer entered into a registration rights agreement (the "June 2025 Registration Rights Agreement") with the June 2025 PIPE Investors, pursuant to which the Issuer agreed to register for resale the Pre-Funded Warrant Shares underlying the Pre-Funded Warrants held by the June 2025 PIPE Investors (the "June 2025 Registrable Securities"). Under the June 2025 Registration Rights Agreement, the Issuer has agreed to file a registration statement (the "June 2025 Registration Statement") covering the resale of the June 2025 Registrable Securities within 30 days after Stockholder Approval (the "Filing Deadline"). The Issuer has agreed to use commercially reasonable efforts to cause such registration statement to become effective as soon as practicable, but in any event no later than 75 days after the initial filing of the June 2025 Registration Statement, subject to extension under the terms of the June 2025 Registration Rights Agreement. The Issuer also agreed to use commercially reasonable efforts to keep such registration statement effective until the date the Pre-Funded Warrant Shares covered by such registration statement have been sold or may be resold pursuant to Rule 144 without restriction. The Issuer has agreed to be responsible for all fees and expenses incurred in connection with the registration of the June 2025 Registrable Securities. The Issuer has granted the June 2025 PIPE Investors customary indemnification rights in connection with the June 2025 Registration Statement. The June 2025 PIPE Investors have also granted the Issuer customary indemnification rights in connection with the June 2025 Registration Statement. The foregoing description of the June 2025 Registration Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the June 2025 Registration Rights Agreement, a copy of which is filed as Exhibit 99.6 hereto and incorporated by reference herein. Voting and Support Agreements In connection with the June 2025 Private Placement, certain stockholders of the Issuer, including the Fund, entered into Voting and Support Agreements (the "Support Agreements") pursuant to which, among other things, each stockholder has agreed, on the terms and subject to the conditions set forth therein, to vote all of their shares in favor of (i) the issuance of the Pre-Funded Warrant Shares and (ii) an amendment to the Issuer's charter that has the effect of increasing the Issuer's authorized shares of common stock. The Support Agreements also restrict the signing stockholders from transferring, selling or otherwise disposing of their shares or related securities except as permitted in the Support Agreements. The shares subject to the Support Agreements collectively represent approximately 63% of the total voting power of the Issuer's common stock as of June 26, 2025. The foregoing description of the Support Agreements does not purport to be complete and is qualified in its entirety by reference to the Form of Support Agreement, a copy of which is filed as Exhibit 99.7 hereto and incorporated by reference herein. Pre-Funded Warrants Each Pre-Funded Warrant has an exercise price of $0.0001 per share of the Issuer's common stock, is exercisable at any time and from time to time on or after the Stockholder Approval and does not expire. Under the terms of the Pre-Funded Warrants, the Issuer may not effect the exercise of any Pre-Funded Warrant, and the Fund will not be entitled to exercise any portion of any Pre-Funded Warrant, which, upon giving effect to such exercise, would cause the Fund (together with its affiliates) to own more than 9.99% of the number of shares of the common stock outstanding immediately after giving effect to such exercise, as such percentage ownership is determined in accordance with the terms of the Pre-Funded Warrants. However, the Fund may increase or decrease such percentage, from time to time, to any other percentage not in excess of 19.99%, provided that any increase in such percentage shall not be effective until 61 days after such notice is delivered to the Issuer. The exercise price and the number of shares of common stock issuable upon exercise of each Pre-Funded Warrant are subject to appropriate adjustment in the event of certain stock dividends and distributions, stock splits, stock combinations, reclassifications or similar events affecting the common stock. In the event of certain fundamental transactions (as described in the Pre-Funded Warrants), a holder of Pre-Funded Warrants will be entitled to receive, upon exercise of the Pre-Funded Warrants, the kind and amount of securities, cash or property that such holder would have received had they exercised in full the Pre-Funded Warrants immediately prior to such fundamental transaction without regard to any limitations on exercise contained in the Pre-Funded Warrants. The foregoing description of the Pre-Funded Warrant does not purport to be complete and is qualified in its entirety by reference to the Form of Pre-Funded Warrant, a copy of which is filed as Exhibit 99.8 hereto and incorporated by reference herein.

Exhibit 99.1 Joint Filing Agreement Exhibit 99.2 Form of Securities Purchase Agreement (incorporated by reference to Exhibit 10.1 to the Issuer's Current Report on Form 8-K filed on December 27, 2024). Exhibit 99.3 Form of Registration Rights Agreement (incorporated by reference to Exhibit 10.2 to the Issuer's Current Report on Form 8-K filed on December 27, 2024). Exhibit 99.4 Form of Common Stock Warrant (incorporated by reference to Exhibit 4.1 to the Issuer's Current Report on Form 8-K filed on December 27, 2024). Exhibit 99.5 Form of Securities Purchase Agreement (incorporated by reference to Exhibit 10.3 to the Issuer's Current Report on Form 8-K filed on June 26, 2025). Exhibit 99.6 Form of Registration Rights Agreement (incorporated by reference to Exhibit 10.4 to the Issuer's Current Report on Form 8-K filed on June 26, 2025). Exhibit 99.7 Form of Voting and Support Agreement (incorporated by reference to Exhibit 10.5 to the Issuer's Current Report on Form 8-K filed on June 26, 2025). Exhibit 99.8 Form of Pre-Funded Warrant to Purchase Common Stock (incorporated by reference to Exhibit 10.1 to the Issuer's Current Report on Form 8-K filed on June 26, 2025).