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    SEC Form 10-Q filed by Avantor Inc.

    10/29/25 9:01:46 AM ET
    $AVTR
    Biotechnology: Laboratory Analytical Instruments
    Industrials
    Get the next $AVTR alert in real time by email
    avtr-20250930
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    UNITED STATES SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549
    ━━━━━━━━━
    FORM 10-Q
    ━━━━━━━━━
    ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
    For the quarterly period ended September 30, 2025
    ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
    For the transition period from __________ to __________
    Commission file number: 001-38912

    avantorlogoa08.jpg
    Avantor, Inc.
    (Exact name of registrant as specified in its charter)
    Delaware82-2758923
    (State or other jurisdiction of incorporation or organization)(I.R.S. Employer Identification No.)
    Radnor Corporate Center, Building One, Suite 200
    100 Matsonford Road
    Radnor, Pennsylvania 19087
    (Address of principal executive offices) (zip code)
    (610) 386-1700
    (Registrant’s telephone number, including area code)
    Securities registered pursuant to Section 12(b) of the Act:
    Title of each classTrading SymbolExchange on which registered
    Common stock, $0.01 par valueAVTRNew York Stock Exchange



    Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ☒ Yes ☐ No
    Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). ☒ Yes ☐ No
    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act. ☒ Large Accelerated Filer ☐ Accelerated Filer ☐ Non-accelerated Filer ☐ Smaller reporting company ☐ Emerging growth company
    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
    Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). ☐ Yes ☒ No
    On October 24, 2025, 681,814,859 shares of common stock, $0.01 par value per share, were outstanding.



    Avantor, Inc. and subsidiaries
    Form 10-Q for the quarterly period ended September 30, 2025
    Table of contents
    Page
    Glossary
    ii
    Cautionary factors regarding forward-looking statements
    iii
    PART I — FINANCIAL INFORMATION
    Item 1. Financial statements
    1
    Item 2. Management’s discussion and analysis of financial condition and results of operations
    29
    Item 3. Quantitative and qualitative disclosures about market risk
    41
    Item 4. Controls and procedures
    41
    PART II — OTHER INFORMATION
    Item 1. Legal proceedings
    42
    Item 1A. Risk factors
    42
    Item 2. Unregistered sales of equity securities and use of proceeds
    42
    Item 3. Defaults upon senior securities
    42
    Item 4. Mine safety disclosures
    42
    Item 5. Other information
    42
    Item 6. Exhibits
    43
    Signature
    44
    i

    Table of contents
    Glossary
    Description
    the Company, we, us, ourAvantor, Inc. and its subsidiaries
    Adjusted EBITDAour earnings or loss before interest, taxes, depreciation, amortization and certain other adjustments
    Adjusted Operating Incomeour earnings or loss before interest, taxes, amortization and certain other adjustments
    Advanced Lab ServicesServices and products designed to optimize and manage end-to-end laboratory operations for customers across industries such as biopharma, education, industrial, and technology sectors
    Annual Reportour annual report on Form 10-K for the year ended December 31, 2024
    AOCIaccumulated other comprehensive income or loss
    Applied SolutionsProprietary formulated solutions for semiconductor manufacturing, proprietary chemicals for healthcare, biopharma, and diagnostic applications as well as chemicals and PPE for industrial applications
    ASCAccounting Standards Codification
    ASUAccounting Standards Update
    BioprocessingProcess ingredients and excipients, single use systems and integrated solutions, and controlled environment consumables used to support the production of biologic drugs and therapies
    CODMchief operating decision maker
    EURIBORthe basic rate of interest used in lending between banks on the European Union interbank market
    FASBthe Financial Accounting Standards Board of the United States
    GAAPUnited States generally accepted accounting principles
    Laboratory Specialty ProductsProprietary chemicals and products for multiple industries, including biopharma, healthcare, industrial, mining, and education, among others
    long-termperiod other than short-term
    OCIother comprehensive income or loss
    RSUrestricted stock units represent awards that will vest annually and awards that contain performance and market conditions
    SECthe United States Securities and Exchange Commission
    SG&A expensesselling, general and administrative expenses
    short-termperiod less than a year from the reporting date
    SiliconesUltra-high purity medical and aerospace grade silicone formulations
    SOFRsecured overnight financing rate
    specialty procurementproduct sales related to customer procurement services
    Total Science SolutionsMission-critical consumables, chemicals, and equipment and instrumentation used by scientists in their labs
    ii

    Table of contents
    Cautionary factors regarding forward-looking statements
    This report contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and are subject to the safe harbor created thereby under the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact included in this report are forward-looking statements. Forward-looking statements discuss our current expectations and projections relating to our financial condition, results of operations, plans, including our cost transformation initiative, objectives, future performance and business. These statements may be preceded by, followed by or include the words “aim,” “anticipate,” “assumption,” “believe,” “continue,” “estimate,” “expect,” “forecast,” “goal,” “guidance,” “intend,” “likely,” “long-term,” “near-term,” “objective,” “opportunity,” “outlook,” “plan,” “potential,” “project,” “projection,” “prospects,” “seek,” “target,” “trend,” “can,” “could,” “may,” “should,” “would,” “will,” the negatives thereof and other words and terms of similar meaning.
    Forward-looking statements are inherently subject to risks, uncertainties and assumptions; they are not guarantees of performance. You should not place undue reliance on these statements. We have based these forward-looking statements on our current expectations and projections about future events. Although we believe that our assumptions made in connection with the forward-looking statements are reasonable, we cannot assure you that the assumptions and expectations will prove to be correct.
    You should understand that the following important factors, in addition to those discussed under Part I, Item 1A “Risk Factors” in our Annual Report, as such risk factors may be updated from time to time in our periodic filings with the SEC and in this report, could affect our future results and could cause those results or other outcomes to differ materially from those expressed or implied in our forward-looking statements:
    •disruptions to our operations;
    •competition from other industry providers;
    •our ability to implement our strategies for improving growth and optimizing costs;
    •our ability to anticipate and respond to changing industry trends;
    •adverse trends in consumer, business, and government spending (including impacts from the U.S government shutdown that started in October 2025);
    •our dependence on sole or limited sources for some essential materials and components;
    •our ability to successfully value and integrate acquired businesses;
    •our products’ satisfaction of applicable quality criteria, specifications and performance standards;
    •our ability to maintain our relationships with key customers;
    •our ability to maintain our relationships with distributors;
    •our ability to maintain our customer base and our expected volume of customer orders;
    iii

    Table of contents
    •our ability to maintain and develop relationships with drug manufacturers and contract manufacturing organizations;
    •the impact of new laws, regulations, or other industry standards;
    •changes in the interest rate environment that increase interest on our borrowings;
    •adverse impacts from currency exchange rates or currency controls imposed by any government in major areas where we operate or otherwise or from potential changes in trade restrictions, tariffs and exchange controls;
    •our ability to implement and improve processing systems and prevent a compromise of our information systems or personal data;
    •our ability to protect our intellectual property and avoid third-party infringement claims;
    •exposure to product liability and other claims in the ordinary course of business;
    •our ability to develop new products responsive to the markets we serve;
    •supply chain constraints and the availability of raw materials;
    •our ability to source certain of our products from certain suppliers;
    •our ability to contain costs in an inflationary environment;
    •our ability to avoid negative outcomes related to the use of chemicals;
    •our ability to maintain highly skilled employees;
    •our ability to maintain a competitive workforce;
    •adverse impact of impairment charges on our goodwill and other intangible assets;
    •currency fluctuations and uncertainties related to doing business outside the United States;
    •our ability to obtain and maintain required regulatory clearances or approvals, which may constrain the commercialization of submitted products;
    •our ability to comply with environmental, health and safety laws and regulations, or the impact of any liability or obligation imposed under such laws or regulations;
    •our indebtedness, which could adversely affect our financial condition or prevent us from fulfilling our debt or contractual obligations;
    •our ability to generate sufficient cash flows or access sufficient additional capital to meet our debt obligations or to fund our other liquidity needs; and
    •our ability to maintain an effective system of internal control over financial reporting.
    iv

    Table of contents
    All forward-looking statements attributable to us or persons acting on our behalf are expressly qualified in their entirety by the foregoing cautionary statements. In addition, all forward-looking statements speak only as of the date of this report. We undertake no obligations to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise other than as required under the federal securities laws.
    v

    Table of contents
    PART I — FINANCIAL INFORMATION
    Item 1.    Financial statements
    Avantor, Inc. and subsidiaries
    Index to unaudited condensed consolidated financial statements
    Page
    Unaudited condensed consolidated balance sheets
    2
    Unaudited condensed consolidated statements of operations
    3
    Unaudited condensed consolidated statements of comprehensive income or loss
    4
    Unaudited condensed consolidated statements of stockholders’ equity
    5
    Unaudited condensed consolidated statements of cash flows
    7
    Notes to unaudited condensed consolidated financial statements
    8
    1

    Table of contents
    Avantor, Inc. and subsidiaries
    Unaudited condensed consolidated balance sheets
    (in millions)
    September 30, 2025
    December 31, 2024
    Assets
    Current assets:
    Cash and cash equivalents$251.9 $261.9 
    Accounts receivable, net of allowances of $29.6 and $30.2
    1,077.7 1,034.5 
    Inventory795.5 731.5 
    Other current assets132.1 118.7 
    Total current assets2,257.2 2,146.6 
    Property, plant and equipment, net of accumulated depreciation and impairment charges of $723.9 and $629.5
    761.6 708.1 
    Other intangible assets, net (see note 7)
    3,266.7 3,360.2 
    Goodwill, net of accumulated impairment losses of $823.8 and $38.8 (see note 7)
    4,984.7 5,539.2 
    Other assets405.7 360.4 
    Total assets$11,675.9 $12,114.5 
    Liabilities and stockholders’ equity
    Current liabilities:
    Current portion of debt$219.8 $821.1 
    Accounts payable691.6 662.8 
    Employee-related liabilities178.5 168.2 
    Accrued interest35.2 48.6 
    Other current liabilities391.4 306.8 
    Total current liabilities1,516.5 2,007.5 
    Debt, net of current portion3,638.1 3,234.7 
    Deferred income tax liabilities548.5 557.3 
    Other liabilities402.6 358.3 
    Total liabilities6,105.7 6,157.8 
    Commitments and contingencies (see note 9)
    Stockholders’ equity:
    Common stock including paid-in capital, 681.9 and 680.8 shares issued and outstanding
    3,973.4 3,937.7 
    Accumulated earnings
    1,620.4 2,203.0 
    Accumulated other comprehensive loss
    (23.6)(184.0)
    Total stockholders’ equity5,570.2 5,956.7 
    Total liabilities and stockholders’ equity$11,675.9 $12,114.5 
    See accompanying notes to the unaudited condensed consolidated financial statements.
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    Avantor, Inc. and subsidiaries
    Unaudited condensed consolidated statements of operations
    (in millions, except per share data)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Net sales$1,623.8 $1,714.4 $4,888.6 $5,097.0 
    Cost of sales1,097.3 1,150.0 3,273.1 3,380.6 
    Gross profit526.5 564.4 1,615.5 1,716.4 
    Selling, general and administrative expenses390.3 439.8 1,203.1 1,269.7 
    Impairment charges785.0 — 785.0 — 
    Operating (loss) income
    (648.8)124.6 (372.6)446.7 
    Interest expense, net(44.2)(48.7)(129.8)(173.9)
    Loss on extinguishment of debt(0.2)(2.1)(0.2)(6.5)
    Other income (expense), net
    3.7 0.7 (19.5)3.4 
    (Loss) income before income taxes
    (689.5)74.5 (522.1)269.7 
    Income tax expense
    (22.3)(16.7)(60.5)(58.6)
    Net (loss) income
    $(711.8)$57.8 $(582.6)$211.1 
    (Loss) earnings per share:
    Basic$(1.04)$0.08 $(0.86)$0.31 
    Diluted$(1.04)$0.08 $(0.86)$0.31 
    Weighted average shares outstanding:
    Basic681.7 680.3 681.4 679.3 
    Diluted681.7 683.0 681.4 682.1 
    See accompanying notes to the unaudited condensed consolidated financial statements.
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    Avantor, Inc. and subsidiaries
    Unaudited condensed consolidated statements of comprehensive income or loss
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Net (loss) income
    $(711.8)$57.8 $(582.6)$211.1 
    Other comprehensive (loss) income:
    Foreign currency translation — unrealized (loss) gain
    (11.5)33.8 116.4 5.7 
    Derivative instruments:

    Unrealized gain (loss)
    1.9 (0.9)7.4 14.3 
    Reclassification of gain into earnings
    (2.0)(14.1)(7.6)(31.0)
    Activity related to defined benefit plans:
    Unrealized (loss) gain
    (0.4)(0.2)2.8 (0.6)
    Reclassification of loss into earnings
    — — 17.3 — 
    Other comprehensive (loss) income before income taxes
    (12.0)18.6 136.3 (11.6)
    Income tax effect(1.2)14.8 24.1 6.7 
    Other comprehensive (loss) income
    (13.2)33.4 160.4 (4.9)
    Comprehensive (loss) income
    $(725.0)$91.2 $(422.2)$206.2 
    See accompanying notes to the unaudited condensed consolidated financial statements.
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    Avantor, Inc. and subsidiaries
    Unaudited condensed consolidated statements of stockholders’ equity
    (in millions)
    Stockholders’ equity
    Common stock including paid-in capitalAccumulated earningsAOCITotal
    SharesAmount
    Balance on June 30, 2025
    681.6 $3,964.1 $2,332.2 $(10.4)$6,285.9 
    Comprehensive loss
    — — (711.8)(13.2)(725.0)
    Stock-based compensation expense— 7.4 — — 7.4 
    Stock option exercises and other common stock transactions0.3 1.9 — — 1.9 
    Balance on September 30, 2025
    681.9 $3,973.4 $1,620.4 $(23.6)$5,570.2 
    Balance on June 30, 2024
    679.6 $3,897.5 $1,644.8 $(107.3)$5,435.0 
    Comprehensive income
    — — 57.8 33.4 91.2 
    Stock-based compensation expense— 11.3 — — 11.3 
    Stock option exercises and other common stock transactions1.0 15.7 — — 15.7 
    Balance on September 30, 2024
    680.6 $3,924.5 $1,702.6 $(73.9)$5,553.2 
    See accompanying notes to the unaudited condensed consolidated financial statements.
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    Avantor, Inc. and subsidiaries
    Unaudited condensed consolidated statements of stockholders’ equity (continued)
    (in millions)
    Stockholders’ equity
    Common stock including paid-in capitalAccumulated earningsAOCITotal
    SharesAmount
    Balance on December 31, 2024
    680.8 $3,937.7 $2,203.0 $(184.0)$5,956.7 
    Comprehensive (loss) income
    — — (582.6)160.4 (422.2)
    Stock-based compensation expense— 36.2 — — 36.2 
    Stock option exercises and other common stock transactions1.1 (0.5)— — (0.5)
    Balance on September 30, 2025
    681.9 $3,973.4 $1,620.4 $(23.6)$5,570.2 
    Balance on December 31, 2023
    676.6 $3,830.1 $1,491.5 $(69.0)$5,252.6 
    Comprehensive income (loss)
    — — 211.1 (4.9)206.2 
    Stock-based compensation expense— 35.3 — — 35.3 
    Stock option exercises and other common stock transactions4.0 59.1 — — 59.1 
    Balance on September 30, 2024
    680.6 $3,924.5 $1,702.6 $(73.9)$5,553.2 
    See accompanying notes to the unaudited condensed consolidated financial statements.
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    Avantor, Inc. and subsidiaries
    Unaudited condensed consolidated statements of cash flows
    (in millions)
    Nine months ended September 30,
    2025
    2024
    Cash flows from operating activities:
    Net (loss) income
    $(582.6)$211.1 
    Reconciling adjustments:
    Depreciation and amortization306.9 304.6 
    Impairment charges785.0 — 
    Stock-based compensation expense
    35.1 35.7 
    Non-cash restructuring charges (see note 8)
    — 16.4 
    Provision for accounts receivable and inventory43.4 55.8 
    Deferred income tax benefit
    (41.9)(75.3)
    Amortization of deferred financing costs6.6 8.6 
    Loss on extinguishment of debt0.2 6.5 
    Foreign currency remeasurement loss
    0.7 3.0 
    Pension termination charges18.1 — 
    Changes in assets and liabilities:
    Accounts receivable10.5 34.2 
    Inventory(66.7)(21.5)
    Accounts payable(4.4)41.9 
    Accrued interest(13.4)(16.5)
    Other assets and liabilities(27.4)63.0 
    Other1.0 — 
    Net cash provided by operating activities
    471.1 667.5 
    Cash flows from investing activities:
    Capital expenditures(93.3)(121.3)
    Other2.5 1.7 
    Net cash used in investing activities
    (90.8)(119.6)
    Cash flows from financing activities:
    Debt borrowings67.7 — 
    Debt repayments(477.3)(585.0)
    Proceeds received from exercise of stock options4.9 67.3 
    Shares repurchased to satisfy employee tax obligations for vested stock-based awards(5.4)(8.2)
    Net cash used in financing activities
    (410.1)(525.9)
    Effect of currency rate changes on cash and cash equivalents19.8 0.6 
    Net change in cash, cash equivalents and restricted cash(10.0)22.6 
    Cash, cash equivalents and restricted cash, beginning of period264.7 287.7 
    Cash, cash equivalents and restricted cash, end of period$254.7 $310.3 
    See accompanying notes to the unaudited condensed consolidated financial statements.
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    Avantor, Inc. and subsidiaries
    Notes to unaudited condensed consolidated financial statements
    1.    Nature of operations and presentation of financial statements
    We are a global manufacturer and distributor that provides products and services to customers in the biopharmaceutical, healthcare, education & government and advanced technologies & applied materials industries.
    Basis of presentation
    The accompanying unaudited condensed consolidated financial statements have been prepared pursuant to SEC regulations whereby certain information normally included in GAAP financial statements has been condensed or omitted. The financial information presented herein reflects all adjustments (consisting only of normal, recurring adjustments) that are, in the opinion of management, necessary for a fair presentation of the results for the interim periods presented. The results for interim periods are not necessarily indicative of the results to be expected for the full year.
    We believe that the disclosures included herein are adequate to make the information presented not misleading in any material respect when read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report. Those audited consolidated financial statements include a summary of our significant accounting policies.
    Principles of consolidation
    All intercompany balances and transactions have been eliminated from the financial statements.
    Use of estimates
    The preparation of financial statements in conformity with GAAP requires us to make estimates and assumptions that affect the amounts reported throughout the financial statements. Actual results could differ from those estimates.
    2.    New accounting standards
    Income Taxes
    In December 2023, the FASB issued ASU 2023-09, Improvements to Income Tax Disclosures, which amends the existing income taxes guidance (ASC Topic 740) to require additional disclosures surrounding annual rate reconciliation, income taxes paid and other income tax related disclosures.
    The amendments in this update are effective for annual periods beginning after December 15, 2024. The Company will first apply this standard to its annual disclosures for the year ending December 31, 2025, which we expect will result in additional disclosures in the Company’s income taxes note to its financial statements, primarily through additional disclosures surrounding the annual rate reconciliation and income taxes paid.
    Disaggregation of Income Statement Expenses (DISE)
    In November 2024, the FASB issued ASU 2024-03, Disaggregation of Income Statement Expenses (DISE), requiring additional disclosure of the nature of expenses included in the income statement. The
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    new standard requires disclosures about specific types of expenses included in the expense captions presented on the face of the income statement as well as disclosures about selling expenses.
    The amendments in this update are effective for annual periods beginning after December 15, 2026 and interim periods within fiscal years beginning after December 15, 2027. Early adoption is permitted. We are currently evaluating the impact of our pending adoption of this standard on our financial statements.
    Other
    There were no other new accounting standards that we expect to have a material impact on our financial position or results of operations upon adoption.
    3.    Earnings per share
    The following table presents the reconciliation of basic and diluted loss per share for the three and nine months ended September 30, 2025:
    (in millions, except per share data)
    Three months ended September 30, 2025Nine months ended September 30, 2025
    Loss (numerator)
    Weighted average shares outstanding (denominator)
    Loss per share
    Loss (numerator)
    Weighted average shares outstanding (denominator)
    Loss per share
    Basic$(711.8)681.7 $(1.04)$(582.6)681.4 $(0.86)
    Dilutive effect of stock-based awards— — — — 
    Diluted$(711.8)681.7 $(1.04)$(582.6)681.4 $(0.86)
    The following table presents the reconciliation of basic and diluted earnings per share for the three and nine months ended September 30, 2024:
    (in millions, except per share data)
    Three months ended September 30, 2024Nine months ended September 30, 2024
    Earnings (numerator)Weighted average shares outstanding (denominator)Earnings per shareEarnings (numerator)Weighted average shares outstanding (denominator)Earnings per share
    Basic$57.8 680.3 $0.08 $211.1 679.3 $0.31 
    Dilutive effect of stock-based awards— 2.7 — 2.8 
    Diluted$57.8 683.0 $0.08 $211.1 682.1 $0.31 
    Certain stock options and RSUs are not included in the diluted earnings (loss) per share calculation when the effect would have been anti-dilutive. The number of anti-dilutive shares not included were 15.5 million and 14.5 million for the three and nine months ended September 30, 2025, respectively, and 4.7 million and 6.1 million for the three and nine months ended September 30, 2024, respectively.
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    4.    Segment financial information
    Our reporting segment structure consists of two reportable business segments: Laboratory Solutions and Bioscience Production. Within our reportable segments, we sell materials & consumables, equipment & instrumentation and services & specialty procurement to customers in the biopharmaceutical, healthcare, education & government and advanced technologies & applied materials industries. Corporate costs are managed on a standalone basis, certain of which are allocated to our reportable segments.
    Adjusted Operating Income is used by the CODM as the measure to evaluate segment profitability. The CODM uses this metric predominantly in the annual budget, forecasting and performance monitoring processes.
    The following table presents information by reportable segment:
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Net sales:
    Laboratory Solutions$1,096.5 $1,171.5 $3,283.6 $3,484.3 
    Bioscience Production527.3 542.9 1,605.0 1,612.7 
    Total$1,623.8 $1,714.4 $4,888.6 $5,097.0 
    Adjusted Operating Income:
    Laboratory Solutions$123.6 $151.5 $395.9 $450.7 
    Bioscience Production127.7 138.1 390.8 409.0 
    Corporate(14.0)(14.8)(54.4)(49.2)
    Total$237.3 $274.8 $732.3 $810.5 
    (in millions)
    Three months ended September 30, 2025Laboratory SolutionsBioscience ProductionCorporateTotal
    Net sales$1,096.5 $527.3 $— $1,623.8 
    Adjusted cost of sales1
    804.2 293.0 — 1,097.2 
    Adjusted operating expenses2
    168.7 106.6 14.0 289.3 
    Adjusted Operating Income$123.6 $127.7 $(14.0)$237.3 
    Nine months ended September 30, 2025Laboratory SolutionsBioscience ProductionCorporateTotal
    Net sales$3,283.6 $1,605.0 $— $4,888.6 
    Adjusted cost of sales1
    2,381.3 891.4 — 3,272.7 
    Adjusted operating expenses2
    506.4 322.8 54.4 883.6 
    Adjusted Operating Income$395.9 $390.8 $(54.4)$732.3 
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    (in millions)
    Three months ended September 30, 2024Laboratory SolutionsBioscience ProductionCorporateTotal
    Net sales$1,171.5 $542.9 $— $1,714.4 
    Adjusted cost of sales1
    837.8 303.8 — 1,141.6 
    Adjusted operating expenses2
    182.2 101.0 14.8 298.0 
    Adjusted Operating Income$151.5 $138.1 $(14.8)$274.8 
    Nine months ended September 30, 2024Laboratory SolutionsBioscience ProductionCorporateTotal
    Net sales$3,484.3 $1,612.7 $— $5,097.0 
    Adjusted cost of sales1
    2,477.1 892.4 — 3,369.5 
    Adjusted operating expenses2
    556.5 311.3 49.2 917.0 
    Adjusted Operating Income$450.7 $409.0 $(49.2)$810.5 
    ━━━━━━━━━
    1.Adjusted cost of sales excludes $0.1 million and $8.4 million of non-GAAP adjustments, for the three months ended September 30, 2025 and September 30, 2024, respectively, and $0.4 million and $11.1 million of non-GAAP adjustments for the nine months ended September 30, 2025 and September 30, 2024, respectively, primarily related to restructuring and severance charges, as described in more detail within the non-GAAP reconciliation presented below.
    2.Adjusted operating expenses excludes $886.0 million and $141.8 million of non-GAAP adjustments for the three months ended September 30, 2025 and September 30, 2024, respectively and $1,104.5 million and $352.7 million of non-GAAP adjustments for the nine months ended September 30, 2025 and September 30, 2024, respectively, primarily related to amortization, impairment charges, transformation expenses, restructuring and severance charges, as described in more detail within the non-GAAP reconciliation presented below.
    The following table presents depreciation and amortization by reportable segment:
    (in millions)
    Depreciation and amortization
    Three months ended September 30,Nine months ended September 30,
    2025
    2024
    20252024
    Laboratory Solutions$52.8 $53.4 $154.3 $160.9 
    Bioscience Production51.7 49.0 152.6 143.7 
    Total$104.5 $102.4 $306.9 $304.6 
    Information about our segments’ assets and capital expenditures is not disclosed because this information is not provided to our CODM.
    The amounts above exclude inter-segment activity because it is not material. All of the net sales presented for each segment are from external customers.
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    The following table presents the reconciliation of Adjusted Operating Income, our segment profitability measure, to (Loss) income before income taxes, the nearest measurement under GAAP:
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Adjusted Operating Income$237.3 $274.8 $732.3 $810.5 
    Amortization(76.1)(75.4)(225.5)(225.6)
    Restructuring and severance charges1
    (2.2)(49.4)(28.0)(82.3)
    Transformation expenses2
    (13.7)(17.1)(49.5)(46.6)
    Reserve for certain legal matters, net3
    (1.6)(7.9)(5.2)(7.9)
    Other4
    (7.5)(0.4)(11.7)(1.4)
    Impairment charges5
    (785.0)— (785.0)— 
    Interest expense, net(44.2)(48.7)(129.8)(173.9)
    Loss on extinguishment of debt(0.2)(2.1)(0.2)(6.5)
    Other income (expense), net
    3.7 0.7 (19.5)3.4 
    (Loss) income before income taxes
    $(689.5)$74.5 $(522.1)$269.7 
    ━━━━━━━━━
    1.Reflects the incremental expenses incurred in the period related to restructuring initiatives to increase profitability and productivity. Costs included in this caption are specific to employee severance, site-related exit costs, and contract termination costs. These expenses represent costs incurred to achieve the Company’s publicly-announced cost transformation initiative.
    2.Represents incremental expenses directly associated with the Company’s publicly-announced cost transformation initiative, primarily related to the cost of external advisors.
    3.Represents charges and legal costs, net of recoveries, in connection with certain litigation and other contingencies that are unrelated to our core operations and not reflective of on-going business and operating results.
    4.Represents other stock-based compensation expense (benefit), a purchase price adjustment related to the sale of our Clinical Services business in 2024, and $6.1 million of severance and transition costs associated with the replacement of our Chief Executive Officer.
    5.As described in note 7.
    The following table presents net sales by product category:
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Proprietary$855.6 $920.5 $2,579.1 $2,718.0 
    Third-party768.2 793.9 2,309.5 2,379.0 
    Total$1,623.8 $1,714.4 $4,888.6 $5,097.0 
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    5.    Supplemental disclosures of cash flow information
    The following table presents supplemental disclosures of cash balances:
    (in millions)
    September 30, 2025
    December 31, 2024
    Cash and cash equivalents$251.9 $261.9 
    Restricted cash classified as other assets2.8 2.8 
    Total$254.7 $264.7 
    (in millions)
    Nine months ended September 30,
    2025
    2024
    Cash flows from operating activities:
    Cash paid for income taxes, net$115.7 $128.1 
    Cash paid for interest, net, excluding financing leases134.0 179.1 
    Cash paid for interest on finance leases1.2 3.9 
    Cash paid under operating leases31.2 33.5 
    Cash flows from financing activities:
    Cash paid under finance leases$4.7 $4.5 
    6.    Inventory
    The following table presents the components of inventory:    
    (in millions)
    September 30, 2025
    December 31, 2024
    Merchandise inventory$476.2 $416.0 
    Finished goods105.8 101.2 
    Raw materials148.0 149.3 
    Work in process65.5 65.0 
    Total$795.5 $731.5 
    7.    Goodwill and other intangible assets
    Goodwill
    We review goodwill for impairment annually on October 1st, or more frequently if events or changes in circumstances indicate that the carrying value of goodwill may not be recoverable.

    As a result of sustained decreases in our publicly quoted share price and market capitalization as well as changes in the operating results of our Distribution reporting unit, formerly referred to as our Buy Sell Lab reporting unit, we conducted an interim test of our goodwill as of September 30, 2025.
    We estimate the fair value of reporting units using a weighted average of two valuation methods based on a discounted cash flows method and a guideline public company method. These valuation methods require management to make various assumptions, including, but not limited to, future profitability, cash flows, including revenues, gross margin, SG&A expenses, capital expenditures, and investments in debt free net working capital, current market assumptions for the discount rates, weighting of valuation
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    methods and the selection of comparable publicly traded companies. Variations in any of these assumptions could result in materially different calculations of fair value.
    Based on the results of the impairment test, the carrying amount of our Distribution reporting unit exceeded its fair value, resulting in a non-deductible, non-cash goodwill impairment charge of $785.0 million, which was recorded in the consolidated statement of operations for the three months ended September 30, 2025. We did not identify impairment of any other long-lived assets in this reporting unit. The remaining reporting units tested were not impaired, as their estimated fair values exceeded their respective carrying amounts as of the interim testing date.
    Following the impairment charge, the carrying value of the Distribution reporting unit is equal to its estimated fair value. Recognition of additional impairment charges may be required in future periods if market conditions, projected results, or other valuation assumptions deteriorate further.
    The following tables present changes in goodwill by reportable segment for the nine months ended September 30, 2025:
    (in millions)
    September 30, 2025
    Laboratory SolutionsBioscience ProductionTotal
    Beginning balance, net$3,651.2 $1,888.0 $5,539.2 
    Currency translation221.7 8.8 230.5 
    Impairment loss(785.0)— (785.0)
    Ending balance, net3,087.9 1,896.8 4,984.7 
    Accumulated impairment losses803.4 20.4 823.8 
    Ending balance, gross$3,891.3 $1,917.2 $5,808.5 
    Other intangible assets
    The following table presents the components of other intangible assets:
    (in millions)
    September 30, 2025
    December 31, 2024
    Gross value
    Accumulated amortization and impairment1
    Carrying valueGross value
    Accumulated amortization and impairment1
    Carrying value
    Customer relationships$4,910.4 $2,108.6 $2,801.8 $4,697.5 $1,840.4 $2,857.1 
    Trade names366.5 267.8 98.7 351.6 240.4 111.2 
    Other641.3 367.4 273.9 626.8 327.2 299.6 
    Total finite-lived$5,918.2 $2,743.8 3,174.4 $5,675.9 $2,408.0 3,267.9 
    Indefinite-lived92.3 92.3 
    Total$3,266.7 $3,360.2 
    ━━━━━━━━━
    1.As of September 30, 2025 and December 31, 2024, accumulated impairment losses on Customer relationships were $65.9 million and on Other were $40.5 million, totaling $106.4 million.
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    8.    Restructuring
    The following table presents restructuring and severance expenses by plan:

    Three months ended September 30,
    Nine months ended September 30,
    (in millions)
    2025
    2024
    2025
    2024
    2024 restructuring program$— $49.4 $— $82.3 
    Other2.2 — 28.0 — 
    Total$2.2 $49.4 $28.0 $82.3 
    Restructuring and severance charges are classified as SG&A expenses or cost of sales depending on the nature of the expense.
    2024 restructuring program
    The 2024 restructuring program is a part of the Company’s multi-year cost transformation initiative designed to right-size the Company’s cost base and optimize its footprint and organizational structure with a focus on driving cost improvement and productivity. No material charges have been incurred under this plan during 2025, and we do not expect to incur any material charges in the future.
    The following table presents information about expenses under the 2024 restructuring program for the periods covered under this report in which the plan was active:
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    As of September 30, 2025
    2025
    2024
    2025
    2024
    Charges incurredExpected remaining chargesTotal expected charges
    Employee severance and related$— $39.7 $— $64.9 $64.3 $— $64.3 
    Facility closure— 0.4 — 1.0 1.6 — 1.6 
    Other— 9.3 — 16.4 16.9 — 16.9 
    Total$— $49.4 $— $82.3 $82.8 $— $82.8 
    Laboratory Solutions$— $26.0 $— $41.9 $41.3 $— $41.3 
    Bioscience Production — 23.4 — 39.5 40.6 — 40.6 
    Corporate— — — 0.9 0.9 — 0.9 
    Total$— $49.4 $— $82.3 $82.8 $— $82.8 
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    Other charges in the table above primarily relate to the write-downs of the carrying value of assets that we plan to dispose of under the program.
    The following table presents changes to accrued employee severance and related expenses under the 2024 restructuring program, which are primarily classified as employee-related current liabilities:
    (in millions)
    Nine months ended September 30,
    2025
    Beginning balance$21.3 
    Expenses— 
    Cash payments(10.3)
    Currency translation(0.9)
    Ending balance$10.1 
    9.    Commitments and contingencies
    Our business involves commitments and contingencies related to compliance with environmental laws and regulations, the manufacture and sale of products and litigation. The ultimate resolution of contingencies is subject to significant uncertainty, and it is reasonably possible that contingencies could be decided unfavorably against us.
    Environmental laws and regulations
    Our environmental liabilities are subject to changing governmental policy and regulations, discovery of unknown conditions, judicial proceedings, method and extent of remediation, existence of other potentially responsible parties and future changes in technology. We believe that known and unknown environmental matters, if not resolved favorably, could have a material effect on our financial position, liquidity and profitability. Matters to be disclosed are as follows:
    The New Jersey Department of Environmental Protection has ordered us to remediate groundwater conditions near our plant in Phillipsburg, New Jersey. At September 30, 2025, our accrued obligation under this order is $2.3 million, which is calculated based on expected cash payments discounted at rates ranging from 3.6% to 4.8% between 2025 and 2045. The undiscounted amount of that obligation is $3.5 million. We are indemnified against any losses incurred in this matter as stipulated through the agreement and guaranty referenced in our Annual Report.
    In 2016, we assessed the environmental condition of our chemical manufacturing site in Gliwice, Poland. Our assessment revealed specific types of soil and groundwater contamination throughout the site. We are also monitoring the condition of a closed landfill on that site. These matters are not covered by our indemnification arrangement because they relate to an operation we subsequently acquired. At September 30, 2025, our balance sheet includes a liability of $1.2 million for remediation and monitoring costs. That liability is estimated primarily on discounted expected remediation payments and is not materially different from its undiscounted amount.
    Manufacture and sale of products
    Our business involves risk of product liability, patent infringement and other claims in the ordinary course of business arising from the products that we produce ourselves or obtain from our suppliers, as well as
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    from the services we provide. Our exposure to such claims may increase to the extent that we expand our manufacturing operations or service offerings.
    We maintain insurance policies to protect us against these risks, including product liability insurance. In many cases the suppliers of products we distribute have indemnified us against such claims. Our insurance coverage or indemnification agreements with suppliers may not be adequate in all pending or any future cases brought against us. Furthermore, our ability to recover under any insurance or indemnification arrangements is subject to the financial viability of our insurers, our suppliers and our suppliers’ insurers, as well as legal enforcement under the local laws governing the arrangements.
    We have entered into indemnification agreements with customers of our self-manufactured products to protect them from liabilities and losses arising from our negligence, willful misconduct or sale of defective products. To date, we have not incurred material costs to defend lawsuits or settle claims related to these indemnification provisions.
    Litigation
    At September 30, 2025, there was no outstanding litigation that we believe would result in material losses if decided against us, and we do not believe that there are any unasserted matters that are reasonably possible to result in a material loss.
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    10.    Debt
    The following table presents information about our debt:
    (dollars in millions)
    September 30, 2025
    December 31, 2024
    Interest termsRateAmount
    Receivables facility
    SOFR1 plus 0.80%
    5.03%
    $192.7 $125.0 
    Senior secured credit facilities:
    Euro term loans B-4
    EURIBOR plus 2.50%
    4.41%
    87.1 81.6 
    Euro term loans B-5
    EURIBOR plus 2.00%
    3.91%
    365.0 324.5 
    U.S. dollar term loans B-6
    SOFR1 plus 2.00%
    6.26%
    80.8 86.6 
    2.625% secured notesfixed rate
    2.625%
    293.2 672.6 
    3.875% unsecured notesfixed rate
    3.875%
    800.0 800.0 
    3.875% unsecured notesfixed rate
    3.875%
    469.2 413.9 
    4.625% unsecured notesfixed rate
    4.625%
    1,550.0 1,550.0 
    Finance lease liabilities28.1 15.0 
    Other8.1 8.6 
    Total debt, gross3,874.2 4,077.8 
    Less: unamortized deferred financing costs(16.3)(22.0)
    Total debt$3,857.9 $4,055.8 
    Classification on balance sheets:
    Current portion of debt$219.8 $821.1 
    Debt, net of current portion3,638.1 3,234.7 
    ━━━━━━━━━
    1.SOFR includes credit spread adjustment.
    Interest expense, net includes interest income of $11.9 million and $26.8 million for the three months ended September 30, 2025 and September 30, 2024, respectively, and $30.8 million and $62.6 million for the nine months ended September 30, 2025 and September 30, 2024, respectively. The interest income primarily relates to income on our interest rate swaps and cross currency swaps discussed in note 15.
    Credit facilities
    The following table presents availability under our credit facilities:
    (in millions)
    September 30, 2025
    Receivables facilityRevolving credit facilityTotal
    Capacity$238.2 $975.0 $1,213.2 
    Undrawn letters of credit outstanding(3.6)(7.5)(11.1)
    Outstanding borrowings(192.7)— (192.7)
    Unused availability$41.9 $967.5 $1,009.4 
    Capacity under the receivables facility is calculated as the lower of eligible borrowing base or facility limit of $400.0 million. Eligible borrowing base is determined as total available accounts receivable, less
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    ineligible accounts receivable and other adjustments. At September 30, 2025, total available accounts receivable under the receivables facility were $500.6 million.
    Senior secured credit facilities
    On April 2, 2024, we amended the credit agreement to reprice the U.S. Dollar term loan under our senior secured credit facilities. Pursuant to the agreement, the interest rate applicable to the U.S. Dollar term loan reduced from SOFR plus a spread of 2.25% per annum to SOFR plus a spread of 2.00% per annum. The principal amount of U.S. Dollar term loan outstanding immediately prior to the amendment and the outstanding principal amount of U.S. Dollar term loan immediately following the amendment each totaled $772.4 million. The final stated maturity of the U.S. Dollar term loan remains November 8, 2027. The costs to complete the amendment were not material.
    During the quarter ended September 30, 2025, we made an optional prepayment of $457.4 million on our 2.625% secured notes that mature on November 1, 2025. Loss on extinguishment of debt recorded in connection with this prepayment was immaterial.
    Debt covenants
    During the quarter ended September 30, 2025, our debt agreements included representations and covenants that we consider usual and customary, and our receivables facility and senior secured credit facilities included a financial covenant that would become applicable for periods in which we have drawn more than 35% of our revolving credit facility under the senior secured credit facilities. In that circumstance, we would not have been permitted to have combined borrowings on our senior secured credit facilities and secured notes in excess of a pro forma net leverage ratio, as defined in our credit agreements (as in effect during the quarter ended September 30, 2025). As we had not drawn more than 35% of our revolving credit facility in this period, this covenant was not applicable at September 30, 2025.
    Transactions subsequent to period-end
    In October 2025, we issued €400.0 million and €550.0 million of senior secured term loans, maturing in October 2030 and October 2032, respectively. These loans bear interest at EURIBOR plus 150 basis points and EURIBOR plus 250 basis points, respectively. The proceeds from these issuances, along with cash on hand, were used to repay our outstanding U.S. dollar term loans B-6, Euro term loans B-4, Euro term loans B-5, the remaining 2.625% secured notes, and the receivables facility.
    In connection with the refinancing, we amended our revolving credit facility to obtain an additional $425.0 million in available funding, increasing the total availability under the facility to $1,400.0 million. The revolving credit facility will mature in October 2030. Both the newly issued senior secured term loans and the amended revolving credit facility include covenants that we consider to be usual and customary. As part of the refinancing and addition of the new €400.0 million term loan, (i) the leverage-based financial covenant in the credit facility agreement became a full-time financial maintenance covenant, whereas previously it had been a “springing covenant”, as described in the section above, and (ii) a new consolidated interest coverage ratio financial maintenance covenant was added to the credit
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    facilities agreement, in both cases on usual and customary terms for facility agreements governing these types of senior secured term loan and revolving credit facilities.
    Also in October 2025, we terminated both our receivables facility and outstanding interest rate swap with a notional value of $100.0 million. The costs associated with terminating these arrangements were not material.
    In accordance with ASC 470-10-45-14 and ASC 855, we reclassified the 2.625% secured notes and Euro term loans B-5 from current liabilities to noncurrent liabilities in the accompanying balance sheet as of September 30, 2025, as the refinancing was completed prior to the issuance of these financial statements.
    11.    Accumulated other comprehensive income (loss)
    The following table presents changes in the components of AOCI:
    (in millions)
    Foreign currency translationDerivative instrumentsDefined benefit plansTotal
    Balance at June 30, 2025
    $(23.8)$0.1 $13.3 $(10.4)
    Unrealized (loss) gain
    (11.5)1.9 (0.4)(10.0)
    Reclassification of gain into earnings
    — (2.0)— (2.0)
    Change due to income taxes(1.2)— — (1.2)
    Balance at September 30, 2025
    $(36.5)$— $12.9 $(23.6)
    Balance at June 30, 2024
    $(119.5)$11.3 $0.9 $(107.3)
    Unrealized gain (loss)
    33.8 (0.9)(0.2)32.7 
    Reclassification of gain into earnings
    — (14.1)— (14.1)
    Change due to income taxes11.2 3.6 — 14.8 
    Balance at September 30, 2024
    $(74.5)$(0.1)$0.7 $(73.9)
    Balance at December 31, 2024
    $(177.4)$0.2 $(6.8)$(184.0)
    Unrealized gain
    116.4 7.4 2.8 126.6 
    Reclassification of (gain) loss into earnings
    — (7.6)17.3 9.7 
    Change due to income taxes24.5 — (0.4)24.1 
    Balance at September 30, 2025
    $(36.5)$— $12.9 $(23.6)
    Balance at December 31, 2023
    $(82.8)$12.6 $1.2 $(69.0)
    Unrealized gain (loss)
    5.7 14.3 (0.6)19.4 
    Reclassification of gain into earnings
    — (31.0)— (31.0)
    Change due to income taxes2.6 4.0 0.1 6.7 
    Balance at September 30, 2024
    $(74.5)$(0.1)$0.7 $(73.9)
    The reclassifications effects shown above were immaterial to the financial statements and were made to either cost of sales, SG&A expense, other income (expense) or interest expense depending upon the
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    nature of the underlying transaction. The income tax effects in the three and nine months ended September 30, 2025 on foreign currency translation were due to our cross-currency swap discussed in note 15.
    12.    Stock-based compensation
    The following table presents the components of stock-based compensation expense:
    (in millions)
    Classification
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Stock optionsEquity$3.0 $2.5 $7.8 $8.2 
    RSUsEquity4.1 8.3 27.5 25.9 
    OtherBoth0.2 1.1 (0.2)1.6 
    Total$7.3 $11.9 $35.1 $35.7 
    Award classification:
    Equity$7.4 $11.3 $36.2 $35.3 
    Liability(0.1)0.6 (1.1)0.4 
    At September 30, 2025, unvested awards have remaining expense of $78.3 million to be recognized over a weighted average period of 1.6 years.
    Stock options
    The following table presents information about outstanding stock options:
    (options and intrinsic value in millions)
    Number of optionsWeighted average exercise price per optionAggregate intrinsic valueWeighted average remaining term
    Balance at December 31, 2024
    11.9 $21.94 
    Granted1.5 16.15 
    Exercised(0.1)7.67 
    Forfeited(1.1)23.31 
    Balance at September 30, 2025
    12.2 $21.17 $0.1 5.8 years
    Expected to vest2.0 19.41 — 8.8 years
    Vested10.2 21.52 0.1 4.6 years
    During the nine months ended September 30, 2025, we granted stock options that have a contractual life of ten years and will vest annually over three years, subject to the recipient continuously providing service to us through each such date.
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    RSUs
    The following table presents information about unvested RSUs:
    (awards in millions)
    Number of awardsWeighted average grant date fair value per award
    Balance at December 31, 2024
    4.6 $26.63 
    Granted4.7 15.48 
    Vested(1.3)25.96 
    Forfeited(1.5)22.26 
    Balance at September 30, 2025
    6.5 $18.56 
    During the nine months ended September 30, 2025, we granted RSUs that will vest annually over one to three years, as specified in the terms of the underlying grant agreements, subject to the recipient continuously providing service to us throughout the vesting period. Certain of those awards contain performance and market conditions that impact the number of shares that will ultimately vest. We recorded expense on such awards of $(5.4) million and $1.8 million for the three months ended September 30, 2025 and September 30, 2024, respectively, and $1.6 million and $6.6 million for the nine months ended September 30, 2025 and September 30, 2024, respectively. The expense reversal for the three months ended September 30, 2025 was primarily driven by the forfeiture of awards following the departure of certain executives.
    13.    Other income or expense, net
    The following table presents the components of other income or expense, net:
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Net foreign currency gain (loss) from financing activities
    $1.5 $— $(5.6)

    $1.8 
    Income (expense) related to defined benefit plans
    1.5 0.7 (16.3)

    1.6 
    Other0.7 — 2.4 — 
    Other income (expense), net
    $3.7 $0.7 $(19.5)$3.4 
    Other income or expense for the nine months ended September 30, 2025 primarily relates to pension termination costs and the expected returns on defined benefit plan assets.
    As described in our Annual Report, we approved the termination of one of our two U.S. Pension Plans in 2024. The pension liability for this plan was partially settled in December 2024 through lump sum distribution payments made to plan participants.
    The remaining pension liability was settled in the first quarter of 2025, primarily through the purchase of annuity contracts totaling $97.7 million. As a result of the settlement, we recorded $16.3 million of pension termination costs for the nine months ended September 30, 2025, which were primarily recognized in other income or expense.
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    The remaining pension surplus from the plan, approximately $48.0 million, will be used by the Company as prescribed by applicable regulations to fund a Qualified Replacement Plan, which will primarily fund future contributions to the Avantor U.S. 401(k) defined contribution plan.
    14.    Income taxes
    The following table presents the relationship between income tax expense and (loss) income before income taxes:
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    (Loss) income before income taxes
    $(689.5)$74.5$(522.1)$269.7
    Income tax expense
    (22.3)(16.7)(60.5)(58.6)
    Effective income tax rate(3.2)%22.4 %(11.6)%21.7 %
    Income tax expense in the quarter is based upon the estimated income for the full year. The composition of the income in different countries and adjustments, if any, in the applicable quarterly periods influences our expense.
    The relationship between pre-tax income and income tax expense is affected by the impact of losses for which we cannot claim a tax benefit, non-deductible expenses and other items that increase tax expense without a relationship to income, such as withholding taxes and changes with respect to uncertain tax positions.
    The change in the effective tax rate for the three and nine months ended September 30, 2025, when compared to the three and nine months ended September 30, 2024, is primarily due to a goodwill impairment charge recorded in the third quarter of 2025 related to our Distribution reporting unit, as described in note 7, and a year-to-date shortfall in the tax deduction arising from the exercise of stock options, in comparison to the related tax expense previously taken on such instruments.
    On July 4, 2025, the U.S. enacted H.R. 1, commonly referred to as the One Big Beautiful Bill Act (“Act”). As a result of the Act, we anticipate a reduction in our current cash tax obligations of approximately $40.0 million due to changes to several provisions, including the reinstatement of immediate expensing for domestic research and development expenditures, the extension of 100% bonus depreciation for qualified properties and the relaxation of limitations on the deductibility of business interest expense. The impact on income tax expense resulting from the Act is expected to be immaterial.
    15.    Derivative and hedging activities
    Hedging instruments:
    We engage in hedging activities to reduce our exposure to foreign currency exchange rates and interest rates. Our hedging activities are designed to manage specific risks according to our strategies, as summarized below, which may change from time to time. Our hedging activities consist of the following:
    •Economic hedges — We are exposed to changes in foreign currency exchange rates on certain of our euro-denominated term loans and notes that move inversely from our portfolio of euro-
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    denominated intercompany loans. The currency effects for these non-derivative instruments are recorded through earnings in the period of change and substantially offset one another;
    •Other hedging activities — Certain of our subsidiaries hedge short-term foreign currency denominated business transactions, external debt and intercompany financing transactions using foreign currency forward contracts. These activities were not material to our consolidated financial statements.
    Cash flow hedges of interest rate risk
    Our objectives in using interest rate derivatives are to add stability to interest expense and to manage its exposure to interest rate movements. To accomplish this objective, the Company primarily uses interest rate swaps as part of its interest rate risk management strategy. Interest rate swaps designated as cash flow hedges involve the receipt of variable amounts from a counterparty in exchange for the Company making fixed-rate payments over the life of the agreements without exchange of the underlying notional amount.
    For derivatives designated and that qualify as cash flow hedges of interest rate risk, the gain or loss on the derivative is recorded in AOCI and subsequently reclassified into interest expense in the same period(s) during which the hedged transaction affects earnings. Amounts reported in AOCI related to derivatives will be reclassified to interest expense as interest payments are made on the Company’s variable-rate debt. During the next twelve months, the Company estimates that an immaterial amount will be reclassified as an increase to interest expense.
    During the quarter ended September 30, 2024, the hedging relationship between our $750.0 million notional value interest rate swap and underlying hedged item became ineffective as the hedged forecast transaction was deemed no longer probable of occurring. Due to the ineffectiveness, hedge accounting was discontinued.
    As of September 30, 2025, the Company had the following outstanding interest rate derivatives that were designated as cash flow hedges of interest rate risk:
    (dollars in millions)
    Interest rate derivativeNumber of instrumentsNotional
    Interest rate swaps1$100.0 
    Effect of cash flow hedge accounting on AOCI
    The table below presents the effect of cash flow hedge accounting on AOCI for the three and nine months ended September 30, 2025 and September 30, 2024.
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    (in millions)
    Hedging relationshipsAmount of gain or (loss) recognized in OCI on DerivativeLocation of gain or (loss) reclassified from AOCI into incomeAmount of gain or (loss) reclassified from AOCI into income
    Three months ended September 30,
    Nine months ended September 30,
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    2025
    2024
    2025
    2024
    Interest rate products
    $— $(4.0)$0.1 $4.8 
    Interest expense, net
    $0.1 $11.0 $0.3 $21.5 
    Total$— $(4.0)$0.1 $4.8 $0.1 $11.0 $0.3 $21.5 
    Effect of cash flow hedge accounting on the income statement
    The table below presents the effect of our derivative financial instruments on the statement of operations for the three and nine months ended September 30, 2025 and September 30, 2024.
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    (in millions)Interest expense, netInterest expense, netInterest expense, netInterest expense, net
    Total amounts of line items presented in the statements of operations where the effects of cash flow hedges are recorded$(44.2)$(48.7)$(129.8)$(173.9)
    Amount of gain reclassified from AOCI into income$0.1 $11.0 $0.3 $21.5 
    Net investment hedges
    We are exposed to fluctuations in foreign exchange rates on investments we hold in foreign entities, specifically our net investment in EUR functional currency consolidated subsidiaries, against the risk of changes in the EUR-USD exchange rate.
    For derivatives designated as net investment hedges, the gain or loss on the derivative is reported in AOCI as part of the cumulative translation adjustment. Amounts are reclassified out of AOCI into earnings in the event the hedged net investment is either sold or substantially liquidated.
    As of September 30, 2025, we had the following outstanding foreign currency derivatives that were used to hedge its net investments in foreign operations:
    (value in millions)
    Foreign currency derivative
    Number of instruments
    Notional sold
    Notional purchased
    Cross-currency swaps
    3 €732.1 $750.0 
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    As of December 31, 2024, we held a cross-currency swap with a notional amount of $750.0 million, maturing in April 2025. In April 2025, we completed a transaction to effectively amend and extend the cross-currency swap maturing in April 2025. The liability position of the original cross-currency swap was blended and extended into three separate cross-currency swap agreements, each with a notional amount of $250.0 million, maturing in April 2027, April 2028, and April 2029, respectively.
    Effect of net investment hedges on AOCI and the income statement
    The table below presents the effect of our net investment hedges on AOCI and the statement of operations for the three and nine months ended September 30, 2025 and September 30, 2024.
    Effect of Net Investment Hedges on AOCI and the Income Statement
    (in millions)
    Hedging relationships
    Amount of gain or (loss) recognized in OCI on Derivative
    Location of gain or (loss) recognized in income on Derivative (amount excluded from effectiveness testing)
    Amount of gain or (loss) recognized in income on Derivative (amount excluded from effectiveness testing)
    September 30,
    September 30,
    2025
    2024
    2025
    2024
    Three months ended:
    Cross currency swaps
    $6.8 $(26.3)
    Interest expense, net
    $1.9 $3.1 
    Total$6.8 $(26.3)$1.9 $3.1 
    Nine months ended:
    Cross currency swaps
    $(93.9)$2.0 
    Interest expense, net
    $7.2 $9.5 
    Total$(93.9)$2.0 $7.2 $9.5 
    The Company did not reclassify any other deferred gains or losses related to cash flow hedges from accumulated other comprehensive income (loss) to earnings for the three and nine months ended September 30, 2025 and September 30, 2024 other than those mentioned above.
    The table below presents the fair value of our derivative financial instruments as well as their classification on the Balance Sheet as of September 30, 2025 and December 31, 2024:
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    Derivative assets
    Derivative liabilities
    September 30, 2025
    December 31, 2024
    September 30, 2025
    December 31, 2024
    (in millions)
    Balance sheet location
    Fair value
    Balance sheet location
    Fair value
    Balance sheet location
    Fair value
    Balance sheet location
    Fair value
    Derivatives designated as hedging instruments:
    Interest rate products
    Other current assets
    $— 
    Other current assets
    $0.3 
    Other current liabilities
    $— 
    Other current liabilities
    $— 
    Foreign exchange products
    Other current assets
    — 
    Other current assets
    — 
    Other current liabilities
    (108.1)
    Other current liabilities
    (7.0)
    Total
    $— $0.3 $(108.1)$(7.0)
    Non-derivative financial instruments which are designated as hedging instruments:
    We designated all of our outstanding €400.0 million 3.875% senior unsecured notes, issued on July 17, 2020, and maturing on July 15, 2028, as a hedge of our net investment in certain of our European operations. For instruments that are designated and qualify as net investment hedges, the foreign currency transactional gains or losses are reported as a component of AOCI.
    In October 2024, the Company de-designated these outstanding €400.0 million 3.875% senior unsecured notes as a hedge of our net investment in certain of our European operations. The de-designation had no impact on earnings as the accumulated gain on the net investment hedge is only reclassified into earnings upon a liquidation event or deconsolidation of a hedged foreign subsidiary.
    The accumulated gain related to the foreign currency denominated debt previously designated as a net investment hedge classified in the foreign currency translation adjustment component of AOCI was $6.0 million as of September 30, 2025 and December 31, 2024.
    The amount of loss related to the foreign currency denominated debt designated as net investment hedges classified in the foreign currency translation adjustment component of other comprehensive income or loss for the three and nine months ended September 30, 2025 and September 30, 2024 are presented below:
    (in millions)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    Net investment hedges$— $17.0 $— $3.3 
    16.    Financial instruments and fair value measurements
    Our financial instruments include cash and cash equivalents, accounts receivable, accounts payable and debt.
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    Assets and liabilities for which fair value is only disclosed
    The carrying amount of cash and cash equivalents was the same as its fair value and is a Level 1 measurement. The carrying amounts for trade accounts receivable and accounts payable approximated fair value due to their short-term nature and are Level 2 measurements.
    The following table presents the gross amounts, which exclude unamortized deferred financing costs, and the fair values of debt instruments:
    (in millions)
    September 30, 2025
    December 31, 2024
    Gross amountFair valueGross amountFair value
    Receivables facility$192.7 $192.7 $125.0 $125.0 
    Senior secured credit facilities:
    Euro term loans B-487.1 87.7 81.6 82.1 
    Euro term loans B-5365.0 365.5 324.5 326.1 
    U.S. dollar term loans B-680.8 81.3 86.6 87.2 
    2.625% secured notes293.2 293.2 672.6 668.4 
    3.875% unsecured notes800.0 762.4 800.0 729.9 
    3.875% unsecured notes469.2 469.3 413.9 413.6 
    4.625 % unsecured notes1,550.0 1,525.8 1,550.0 1,480.6 
    Finance lease liabilities28.1 28.1 15.0 15.0 
    Other8.1 8.1 8.6 8.6 
    Total$3,874.2 $3,814.1 $4,077.8 $3,936.5 
    The fair values of debt instruments are based on standard pricing models that take into account the present value of future cash flows, and in some cases private trading data, which are Level 2 measurements.
    Certain financial and non-financial assets and liabilities are measured at fair value on a nonrecurring basis and are subject to fair value adjustments in specific circumstances, such as when indicators of impairment are present. As discussed in note 7, during the third quarter of 2025, goodwill associated with our Distribution reporting unit was determined to be impaired. As a result, the carrying amount was reduced to its estimated fair value of $3,500.0 million, resulting in an impairment charge of $785.0 million. We estimated the fair value of the Distribution reporting unit using Level 3 inputs under the fair value hierarchy, which included a discounted cash flow analysis.
    17.    Subsequent events
    In October 2025, our Board of Directors authorized the repurchase of up to $500.0 million of our common stock, exclusive of fees, commissions and related transaction expenses. Repurchases may be funded through our available cash, borrowings under existing credit facilities or other financing arrangements approved by the Board of Directors. Management is authorized to repurchase our common stock on the open market or in privately negotiated transactions, through one or more Rule 10b5-1 trading plans, Rule 10b-18 repurchase programs, accelerated share repurchase programs, including any collateral arrangements, or a combination thereof. The timing, manner, price and amount of repurchases will be determined by management depending upon economic, market and other conditions. The repurchase program may be modified, suspended, or terminated at any time. Repurchases under the program will be held as treasury shares.
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    Item 2.    Management’s discussion and analysis of financial condition and results of operations
    This discussion contains forward-looking statements that reflect our plans, estimates and beliefs. Our actual results may differ materially from those contained in or implied by any forward-looking statements. See “Cautionary factors regarding forward-looking statements.”
    Basis of presentation
    This discussion should be read in conjunction with the accompanying unaudited condensed consolidated financial statements and notes. Pursuant to SEC rules for reports covering interim periods, we have prepared this discussion and analysis to enable you to assess material changes in our financial condition and results of operations since December 31, 2024, the date of our Annual Report. Therefore, we encourage you to read this discussion and analysis in conjunction with our Annual Report.
    Overview
    During the three months ended September 30, 2025, we recorded net sales of $1,623.8 million, net loss of $711.8 million, Adjusted EBITDA of $267.9 million and Adjusted Operating Income of $237.3 million. Net sales declined 5.3%, which included a 4.7% organic net sales decrease compared to the same period in 2024. See “Reconciliations of non-GAAP measures” for reconciliations of net (loss) income to Adjusted EBITDA and Adjusted Operating Income, and net (loss) income margin to Adjusted EBITDA margin and Adjusted Operating Income margin. See “Results of operations” for a reconciliation and explanation of changes of net sales growth (decline) to organic net sales growth (decline).
    Factors and current trends affecting our business and results of operations
    The following updates the factors and current trends disclosed in our Annual Report. These updates may affect our performance and financial condition in future periods.
    Our results are impacted by a divestiture to further refine our business model
    We completed the sale of our Clinical Services business, a component of the Company’s Laboratory Solutions reportable segment, on October 17, 2024. The Clinical Services business was not classified as a discontinued operation as it did not represent a strategic shift that will have a major effect on the Company’s operations and financial results.
    We have been impacted by inflationary pressures
    We have experienced inflationary pressures across all of our cost categories. While we have implemented pricing and productivity measures to combat these pressures, they may continue to adversely impact our results.
    We continue to invest in a differentiated innovation model
    We are engaging with our customers early in their product development cycles to advance their programs from research and discovery through development and commercialization. These projects include enhancing product purity and performance characteristics, improving product packaging and streamlining workflows. We are also developing new products in emerging areas of science such as cell and gene therapy.
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    We continue to advance our cost transformation initiative to reduce our expenses
    We are advancing a global cost transformation initiative to further enhance productivity through increased organizational efficiency, footprint optimization, reduced cost-to-serve and procurement savings that are expected to generate approximately $300 million in run rate gross cost savings by the end of 2026.
    We have expanded this initiative and now expect to generate approximately $400 million in run rate gross savings by the end of 2027.
    Fluctuations in foreign currency rates impact our results
    Our consolidated results of operations are comprised of many different functional currencies that translate into our U.S. dollar reporting currency. The movement of the U.S. dollar against those functional currencies, particularly the Euro, has caused significant variability in our results and may continue to do so in the future.
    Our results may be impacted by changes in trade policy
    The imposition of tariffs and other trade restrictions by the U.S., as well as reciprocal trade restrictions imposed by other countries, could adversely affect global economies, financial markets and the overall environment in which we do business.
    Key indicators of performance and financial condition
    To evaluate our performance, we monitor a number of key indicators. As appropriate, we supplement our results of operations determined in accordance with GAAP with certain non-GAAP financial measurements that we believe are useful to investors, creditors and others in assessing our performance. These measures should not be considered in isolation or as a substitute for reported GAAP results because they may include or exclude certain items as compared to similar GAAP-based measures, and such measures may not be comparable to similarly titled measures reported by other companies. Rather, these measures should be considered as an additional way of viewing aspects of our operations that provide a more complete understanding of our business.
    The key indicators that we monitor are as follows:
    •Net sales, gross margin, operating income, operating income margin, net income or loss and net income or loss margin. These measures are discussed in the section entitled “Results of operations”;
    •Organic net sales growth (decline), which is a non-GAAP measure discussed in the section entitled “Results of operations.” Organic net sales growth (decline) eliminates from our reported net sales change the impacts of revenues from acquisitions and divestitures that occurred in the last year (as applicable) and changes in foreign currency exchange rates. We believe that this measurement is useful to investors as a way to measure and evaluate our underlying commercial operating performance consistently across our segments and the periods presented. This measurement is used by our management for the same reason. Reconciliations to the change in reported net sales, the most directly comparable GAAP financial measure, are included in the section entitled “Results of operations”;
    •Adjusted EBITDA and Adjusted EBITDA margin, which are non-GAAP measures discussed in the section entitled “Results of operations.” Adjusted EBITDA is our net income or loss adjusted
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    for the following items: (i) interest expense, (ii) income tax expense, (iii) amortization of acquired intangible assets, (iv) depreciation expense, (v) losses on extinguishment of debt, (vi) charges associated with the impairment of certain assets, (vii) gain on sale of business, and (viii) certain other adjustments. Adjusted EBITDA margin is Adjusted EBITDA divided by net sales as determined under GAAP. We believe that these measurements are useful to investors as ways to analyze the underlying trends in our business consistently across the periods presented. These measurements are used by our management for the same reason. A reconciliation of net income or loss and net income or loss margin, the most directly comparable GAAP financial measures, to Adjusted EBITDA and Adjusted EBITDA margin, respectively, are included in the section entitled “Reconciliations of non-GAAP measures”;
    •Adjusted Operating Income and Adjusted Operating Income margin, which are non-GAAP measures discussed in the section entitled “Results of operations.” Adjusted Operating Income is our net income or loss adjusted for the following items: (i) interest expense, (ii) income tax expense, (iii) amortization of acquired intangible assets, (iv) losses on extinguishment of debt, (v) charges associated with the impairment of certain assets, (vi) gain on sale of business, and (vii) certain other adjustments. This measurement is our segment reporting profitability measure under GAAP. Adjusted Operating Income margin is Adjusted Operating Income divided by net sales as determined under GAAP. We believe that these measurements are useful to investors as ways to analyze the underlying trends in our business consistently across the periods presented. These measurements are used by our management for the same reason. A reconciliation of net income or loss and net income or loss margin, the most directly comparable GAAP financial measures, to Adjusted Operating Income and Adjusted Operating Income margin, respectively, are included in the section entitled “Reconciliations of non-GAAP measures”;
    •Cash flows from operating activities, which we discuss in the section entitled “Liquidity and capital resources—Historical cash flows”;
    •Free cash flow, which is a non-GAAP measure, is equal to our cash flows from operating activities, less capital expenditures, plus direct transaction costs and income taxes paid related to acquisitions and divestitures (as applicable) in the period. We believe that this measurement is useful to investors as it provides a view on the Company’s ability to generate cash for use in financing or investing activities. This measurement is used by management for the same reason. A reconciliation of cash flows from operating activities, the most directly comparable GAAP financial measure, to free cash flow, is included in the section entitled “Liquidity and capital resources—Historical cash flows.”
    Results of operations
    We present results of operations in the same way that we manage our business, evaluate our performance and allocate our resources. We also provide discussion of net sales and Adjusted Operating Income by segment: Laboratory Solutions and Bioscience Production. Corporate costs are managed on a standalone basis, certain of which are allocated to our reportable segments.
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    Executive summary
    (dollars in millions)
    Three months ended September 30,Change
    20252024
    Net sales$1,623.8 $1,714.4 $(90.6)
    Gross margin32.4 %32.9 %(50) bps
    Operating (loss) income
    $(648.8)$124.6 $(773.4)
    Operating (loss) income margin
    (40.0)%7.3 %(4,730) bps
    Net (loss) income
    $(711.8)$57.8 $(769.6)
    Net (loss) income margin
    (43.8)%3.4 %(4,720) bps
    Adjusted EBITDA$267.9 $302.5 $(34.6)
    Adjusted EBITDA margin16.5 %17.6 %(110) bps
    Adjusted Operating Income$237.3 $274.8 $(37.5)
    Adjusted Operating Income margin14.6 %16.0 %(140) bps
    The third quarter net sales decline was primarily driven by the divestiture of our Clinical Services business within our Advanced Lab Services business, and by reduced customer demand within our Total Science Solutions business, both impacting the Laboratory Solutions segment. These factors contributed to a contraction in gross profit. The decrease in operating income was caused primarily by a non-cash goodwill impairment charge in our Distribution reporting unit, as described in note 7. Lower gross profit resulted in reduced Adjusted Operating Income and Adjusted EBITDA, partially offset by a reduction in SG&A expenses.
    Net Sales
    Three months ended
    (in millions)
    Three months ended September 30,
    Reconciliation of net sales growth (decline) to organic net sales growth (decline)
    Net sales growth (decline)Foreign currency impactDivestiture impactOrganic net sales growth (decline)
    2025
    2024
    Laboratory Solutions$1,096.5 $1,171.5 $(75.0)$31.0 $(48.4)$(57.6)
    Bioscience Production527.3 542.9 (15.6)7.7 — (23.3)
    Total$1,623.8 $1,714.4 $(90.6)$38.7 $(48.4)$(80.9)
    Net sales decreased $90.6 million or 5.3%, which included $38.7 million or 2.2% of favorable foreign currency impact and $48.4 million or 2.8% of impact related to our Clinical Services divestiture. Organic net sales decreased by $80.9 million or 4.7%.
    In the Laboratory Solutions segment, net sales decreased by $75.0 million or 6.4%, which included $31.0 million or 2.6% of favorable foreign currency impact and $48.4 million or 4.1% of impact related to our Clinical Services divestiture. Organic net sales decreased by $57.6 million or 4.9%. The sales decrease was primarily driven by lower demand for consumables and equipment & instrumentation in our Total Science Solutions business within the Laboratory Solutions segment due to the uncertainty around funding and increased competitive intensity.
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    In the Bioscience Production segment, net sales decreased by $15.6 million or 2.9%, which included $7.7 million or 1.4% of favorable foreign currency impact. Organic net sales decreased by $23.3 million or 4.3%. The sales decrease was primarily driven by lower sales volume in Silicones, partially offset by higher demand for our formulated offerings to customers in the semiconductor industry.
    Nine months ended
    (in millions)
    Nine months ended September 30,
    Reconciliation of net sales growth (decline) to organic net sales growth (decline)
    Net sales growth (decline)Foreign currency impactDivestiture impactOrganic net sales growth (decline)
    2025
    2024
    Laboratory Solutions$3,283.6 $3,484.3 $(200.7)$42.1 $(140.6)$(102.2)
    Bioscience Production1,605.0 1,612.7 (7.7)9.0 — (16.7)
    Total$4,888.6 $5,097.0 $(208.4)$51.1 $(140.6)$(118.9)
    Net sales decreased $208.4 million or 4.1%, which included $51.1 million or 1.0% of favorable foreign currency impact and $140.6 million or 2.8% of impact related to our Clinical Services divestiture. Organic decline in net sales was $118.9 million or 2.3%.
    In the Laboratory Solutions segment, net sales decreased $200.7 million or 5.8%, which included $42.1 million or 1.1% of favorable foreign currency impact and $140.6 million or 4.0% of impact related to our Clinical Services divestiture. Organic net sales decreased $102.2 million or 2.9%. The sales decline was primarily driven by decreased demand for consumables and equipment and instrumentation from our Total Science Solutions business due to the uncertainty around funding and increased competitive intensity.
    In the Bioscience Production segment, net sales decreased $7.7 million or 0.5%, which included $9.0 million or 0.5% of favorable foreign currency impact. Organic net sales decreased by $16.7 million or 1.0%. The sales decrease was primarily driven by lower demand for third party clean room consumables due to lower usage, and by declines in our proprietary clinical and industrial chemicals offerings. These decreases were partially offset by growth in process ingredients and excipients and single-use solutions in our bioprocessing business.
    Gross margin
    Three months ended September 30,
    Change
    Nine months ended September 30,
    Change
    2025
    2024
    2025
    2024
    Gross margin32.4 %32.9 %(50) bps33.0 %33.7 %(70) bps
    Three and nine months ended
    Gross margin for the three months ended September 30, 2025 contracted by 50 basis points due to inflationary pressures and unfavorable manufacturing variances, partially offset by improved product mix. For the nine months ended September 30, 2025, margin contracted 70 basis points driven by inflationary pressures, unfavorable manufacturing variances and the divestiture of our Clinical Services business, partially offset by lower inventory reserves.
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    Operating (loss) income
    (in millions)
    Three months ended September 30,
    Change
    Nine months ended September 30,
    Change
    2025
    2024
    2025
    2024
    Gross profit$526.5 $564.4 $(37.9)$1,615.5 $1,716.4 $(100.9)
    Operating expenses (excluding impairment
    charges)
    390.3 439.8 (49.5)1,203.1 1,269.7 (66.6)
    Impairment charges785.0 — 785.0 785.0 — 785.0 
    Operating (loss) income
    $(648.8)$124.6 $(773.4)$(372.6)$446.7 $(819.3)
    Three and nine months ended
    Operating (loss) income for the three months ended September 30, 2025 decreased primarily due to a non-cash impairment charge in our Distribution reporting unit and lower gross profit, as previously discussed, partially offset by a reduction of SG&A expenses. The reduction in SG&A expenses was driven by lower restructuring and severance charges, savings from our cost transformation initiative and the divestiture of our Clinical Services business.
    Operating (loss) income for the nine months ended September 30, 2025 decreased primarily due to a non-cash impairment charge in our Distribution Lab reporting unit and lower gross profit, as previously discussed, partially offset by a reduction of SG&A expenses. The reduction in SG&A expenses was driven by lower restructuring and severance charges, savings from our cost transformation initiative and the divestiture of our Clinical Services business.
    Net (loss) income
    (in millions)
    Three months ended September 30,
    Change
    Nine months ended September 30,
    Change
    2025
    2024
    2025
    2024
    Operating (loss) income
    $(648.8)$124.6 $(773.4)$(372.6)$446.7 $(819.3)
    Interest expense, net(44.2)(48.7)4.5 (129.8)(173.9)44.1 
    Loss on extinguishment of debt(0.2)(2.1)1.9 (0.2)(6.5)6.3 
    Other income (expense), net
    3.7 0.7 3.0 (19.5)3.4 (22.9)
    Income tax expense
    (22.3)(16.7)(5.6)(60.5)(58.6)(1.9)
    Net (loss) income
    $(711.8)$57.8 $(769.6)$(582.6)$211.1 $(793.7)
    Three and nine months ended
    Net (loss) income for the three months ended September 30, 2025 decreased primarily due to lower operating (loss) income, as previously discussed, and higher income tax expense, partially offset by lower interest expense resulting from debt repayments made over the last twelve months.
    Net (loss) income for the nine months ended September 30, 2025 decreased primarily due to lower operating (loss) income, as previously discussed, and pension termination charges, partially offset by lower interest expense resulting from debt repayments made over the last twelve months.
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    Adjusted EBITDA and Adjusted EBITDA margin
    For reconciliations of Adjusted EBITDA and Adjusted EBITDA margin to net (loss) income and net (loss) income margin, respectively, the most directly comparable measures under GAAP, see “Reconciliations of non-GAAP financial measures.”
    (dollars in millions)
    Three months ended September 30,
    Change
    Nine months ended September 30,
    Change
    2025
    2024
    2025
    2024
    Adjusted EBITDA
    $267.9$302.5$(34.6)$817.3$891.1$(73.8)
    Adjusted EBITDA margin16.5 %17.6 %(110) bps16.7 %17.5 %(80) bps
    Three and nine months ended
    For the three months ended September 30, 2025, Adjusted EBITDA decreased by $34.6 million or 11.4%, which included a favorable foreign currency translation impact of $6.4 million or 2.2%. The remaining decline of $41.0 million or 13.6% was primarily driven by the divestiture of our Clinical Services business and lower gross profit, partially offset by savings from our cost transformation initiative.
    For the nine months ended September 30, 2025, Adjusted EBITDA decreased by $73.8 million or 8.3%, which included a favorable foreign currency translation impact of $8.4 million or 0.9%. The remaining decline of $82.2 million or 9.2% was primarily driven by the divestiture of our Clinical Services business and lower gross profit, partially offset by savings from our cost transformation initiative.
    Adjusted Operating Income and Adjusted Operating Income margin
    For reconciliations of Adjusted Operating Income and Adjusted Operating Income margin to net (loss) income and net (loss) income margin, respectively, the most directly comparable measures under GAAP, see “Reconciliations of non-GAAP financial measures.”
    (dollars in millions)
    Three months ended September 30,
    Change
    Nine months ended September 30,
    Change
    2025
    2024
    2025
    2024
    Adjusted Operating Income:
    Laboratory Solutions$123.6$151.5$(27.9)$395.9$450.7$(54.8)
    Bioscience Production127.7138.1(10.4)390.8409.0(18.2)
    Corporate(14.0)(14.8)0.8 (54.4)(49.2)(5.2)
    Total$237.3$274.8$(37.5)$732.3$810.5$(78.2)
    Adjusted Operating Income margin14.6 %16.0 %(140) bps15.0 %15.9 %(90) bps
    Three months ended
    Adjusted Operating Income decreased $37.5 million or 13.6%, which included a favorable foreign currency translation impact of $5.4 million or 2.0%. The remaining decline of $42.9 million or 15.6% is further discussed below.
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    In the Laboratory Solutions segment, Adjusted Operating Income declined $27.9 million or 18.4%, or 20.7% when adjusted for favorable foreign currency translation impact. The decrease was primarily due to the divestiture of our Clinical Services business, lower sales volume and inflationary pressures, partially offset by savings from our cost transformation initiative.
    In the Bioscience Production segment, Adjusted Operating Income declined $10.4 million or 7.5%, or 8.9% when adjusted for favorable foreign currency translation impact. The decrease was primarily driven by lower sales volume, partially offset by commercial excellence.
    In Corporate, Adjusted Operating Income decreased $0.8 million due to various immaterial factors.
    Nine months ended
    Adjusted Operating Income decreased $78.2 million or 9.6%, which included a favorable foreign currency translation impact of $6.8 million or 0.9%. The remaining decline was $85.0 million or 10.5%, which is further discussed below.
    In the Laboratory Solutions segment, Adjusted Operating Income declined $54.8 million or 12.2%, or 13.2% when adjusted for favorable foreign currency translation impact. The decrease was primarily due to the divestiture of our Clinical Services business, lower sales volumes and inflationary pressures, partially offset by savings from our cost transformation initiative.
    In the Bioscience Production segment, Adjusted Operating Income declined $18.2 million or 4.4%, or 5.0% when adjusted for favorable foreign currency translation impact. The decrease was primarily driven by lower sales volume and unfavorable manufacturing variances, partially offset by commercial excellence and savings from our cost transformation initiative.
    In Corporate, Adjusted Operating Income decreased $5.2 million due to immaterial offsetting factors.
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    Reconciliations of non-GAAP measures
    The following table presents the reconciliation of net (loss) income and net (loss) income margin to Adjusted EBITDA and Adjusted EBITDA margin, respectively:
    (dollars in millions, % based on net sales)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    $%$%$%$%
    Net (loss) income
    $(711.8)(43.8)%$57.8 3.4 %$(582.6)(11.9)%$211.1 4.1 %
    Interest expense, net44.2 2.7 %48.7 2.8 %129.8 2.7 %173.9 3.4 %
    Income tax expense
    22.3 1.4 %16.7 1.0 %60.5 1.1 %58.6 1.2 %
    Depreciation and amortization104.5 6.5 %102.4 5.9 %306.9 6.3 %304.6 5.9 %
    Loss on extinguishment of debt0.2 — %2.1 0.1 %0.2 — %6.5 0.1 %
    Restructuring and severance charges1
    2.2 0.1 %49.4 2.9 %28.0 0.6 %82.3 1.7 %
    Transformation expenses2
    13.7 0.8 %17.1 1.0 %49.5 1.0 %46.6 0.9 %
    Reserve for certain legal matters, net3
    1.6 0.1 %7.9 0.5 %5.2 0.1 %7.9 0.2 %
    Other4
    7.8 0.5 %0.4 — %18.5 0.4 %(0.4)— %
    Pension termination charges5
    (1.8)(0.1)%— — %16.3 0.3 %— — %
    Impairment charges6
    785.0 48.3 %— — %785.0 16.1 %— — %
    Adjusted EBITDA$267.9 16.5 %$302.5 17.6 %$817.3 16.7 %$891.1 17.5 %
    ━━━━━━━━━
    1.Reflects the incremental expenses incurred in the period related to restructuring initiatives to increase profitability and productivity. Costs included in this caption are specific to employee severance, site-related exit costs, and contract termination costs. These expenses represent costs incurred to achieve the Company’s publicly-announced cost transformation initiative.
    2.Represents incremental expenses directly associated with the Company’s publicly-announced cost transformation initiative, primarily related to the cost of external advisors.
    3.Represents charges and legal costs, net of recoveries, in connection with certain litigation and other contingencies that are unrelated to our core operations and not reflective of on-going business and operating results.
    4.Represents net foreign currency (gain) loss from financing activities, other stock-based compensation expense (benefit), a purchase price adjustment related to the sale of our Clinical Services business in 2024, and $6.1 million of severance and transition costs associated with the replacement of our Chief Executive Officer.
    5.As described in note 13 to our unaudited condensed consolidated financial statements.
    6.As described in note 7 to our unaudited condensed consolidated financial statements.
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    The following table presents the reconciliation of net (loss) income and net (loss) income margin to Adjusted Operating Income and Adjusted Operating Income margin, respectively:
    (dollars in millions, % based on net sales)
    Three months ended September 30,
    Nine months ended September 30,
    2025
    2024
    2025
    2024
    $%$%$%$%
    Net (loss) income
    $(711.8)(43.8)%$57.8 3.4 %$(582.6)(11.9)%$211.1 4.1 %
    Interest expense, net44.2 2.7 %48.7 2.8 %129.8 2.7 %173.9 3.4 %
    Income tax expense
    22.3 1.4 %16.7 1.0 %60.5 1.1 %58.6 1.2 %
    Loss on extinguishment of debt0.2 — %2.1 0.1 %0.2 — %6.5 0.1 %
    Other income (expense), net
    (3.7)(0.3)%(0.7)— %19.5 0.5 %(3.4)(0.1)%
    Operating (loss) income
    (648.8)(40.0)%124.6 7.3 %(372.6)(7.6)%446.7 8.7 %
    Amortization76.1 4.7 %75.4 4.3 %225.5 4.6 %225.6 4.4 %
    Restructuring and severance charges1
    2.2 0.1 %49.4 2.9 %28.0 0.6 %82.3 1.7 %
    Transformation expenses2
    13.7 0.8 %17.1 1.0 %49.5 1.0 %46.6 0.9 %
    Reserve for certain legal matters, net3
    1.6 0.1 %7.9 0.5 %5.2 0.1 %7.9 0.2 %
    Other4
    7.5 0.6 %0.4 — %11.7 0.2 %1.4 — %
    Impairment charges5
    785.0 48.3 %— — %785.0 16.1 %— — %
    Adjusted Operating Income$237.3 14.6 %$274.8 16.0 %$732.3 15.0 %$810.5 15.9 %
    ━━━━━━━━━
    1.Reflects the incremental expenses incurred in the period related to restructuring initiatives to increase profitability and productivity. Costs included in this caption are specific to employee severance, site-related exit costs, and contract termination costs. These expenses represent costs incurred to achieve the Company’s publicly-announced cost transformation initiative.
    2.Represents incremental expenses directly associated with the Company’s publicly-announced cost transformation initiative, primarily related to the cost of external advisors.
    3.Represents charges and legal costs, net of recoveries, in connection with certain litigation and other contingencies that are unrelated to our core operations and not reflective of on-going business and operating results.
    4.Represents other stock-based compensation expense (benefit), a purchase price adjustment related to the sale of our Clinical Services business in 2024, and $6.1 million of severance and transition costs associated with the replacement of our Chief Executive Officer.
    5.As described in note 7 to our unaudited condensed consolidated financial statements.
    Liquidity and capital resources
    We fund short-term cash requirements primarily from operating cash flows and credit facilities. Most of our long-term financing is from indebtedness. For the three and nine months ended September 30, 2025, we generated $207.4 million and $471.1 million of cash from operating activities, respectively, ended the quarter with $251.9 million of cash and cash equivalents and our availability under our credit facilities was $1,009.4 million.
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    As disclosed in Note 10, in connection with the October 2025 refinancing, we amended our revolving credit facility to obtain an additional $425.0 million in available funding, increasing the total availability under the facility to $1,400.0 million.
    In accordance with ASC 470-10-45-14 and ASC 855, we reclassified the 2.625% secured notes and Euro term loans B-5 from current liabilities to noncurrent liabilities in the accompanying balance sheet as of September 30, 2025. As a result of the refinancing, we have no debt repayments due in the next twelve months other than required term loan payments of $20.8 million and repayment of receivables facility borrowings of $192.7 million as of September 30, 2025.
    In October 2025, we repaid the outstanding borrowings and terminated our receivables facility.
    In October 2025, our Board of Directors authorized the repurchase of up to $500.0 million of our common stock, exclusive of fees, commissions and related transaction expenses. Repurchases may be funded through our available cash, borrowings under existing credit facilities or other financing arrangements approved by the Board of Directors. Management is authorized to repurchase our common stock on the open market or in privately negotiated transactions, through one or more Rule 10b5-1 trading plans, Rule 10b-18 repurchase programs, accelerated share repurchase programs, including any collateral arrangements, or a combination thereof. The timing, manner, price and amount of repurchases will be determined by management depending upon economic, market and other conditions. The repurchase program may be modified, suspended, or terminated at any time. Repurchases under the program will be held as treasury shares.
    Liquidity
    The following table presents our primary sources of liquidity:
    (in millions)
    September 30, 2025
    Receivables facilityRevolving credit facilityTotal
    Unused availability under credit facilities:
    Capacity$238.2 $975.0 $1,213.2 
    Undrawn letters of credit outstanding(3.6)(7.5)(11.1)
    Outstanding borrowings(192.7)— (192.7)
    Unused availability$41.9 $967.5 $1,009.4 
    Cash and cash equivalents251.9 
    Total liquidity$1,261.3 
    As of September 30, 2025, some of our credit line availability depends upon maintaining a sufficient borrowing base of eligible accounts receivable. We believe that we have sufficient capital resources to meet our liquidity needs.
    During the period ended September 30, 2025, our debt agreements included representations and covenants that we considered usual and customary, and our receivables facility and senior secured credit facilities included a financial covenant that would become applicable for periods in which we have drawn more than 35% of our revolving credit facility under the senior secured credit facilities. In that circumstance, we would not have been permitted to have combined borrowings on our senior secured credit facilities and secured notes in excess of a pro forma net leverage ratio, as defined in our credit agreements (as in effect during the quarter ended September 30, 2025). As we had not drawn more than
    39

    Table of contents
    35% of our revolving credit facility in this period, this covenant was not applicable at September 30, 2025. As disclosed in note 10, both the newly issued senior secured term loans and the amended revolving credit facility include covenants that we consider to be usual and customary. As part of the refinancing and addition of the new €400.0 million term loan, (i) the leverage-based financial covenant in the credit facility agreement became a full-time financial maintenance covenant, whereas previously it had been a “springing covenant”, and (ii) a new consolidated interest coverage ratio financial maintenance covenant was added to the credit facilities agreement, in both cases on usual and customary terms for facility agreements governing these types of senior secured term loan and revolving credit facilities.
    At September 30, 2025, $224.2 million or 89.0% of our $251.9 million in cash and cash equivalents was held by our non-U.S. subsidiaries and may be subject to certain taxes upon repatriation, primarily where foreign withholding taxes apply.
    Historical cash flows
    The following table presents a summary of cash provided by (used in) various activities:
    (in millions)
    Nine months ended September 30,
    Change
    20252024
    Operating activities:
    Net (loss) income
    $(582.6)$211.1 $(793.7)
    Non-cash items1
    1,154.1 355.3 798.8 
    Working capital changes2
    (49.5)62.3 (111.8)
    All other(50.9)38.8 (89.7)
    Total$471.1 $667.5 $(196.4)
    Investing activities:
    Capital expenditures(93.3)(121.3)28.0 
    Other2.5 1.7 0.8 
    Total$(90.8)$(119.6)$28.8 
    Financing activities(410.1)(525.9)115.8 
    ━━━━━━━━━
    1.Consists of typical non-cash charges including depreciation and amortization, stock-based compensation expense, deferred income tax expense, impairment charges, non-cash restructuring charges and others.
    2.Includes changes to our accounts receivable, inventory, contract assets and accounts payable.
    Cash flows from operating activities provided $196.4 million less cash in 2025, primarily due to a reduction in net income, as previously discussed, higher net working capital requirements and higher incentive compensation payments made in 2025 related to fiscal year 2024.
    Investing activities used $28.8 million less cash in 2025. The change was primarily attributable to a decrease in capital expenditures compared to the prior year.
    Financing activities used $115.8 million less cash in 2025, primarily due to the lower prepayments of term loans and increased borrowings from our receivables facility in the current year, partially offset by a decrease in proceeds from stock option exercises compared to the prior year.
    40

    Table of contents
    Free cash flow
    (in millions)
    Nine months ended September 30,
    Change
    20252024
    Net cash provided by operating activities$471.1 $667.5 $(196.4)
    Capital expenditures(93.3)(121.3)28.0 
    Divestiture-related transaction expenses and taxes paid
    1.4 — 1.4 
    Free cash flow$379.2 $546.2 $(167.0)
    Free cash flow was $167.0 million lower in 2025, primarily due to lower cash flow from operating activities as previously discussed, partially offset by a decrease in capital expenditures.
    Indebtedness
    For information about our indebtedness, refer to the section entitled “Liquidity” and note 10 to our unaudited condensed consolidated financial statements included in Part I, Item 1 — “Financial statements.”
    Item 3.    Quantitative and qualitative disclosures about market risk
    Quantitative and qualitative disclosures about market risk appear in Item 7A “Quantitative and qualitative disclosures about market risk” in our Annual Report. There were no material changes during the quarter ended September 30, 2025 to this information as reported in our Annual Report.
    Item 4.    Controls and procedures
    Management’s evaluation of disclosure controls and procedures
    Our management, with the participation of our Chief Executive Officer and Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)), as of the end of the period covered by this report. Based upon that evaluation, our Chief Executive Officer and Chief Financial Officer concluded that, as of September 30, 2025, the design and operation of our disclosure controls and procedures were effective to accomplish their objectives at the reasonable assurance level.
    Changes in internal control over financial reporting
    There have been no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Securities Exchange Act of 1934) during the fiscal quarter ended September 30, 2025, that have materially affected or are reasonably likely to materially affect our internal control over financial reporting.
    PART II — OTHER INFORMATION
    41

    Table of contents
    Item 1.    Legal proceedings
    For additional information regarding legal proceedings and matters, see note 9 to our unaudited condensed consolidated financial statements included in Part I, Item 1 — “Financial statements,” in this report, which information is incorporated into this item by reference.
    Item 1A.    Risk factors
    For information regarding factors that could affect the Company's results of operations, financial condition and liquidity, see the risk factors discussed in Part I, Item 1A “Risk Factors” in our Annual Report for the year ended December 31, 2024, as supplemented by Part II, Item 1A “Risk Factors” in our Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2025. There have been no material changes to the risk factors disclosed in Part I, Item 1A “Risk Factors” in our Annual Report for the year ended December 31, 2024, as supplemented by Part II, Item 1A “Risk Factors” in our Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2025.
    Item 2.    Unregistered sales of equity securities and use of proceeds
    None.
    Item 3.    Defaults upon senior securities
    None.
    Item 4.    Mine safety disclosures
    Not applicable.
    Item 5.    Other information
    Securities Trading Plans of Directors and Officers
    No directors or officers, as defined in Rule 16a-1(f) of the Securities Exchange Act of 1934, of the Company adopted or terminated (i) a Rule 10b5-1 trading arrangement, as defined in Item 408(a) under Regulation S-K, or (ii) a non-Rule 10b5-1 trading arrangement, as defined in Item 408(c) under Regulation S-K, during the three months ended September 30, 2025.
    42

    Table of contents
    Item 6.    Exhibits
    Location of exhibits
    Exhibit no.Exhibit descriptionFormExhibit no.Filing date
    10.1^
    Contract of Employment, issued on July 11, 2025, between the Company and Emmanuel Ligner
    *
    31.1
    Certification of Principal Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
    *
    31.2
    Certification of Principal Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
    *
    32.1
    Certification of Principal Executive Officer pursuant to 18 U.S.C. 1350 (Section 906 of the Sarbanes-Oxley Act of 2002)
    **
    32.2
    Certification of Principal Financial Officer pursuant to 18 U.S.C. 1350 (Section 906 of the Sarbanes-Oxley Act of 2002)
    **
    101XBRL exhibits*
    104Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)*
    ━━━━━━━━━
    *        Filed herewith
    **        Furnished herewith
    ^    Indicates management contract or compensatory plan, contract or arrangement.
    43

    Table of contents
    SIGNATURE
    Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
    Avantor, Inc.
    Date: October 29, 2025By:/s/ Steven Eck
    Name:Steven Eck
    Title:Senior Vice President, Chief Accounting Officer (Principal Accounting Officer)
    44
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