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    SEC Form SC 13D/A filed by Alpine Immune Sciences Inc. (Amendment)

    4/30/24 4:20:00 PM ET
    $ALPN
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ALPN alert in real time by email
    SC 13D/A 1 tm2413060d1_sc13da.htm SC 13D/A

     

     

     

    UNITED STATES 

    SECURITIES AND EXCHANGE COMMISSION 

    Washington, D.C. 20549

     

    SCHEDULE 13D

     

    Under the Securities Exchange Act of 1934 

    (Amendment No. 5)*

     

    Alpine Immune Sciences, Inc. 

    (Name of Issuer)

     

    Common Stock, $0.001 par value per share 

    (Title of Class of Securities)

     

    02083G100 

    (CUSIP Number)

     

    Decheng Capital China Life Sciences USD Fund III, L.P. 

    Ugland House, PO Box 309, Grand Cayman 

    KY1-1104, Cayman Islands 

    +1- 345-949-8066 

    (Name, Address and Telephone Number of Person 

    Authorized to Receive Notices and Communications)

     

    April 10, 2024 

    (Date of Event Which Requires Filing of this Statement)

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

     

    * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

      

    CUSIP No.   02083G100
    1.

    Names of Reporting Persons

    Decheng Capital China Life Sciences USD Fund III, L.P.

    2. Check the Appropriate Box if a Member of a Group (See Instructions)
     

    (a)

    (b)

    ¨

    x

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    WC

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Cayman Islands

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    6,582,380 (1)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    6,582,380 (1)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    6,582,380 (1)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    10.0% (2)

    14.

    Type of Reporting Person (See Instructions)

    PN

           

     

    (1)Shares are held directly by Decheng Capital China Life Sciences USD Fund III, L.P. (the “Fund”). Decheng Capital Management III (Cayman), LLC (the “General Partner”) is the general partner of the Fund and Xiangmin Cui is the sole manager of the General Partner. The Fund, the General Partner and Dr. Cui may be deemed to share voting and dispositive power with respect to the shares held directly by the Fund.

     

    (2)This percentage is calculated based upon 65,560,484 shares of Common Stock outstanding on April 9, 2024, as disclosed in the Issuer’s Annual Report, as amended, on Form 10K filed with the Securities and Exchange Commission (the “SEC”) on April 26, 2024.

      

     

     

    CUSIP No.   02083G100
    1.

    Names of Reporting Persons

    Decheng Capital Management III (Cayman), LLC

    2. Check the Appropriate Box if a Member of a Group (See Instructions)
     

    (a)

    (b)

    ¨

    x

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Cayman Islands

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    6,582,380 (1)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    6,582,380 (1)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    6,582,380 (1)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    10.0% (2)

    14.

    Type of Reporting Person (See Instructions)

    OO

           

     

    (1)Shares are held directly by the Fund. The General Partner is the general partner of the Fund and Xiangmin Cui is the sole manager of the General Partner. The Fund, the General Partner and Dr. Cui may be deemed to share voting and dispositive power with respect to the shares held directly by the Fund.

     

    (2)This percentage is calculated based upon 65,560,484 shares of Common Stock outstanding on April 9, 2024, as disclosed in the Issuer’s Annual Report, as amended, on Form 10K filed with the SEC on April 26, 2024.

     

     

      

    CUSIP No.   02083G100
    1.

    Names of Reporting Persons

    Decheng Capital Global Healthcare Fund (Master), LP

    2. Check the Appropriate Box if a Member of a Group (See Instructions)
     

    (a)

    (b)

    ¨

    x

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    WC

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Cayman Islands

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    1,735,544 (1)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    1,735,544 (1)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    1,735,544 (1)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    2.6% (2)

    14.

    Type of Reporting Person (See Instructions)

    PN

             

     

    (1)Shares are held directly by Decheng Capital Global Healthcare Fund (Master), LP (“Healthcare”). Decheng Capital Global Healthcare GP, LLC ( “Healthcare GP”) is the general partner of Healthcare and Xiangmin Cui is the indirect managing member and ultimate beneficial owner of Healthcare GP. Healthcare, Healthcare GP and Dr. Cui may be deemed to share voting and dispositive power with respect to the shares held directly by Healthcare.

     

    (2)This percentage is calculated based upon 65,560,484 shares of Common Stock outstanding on April 9, 2024, as disclosed in the Issuer’s Annual Report, as amended, on Form 10K filed with the SEC on April 26, 2024.

      

     

     

    CUSIP No.   02083G100
    1.

    Names of Reporting Persons

    Decheng Capital Global Healthcare GP, LLC

    2. Check the Appropriate Box if a Member of a Group (See Instructions)
     

    (a)

    (b)

    ¨

    x

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    Cayman Islands

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    0

    8.

    Shared Voting Power

    1,735,544 (1)

    9.

    Sole Dispositive Power

    0

    10.

    Shared Dispositive Power

    1,735,544 (1)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    1,735,544 (1)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    2.6% (2)

    14.

    Type of Reporting Person (See Instructions)

    OO

             

     

    (1)Shares are held directly by Healthcare. Healthcare GP is the general partner of Healthcare and Xiangmin Cui is the indirect managing member and ultimate beneficial owner of Healthcare GP. Healthcare, Healthcare GP and Dr. Cui may be deemed to share voting and dispositive power with respect to the shares held directly by Healthcare.

     

    (2)This percentage is calculated based upon 65,560,484 shares of Common Stock outstanding on April 9, 2024, as disclosed in the Issuer’s Annual Report, as amended, on Form 10K filed with the SEC on April 26, 2024.

      

     

     

    CUSIP No.   02083G100
    1.

    Names of Reporting Persons

    Xiangmin Cui

    2. Check the Appropriate Box if a Member of a Group (See Instructions)
     

    (a)

    (b)

    ¨

    x

    3. SEC Use Only
    4.

    Source of Funds (See Instructions)

    AF

    5. Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)    ¨
    6.

    Citizenship or Place of Organization

    United States

    Number of

    Shares

    Beneficially

    Owned by

    Each

    Reporting

    Person With

    7.

    Sole Voting Power

    50,242 (1)

    8.

    Shared Voting Power

    8,317,924 (2)

    9.

    Sole Dispositive Power

    50,242 (1)

    10.

    Shared Dispositive Power

    8,317,924 (2)

    11.

    Aggregate Amount Beneficially Owned by Each Reporting Person

    8,368,166 (1) (2)

    12. Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)    ¨
    13.

    Percent of Class Represented by Amount in Row (11)

    12.8% (3)

    14.

    Type of Reporting Person (See Instructions)

    IN

             

     

    (1)Pursuant to the Issuer’s non-employee director compensation policy, Dr. Cui has received a series of stock option grants for services as a director of the Issuer, which options are subject to vesting schedules. Dr. Cui beneficially owns 50,242 shares of Common Stock that may be acquired upon exercise of these options that are exercisable within 60 days of the date of this filing.

     

    (2)Consists of (i) 6,582,380 shares of the Common Stock held directly by the Fund and (ii) 1,735,544 shares of Common Stock held directly by Healthcare. The General Partner is the general partner of the Fund and Dr. Cui is the sole manager of the General Partner. The Fund, the General Partner and Dr. Cui may be deemed to share voting and dispositive power with respect to the shares held directly by the Fund. Healthcare GP is the general partner of Healthcare and Dr. Cui is the indirect managing member and ultimate beneficial owner of Healthcare GP. Healthcare, Healthcare GP and Dr. Cui may be deemed to share voting and dispositive power with respect to the shares held directly by Healthcare.

     

    (3)This percentage is calculated based upon 65,610,726 shares of the Issuer’s Common Stock outstanding, which is the sum of: (i) 65,560,484 shares of Common Stock outstanding on April 9, 2024, as disclosed in the Issuer’s Annual Report, as amended, on Form 10K filed with the SEC on April 26, 2024 and (ii) 50,242 shares of Common Stock issuable upon exercise of stock options, which are exercisable within 60 days of the date of this filing.

      

     

     

    INTRODUCTION

      

    This Amendment No. 5 (“Amendment No. 5”) to Schedule 13D supplements and amends the initial Schedule 13D originally filed by the undersigned with the Securities and Exchange Commission (the “SEC”) on January 24, 2019, as amended by Amendment No. 1 thereto filed with the SEC on August, 3, 2020, Amendment No. 2 thereto filed with the SEC on September 9, 2021, Amendment No. 3 thereto filed with the SEC on September 27, 2022, and Amendment No. 4 thereto filed with the SEC on November 14, 2023 (as so amended, the “Original Schedule 13D”). Information reported in the Original Schedule 13D remains in effect except to the extent that it is amended, restated or superseded by information contained in this Amendment No. 5. Capitalized terms used but not defined in this Amendment No. 5 have the respective meanings set forth in the Original Schedule 13D. All references in the Original Schedule 13D and this Amendment No. 5 shall be deemed to refer to the Schedule 13D as amended and supplemented by this Amendment.

     

    Item 4.Purpose of Transaction

     

    Item 4 of the Original Schedule 13D is hereby amended and supplemented by adding the following paragraphs at the end of Item 4:

     

    On April 10, 2024, the Issuer entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (“Parent”), Adams Merger Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent (“Merger Sub”). The Merger Agreement provides that, subject to the terms of the Merger Agreement, Merger Sub will commence a cash tender offer (the “Offer”) to purchase all of the outstanding shares of common stock of the Issuer, par value $0.001 per share (the “Shares”), at a price of $65.00 per share (the “Offer Price”), net to the seller in cash, without interest, and subject to applicable withholding taxes.

     

    Following consummation of the Offer, Merger Sub will merge with and into the Issuer, with the Issuer surviving as a wholly owned subsidiary of Parent (the “Merger”). In the Merger, each Share issued and outstanding immediately prior to the effective time of the Merger that is not tendered and accepted pursuant to the Offer (other than the Shares owned by the Issuer, Shares held by Parent or Merger Sub, and Shares as to which appraisal rights have been perfected in accordance with applicable law) will be canceled and converted into the right to receive the Offer Price (the “Merger Consideration”), net to the seller in cash, without interest, and subject to applicable withholding taxes, on the terms and conditions set forth in the Merger Agreement. Immediately prior to the effective time of the Merger, all outstanding unvested stock options and unvested restricted stock units will become fully vested, and at the effective time of the Merger, each stock option and restricted stock unit will be canceled and converted into the right to receive an amount in cash equal to the Merger Consideration (or, in the case of stock options, the difference between the Merger Consideration and the applicable per share exercise price), less any applicable withholding taxes.

     

    On April 10, 2024, in connection with the Merger Agreement, certain stockholders, including the Fund and Healthcare, (collectively, the “Supporting Stockholders”), entered into a Tender and Support Agreement (together, the “Tender and Support Agreements”) with Parent and Merger Sub. The Tender and Support Agreements provide, among other things, that each of the Supporting Stockholders will tender all of the Shares held by such Supporting Stockholder, as applicable, in the Offer.

     

    The foregoing description of the Tender and Support Agreements does not purport to be complete and is qualified in its entirety by reference to the full text of the Tender and Support Agreements, the form of which is attached hereto as Exhibit K and are incorporated herein by reference.

     

    Item 5.Interest in Securities of the Issuer

     

    Item 5 of the Original Schedule 13D is hereby amended and restated in its entirety as follows:

     

    (a)As of the date hereof, (i) the Fund is the record owner of 6,582,380 shares of Common Stock; and (ii) Healthcare is the record owner of 1,735,544 shares of Common Stock. The Fund is controlled by the General Partner and Dr. Cui. As such, each of the General Partner and Dr. Cui may be deemed to share voting and dispositive power over the shares held by the Fund and both the General Partner and Dr. Cui may be deemed to beneficially own the shares held directly by the Fund. Healthcare is controlled directly by Healthcare GP and indirectly by Dr. Cui. As such, each of the Healthcare GP and Dr. Cui may be deemed to share voting and dispositive power over the shares held by Healthcare and both Healthcare GP and Dr. Cui may be deemed to beneficially own the shares held directly by Healthcare. In addition, Dr. Cui beneficially owns 50,242 shares of Common Stock that may be acquired upon exercise of options that are exercisable within 60 days of the date of this filing, which were granted to Dr. Cui pursuant to the Issuer’s non-employee director compensation policy.

     

     

     

    (b)

     

       Number of Shares of Common Stock 
       Power to Vote or
    Direct the Vote
       Power to Dispose or
    Direct the Disposition
     
    Reporting Person  Sole   Shared   Sole   Shared 
    Decheng Capital China Life Sciences USD Fund III, L.P.   0    6,582,380    0    6,582,380 
    Decheng Capital Management III (Cayman), LLC   0    6,582,380    0    6,582,380 
    Decheng Capital Global Healthcare Fund (Master), LP   0    1,735,544    0    1,735,544 
    Decheng Capital Global Healthcare GP, LLC   0    1,735,544    0    1,735,544 
    Xiangmin Cui   50,242    8,317,924    50,242    8,317,924 

     

    (c)Except as set forth in this Item 3, the Reporting Persons have not effected any transactions in the securities of the Issuer in the last 60 days.

     

    (d)No other person is known by the Reporting Persons to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Common Stock beneficially owned by the Reporting Persons.

     

    (e)Not applicable.

     

    Item 6.Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

     

    Item 6 of the Original Schedule 13D is hereby amended and supplemented by adding the following paragraph at the end of Item 6:

     

    The information set forth or incorporated in Item 4 is hereby incorporated by reference in its entirety into this Item 6.

     

    Item 7.Material to be Filed as Exhibits

     

    Item 7 of the Original Schedule 13D is hereby amended and supplemented by adding the following paragraph at the end of Item 7:

     

    KForm of Tender and Support Agreement (incorporated by reference to Exhibit 10.1 to the Issuer’s Current Report on Form 8-K (File No. 001-37449), filed on April 10, 2024).

     

     

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: April 30, 2024

     

      Decheng Capital China Life Sciences USD Fund III, L.P.
       
      By its General Partner
      Decheng Capital Management III (Cayman), LLC
       
      By:    /s/ Xiangmin Cui 
      Name:    Xiangmin Cui 
      Title:    Manager
       
      Decheng Capital Management III (Cayman), LLC
       
      By:   /s/ Xiangmin Cui 
      Name:   Xiangmin Cui 
      Title:   Manager
       
      Decheng Capital Global Healthcare Fund (Master), LP
       
      By its General Partner 
      Decheng Capital Global Healthcare GP, LLC
       
      By its Manager 
      Decheng Capital SV LLC
       
      By its Manager 
      Decheng Capital LLC
       
      By:   /s/ Xiangmin Cui 
      Name:   Xiangmin Cui 
      Title:   Manager
       
      Decheng Capital Global Healthcare GP, LLC
       
      By its Manager 
      Decheng Capital SV LLC
       
      By its Manager 
      Decheng Capital LLC
       
      By:   /s/ Xiangmin Cui 
      Name:   Xiangmin Cui 
      Title:   Manager
       
      /s/ Xiangmin Cui 
      Xiangmin Cui

     

     

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      Berenberg initiated coverage of Alpine Immune Sciences with a rating of Buy and set a new price target of $18.00

      10/18/23 7:51:16 AM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ALPN
    Leadership Updates

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    • Frazier Life Sciences Appoints Biotech Innovators Mitchell H. Gold and Stanford L. Peng as Venture Partners

      Frazier Life Sciences (FLS), a longstanding investment firm focused on innovative therapeutics, today announced the appointments of Mitchell H. Gold, M.D., and Stanford L. Peng, M.D., Ph.D., as Venture Partners. "We believe Mitch and Stanford bring exceptional leadership and experience that will elevate our ability to create and nurture breakthrough biopharmaceutical companies," said Jamie Topper, M.D., Ph.D., Managing Partner at FLS. "Mitch's history of building transformative companies, his relentless pursuit of scientific excellence and his proven ability to identify transformative scientific and investment opportunities make him a valuable addition to our team. Similarly, Stanford's p

      1/9/25 8:00:00 AM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Alpine Immune Sciences Announces Appointment of Wolfgang Dummer, M.D., Ph.D., as Chief Medical Officer and Grant under Nasdaq Listing Rule 5635(c)

      Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for autoimmune and inflammatory diseases, today announced the appointment of Wolfgang Dummer, M.D., Ph.D., to Chief Medical Officer effective October 2, 2023. He succeeds Andrew Sandler, M.D., who will transition responsibilities to Dr. Dummer through the remainder of the year. "Wolfgang is a highly accomplished drug developer with deep expertise in rare disease, immunology, and immunotherapy. His experience working across all phases of clinical development through regulatory approval will be important as we continue to advance our pipeline of new therapie

      10/4/23 8:00:00 AM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Alpine Immune Sciences Announces Appointment of M. Christina Yi as Chief Technology Officer and Grant under Nasdaq Listing Rule 5635(c)

      Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for autoimmune and inflammatory diseases, today announced the appointment of M. Christina Yi to Chief Technology Officer effective August 21, 2023. Ms. Yi has more than 25 years of biopharmaceuticals leadership experience, including manufacturing, quality, and supply chain. She succeeds Wayne Gombotz, Ph.D., who will retire in August. "Christina is an accomplished industry leader and will be a key addition to our executive team as we prepare for a broad development plan for povetacicept. Her expertise and leadership will be important to Alpine as we contin

      8/22/23 4:30:00 PM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ALPN
    Financials

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    • Vertex Enters Into Agreement to Acquire Alpine Immune Sciences

      - Alpine is a clinical stage biotechnology company focused on discovering and developing innovative, protein-based immunotherapies - - Alpine's lead product, povetacicept, demonstrated best-in-class potential in patients with IgA nephropathy (IgAN); Phase 3 to initiate in H2 2024 - - Povetacicept holds promise as a pipeline-in-a-product, with clinical studies in additional serious diseases underway - - Alpine's protein engineering and immunotherapy expertise augments Vertex's toolbox and capabilities - - Vertex to host investor call today, April 10, at 4:30 pm ET - Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) and Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a biotechnology com

      4/10/24 4:01:00 PM ET
      $ALPN
      $VRTX
      Biotechnology: Pharmaceutical Preparations
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    • Alpine Immune Sciences to Report Fourth Quarter and Full Year 2023 Financial Results

      Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for autoimmune and inflammatory diseases, today announced the Company will release fourth quarter and full year 2023 financial results on Monday, March 18, 2024, after the close of market. The Company will host a corresponding conference call and live webcast at 4:30 p.m. ET/1:30 p.m. PT on the same day. Conference Call and Webcast Information The link to the webcast will be available in the investor relations section of the Company's website at https://ir.alpineimmunesciences.com/events and a replay will be available on the Company's website for 90 days

      3/7/24 4:30:00 PM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Alpine Immune Sciences Presents Initial Clinical Data on Povetacicept in Autoimmune Glomerulonephritis in a Late-Breaking Poster Session at the American Society of Nephrology Kidney Week 2023

      -- Low-dose povetacicept (80 mg administered once every four weeks) was well tolerated during subcutaneous administration and reduced UPCR by greater than 50% in IgA nephropathy -- -- Higher dose povetacicept (240 mg) administered once every four weeks currently being explored -- -- Based on this data Alpine will now seek to begin a pivotal phase 3 IgAN study in the second half of 2024 -- -- Company to host virtual investor call and webcast today at 4:30 pm ET with James Tumlin, M.D. and Jonathan Barratt, Ph.D., FRCP -- Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for autoimmune and inflammator

      11/2/23 9:00:00 AM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care

    $ALPN
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    • SEC Form SC 13D/A filed by Alpine Immune Sciences Inc. (Amendment)

      SC 13D/A - ALPINE IMMUNE SCIENCES, INC. (0001626199) (Subject)

      5/21/24 4:49:22 PM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13D/A filed by Alpine Immune Sciences Inc. (Amendment)

      SC 13D/A - ALPINE IMMUNE SCIENCES, INC. (0001626199) (Subject)

      5/21/24 10:21:59 AM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form SC 13D/A filed by Alpine Immune Sciences Inc. (Amendment)

      SC 13D/A - ALPINE IMMUNE SCIENCES, INC. (0001626199) (Subject)

      4/30/24 4:20:00 PM ET
      $ALPN
      Biotechnology: Pharmaceutical Preparations
      Health Care