SC 13D/A 1 tm246499d1_sc13da.htm SC 13D/A

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13D

(RULE 13d-101)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a)

AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a)

(Amendment No. 3)*

NuCana plc

(Name of Issuer)

American Depositary Shares representing Ordinary Shares, nominal value £0.04 per share

(Title of Class of Securities)

67022C106

(CUSIP Number)

Nathalie Auber

Sofinnova Investments, Inc.

3000 Sand Hill Road, Bldg 4, Suite 250

Menlo Park, CA 94025

(650) 681-8420

(Name, Address and Telephone Number of Person

Authorized to Receive Notices and Communications)

COPY TO:

Jonathan Goodwin

c/o Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP

550 Allerton Street, Redwood City, CA 94063

(650) 321-2400

December 27, 2023

(Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box ¨

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 240.13d-7 for other parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

This information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP NO. 67022C106

13D

Page 2 of 18

1	NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Sofinnova Venture Partners VIII, L.P. (“SVP VIII”)
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ¨ (b) x
3	SEC USE ONLY
4	SOURCE OF FUNDS WC
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	7	SOLE VOTING POWER 4,479,355 Ordinary Shares (including 479,355 Ordinary Shares represented by 479,355 American Depositary Shares), except that Sofinnova Management VIII, L.L.C. (“SM VIII”), the general partner of SVP VIII, may be deemed to have sole voting power, and Dr. James I. Healy (“Healy”), the managing member of SM VIII, may be deemed to have sole power to vote these shares.
	8	SHARED VOTING POWER See response to row 7.
	9	SOLE DISPOSITIVE POWER 4,479,355 Ordinary Shares (including 479,355 Ordinary Shares represented by 479,355 American Depositary Shares), except that SM VIII, the general partner of SVP VIII, may be deemed to have sole dispositive power and Healy, the managing member of SM VIII, may be deemed to have sole dispositive power over these shares.
	10	SHARED DISPOSITIVE POWER See response to row 9.

11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON	4,479,355
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES	¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11	8.5%
14	TYPE OF REPORTING PERSON	PN

CUSIP NO. 67022C106

13D

Page 3 of 18

1	NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Sofinnova Management VIII, L.L.C. (“SM VIII”)
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ¨ (b) x
3	SEC USE ONLY
4	SOURCE OF FUNDS AF
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	7	SOLE VOTING POWER 4,479,355 Ordinary Shares (including 479,355 Ordinary Shares represented by 479,355 American Depositary Shares), all of which are owned directly by SVP VIII. SM VIII, the general partner of SVP VIII, may be deemed to have sole voting power, and Healy, the managing member of SM VIII, may be deemed to have sole power to vote these shares.
	8	SHARED VOTING POWER See response to row 7.
	9	SOLE DISPOSITIVE POWER 4,479,355 Ordinary Shares (including 479,355 Ordinary Shares represented by 479,355 American Depositary Shares), all of which are owned directly by SVP VIII. SM VIII, the general partner of SVP VIII, may be deemed to have sole dispositive power, and Healy, the managing member of SM VIII, may be deemed to have sole dispositive power over these shares.
	10	SHARED DISPOSITIVE POWER See response to row 9.

11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON	4,479,355
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES	¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11	8.5%
14	TYPE OF REPORTING PERSON	OO

CUSIP NO. 67022C106

13D

Page 4 of 18

1	NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Dr. James I. Healy (“Healy”)
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ¨ (b) x
3	SEC USE ONLY
4	SOURCE OF FUNDS AF
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
6	CITIZENSHIP OR PLACE OF ORGANIZATION U.S. Citizen

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	7	SOLE VOTING POWER 4,560,617 Ordinary Shares (including 484,635 Ordinary Shares represented by 484,635 American Depositary Shares), of which 4,479,355 are owned directly by SVP VIII and 81,262 are owned directly by Healy. SM VIII, the general partner of SVP VIII, may be deemed to have sole voting power of the shares owned directly by SVP VIII. Healy, the managing member of SM VIII, may be deemed to have sole power to vote these shares.
	8	SHARED VOTING POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Healy, a managing member of SM X LLC, may be deemed to have shared power to vote these shares.
	9	SOLE DISPOSITIVE POWER 4,560,617 Ordinary Shares (including 484,635 Ordinary Shares represented by 484,635 American Depositary Shares), of which 4,479,355 are owned directly by SVP VIII and 81,262 are owned directly by Healy. SM VIII, the general partner of SVP VIII, may be deemed to have sole dispositive power of the shares owned directly by SVP VIII. Healy, the managing member of SM VIII and a director of the Issuer, may be deemed to have sole dispositive power over these shares.
	10	SHARED DISPOSITIVE POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy, a managing member of SM X LLC, may be deemed to have shared dispositive power over these shares.

11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON	6,283,392
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES	¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11	11.9%
14	TYPE OF REPORTING PERSON	IN

CUSIP NO. 67022C106

13D

Page 5 of 18

1	NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Dr. Maha Katabi (“Katabi”)
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ¨ (b) x
3	SEC USE ONLY
4	SOURCE OF FUNDS AF
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
6	CITIZENSHIP OR PLACE OF ORGANIZATION Canadian Citizen

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	7	SOLE VOTING POWER -0-
	8	SHARED VOTING POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Katabi, a managing member of SM X LLC, may be deemed to have shared power to vote these shares.
	9	SOLE DISPOSITIVE POWER -0-
	10	SHARED DISPOSITIVE POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Katabi, a managing member of SM X LLC, may be deemed to have shared dispositive power over these shares.

11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON	1,722,775
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES	¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11	3.3%
14	TYPE OF REPORTING PERSON	IN

CUSIP NO. 67022C106

13D

Page 6 of 18

1	NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Sofinnova Venture Partners X, L.P. (“SVP X”)
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ¨ (b) x
3	SEC USE ONLY
4	SOURCE OF FUNDS WC
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	7	SOLE VOTING POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), except that Sofinnova Management X, L.P. (“SM X LP”), the general partner of SVP X, may be deemed to have sole voting power, Sofinnova Management X-A, L.L.C. (“SM X LLC”), the general partner of SM X LP, may be deemed to have sole voting power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared power to vote these shares.
	8	SHARED VOTING POWER See response to row 7.
	9	SOLE DISPOSITIVE POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), except that SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared dispositive power over these shares.
	10	SHARED DISPOSITIVE POWER See response to row 9.

11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON	1,722,775
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES	¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11	3.3%
14	TYPE OF REPORTING PERSON	PN

CUSIP NO. 67022C106

13D

Page 7 of 18

1	NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Sofinnova Management X, L.P. (“SM X LP”)
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ¨ (b) x
3	SEC USE ONLY
4	SOURCE OF FUNDS AF
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	7	SOLE VOTING POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared power to vote these shares.
	8	SHARED VOTING POWER See response to row 7.
	9	SOLE DISPOSITIVE POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared dispositive power over these shares.
	10	SHARED DISPOSITIVE POWER See response to row 9.

11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON	1,722,775
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES	¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11	3.3%
14	TYPE OF REPORTING PERSON	PN

CUSIP NO. 67022C106

13D

Page 8 of 18

1	NAME OF REPORTING PERSON I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Sofinnova Management X-A, L.L.C. (“SM X LLC”)
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ¨ (b) x
3	SEC USE ONLY
4	SOURCE OF FUNDS AF
5	CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
6	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	7	SOLE VOTING POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole voting power, SM X LLC, the general partner of SM X LP, may be deemed to have sole voting power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared power to vote these shares.
	8	SHARED VOTING POWER See response to row 7.
	9	SOLE DISPOSITIVE POWER 1,722,775 Ordinary Shares (including 1,722,775 Ordinary Shares represented by 1,722,775 American Depositary Shares), all of which are owned directly by SVP X. SM X LP, the general partner of SVP X, may be deemed to have sole dispositive power, SM X LLC, the general partner of SM X LP, may be deemed to have sole dispositive power, and Healy and Katabi, the managing members of SM X LLC, may be deemed to have shared dispositive power over these shares.
	10	SHARED DISPOSITIVE POWER See response to row 9.

11	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON	1,722,775
12	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES	¨
13	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11	3.3%
14	TYPE OF REPORTING PERSON	OO

CUSIP NO. 67022C106

13D

Page 9 of 18

Statement on Schedule 13D

This Amendment No. 3 (“Amendment No. 3”) amends and restates the Statement on Schedule 13D that was originally filed on October 11, 2017 and amended on October 5, 2020 and February 28, 2022 (as amended, the “Original Schedule 13D”). This Amendment No. 3 relates to the beneficial ownership of Ordinary Shares, nominal value £0.04 per share (“Ordinary Shares”) represented by American Depositary Shares (“ADSs”), of NuCana plc, a public limited company incorporated in England and Wales (“Issuer”). This Amendment No. 3 is being filed by Sofinnova Venture Partners VIII, L.P., a Delaware limited partnership (“SVP VIII”), Sofinnova Management VIII, L.L.C., a Delaware limited liability company (“SM VIII”), Sofinnova Venture Partners X, L.P., a Delaware limited partnership (“SVP X”), Sofinnova Management X, L.P., a Delaware limited partnership (“SM X LP”), Sofinnova Management X-A, L.L.C., a Delaware limited liability company (“SM X LLC”), Dr. James I. Healy (“Healy”), and Dr. Maha Katabi (“Katabi” and collectively with SVP VIII, SM VIII, SVP X, SM X LP, SM X LLC, and Healy, the “Reporting Persons”). This Amendment No. 3 is being filed to reflect the disposition of Ordinary Shares represented by ADSs by the Reporting Persons.

ITEM 1.

SECURITY AND ISSUER.

(a)

The class of equity securities to which this statement relates is the Ordinary Shares of the Issuer.

(b)

The Issuer’s principal executive offices are located at 3 Lochside Way, Edinburgh, EH12 9DT, United Kingdom.

ITEM 2.

IDENTITY AND BACKGROUND.

(a) The persons and entities filing this Schedule 13D are SVP VIII, SM VIII, SVP X, SM X LP, SM X LLC, Healy, and Katabi. SM VIII, the general partner of SVP VIII, may be deemed to have sole power to vote and sole power to dispose of shares of the Issuer directly owned by SVP VIII. SM X LP, the general partner of SVP X, and SM X LLC, the general partner of SM X LP, may be deemed to have sole power to vote and sole power to dispose of shares of the Issuer directly owned by SVP X. Healy may be deemed to have sole power to vote and sole power to dispose of shares of the Issuer directly owned by Healy.

(b) The address of the principal place of business for each of the Reporting Persons is c/o Sofinnova Investments, Inc., 3000 Sand Hill Road, Bldg 4, Suite 250, Menlo Park, California 94025.

(c) The principal occupation of each of the Reporting Persons is the venture capital investment business. The principal business of SVP VIII and SVP X is to make investments in private and public companies. The principal business of SM VIII is to serve as the general partner of SVP VIII, the principal business of SM X LP is to serve as the general partner of SVP X, and the principal business of SM X LLC is to serve as the general partner of SM X LP. Healy is the managing member of SM VIII. Healy and Katabi are the managing members of SM X LLC. Healy was a director of the Issuer until April 27, 2022.

(d) During the last five years, none of the Reporting Persons has been convicted in any criminal proceeding (excluding traffic violations or similar misdemeanors).

(e) During the last five years, none of the Reporting Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

(f) SVP VIII is a Delaware limited partnership. SM VIII is a Delaware limited liability company. SVP X is a Delaware limited partnership. SM X LP is a Delaware limited partnership. SM X LLC is a Delaware limited liability company. Healy is a U.S. citizen. Katabi is a Canadian citizen.

CUSIP NO. 67022C106

13D

Page 10 of 18

ITEM 3.

SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

On April 11, 2014, SVP VIII purchased an aggregate of 16,000,000 series B convertible participating shares (“Series B Shares”), at a price of £1.00 per share for an aggregate subscription price of £16,000,000. On September 14, 2017, the Issuer completed a one-for-four reverse share split. This had the effect of consolidating every four Series B Shares of £0.001 to one Series B Share of £0.004. As further described in the Issuer’s Prospectus filed pursuant to Rule 424(b)(4) on September 29, 2017 with the Securities and Exchange Commission (the “Prospectus”) under the heading “Series B Convertible Participating Shares,” immediately prior to the completion of the Issuer’s initial public offering of ADSs (the “Offering”), each Series B Share automatically converted into one Ordinary Share.

On December 12, 2016, the Issuer granted Healy options to purchase Ordinary Shares pursuant to the Issuer’s 2016 Share Option Scheme. Healy exercised such options prior to the Offering, and accordingly, immediately following the Offering, holds 45,750 Ordinary Shares through the Healy Family Trust. Such Ordinary Shares are subject to repurchase by the Issuer if Healy ceases to be a director of the Issuer during the four years following the grant date with 100% of such Ordinary Shares subject to repurchase during the first year following the grant date, 75% of such Ordinary Shares subject to repurchase during the second year following the grant date, 50% of such Ordinary Shares subject to repurchase during the third year following the grant date, and 25% of such Ordinary Shares subject to repurchase during the fourth year following the grant date. The Issuer’s 2016 Share Option Scheme is described more fully in the Prospectus.

In connection with the Offering, SVP VIII purchased 666,666 ADSs at $15.00 per ADS, or $9,999,990.00 in the aggregate. Such purchase occurred pursuant to and on the terms set forth in the Prospectus. Each ADS represents one Ordinary Share.

On May 15, 2019, the Issuer granted Healy options to purchase 25,000 Ordinary Shares at an exercise price of £11.26 per share pursuant to the Issuer’s 2016 Share Option Scheme. The shares underlying this option vest in four annual installments, subject to Healy’s continuous service as a director of the Issuer as of such vesting date.

On June 10, 2020, the Issuer granted Healy options to purchase 47,832 Ordinary Shares at an exercise price of £4.78 per share pursuant to the Issuer’s 2016 Share Option Scheme. The shares underlying this option vest in four annual installments, subject to Healy’s continuous service as a director of the Issuer as of such vesting date.

On September 9, 2020, the Issuer granted Healy options to purchase 9,567 Ordinary Shares at an exercise price of £0.04 per share pursuant to the Issuer’s 2020 Long-Term Incentive Plan. The shares underlying this option vest in four annual installments, subject to Healy’s continuous service as a director of the Issuer as of such vesting date. Healy exercised such portion of such options equal to 2,392 Ordinary Shares on September 9, 2021.

The Issuer filed a Prospectus Supplement pursuant to Rule 424(b)(5) on September 17, 2020 with the Securities and Exchange Commission (the “Prospectus Supplement”) that details the Issuer’s offering of 15,555,556 ADSs (the “Secondary Offering”). As further described in the Prospectus Supplement, each ADS represents one Ordinary Share.

In connection with the Secondary Offering, SVP VIII purchased 1,111,111 ADSs at $4.50 per ADS, or $4,999,999.50 in the aggregate, and SVP X purchased 2,222,222 ADSs at $4.50 per ADS, or $9,999,999 in the aggregate. Such purchases occurred pursuant to and on the terms set forth in the Prospectus Supplement.

On February 10, 2021, the Issuer granted Healy options to purchase 23,100 Ordinary Shares at an exercise price of £4.53 per share pursuant to the Issuer’s 2016 Share Option Scheme and 11,550 Ordinary Shares at an exercise price of £0.04 per share pursuant to the Issuer’s 2020 Long-Term Incentive Plan. The shares underlying these options vest in four equal installments, subject to Healy’s continuous service as a director of the Issuer as of such vesting date.

On September 15, 2021, the Issuer granted Healy options to purchase 29,700 Ordinary Shares at an exercise price of £1.71 per share pursuant to the Issuer’s 2016 Share Option Scheme and 14,850 Ordinary Shares at an exercise price of £0.04 per share pursuant to the Issuer’s 2020 Long-Term Incentive Plan. The shares underlying these options vest in four equal installments, subject to Healy’s continuous service as a director of the Issuer as of such vesting date.

CUSIP NO. 67022C106

13D

Page 11 of 18

On December 1, 2023, SVP VIII sold 40,504 ADSs at a price of $0.4102 per ADS, or $16,614.74 in the aggregate, and SVP X sold 15,579 ADSs at a price of $0.4102 per ADS, or $6,390.51 in the aggregate, in open market sales.

On December 4, 2023, SVP VIII sold 13,168 ADSs at a price of $0.4200 per ADS, or $5,530.56 in the aggregate, and SVP X sold 5,064 ADSs at a price of $0.4200 per ADS, or $2,126.88 in the aggregate, in open market sales.

On December 5, 2023, SVP VIII sold 8,812 ADSs at a price of $0.4082 per ADS, or $3,597.06 in the aggregate, and SVP X sold 3,389 ADSs at a price of $0.4082 per ADS, or $1,383.39 in the aggregate, in open market sales.

On December 11, 2023, SVP VIII sold 35,006 ADSs at a price of $0.3546 per ADS, or $12,413.13 in the aggregate, and SVP X sold 13,465 ADSs at a price of $0.3546 per ADS, or $4,774.69 in the aggregate, in open market sales.

On December 12, 2023, SVP VIII sold 2,644 ADSs at a price of $0.3570 per ADS, or $943.91 in the aggregate, and SVP X sold 1,017 ADSs at a price of $0.3570 per ADS, or $363.07 in the aggregate, in open market sales.

On December 13, 2023, SVP VIII sold 87,775 ADSs at a price of $0.3515 per ADS, or $30,852.91 in the aggregate, and SVP X sold 33,764 ADSs at a price of $0.3515 per ADS, or $11,868.05 in the aggregate, in open market sales.

On December 14, 2023, SVP VIII sold 42,410 ADSs at a price of $0.3512 per ADS, or $14,894.39 in the aggregate, and SVP X sold 16,314 ADSs at a price of $0.3512 per ADS, or $5,729.48 in the aggregate, in open market sales.

On December 15, 2023, SVP VIII sold 17,396 ADSs at a price of $0.3501 per ADS, or $6,090.34 in the aggregate, and SVP X sold 6,691 ADSs at a price of $0.3501 per ADS, or $2,342.52 in the aggregate, in open market sales.

On December 19, 2023, SVP VIII sold 3,599 ADSs at a price of $0.3521 per ADS, or $1,267.21 in the aggregate, and SVP X sold 1,385 ADSs at a price of $0.3521 per ADS, or $487.66 in the aggregate, in open market sales.

On December 20, 2023, SVP VIII sold 30,028 ADSs at a price of $0.3207 per ADS, or $9,629.98 in the aggregate, and SVP X sold 11,551 ADSs at a price of $0.3207 per ADS, or $3,704.41 in the aggregate, in open market sales.

On December 21, 2023, SVP VIII sold 42,817 ADSs at a price of $0.3000 per ADS, or $12,845.10 in the aggregate, and SVP X sold 16,470 ADSs at a price of $0.3000 per ADS, or $4,941.00 in the aggregate, in open market sales.

On December 27, 2023, SVP VIII sold 287,265 ADSs at a price of $0.3273 per ADS, or $94,021.83 in the aggregate, and SVP X sold 110,499 ADSs at a price of $0.3273 per ADS, or $36,166.32 in the aggregate, in open market sales.

On December 28, 2023, SVP VIII sold 40,801 ADSs at a price of $0.3211 per ADS, or $13,101.20 in the aggregate, and SVP X sold 15,694 ADSs at a price of $0.3211 per ADS, or $5,039.34 in the aggregate, in open market sales.

On December 29, 2023, SVP VIII sold 9,224 ADSs at a price of $0.3007 per ADS, or $2,773.66 in the aggregate, and SVP X sold 3,548 ADSs at a price of $0.3007 per ADS, or $1,066.88 in the aggregate, in open market sales.

On January 2, 2024, SVP VIII sold 37,679 ADSs at a price of $0.3206 per ADS, or $12,079.89 in the aggregate, and SVP X sold 14,494 ADSs at a price of $0.3206 per ADS, or $4,646.78 in the aggregate, in open market sales.

On January 3, 2024, SVP VIII sold 14,742 ADSs at a price of $0.3124 per ADS, or $4,605.40 in the aggregate, and SVP X sold 5,671 ADSs at a price of $0.3124 per ADS, or $1,771.62 in the aggregate, in open market sales.

On January 4, 2024, SVP VIII sold 14,945 ADSs at a price of $0.3020 per ADS, or $4,513.39 in the aggregate, and SVP X sold 5,749 ADSs at a price of $0.3020 per ADS, or $1,736.20 in the aggregate, in open market sales.

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On January 5, 2024, SVP VIII sold 10,400 ADSs at a price of $0.3008 per ADS, or $3,128.32 in the aggregate, and SVP X sold 4,000 ADSs at a price of $0.3008 per ADS, or $1,203.20 in the aggregate, in open market sales.

On January 8, 2024, SVP VIII sold 24,742 ADSs at a price of $0.3032 per ADS, or $7,501.77 in the aggregate, and SVP X sold 9,517 ADSs at a price of $0.3032 per ADS, or $2,885.55 in the aggregate, in open market sales.

On January 10, 2024, SVP VIII sold 12,488 ADSs at a price of $0.3005 per ADS, or $3,752.64 in the aggregate, and SVP X sold 4,803 ADSs at a price of $0.3005 per ADS, or $1,443.30 in the aggregate, in open market sales.

On January 18, 2024, SVP VIII sold 8,146 ADSs at a price of $0.3001 per ADS, or $2,444.61 in the aggregate, and SVP X sold 3,134 ADSs at a price of $0.3001 per ADS, or $940.51 in the aggregate, in open market sales.

On January 19, 2024, SVP VIII sold 599 ADSs at a price of $0.3000 per ADS, or $179.70 in the aggregate, and SVP X sold 230 ADSs at a price of $0.3000 per ADS, or $69.00 in the aggregate, in open market sales.

On January 24, 2024, SVP VIII sold 35,552 ADSs at a price of $0.3050 per ADS, or $10,843.36 in the aggregate, and SVP X sold 13,676 ADSs at a price of $0.3050 per ADS, or $4,171.18 in the aggregate, in open market sales.

On January 26, 2024, SVP VIII sold 166,572 ADSs at a price of $0.3063 per ADS, or $51,021.00 in the aggregate, and SVP X sold 64,073 ADSs at a price of $0.3063 per ADS, or $19,625.56 in the aggregate, in open market sales.

On January 29, 2024, SVP VIII sold 45,474 ADSs at a price of $0.3100 per ADS, or $14,096.94 in the aggregate, and SVP X sold 17,492 ADSs at a price of $0.3100 per ADS, or $5,422.52 in the aggregate, in open market sales.

On January 30, 2024, SVP VIII sold 53,867 ADSs at a price of $0.3003 per ADS, or $16,176.26 in the aggregate, and SVP X sold 20,720 ADSs at a price of $0.3003 per ADS, or $6,222.22 in the aggregate, in open market sales.

On January 31, 2024, SVP VIII sold 9,588 ADSs at a price of $0.3006 per ADS, or $2,882.15 in the aggregate, and SVP X sold 3,688 ADSs at a price of $0.3006 per ADS, or $1,108.61 in the aggregate, in open market sales.

On February 1, 2024, SVP VIII sold 30,304 ADSs at a price of $0.3002 per ADS, or $9,097.26 in the aggregate, and SVP X sold 11,656 ADSs at a price of $0.3002 per ADS, or $3,499.13 in the aggregate, in open market sales.

On February 2, 2024, SVP VIII sold 1,503 ADSs at a price of $0.3006 per ADS, or $451.80 in the aggregate, and SVP X sold 578 ADSs at a price of $0.3006 per ADS, or $173.75 in the aggregate, in open market sales.

On February 12, 2024, SVP VIII sold 98,505 ADSs at a price of $0.3033 per ADS, or $29,876.57 in the aggregate, and SVP X sold 37,891 ADSs at a price of $0.3033 per ADS, or $11,492.34 in the aggregate, in open market sales.

On February 13, 2024, SVP VIII sold 433 ADSs at a price of $0.3200 per ADS, or $138.56 in the aggregate, and SVP X sold 167 ADSs at a price of $0.3200 per ADS, or $53.44 in the aggregate, in open market sales.

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On February 14, 2024, SVP VIII sold 62,195 ADSs at a price of $0.3001 per ADS, or $18,664.72 in the aggregate, and SVP X sold 23,924 ADSs at a price of $0.3001 per ADS, or $7,179.59 in the aggregate, in open market sales.

On February 20, 2024, SVP VIII sold 9,239 ADSs at a price of $0.3501 per ADS, or $3,234.57 in the aggregate, and SVP X sold 3,554 ADSs at a price of $0.3501 per ADS, or $1,244.26 in the aggregate, in open market sales.

Unless noted above, the source of the funds for all purchases and acquisitions by the Reporting Persons was from working capital. Certain purchases by SVP VIII and SVP X were made using their working capital funded partially through a line of credit with Silicon Valley Bank in the normal course of business and then paid down from the proceeds from investor capital calls.

Unless noted above, no part of the purchase price was borrowed by any Reporting Person for the purpose of acquiring any securities discussed in this Item 3.

ITEM 4.

PURPOSE OF TRANSACTION.

The Reporting Persons hold their securities of the Issuer for investment purposes. Depending on the factors discussed herein, the Reporting Persons may, from time to time, acquire additional Ordinary Shares and/or retain and/or sell all or a portion of the Ordinary Shares held by the Reporting Persons in the open market or in privately negotiated transactions, block sales or otherwise or pursuant to ordinary stock exchange transactions effected through one or more broker-dealers whether individually or utilizing specific pricing or other instructions (including by means of Rule 10b5-1 programs), and/or may distribute the Ordinary Shares held by the Reporting Persons to their respective members or limited partners. Any actions the Reporting Persons might undertake will be dependent upon the Reporting Persons’ review of numerous factors, including, among other things, the price levels of the Ordinary Shares, general market and economic conditions, ongoing evaluation of the Issuer’s business, financial condition, operations and prospects; the relative attractiveness of alternative business and investment opportunities, and other future developments. Except as set forth above, the Reporting Persons have no present plans or intentions which would result in or relate to any of the transactions described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

ITEM 5.

INTEREST IN SECURITIES OF THE ISSUER.

(a,b) Regarding aggregate beneficial ownership, see Row 11 of the cover page of each Reporting Person. Regarding percentage beneficial ownership, see Row 13 of the cover page of each Reporting Person. Regarding sole power to vote shares, see Row 7 of the cover page of each Reporting Person. Regarding shared power to vote shares, see Row 8 of the cover page of each Reporting Person. Regarding sole power to dispose of shares, see Row 9 of the cover page of each Reporting Person. Regarding shared power to dispose of shares, see Row 10 of the cover page of each Reporting Person. Percentage calculations were made using 52,793,000 as the number of shares of Ordinary Shares outstanding as of September 30, 2023 as reported by the Issuer in its Form 6-K (File No. 001-38215) filed on November 16, 2023.

(c) Except as set forth in Item 3 above, the Reporting Persons have not effected any transaction in the Ordinary Shares of the Issuer during the past 60 days.

(d) Under certain circumstances set forth in the limited partnership agreement of SVP VIII, the general partner and limited partners of SVP VIII may be deemed to have the right to receive dividends from, or the proceeds from, the sale of shares of the Issuer owned by such entity of which they are a partner. Under certain circumstances set forth in the limited partnership agreement of SVP X, the general partner and limited partners of SVP X may be deemed to have the right to receive dividends from, or the proceeds from, the sale of shares of the Issuer owned by such entity of which they are a partner.

(e) Not applicable.

ITEM 6.

CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO SECURITIES OF THE ISSUER.

Certain of the Reporting Persons have entered into a registration rights agreement with the Issuer to be effective upon the completion of the Offering and pursuant to which the Issuer has agreed under specified circumstances to file a registration statement to register the resale of the Ordinary Shares held by such Reporting Persons and other shareholders, as well as to cooperate in specified public offerings of such shares. The Form of Registration Rights Agreement is incorporated herein by reference to Exhibit 1.9 to the Issuer’s Amendment No. 1 to Form F-1 Registration Statement (File No. 333-220321).

Healy, in his capacity as a director of the Issuer, along with the other directors of the Issuer, entered into a Deed of Indemnity with the Issuer, as more fully described in the Prospectus. Such description and form of Deed of Indemnity is incorporated herein by reference to Exhibit 10.10 to the Issuer’s Amendment No. 2 to Form F-1 Registration Statement (File No. 333-220321).

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SVP VIII and Healy have agreed that, subject to specified limited exceptions, for a period of 180 days from the date of the Prospectus, they will not, without the prior written consent of Citigroup Global Markets Inc., Jefferies LLC and Cowen and Company, LLC, offer, sell, contract, sell, pledge or otherwise dispose of, including the filing of a registration statement in respect of, or hedge any of their Ordinary Shares, ADSs, or any securities convertible into, or exercisable or exchangeable for Ordinary Shares; provided, that these restrictions do not apply to ADSs purchased in this offering, among other exceptions. Citigroup Global Markets Inc., Jefferies LLC and Cowen and Company, LLC in their sole discretion may release any of the securities subject to these lock-up agreements at any time, which, in the case of officers and directors, shall be with notice. The Form of Lock-up Agreement is incorporated herein by reference to Exhibit A to Exhibit 1.1 to the Issuer’s Amendment No. 1 to Form F-1 Registration Statement (File No. 333-220321).

In connection with the Secondary Offering, SVP VIII has agreed that for a period of 60 days from the date of the Prospectus Supplement and Healy has agreed that for a period of 90 days from the date of the Prospectus Supplement, subject to specified exceptions, not to directly or indirectly: (i) sell, offer, contract or grant any option to sell (including any short sale), pledge, transfer, establish an open “put equivalent position” within the meaning of Rule 16a-l(h) under the Securities Exchange Act of 1934, as amended, (ii) otherwise dispose of any Ordinary Shares or ADSs, options or warrants to acquire Ordinary Shares or ADSs, or securities exchangeable or exercisable for or convertible into Ordinary Shares or ADSs currently or hereafter owned either of record or beneficially, or (iii) publicly announce an intention to do any of the foregoing without the prior written consent of Jefferies LLC, Cowen and Company LLC and William Blair & Company, L.L.C. The Form of Lock-up Agreement is incorporated herein by reference to Exhibit A to Exhibit 1.1 to the Issuer’s Form 6-K (File No. 001-38215) filed on September 18, 2020.

ITEM 7.

MATERIAL TO BE FILED AS EXHIBITS.

EXHIBIT A	Agreement of Joint Filing.
EXHIBIT B	Power of Attorney.
EXHIBIT C	Form of Lock-Up Agreement described in Item 6, filed as Exhibit A to Exhibit 1.1 to the Issuer’s Amendment No. 1 to Form F-1 Registration Statement (File No. 333-220321) and incorporated herein by reference.
EXHIBIT D	Form of Registration Rights Agreement described in Item 6, filed as Exhibit 1.9 to the Issuer’s Amendment No. 1 to Form F-1 Registration Statement (File No. 333-220321) and incorporated herein by reference.
EXHIBIT E	Form of Deed of Indemnity for directors and executive officers, filed as Exhibit 10.10 to the Issuer’s Amendment No. 2 to Form F-1 Registration Statement (File No. 333-220321) and incorporated herein by reference.
EXHIBIT F	Form of Lock-Up Agreement described in Item 6, filed as Exhibit A to Exhibit 1.1 to the Issuer’s Form 6-K (File No. 001-38215) on September 18, 2020 and incorporated herein by reference.

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SIGNATURES

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 27, 2024

SOFINNOVA VENTURE PARTNERS VIII, L.P., a Delaware Limited Partnership		SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership

By: SOFINNOVA MANAGEMENT VIII, L.L.C., a Delaware Limited Liability Company		By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company
Its: General Partner		Its: General Partner

By:	/s/ Nathalie Auber	By:	/s/ Nathalie Auber

	Nathalie Auber		Nathalie Auber
	Attorney-in-Fact		Attorney-in-Fact

SOFINNOVA MANAGEMENT VIII, L.L.C., a Delaware Limited Liability Company		SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company

By:	/s/ Nathalie Auber	By:	/s/ Nathalie Auber

	Nathalie Auber		Nathalie Auber
	Attorney-in-Fact		Attorney-in-Fact

SOFINNOVA VENTURE PARTNERS X, L.P., a Delaware Limited Partnership		DR. JAMES I. HEALY
		DR. MAHA KATABI
By: SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership
Its: General Partner		By:	/s/ Nathalie Auber

			Nathalie Auber
By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company			Attorney-in-Fact
Its: General Partner

By:	/s/ Nathalie Auber
	Nathalie Auber
	Attorney-in-Fact

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EXHIBIT INDEX

Exhibit		Description

A		Agreement of Joint Filing.
B		Power of Attorney.
C		Form of Lock-Up Agreement described in Item 6, filed as Exhibit A to Exhibit 1.1 to the Issuer’s Amendment No. 1 to Form F-1 Registration Statement (File No. 333-220321) and incorporated herein by reference.
D		Form of Registration Rights Agreement described in Item 6, filed as Exhibit 1.9 to the Issuer’s Amendment No. 1 to Form F-1 Registration Statement (File No. 333-220321) and incorporated herein by reference.
E		Form of Deed of Indemnity for directors and executive officers, filed as Exhibit 10.10 to the Issuer’s Amendment No. 2 to Form F-1 Registration Statement (File No. 333-220321) and incorporated herein by reference.
F		Form of Lock-Up Agreement described in Item 6, filed as Exhibit A to Exhibit 1.1 to the Issuer’s Form 6-K (File No. 001-38215) on September 18, 2020 and incorporated herein by reference.

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exhibit A

Agreement of Joint Filing

The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Ordinary Shares of NuCana plc shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D.

Date: February 27, 2024

SOFINNOVA VENTURE PARTNERS VIII, L.P., a Delaware Limited Partnership		SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership

By: SOFINNOVA MANAGEMENT VIII, L.L.C., a Delaware Limited Liability Company		By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company
Its: General Partner		Its: General Partner

By:	/s/ Nathalie Auber	By:	/s/ Nathalie Auber

	Nathalie Auber		Nathalie Auber
	Attorney-in-Fact		Attorney-in-Fact

SOFINNOVA MANAGEMENT VIII, L.L.C., a Delaware Limited Liability Company		SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company

By:	/s/ Nathalie Auber	By:	/s/ Nathalie Auber

	Nathalie Auber		Nathalie Auber
	Attorney-in-Fact		Attorney-in-Fact

SOFINNOVA VENTURE PARTNERS X, L.P., a Delaware Limited Partnership		DR. JAMES I. HEALY
		DR. MAHA KATABI
By: SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership
Its: General Partner		By:	/s/ Nathalie Auber

			Nathalie Auber
By: SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company			Attorney-in-Fact
Its: General Partner

By:	/s/ Nathalie Auber
	Nathalie Auber
	Attorney-in-Fact

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exhibit B

Power of Attorney

Nathalie Auber has signed this Schedule 13D as Attorney-In-Fact. Note that copies of the applicable Power of Attorney are already on file with the appropriate agencies.

SEC Form SC 13D/A filed by NuCana plc (Amendment)