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    SEC Form SC 13D filed by Sigilon Therapeutics Inc.

    7/7/23 4:33:26 PM ET
    $SGTX
    Medicinal Chemicals and Botanical Products
    Health Care
    Get the next $SGTX alert in real time by email
    SC 13D 1 d266530dsc13d.htm SC 13D SC 13D

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

     

     

    Sigilon Therapeutics, Inc.

    (Name of Issuer)

    Common Stock, $0.001 par value per share

    (Title of Class of Securities)

    82657L107

    (CUSIP Number)

    Anat Hakim

    Executive Vice President, General Counsel and Secretary

    Eli Lilly and Company

    Lilly Corporate Center

    Indianapolis, Indiana 46285

    Telephone: (317) 276-2000

    (Name, Address, and Telephone Number of Person Authorized to Receive Notices and Communications)

    Copy to:

    Howard Kenny

    Russell M. Franklin

    Morgan, Lewis & Bockius LLP

    101 Park Avenue

    New York, New York 10178

    (212) 309-6000

    June 28, 2023

    (Date of Event Which Requires Filing of This Statement)

     

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

     

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent.

     

     

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of section 18 of the Securities Exchange Act of 1934 (the “Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     


      1    

      NAMES OF REPORTING PERSON

     

      ELI LILLY AND COMPANY

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

      (a)  ☐        (b)  ☐

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (SEE INSTRUCTIONS)

     

      OO

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      INDIANA

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

         7    

      SOLE VOTING POWER

     

      211,110

         8  

      SHARED VOTING POWER

     

      797,720*

         9  

      SOLE DISPOSITIVE POWER

     

      211,110

       10  

      SHARED DISPOSITIVE POWER

     

      0

    11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      1,008,830*

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

      40.3%*

    14  

      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

     

      CO

     

    *

    The reported amount reflects (i) 211,110 shares of common stock, par value $0.001 per share, of Sigilon Therapeutics, Inc. beneficially owned by Eli Lilly and Company, as well as (ii) shares that may be deemed to be beneficially owned by the Reporting Persons as a result of certain voting rights pursuant to the Tender and Support Agreement described in Item 4 below. The reported amount is adjusted for the 1-for-13 reverse stock split of the Issuer, effective as of May 22, 2023, as reported by the Issuer in its Current Report on Form 8-K, filed on May 22, 2023 (the “Reverse Stock Split”).


      1    

      NAMES OF REPORTING PERSON

     

      SHENANDOAH ACQUISITION CORPORATION

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

      (a)  ☐        (b)  ☐

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (SEE INSTRUCTIONS)

     

      AF

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      DELAWARE

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

         7    

      SOLE VOTING POWER

     

      0

         8  

      SHARED VOTING POWER

     

      797,720*

         9  

      SOLE DISPOSITIVE POWER

     

      0

       10  

      SHARED DISPOSITIVE POWER

     

      0

    11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      797,720*

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     

      31.9%*

    14  

      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

     

      CO

     

    *

    The reported amount reflects shares of common stock, par value $0.001 per share, of Sigilon Therapeutics, Inc. that may be deemed to be beneficially owned by the Reporting Persons as a result of certain voting rights pursuant to the Tender and Support Agreement described in Item 4 below. The reported amount is adjusted for the Reverse Stock Split.


    Explanatory Note

    This Schedule 13D supersedes the Schedule 13G filed on February 12, 2021 by Eli Lilly and Company relating to shares of common stock, par value $0.001 per share of Sigilon Therapeutics, Inc., which disclosed the beneficial ownership of 211,110 Shares (as defined below) (the “Owned Shares”). This Schedule 13D is being filed because the filer may no longer qualify to file on Schedule 13G. See Item 4 below.

     

    Item 1.

    SECURITY AND ISSUER

    This statement relates to the common stock, par value $0.001 per share (the “Shares”), issued by Sigilon Therapeutics, Inc. (the “Issuer”). The principal executive offices of the Issuer are located at 100 Binney Street Cambridge, MA 02142.

     

    Item 2.

    IDENTITY AND BACKGROUND

    This statement is being filed pursuant to Rule 13d-1 under the Act by Eli Lilly and Company, an Indiana corporation (“Lilly”), and Shenandoah Acquisition Corporation, a Delaware corporation and a wholly owned subsidiary of Lilly (“Purchaser” and, together with Lilly, the “Reporting Persons”). The address of the principal business and the principal office of each of the Reporting Persons is Lilly Corporate Center, Indianapolis, Indiana 46285. The principal business of Lilly is discovering, developing, manufacturing, and selling pharmaceutical products.

    The name, business address, present principal occupation or employment and citizenship of each director and executive officer (including a director and officer who may be a controlling person) of the Reporting Persons is set forth on Schedule A.

    During the last five years, none of the Reporting Persons or, to the knowledge of the Reporting Persons, any of the persons listed on Schedule A attached hereto have been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors) or been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

     

    Item 3.

    SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

    The total amount of funds required by the Reporting Persons to consummate the Offer (as defined below) and purchase all of the outstanding Shares in the Offer and provide funding in connection with the Merger (as defined below) is approximately $34.6 million, plus related fees and expenses. The Reporting Persons expect to fund these payments out of cash on hand. Additionally, the Owned Shares were acquired by Lilly as a private investment in the Issuer before its initial public offering, funded with cash on hand at the time.

    The information set forth or incorporated by reference in Item 4 is incorporated by reference in this Item 3.

     

    Item 4.

    PURPOSE OF TRANSACTION

    This statement is being filed in connection with the Merger Agreement (defined below) and the Tender and Support Agreement (defined below).

     

    On June 28, 2023, Lilly, the Issuer and Purchaser entered into an Agreement and Plan of Merger (the “Merger Agreement”) pursuant to, and upon the terms and subject to the conditions of which, Purchaser will commence a tender offer (the “Offer”) to purchase all of the issued and outstanding Shares in exchange for (a) $14.92 per Share, net to the stockholder in cash, without interest (the “Closing Amount”) and less any applicable tax withholding, plus (b) one non-tradable contingent value right (“CVR”) per Share, which represents the contractual right to receive contingent payments in an aggregate amount of up to $111.64 per CVR, net to the stockholder in cash, without


    interest and less any applicable tax withholding, upon the achievement of certain specified milestones in accordance with the terms and subject to the conditions of a contingent value rights agreement (the “CVR Agreement”) to be entered into with a rights agent selected by Lilly and reasonably acceptable to the Issuer (the Closing Amount plus one CVR, collectively, the “Offer Price”). The obligation of Purchaser to accept for payment and pay for any Shares validly tendered and not validly withdrawn pursuant to the Offer is subject to various conditions set forth in the Merger Agreement, including (i) that there shall have been validly tendered in the Offer and not validly withdrawn prior to the expiration of the Offer that number of Shares that, together with the number of Shares, if any, then owned beneficially by Lilly and Purchaser (together with their wholly owned subsidiaries), would represent a majority of the Shares outstanding as of the consummation of the Offer, (ii) that no court of competent jurisdiction or other governmental body has issued an order, decree, or ruling, enacted any law or taken any other action restraining, enjoining, or otherwise prohibiting the Offer or the Merger, (iii) the accuracy of the Issuer’s representations and warranties set forth in the Merger Agreement, and the performance of the Issuer’s covenants set forth in the Merger Agreement, in each case in certain respects, to specified standards of materiality, and (iv) the other conditions set forth in Annex I to the Merger Agreement.

    After the consummation of the Offer and the satisfaction or waiver of certain conditions, Purchaser will merge with and into the Issuer pursuant to Section 251(h) of the General Corporation Law of the State of Delaware, as amended (the “DGCL”), upon the terms and subject to the conditions set forth in the Merger Agreement, with the Issuer continuing as the surviving corporation and becoming a wholly owned subsidiary of Lilly (the “Merger”). At the effective time of the Merger (the “Effective Time”), each Share issued and outstanding immediately prior to the Effective Time (other than (i) Shares held in the treasury of the Issuer or owned by the Issuer, or owned by Lilly, Purchaser or any direct or indirect wholly owned subsidiary of Lilly or Purchaser or (ii) Shares that are held by stockholders who are entitled to and properly demand appraisal for such Shares in accordance with Section 262 of the DGCL), including each Share that is subject to vesting or forfeiture restrictions granted pursuant to a Company Equity Plan (as defined in the Merger Agreement, and such Shares, “Restricted Stock”), will be converted into the right to receive the Offer Price, without interest and less any applicable tax withholding, from Purchaser.

    The Merger Agreement provides for the following treatment of the Issuer’s equity awards and warrants:

     

      •  

    Each option to purchase Shares granted under a Company Equity Plan (excluding, for the avoidance of doubt, the Company ESPP) (each such option, a “Company Stock Option”) outstanding immediately prior to the Effective Time, whether or not vested, will be cancelled, and, in exchange therefor, the holder of such cancelled Company Stock Option will be entitled to receive (without interest), in consideration of the cancellation of such Company Stock Option, (x) an amount in cash (less applicable tax withholdings) equal to the product of (A) the total number of Shares subject to such Company Stock Option immediately prior to the Effective Time multiplied by (B) the excess, if any, of the Closing Amount over the applicable exercise price per Share under such Company Stock Option and (y) one (1) CVR for each Share subject to such Company Stock Option immediately prior to the Effective Time (without regard to vesting) (the “Option Consideration”); provided that any Company Stock Option that has an exercise price that equals or exceeds the Closing Amount shall be cancelled for no consideration.

     

      •  

    Each Restricted Stock Unit (each such unit, a “Company Restricted Stock Unit”) under a Company Equity Plan that is outstanding immediately prior to the Effective Time, whether or not vested, will be cancelled, and, in exchange therefor, the holder of such cancelled Company Restricted Stock Unit will be entitled to receive (without interest) (x) an amount in cash (less applicable tax withholdings) equal to the product of (A) the total number of Shares issuable in settlement of such Company Restricted Stock Unit immediately prior to the Effective Time multiplied by (B) the Closing Amount and (y) one (1) CVR for each Share subject to such Company Restricted Stock Unit immediately prior to the Effective Time (without regard to vesting).

     

      •  

    Each of the outstanding warrants to purchase Shares (the “Company Warrants”) that is outstanding immediately prior to the Effective Time will be cancelled as of the Effective Time in exchange for the right to receive (a) cash in an amount equal to the product of (i) the total number of Shares subject to such Company Warrant immediately prior to the Effective Time, multiplied by (ii) the excess of (A) the Closing Amount over (B) the exercise price payable per Share under such Company Warrant, and (b) one (1) CVR for each Share subject to such Company Warrant immediately prior to the Effective Time; provided that, any Company Warrant that has an exercise price that equals or exceeds the Closing Amount shall be cancelled for no consideration.


    Concurrently with entry into the Merger Agreement, Lilly and Purchaser entered into a Tender and Support Agreement, dated as of June 28, 2023, with (i) Flagship Ventures Fund V, L.P. and (ii) Flagship Pioneering Special Opportunities Fund II, L.P. (the “Tender and Support Agreement”). Pursuant to the Tender and Support Agreement, each Stockholder (as defined therein) has agreed, among other things, (i) to tender all of the Shares held by such Stockholder (the “Subject Shares”) in the Offer, subject to certain exceptions (including the valid termination of the Merger Agreement), (ii) to vote against other proposals to acquire the Issuer and (iii) to certain other restrictions on its ability to take actions with respect to the Issuer and its Shares.

    In furtherance of each Stockholder’s covenants under the Tender and Support Agreement, and for so long as the Tender and Support Agreement has not been validly terminated, each Stockholder agreed to appoint Lilly as its attorney-in-fact and proxy to vote its Subject Shares, to the full extent of such Stockholder’s voting rights, against the corporate transactions described in the immediately preceding paragraph. Accordingly, shared voting power with respect to, and beneficial ownership of, the Subject Shares may be deemed to have been acquired by Lilly through execution of the Tender and Support Agreement.

    Schedule B attached hereto contains the name and number of Shares beneficially held by each Stockholder (as represented to Lilly by such Stockholder) (in aggregate, the “Covered Shares”).

    The purpose of the Offer is for Lilly, through Purchaser, to acquire control of the Issuer. The Offer would be the first step in Lilly’s acquisition of the entire equity interest in the Issuer. The Offer is intended to facilitate the acquisition of all issued and outstanding Shares. The purpose of the Merger is to acquire all issued and outstanding Shares not tendered and purchased pursuant to the Offer. If the Offer is consummated, Purchaser intends to complete the Merger as soon as practicable thereafter. At the Effective Time, the fifth amended and restated certificate of incorporation and the amended and restated bylaws of the Issuer will be amended and restated in their entirety in each case pursuant to the form attached to the Merger Agreement.

    Following the Merger, the Issuer will become a wholly owned subsidiary of Lilly. In addition, Lilly will cause the Shares to be delisted from the Nasdaq Global Select Market and deregistered under the Act.

    Except as set forth in this statement and in connection with the Merger described above, the Reporting Persons do not have any plan or proposals that relate to or would result in any of the transactions described in Item 4 of this Schedule 13D.

    The foregoing descriptions of the Merger Agreement and the Tender and Support Agreement, and the respective transactions contemplated thereby, do not purport to be complete and are qualified in their entirety by reference to such agreements. A copy of the Merger Agreement (which includes the form of the CVR Agreement as Annex IV), listed as Exhibit 2.1 hereto, is incorporated by reference to Exhibit 2.1 to the Issuer’s Current Report on Form 8-K filed with the Securities and Exchange Commission (“SEC”) on June 29, 2023. A copy of the Tender and Support Agreement is listed as Exhibit 2.2 hereto.

    In connection with the proposed acquisition of the Issuer, Lilly will cause Purchaser to commence the Offer for all of the outstanding Shares. The Offer has not yet commenced. The foregoing is neither an offer to purchase nor a solicitation of an offer to sell any securities, nor is it a substitute for the Offer materials that Lilly and Purchaser will file with the SEC upon commencement of the Offer. A solicitation and offer to buy outstanding Shares will only be made pursuant to the Offer materials that Lilly and Purchaser intend to file with the SEC. At the time the Offer is commenced, Lilly and Purchaser will file a tender offer statement on Schedule TO, and the Issuer will file a solicitation/recommendation statement on Schedule 14D-9 (the “Solicitation/Recommendation Statement”) with the SEC with respect to the Offer. THE OFFER MATERIALS (INCLUDING AN OFFER TO PURCHASE, A RELATED LETTER OF TRANSMITTAL AND CERTAIN OTHER OFFER DOCUMENTS) AND THE SOLICITATION/RECOMMENDATION STATEMENT WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED ACQUISITION AND THE PARTIES THERETO. INVESTORS AND STOCKHOLDERS OF THE ISSUER ARE URGED TO READ THESE DOCUMENTS CAREFULLY WHEN THEY BECOME AVAILABLE (AND EACH AS IT MAY BE AMENDED OR SUPPLEMENTED FROM TIME TO TIME) BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION THAT INVESTORS AND


    STOCKHOLDERS OF THE ISSUER SHOULD CONSIDER BEFORE MAKING ANY DECISION REGARDING TENDERING THEIR SHARES IN THE OFFER. The Offer materials (including the Offer to Purchase and the related Letter of Transmittal), as well as the Solicitation/Recommendation Statement, will be made available to all investors and stockholders of the Issuer at no expense to them at Lilly’s website at investor.lilly.com and (once they become available) will be mailed to the stockholders of the Issuer free of charge. The information contained in, or that can be accessed through, Lilly’s website is not a part of, or incorporated by reference in this filing. The Offer materials (including the Offer to Purchase and the related Letter of Transmittal), as well as the Solicitation/Recommendation Statement, will also be made available for free on the SEC’s website at www.sec.gov.

     

    Item 5.

    INTEREST IN SECURITIES OF THE ISSUER

    (a)-(b) The information relating to the beneficial ownership of the Shares by each of the Reporting Persons set forth in Rows 7 through 13 on each of the cover pages hereto is incorporated by reference herein and is as of the date hereof. Such information is based on 2,501,896 Shares issued and outstanding as of June 28, 2023 (based on the representation by the Issuer in the Merger Agreement) (as adjusted for the Reverse Stock Split).

    Lilly currently has sole beneficial ownership of the Owned Shares.

    As a result of the Tender and Support Agreement, (i) Lilly may be deemed to have the power to vote up the Covered Shares against certain matters set forth in Item 4 above, and thus, Lilly may be deemed to be the beneficial owner of the Covered Shares and (ii) Purchaser may be deemed to be the beneficial owner of the Covered Shares.

    Other than the Owned Shares and those Shares that may be deemed to be beneficially owned in connection with the Tender and Support Agreement, Lilly has not acquired and, for the purposes of Rule 13d-4 promulgated under the Act, does not beneficially own any Shares. Other than those Shares that may be deemed to be beneficially owned in connection with the Tender and Support Agreement, Purchaser has not acquired and, for the purposes of Rule 13d-4 promulgated under the Act, does not beneficially own any Shares.

    The Reporting Persons are not entitled to any rights as stockholders of the Issuer as to the Shares covered by the Tender and Support Agreement, except as otherwise expressly provided in the Tender and Support Agreement. This Schedule 13D shall not be construed as an admission by the Reporting Persons that the Reporting Persons are, for the purposes of Section 13(d) of the Act, the beneficial owners of any Shares covered by the Tender and Support Agreement.

    (c) Except pursuant to the Merger Agreement and the Tender and Support Agreement described above, to the knowledge of the Reporting Persons, no transactions in the class of securities reported have been effected during the past 60 days by any person named in Schedule A or Item 5(a).

    (d) To the knowledge of the Reporting Persons, no person, other than the applicable Stockholder under the applicable Tender and Support Agreement, has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities of the Issuer reported herein.

    (e) Inapplicable.

     

    Item 6.

    CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO SECURITIES OF THE ISSUER

    Except for the Merger Agreement and the Tender and Support Agreement described above, which are incorporated into this Item 6 by reference, to the knowledge of the Reporting Persons, there are no contracts, arrangements, understandings or relationships (legal or otherwise), including, but not limited to, transfer or voting of any of the Shares, finder’s fees, joint ventures, loan or option arrangements, puts or calls, guarantees of profits, division of profits or loss, or the giving or withholding of proxies, among the persons named in Item 2 or between such persons and any other person, with respect to any securities of Issuer, including any securities pledged or otherwise subject to a contingency the occurrence of which would give another person voting power or investment power over such securities.


    Item 7.

    MATERIAL TO BE FILED AS EXHIBITS

     

    Exhibit

      

    Description

    2.1    Agreement and Plan of Merger, dated as of June  28, 2023, by and among Eli Lilly and Company, Shenandoah Acquisition Corporation and Sigilon Therapeutics, Inc. (incorporated by reference to Exhibit 2.1 to the Current Report on Form 8-K filed by Sigilon Therapeutics, Inc. with the SEC on June 29, 2023).
    2.2*    Tender and Support Agreement, dated June  28, 2023, by and among Eli Lilly and Company, Shenandoah Acquisition Corporation, Flagship Ventures Fund V, L.P. and Flagship Pioneering Special Opportunities Fund II, L.P.
    99.1*    Joint Filing Agreement, dated as of July 7, 2023, by and among Eli Lilly and Company and Shenandoah Acquisition Corporation.*

     

    *

    Filed herewith.


    SIGNATURES

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

        ELI LILLY AND COMPANY
    Date: July 7, 2023     By:  

    /s/ Anat Ashkenazi

        Name:   Anat Ashkenazi
        Title:   Executive Vice President and Chief Financial Officer
        SHENANDOAH ACQUISITION CORPORATION
    Date: July 7, 2023     By:  

    /s/ Philip L. Johnson

        Name:   Philip L. Johnson
        Title:   President

     


    SCHEDULE A

     

    1.

    Eli Lilly and Company

    The name, business address, title, and present principal occupation or employment of each of the directors and executive officers of Lilly are set forth below. The address of Lilly is: Lilly Corporate Center, Indianapolis, Indiana 46285. Unless otherwise indicated, each occupation set forth opposite an individual’s name refers to Lilly. Unless otherwise indicated below, all of the persons listed below are citizens of the United States of America.

     

    Name    Present Principal Occupation Including Name and Address of Employer
    Directors   
    Ralph Alvarez    Director; Operating Partner, Advent International Corporation
    Katherine Baicker, Ph.D.    Director; Provost, University of Chicago and Professor, Harris School of Public Policy
    J. Erik Fyrwald    Director; President and Chief Executive Officer, Syngenta
    Mary Lynne Hedley, Ph.D.    Director; Senior Scientific Fellow, Broad Institute of MIT and Harvard
    Jamere Jackson    Director; Executive Vice President and Chief Financial Officer, AutoZone, Inc.
    Kimberly H. Johnson    Director; Chief Operating Officer, T. Rowe Price Group, Inc.
    William G. Kaelin Jr., M.D.    Director; Professor of Medicine, Harvard Medical School
    Juan R. Luciano   

    Director; Chairman and Chief Executive Officer, Archer Daniels Midland Company

    Citizenship: United States and Argentina

    David A. Ricks    Director; Chairman, Chief Executive Officer, Eli Lilly and Company
    Marschall S. Runge, M.D., Ph.D.    Director; Chief Executive Officer of Michigan Medicine, Executive Vice President and Medical School Dean at the University of Michigan
    Gabrielle Sulzberger    Director; Chair of Global ESG Advisory at Teneo
    Karen Walker   

    Director; Operating Partner, The Goldman Sachs Group, Inc.

    Citizenship: United States and United Kingdom

    Executive Officers (Who Are Not Directors)   
    Anat Ashkenazi   

    Executive Vice President and Chief Financial Officer

    Citizenship: United States and Israel

    Eric Dozier    Executive Vice President, Human Resources and Diversity
    Anat Hakim   

    Executive Vice President, General Counsel and Secretary

    Citizenship: United States and Israel

    Edgardo Hernandez    Executive Vice President and President, Manufacturing Operations
    Patrik Jonsson    Executive Vice President; President, Lilly Immunology; President, Lilly USA; and Chief Customer Officer
    Michael B. Mason    Executive Vice President and President, Lilly Diabetes
    Johna L. Norton    Executive Vice President, Global Quality
    Leigh Ann Pusey    Executive Vice President, Corporate Affairs and Communications
    Diogo Rau    Executive Vice President and Chief Information and Digital Officer
    Daniel Skovronsky, M.D., Ph.D.    Executive Vice President, Chief Scientific and Medical Officer, and President, Lilly Research Laboratories
    Jacob Van Naarden    Executive Vice President and President, Loxo@Lilly
    Alonzo Weems    Executive Vice President, Enterprise Risk Management, and Chief Ethics and Compliance Officer
    Anne E. White    Executive Vice President and President, Lilly Neuroscience
    Ilya Yuffa    Executive Vice President and President, Lilly International


    2.

    Shenandoah Acquisition Corporation

    The name, business address, title, and present principal occupation or employment of each of the directors and executive officers of Purchaser are set forth below. The address of Purchaser is: Lilly Corporate Center, Indianapolis, Indiana 46285. Where applicable, the business address listed for each individual not principally employed by Purchaser is the address of the corporation or other organization that principally employs that individual as listed below. Unless otherwise indicated, each occupation set forth opposite an individual’s name refers to Lilly. Unless otherwise indicated below, all of the persons listed below are citizens of the United States of America.

     

    Name    Present Principal Occupation Including Name and Address of Employer
    Directors and Executive Officers   
    Philip L. Johnson    Director and President
    Michael C. Thompson    Director and Treasurer
    Directors (Who Are Not Executive Officers)   
    Gordon J. Brooks    Director
    Executive Officers (Who Are Not Directors)   
    Christopher Anderson    Secretary
    Jonathan Groff    Assistant Secretary
    Katie Lodato    Assistant Treasurer


    SCHEDULE B

     

    Stockholder

       Shares Beneficially
    Owned(1)
     

    Flagship Ventures Fund V LP

         683,760  

    Flagship Pioneering Special Opportunities Fund II LP

         113,960  

     

    (1)

    As of June 28, 2023, as provided by such Stockholder.

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    11/30/2021$9.00 → $4.50Equal-Weight
    Morgan Stanley
    11/30/2021$15.00 → $4.00Buy → Hold
    Jefferies
    10/29/2021$14.00Buy
    BTIG
    8/2/2021$15.00Buy
    Jefferies
    7/19/2021$62.00 → $43.00Buy
    Canaccord Genuity
    7/16/2021$45.00 → $9.00Equal-Weight
    Morgan Stanley
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    $SGTX
    Leadership Updates

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    • Flagship Pioneering Bolsters Executive Team with Appointment of Michelle C. Werner as CEO-Partner and CEO of Alltrna

      Werner Brings More Than Two Decades of Pharmaceutical Leadership to the Role CAMBRIDGE, Mass., April 11, 2022 /PRNewswire/ -- Flagship Pioneering, the bioplatform innovation company, today announced it has strengthened its executive leadership team with the appointment of Michelle C. Werner to the dual role of CEO-Partner of Flagship Pioneering and Chief Executive Officer of Alltrna. Werner brings to Flagship significant experience as a global pharmaceutical leader spanning both Commercial and Research and Development (R&D) responsibilities.  Werner most recently served as Wo

      4/11/22 6:00:00 AM ET
      $AXLA
      $CDAK
      $DNLI
      $EVLO
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
      Medicinal Chemicals and Botanical Products
      Biotechnology: Pharmaceutical Preparations
    • Sigilon Therapeutics Reports Fourth Quarter and Full Year 2021 Financial Results and Recent Business Highlights

      Announced strategic reprioritization, with plans to advance mucopolysaccharidosis type I (MPS-1) and diabetes as lead indications as well as continued platform optimization Strengthened leadership team with appointment of new Chief Technical Operations Officer and other key leadership changes Current cash position expected to fund operating plans into 2024 CAMBRIDGE, Mass., March 14, 2022 (GLOBE NEWSWIRE) -- Sigilon Therapeutics, Inc. (NASDAQ:SGTX), a biotechnology company that seeks to develop functional cures for chronic diseases through its Shielded Living Therapeutics™ platform, today reported financial results for the fourth quarter and full year ended December 31, 2021 as well as

      3/14/22 4:15:00 PM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
      Health Care
    • Alltrna Appoints Rare Disease Clinical Research Expert, Dr. Anne Pariser, as Vice President, Medical and Regulatory Affairs

      CAMBRIDGE, Mass., Feb. 28, 2022 /PRNewswire/ -- Alltrna, a Flagship Pioneering company unlocking transfer RNA (tRNA) biology and pioneering tRNA therapeutics to regulate the protein universe and resolve disease, today announced the appointment of Anne Pariser, M.D., as Vice President, Medical and Regulatory Affairs. Prior to joining Alltrna, Dr. Pariser was the Director of the Office of Rare Diseases Research (ORDR) at the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), whose mission is to advance rare diseases research through a variety of research programs. Prior to ORDR, she worked at the U.S. Food and Drug Administration (FDA) Center for

      2/28/22 9:00:00 AM ET
      $AXLA
      $CDAK
      $DNLI
      $EVLO
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
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      Biotechnology: Pharmaceutical Preparations

    $SGTX
    Insider Trading

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    • SEC Form 4 filed by Flagship Ventures Fund V General Partner Llc

      4 - Sigilon Therapeutics, Inc. (0001821323) (Issuer)

      8/15/23 4:15:09 PM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    • SEC Form 4: Eli Lilly & Co bought $25,639,916 worth of shares (1,718,493 units at $14.92)

      4 - Sigilon Therapeutics, Inc. (0001821323) (Issuer)

      8/14/23 4:30:10 PM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    • SEC Form 4 filed by Cole Douglas G.

      4 - Sigilon Therapeutics, Inc. (0001821323) (Issuer)

      8/11/23 4:10:53 PM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
      Health Care

    $SGTX
    Analyst Ratings

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    • Canaccord Genuity reiterated coverage on Sigilon Therapeutics with a new price target

      Canaccord Genuity reiterated coverage of Sigilon Therapeutics with a rating of Buy and set a new price target of $7.00 from $12.00 previously

      12/23/21 8:02:09 AM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    • Barclays reiterated coverage on Sigilon Therapeutics with a new price target

      Barclays reiterated coverage of Sigilon Therapeutics with a rating of Overweight and set a new price target of $7.00 from $16.00 previously

      12/1/21 7:25:00 AM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    • Morgan Stanley reiterated coverage on Sigilon Therapeutics with a new price target

      Morgan Stanley reiterated coverage of Sigilon Therapeutics with a rating of Equal-Weight and set a new price target of $4.50 from $9.00 previously

      11/30/21 8:00:57 AM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    $SGTX
    Financials

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    • Sigilon Therapeutics Reports First Quarter 2021 Financial Results and Business Highlights

      CAMBRIDGE, Mass., May 10, 2021 (GLOBE NEWSWIRE) -- Sigilon Therapeutics, Inc. (NASDAQ:SGTX), a biotechnology company that seeks to develop functional cures for chronic diseases through its Shielded Living Therapeutics™ platform, today reported financial results for the first quarter ended March 31, 2021 as well as certain other business highlights. "We are continuing to execute on our business plan in 2021, as we advance the clinical development of our lead product candidate for hemophilia A, while at the same time working to strengthen our team, expanding our pipeline and further validating the potential of our Shielded Living Therapeutics™, or SLTx, platform," commented Rogerio Vivald

      5/10/21 4:05:00 PM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    $SGTX
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    • Lilly Completes Acquisition of Sigilon Therapeutics

      INDIANAPOLIS, Aug. 14, 2023 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced the successful completion of its acquisition of Sigilon Therapeutics, Inc. (NASDAQ:SGTX). The acquisition allows Lilly to continue researching and developing encapsulated cell therapies, including SIG-002, for the treatment of type 1 diabetes. "Make life better – that's the phrase that guides everything we do at Lilly," said Ruth Gimeno, Ph.D., group vice president, diabetes, obesity and cardiometabolic research at Lilly. "We are excited to welcome our new colleagues from Sigilon to Lilly; together, we will strive to provide solutions for people living with type 1 diabetes that absolves them of cons

      8/14/23 7:25:00 AM ET
      $LLY
      $SGTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
      Medicinal Chemicals and Botanical Products
    • Lifshitz Law PLLC Announces Investigations of KLR, CFMS, TALS, and SGTX

      NEW YORK, July 15, 2023 (GLOBE NEWSWIRE) -- Kaleyra, Inc. (NYSE:KLR) Lifshitz Law PLLC announces an investigation into possible breach of fiduciary duties in connection with the sale of KLR to Tata Communications Limited for $7.25 per share in cash. If you are a KLR investor, and would like additional information about our investigation, please complete the Information Request Form or contact Joshua Lifshitz, Esq. by telephone at (516)493-9780 or e-mail at [email protected]. Conformis Inc. (NASDAQ:CFMS) Lifshitz Law PLLC announces an investigation into possible breach of fiduciary duties in connection with the sale of CFMS to Restor3d, Inc. for $2.27 per share in cash.

      7/15/23 8:07:00 PM ET
      $CFMS
      $KLR
      $SGTX
      $TALS
      Industrial Specialties
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    • Lilly to Acquire Sigilon Therapeutics

      INDIANAPOLIS and CAMBRIDGE, Mass., June 29, 2023 /PRNewswire/ -- Eli Lilly and Company (NYSE:LLY) and Sigilon Therapeutics, Inc. (NASDAQ:SGTX) today announced a definitive agreement for Lilly to acquire Sigilon, a biopharmaceutical company that seeks to develop functional cures for patients with a broad range of acute and chronic diseases. Since 2018, Lilly and Sigilon have worked together to develop encapsulated cell therapies, including SIG-002, for the treatment of type 1 diabetes. The goal of these therapies is to free patients from constant disease management by sensing blood glucose levels, restoring insulin production and releasing it over the long term. "Despite significant advanceme

      6/29/23 6:45:00 AM ET
      $LLY
      $SGTX
      Biotechnology: Pharmaceutical Preparations
      Health Care
      Medicinal Chemicals and Botanical Products

    $SGTX
    SEC Filings

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    • SEC Form 15-12G filed by Sigilon Therapeutics Inc.

      15-12G - Sigilon Therapeutics, Inc. (0001821323) (Filer)

      8/21/23 8:22:25 AM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    • SEC Form EFFECT filed by Sigilon Therapeutics Inc.

      EFFECT - Sigilon Therapeutics, Inc. (0001821323) (Filer)

      8/16/23 12:15:09 AM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    • SEC Form S-8 POS filed by Sigilon Therapeutics Inc.

      S-8 POS - Sigilon Therapeutics, Inc. (0001821323) (Filer)

      8/11/23 4:28:57 PM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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    $SGTX
    Large Ownership Changes

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    • SEC Form SC 13G/A filed by Sigilon Therapeutics Inc. (Amendment)

      SC 13G/A - Sigilon Therapeutics, Inc. (0001821323) (Subject)

      2/14/24 4:36:53 PM ET
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      Medicinal Chemicals and Botanical Products
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    • SEC Form SC 13D/A filed by Sigilon Therapeutics Inc. (Amendment)

      SC 13D/A - Sigilon Therapeutics, Inc. (0001821323) (Subject)

      8/14/23 4:30:34 PM ET
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      Medicinal Chemicals and Botanical Products
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    • SEC Form SC 13D filed by Sigilon Therapeutics Inc.

      SC 13D - Sigilon Therapeutics, Inc. (0001821323) (Subject)

      7/7/23 4:33:26 PM ET
      $SGTX
      Medicinal Chemicals and Botanical Products
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