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    SEC Form SC 13D/A filed by Vor Biopharma Inc. (Amendment)

    2/14/24 4:17:24 PM ET
    $VOR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $VOR alert in real time by email
    SC 13D/A 1 tm245508d1_sc13da.htm SC 13D/A

     

     

     

      UNITED STATES  
      SECURITIES AND EXCHANGE COMMISSION  
      Washington, D.C. 20549  
         
      SCHEDULE 13D  

     

    Under the Securities Exchange Act of 1934
    (Amendment No. 1)*

     

    Vor Biopharma Inc.

    (Name of Issuer)

     

    Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

     

    929033108

    (CUSIP Number)

     

    Paul A. Stone

    Chief Legal Officer

    5AM Venture Management, LLC

    501 2nd Street, Suite 350

    San Francisco, CA 94107

    (415) 993-8565

    (Name, Address and Telephone Number of Person
    Authorized to Receive Notices and Communications)

     

    February 14, 2024

    (Date of Event Which Requires Filing of this Statement)

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

     

    * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

     

    CUSIP No.   929033108
      1. Names of Reporting Persons
    5AM Ventures VI, L.P.
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  x (1)
      3. SEC Use Only
      4. Source of Funds (See Instructions)
    WC
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
      6. Citizenship or Place of Organization
    Delaware
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
    8. Shared Voting Power
     4,595,089 shares of Common Stock (2)
    9. Sole Dispositive Power
     0
    10. Shared Dispositive Power
    4,595,089 shares of Common Stock (2)
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
     4,595,089 shares of Common Stock (2)
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
      13. Percent of Class Represented by Amount in Row (11)
     6.8% (3)
      14. Type of Reporting Person (See Instructions)
    PN
               

    (1)This Schedule 13D is filed by 5AM Ventures VI, L.P. (“5AM VI”), 5AM Partners VI, LLC (“5AM Partners VI”), 5AM Opportunities I, L.P. (“5AM Opportunities”), 5AM Opportunities I (GP), LLC (“5AM Opportunities GP”), Andrew J. Schwab (“Schwab”) and Dr. Kush Parmar (“Dr. Parmar”), with 5AM VI, 5AM Partners VI, 5AM Opportunities, 5AM Opportunities GP and Schwab, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)These shares are held by 5AM VI. Schwab and Dr. Parmar, as Managing Members of 5AM Partners VI, share voting and investment authority over the shares held by 5AM VI.

     

    (3)This percentage is calculated based upon 67,805,687 shares of Common Stock outstanding as of November 3, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the “SEC”) on November 7, 2023.

     

     

     

     

    CUSIP No.   929033108
      1. Names of Reporting Persons
    5AM Partners VI, LLC
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  x (1)
      3. SEC Use Only
      4. Source of Funds (See Instructions)
    AF
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
      6. Citizenship or Place of Organization
    Delaware
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
    8. Shared Voting Power
     4,595,089 shares of Common Stock (2)
    9. Sole Dispositive Power
     0
    10. Shared Dispositive Power
    4,595,089 shares of Common Stock (2)
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
     4,595,089 shares of Common Stock (2)
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
      13. Percent of Class Represented by Amount in Row (11)
     6.8% (3)
      14. Type of Reporting Person (See Instructions)
    OO
               

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 4,595,089 shares held by 5AM VI. Schwab and Dr. Parmar, as Managing Members of 5AM Partners VI, share voting and investment authority over the shares held by 5AM VI.

     

    (3)This percentage is calculated based upon 67,805,687 shares of Common Stock outstanding as of November 3, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 7, 2023.

     

     

     

     

    CUSIP No.   929033108
      1. Names of Reporting Persons
    5AM Opportunities I, L.P.
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  x (1)
      3. SEC Use Only
      4. Source of Funds (See Instructions)
    WC
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
      6. Citizenship or Place of Organization
    Delaware
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
    8. Shared Voting Power
     1,766,634 shares of Common Stock (2)
    9. Sole Dispositive Power
     0
    10. Shared Dispositive Power
    1,766,634 shares of Common Stock (2)
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
    1,766,634 shares of Common Stock (2)
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
      13. Percent of Class Represented by Amount in Row (11)
     2.6% (3)
      14. Type of Reporting Person (See Instructions)
    PN
               

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)These shares are held by 5AM Opportunities. Schwab and Dr. Parmar, as Managing Members of 5AM Opportunities GP, share voting and investment authority over the shares held by 5AM Opportunities.

     

    (3)This percentage is calculated based upon 67,805,687 shares of Common Stock outstanding as of November 3, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 7, 2023.

     

     

     

     

    CUSIP No.   929033108
      1. Names of Reporting Persons
    5AM Opportunities I (GP), LLC
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  x (1)
      3. SEC Use Only
      4. Source of Funds (See Instructions)
    AF
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
      6. Citizenship or Place of Organization
    Delaware
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
    8. Shared Voting Power
     1,766,634 shares of Common Stock (2)
    9. Sole Dispositive Power
     0
    10. Shared Dispositive Power
    1,766,634 shares of Common Stock (2)
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
     1,766,634 shares of Common Stock (2)
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
      13. Percent of Class Represented by Amount in Row (11)
     2.6% (3)
      14. Type of Reporting Person (See Instructions)
    OO
               

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes 1,766,634 shares held by 5AM Opportunities. Schwab and Dr. Parmar, as Managing Members of 5AM Opportunities GP, share voting and investment authority over the shares held by 5AM Opportunities.

     

    (3)This percentage is calculated based upon 67,805,687 shares of Common Stock outstanding as of November 3, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 7, 2023.

     

     

     

     

    CUSIP No.   929033108
      1. Names of Reporting Persons
    Andrew J. Schwab
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  x (1)
      3. SEC Use Only
      4. Source of Funds (See Instructions)
    AF
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
      6. Citizenship or Place of Organization
    United States
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
    8. Shared Voting Power
     6,361,723 shares of Common Stock (2)
    9. Sole Dispositive Power
     0
    10. Shared Dispositive Power
    6,361,723 shares of Common Stock (2)
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
     6,361,723 shares of Common Stock (2)
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
      13. Percent of Class Represented by Amount in Row (11)
     9.4% (3)
      14. Type of Reporting Person (See Instructions)
    IN
               

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes (i) 4,595,089 shares held by 5AM VI; and (ii) 1,766,634 shares held by 5AM Opportunities. Schwab and Dr. Parmar, as Managing Members of 5AM Partners VI, share voting and investment authority over the shares held by 5AM VI. Schwab and Dr. Parmar, as Managing Members of 5AM Opportunities GP, share voting and investment authority over the shares held by 5AM Opportunities.

     

    (3)This percentage is calculated based upon 67,805,687 shares of Common Stock outstanding as of November 3, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 7, 2023.

     

     

     

     

    CUSIP No.   929033108
      1. Names of Reporting Persons
    Dr. Kush Parmar
      2. Check the Appropriate Box if a Member of a Group (See Instructions)
        (a)  ¨
        (b)  x (1)
      3. SEC Use Only
      4. Source of Funds (See Instructions)
    AF
      5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)     ¨
      6. Citizenship or Place of Organization
    United States
    Number of
    Shares
    Beneficially
    Owned by
    Each
    Reporting
    Person With
    7. Sole Voting Power
    0
    8. Shared Voting Power
     6,361,723 shares of Common Stock (2)
    9. Sole Dispositive Power
     0
    10. Shared Dispositive Power
    6,361,723 shares of Common Stock (2)
      11. Aggregate Amount Beneficially Owned by Each Reporting Person
     6,361,723 shares of Common Stock (2)
      12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)   ¨
      13. Percent of Class Represented by Amount in Row (11)
     9.4% (3)
      14. Type of Reporting Person (See Instructions)
    IN
               

    (1)This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D.

     

    (2)Includes (i) 4,595,089 shares held by 5AM VI; and (ii) 1,766,634 shares held by 5AM Opportunities. Schwab and Dr. Parmar, as Managing Members of 5AM Partners VI, share voting and investment authority over the shares held by 5AM VI. Schwab and Dr. Parmar, as Managing Members of 5AM Opportunities GP, share voting and investment authority over the shares held by 5AM Opportunities.

     

    (3)This percentage is calculated based upon 67,805,687 shares of Common Stock outstanding as of November 3, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 7, 2023.

     

     

     

     

    Explanatory Note:      This Amendment No. 1 (the “Amendment”), which amends the Schedule 13D filed with the Securities and Exchange Commission (the “SEC”) on February 19, 2021 (the “Original Schedule 13D”) filed on behalf of 5AM Ventures VI, L.P. (“5AM VI”), 5AM Partners VI, LLC (“5AM Partners VI”), 5AM Opportunities I, L.P. (“5AM Opportunities”), 5AM Opportunities I (GP), LLC (“5AM Opportunities GP”), Andrew J. Schwab (“Schwab”) and Dr. Kush Parmar (“Dr. Parmar” and, with 5AM Partners VI, 5AM VI, 5AM Opportunities, 5AM Opportunities GP and Schwab, collectively, the “Reporting Persons”), relates to the Common Stock of Vor Biopharma Inc., a Delaware corporation (the “Issuer” or “Vor”). This Amendment to the Original Schedule 13D is being filed solely to update the benefical ownership percentages of the Reporting Persons resulting from an increase in the totalnumber of shares of Common Stock outstanding and not due to any transaction by the Reporting Persons.

     

    Item 5.Interest in Securities of the Issuer

     

    Item 5 of the Original Schedule 13D is hereby amended and restated as follows:

     

    (a) – (b).       The following information with respect to the ownership of the Common Stock of the Issuer by the persons filing this statement on Schedule 13D is provided as of February 14, 2024:

     

    Reporting Persons  Shares Held
    Directly
       Sole Voting
    Power
       Shared
    Voting
    Power(1)
       Sole
    Dispositive
    Power
       Shared
    Dispositive
    Power (1)
       Beneficial
    Ownership
       Percentage
    of Class (3)
     
    5AM VI   4,595,089    0    4,595,089    0    4,595,089    4,595,089    6.8%
    5AM Partners VI (1)   0    0    4,595,089    0    4,595,089    4,595,089    6.8%
    5AM Opportunities   1,766,634    0    1,766,634    0    1,766,634    1,766,634    2.6%
    5AM Opportunities GP (2)   0    0    1,766,634    0    1,766,634    1,766,634    2.6%
    Schwab (1) (2)   0    0    6,361,723    0    6,361,723    6,361,723    9.4%
    Dr. Parmar (1) (2)   0    0    6,361,723    0    6,361,723    6,361,723    9.4%

     

    (1)Includes 4,595,089 shares of Common Stock held by 5AM VI. Schwab and Dr. Parmar, as Managing Members of 5AM Partners VI, share voting and investment authority over the shares held by 5AM VI.

     

    (2)Includes 1,766,634 shares of Common Stock held by 5AM Opportunities. Schwab and Dr. Parmar, as Managing Members of 5AM Opportunities GP, share voting and investment authority over the shares held by 5AM Opportunities.

     

    (3)This percentage is calculated based upon 67,805,687 shares of Common Stock outstanding as of November 3, 2023, as reported in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on November 7, 2023.

     

    (c)Except as set forth herein, none of the Reporting Persons has effected any transactions in shares of the Issuer’s Common Stock during the last 60 days.

     

    (d)No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by any of the Reporting Persons.

     

    (e)Not applicable.

     

    Item 7.Material to be Filed as Exhibits

     

    A.Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (incorporated by reference to the Original Schedule 13D, filed on February 19, 2021).

     

    B.Amended and Restated Investors’ Rights Agreement, dated June 30, 2020 (incorporated by reference to Exhibit 4.2 to the Issuer’s Registration Statement on Form S-1 (SEC 333-252175), filed with the SEC on February 3, 2021).

     

     

     

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: February 14, 2024

     

    5AM Ventures VI, L.P.   5AM Opportunities I, L.P.
         
    By: 5AM Partners VI, LLC   By: 5AM Opportunities I (GP), LLC
    its General Partner     its General Partner  
         
    By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab  
    Name: Andrew J. Schwab   Name: Andrew J. Schwab  
    Title: Managing Member   Title: Managing Member  
         
    5AM Partners VI, LLC     5AM Opportunities I (GP), LLC  
         
    By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab  
    Name: Andrew J. Schwab     Name: Andrew J. Schwab  
    Title: Managing Member     Title: Managing Member  
         
      /s/ Andrew J. Schwab       /s/ Dr. Kush Parmar
      Andrew J. Schwab     Dr. Kush Parmar

     

      ATTENTION  
    Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).

     

     

     

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      Preliminary data suggests improved relapse-free survival compared to published groups of acute myeloid leukemia (AML) patients at high risk of relapse post-transplantTrem-cel + Mylotarg continue to demonstrate engraftment, shielding, and broadened therapeutic windowCompany has received supportive feedback from the FDA regarding a registrational clinical trial design CAMBRIDGE, Mass., Dec. 09, 2024 (GLOBE NEWSWIRE) -- Vor Bio (NASDAQ:VOR), a clinical-stage cell and genome engineering company, today announced updated clinical data from its ongoing Phase 1/2 VBP101 study of patients with relapsed/refractory AML receiving trem-cel followed by Mylotarg™. The data, which was presented in a post

      12/9/24 7:30:00 AM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    • New Clinical Data Validates Vor Bio's Approach of Using Shielded Transplants to Deliver Targeted Therapies

      Trem-cel + Mylotarg demonstrated engraftment, shielding, broadened therapeutic window, and patient benefitVCAR33ALLO demonstrates encouraging biomarker data at lowest dose New asset VADC45 with significant potential opportunities across oncology, gene therapy, and autoimmune disorders CAMBRIDGE, Mass., Sept. 05, 2024 (GLOBE NEWSWIRE) -- Vor Bio (NASDAQ:VOR), a clinical-stage cell and genome engineering company, today announced new clinical data from its ongoing Phase 1/2 VBP101 study of patients with relapsed/refractory AML receiving trem-cel followed by Mylotarg™. The data demonstrated reliable engraftment, shielding from Mylotarg on-target toxicity, a broadened Mylotarg therapeutic wind

      9/5/24 4:01:00 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    SEC Filings

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    • Vor Biopharma Inc. filed SEC Form 8-K: Costs Associated with Exit or Disposal Activities

      8-K - Vor Biopharma Inc. (0001817229) (Filer)

      5/8/25 8:35:56 AM ET
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    • SEC Form DEFR14A filed by Vor Biopharma Inc.

      DEFR14A - Vor Biopharma Inc. (0001817229) (Filer)

      4/30/25 4:04:48 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    • SEC Form 8-K filed by Vor Biopharma Inc.

      8-K - Vor Biopharma Inc. (0001817229) (Filer)

      4/25/25 4:01:13 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    $VOR
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

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    • Large owner Reprogrammed Interchange Llc bought 38,974,101 shares (SEC Form 4)

      4 - Vor Biopharma Inc. (0001817229) (Issuer)

      1/2/25 7:42:04 PM ET
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    $VOR
    Leadership Updates

    Live Leadership Updates

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    • Vor Bio Appoints Life Sciences and Technology Investor and Entrepreneur, Mr. Erez Kalir to its Board of Directors

      CAMBRIDGE, Mass., Jan. 08, 2025 (GLOBE NEWSWIRE) -- Vor Bio (NASDAQ:VOR), a clinical-stage cell and genome engineering company, today announced the appointment of Mr. Erez Kalir to its Board of Directors. The appointment represents a new seat on Vor Bio's Board of Directors, which has been created in connection with the recent private investment in public equity financing (PIPE) which was led by Reid Hoffman. Mr. Kalir will serve as the director designee of Reprogrammed Interchange, LLC, Mr. Hoffman's investment fund. Mr. Kalir brings a wealth of experience as an investor, entrepreneur, and thought leader with a deep focus on life sciences and technology. Currently the Managing Member of

      1/8/25 9:00:00 AM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Vor Bio Appoints Seasoned Healthcare Institutional Investor, Han Choi, M.D., LL.M., as Chief Financial Officer

      CAMBRIDGE, Mass., Sept. 30, 2024 (GLOBE NEWSWIRE) -- Vor Bio (NASDAQ:VOR), a clinical-stage cell and genome engineering company, today announced the appointment of Han Choi, M.D., LL.M., as its new Chief Financial Officer, effective immediately. Dr. Choi will join the Vor Bio leadership team and will report directly to the company's President and Chief Executive Officer, Dr. Robert Ang. Dr. Choi brings to Vor Bio over twenty-five years of experience in public and private investment management, business development, and corporate strategy within the pharmaceutical and biotechnology industry. His deep expertise in structuring corporate partnerships and investments, managing complex transact

      9/30/24 7:00:00 AM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Vor Bio Appoints Accomplished Oncology and Cancer Immunotherapy R&D Executive, Fouad Namouni, M.D., to its Board of Directors

      CAMBRIDGE, Mass., May 02, 2024 (GLOBE NEWSWIRE) -- Vor Bio (NASDAQ:VOR), a clinical-stage cell and genome engineering company, today announced the appointment of Fouad Namouni, M.D., to its Board of Directors. Dr. Namouni currently serves as President of Research & Development at Blueprint Medicines, bringing a wealth of industry experience and expertise to Vor Bio's Board. In his role at Blueprint Medicines, Dr. Namouni has demonstrated exceptional leadership in building the company's fully integrated business and advancing a broad pipeline of innovative medicines to address significant medical needs in oncology/hematology and allergy/inflammation. With over two decades of experience in

      5/2/24 4:01:00 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    • Amendment: SEC Form SC 13G/A filed by Vor Biopharma Inc.

      SC 13G/A - Vor Biopharma Inc. (0001817229) (Subject)

      11/14/24 4:33:50 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    • SEC Form SC 13D/A filed by Vor Biopharma Inc. (Amendment)

      SC 13D/A - Vor Biopharma Inc. (0001817229) (Subject)

      2/14/24 4:17:24 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
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    • SEC Form SC 13G/A filed by Vor Biopharma Inc. (Amendment)

      SC 13G/A - Vor Biopharma Inc. (0001817229) (Subject)

      2/14/24 4:08:06 PM ET
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      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care