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    SEC Form SC 13D/A filed by Sierra Oncology Inc. (Amendment)

    5/6/22 4:33:35 PM ET
    $SRRA
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $SRRA alert in real time by email
    SC 13D/A 1 d547720dsc13da.htm SC 13D/A SC 13D/A

     

     

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 4)

     

     

    SIERRA ONCOLOGY, INC.

    (Name of Issuer)

    Common Stock, $0.001 par value per share

    (Title of Class of Securities)

    82640U404

    (CUSIP Number)

    Patrick G. Enright

    Managing Member

    Longitude Capital Partners III, LLC

    2740 Sand Hill Road, 2nd Floor

    Menlo Park, CA 94025

    (650) 854-5700

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

    April 27, 2022

    (Date of Event Which Requires Filing of this Statement)

     

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box ☐.

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

    (Continued on following pages)

     

     

     


      1    

      NAMES OF REPORTING PERSONS

     

      Longitude Capital Partners III, LLC

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)

      (a)  ☐        (b)  ☒

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (see instructions)

     

      AF

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

         7     

      SOLE VOTING POWER

     

      0

         8   

      SHARED VOTING POWER

     

      1,477,125 (1)

         9   

      SOLE DISPOSITIVE POWER

     

      0

       10   

      SHARED DISPOSITIVE POWER

     

      1,477,125 (1)

    11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      1,477,125 (1)

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (see instructions)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

     

      5.7% (2)

    14  

      TYPE OF REPORTING PERSON (see instructions)

     

      OO

     

    (1)

    Represents shares of Common Stock issuable upon the exercise of Series A warrants held of record by LVPIII (as defined in Item 2(a) below) which are exercisable within 60 days of the date hereof. LCPIII (as defined in Item 2(a) below) is the general partner of LVPIII and may be deemed to have voting, investment and dispositive power with respect to the securities held by LVPIII. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCPIII and may each be deemed to share voting, investment and dispositive power with respect to these securities.

    (2)

    Based on (i) 24,419,349 shares of Common Stock outstanding as of April 25, 2022, as reported by the Issuer in its Annual Report on From 10K/A, filed with the Commission (as defined in Item 2(a) below) on April 29, 2022 (the “10K/A”), plus (ii) an aggregate of 1,477,125 shares of Common Stock underlying the Series A warrants held by LVPIII which are exercisable within 60 days of the date hereof.


      1    

      NAMES OF REPORTING PERSONS

     

      Longitude Venture Partners III, L.P.

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)

      (a)  ☐        (b)  ☒

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (see instructions)

     

      WC

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

         7     

      SOLE VOTING POWER

     

      0

         8   

      SHARED VOTING POWER

     

      1,477,125 (1)

         9   

      SOLE DISPOSITIVE POWER

     

      0

       10   

      SHARED DISPOSITIVE POWER

     

      1,477,125 (1)

    11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      1,477,125 (1)

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (see instructions)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

     

      5.7% (2)

    14  

      TYPE OF REPORTING PERSON (see instructions)

     

      PN

     

    (1)

    Represents shares of Common Stock issuable upon the exercise of Series A warrants held of record by LVPIII which are exercisable within 60 days of the date hereof. LCPIII is the general partner of LVPIII and may be deemed to have voting, investment and dispositive power with respect to the securities held by LVPIII. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCPIII and may each be deemed to share voting, investment and dispositive power with respect to these securities.

    (2)

    Based on (i) 24,419,349 shares of Common Stock outstanding as of April 25, 2022, as reported by the Issuer in the 10K/A, plus (ii) an aggregate of 1,477,125 shares of Common Stock underlying the Series A warrants held by LVPIII which are exercisable within 60 days of the date hereof.


      1    

      NAMES OF REPORTING PERSONS

     

      Longitude Prime Partners, LLC

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)

      (a)  ☐        (b)  ☒

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (see instructions)

     

      AF

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

         7     

      SOLE VOTING POWER

     

      0

         8   

      SHARED VOTING POWER

     

      0

         9   

      SOLE DISPOSITIVE POWER

     

      0

       10   

      SHARED DISPOSITIVE POWER

     

      0

    11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      0

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (see instructions)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

     

      0.0%

    14  

      TYPE OF REPORTING PERSON (see instructions)

     

      OO


      1    

      NAMES OF REPORTING PERSONS

     

      Longitude Prime Fund, L.P.

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)

      (a)  ☐        (b)  ☒

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (see instructions)

     

      WC

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Delaware

    NUMBER OF

    SHARES

    BENEFICIALLY

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

     

         7     

      SOLE VOTING POWER

     

      0

         8   

      SHARED VOTING POWER

     

      0

         9   

      SOLE DISPOSITIVE POWER

     

      0

       10   

      SHARED DISPOSITIVE POWER

     

      0

    11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      0

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (see instructions)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

     

      0.0%

    14  

      TYPE OF REPORTING PERSON (see instructions)

     

      PN


      1    

      NAMES OF REPORTING PERSONS

     

      Patrick G. Enright

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)

      (a)  ☐        (b)  ☒

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (see instructions)

     

      AF

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      United States of America

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

       7    

      SOLE VOTING POWER

     

      8,015 (1)

       8  

      SHARED VOTING POWER

     

      1,477,125 (2)

       9  

      SOLE DISPOSITIVE POWER

     

      8,015 (1)

       10  

      SHARED DISPOSITIVE POWER

     

      1,477,125 (2)

      11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      1,485,140 (1)(2)

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (see instructions)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

     

      5.7% (3)

    14  

      TYPE OF REPORTING PERSON (see instructions)

     

      IN

     

    (1)

    Represents shares held directly by Patrick G. Enright.

    (2)

    Represents shares of Common Stock issuable upon the exercise of Series A warrants held of record by LVPIII which are exercisable within 60 days of the date hereof. LCPIII is the general partner of LVPIII and may be deemed to have voting, investment and dispositive power with respect to the securities held by LVPIII. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCPIII and may each be deemed to share voting, investment and dispositive power with respect to these securities.

    (3)

    Based on (i) 24,419,349 shares of Common Stock outstanding as of April 25, 2022, as reported by the Issuer in the 10K/A, plus (ii) an aggregate of 1,477,125 shares of Common Stock underlying the Series A warrants held by LVPIII which are exercisable within 60 days of the date hereof.


      1    

      NAMES OF REPORTING PERSONS

     

      Juliet Tammenoms Bakker

      2  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see instructions)

      (a)  ☐        (b)  ☒

     

      3  

      SEC USE ONLY

     

      4  

      SOURCE OF FUNDS (see instructions)

     

      AF

      5  

      CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)

     

      ☐

      6  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      United States of America

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

       7    

      SOLE VOTING POWER

     

      5,611 (1)

       8  

      SHARED VOTING POWER

     

      1,479,529 (2)

       9  

      SOLE DISPOSITIVE POWER

     

      5,611(1)

       10  

      SHARED DISPOSITIVE POWER

     

      1,479,529 (2)

      11    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      1,485,140 (1)(2)

    12  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (see instructions)

     

      ☐

    13  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

     

      5.7% (3)

    14  

      TYPE OF REPORTING PERSON (see instructions)

     

      IN

     

    (1)

    Represents shares held directly by Juliet Tammenoms Bakker.

    (2)

    Consists of (i) 1,477,125 shares of Common Stock issuable upon the exercise of Series A warrants held of record by LVPIII which are exercisable within 60 days of the date hereof. LCPIII is the general partner of LVPIII and may be deemed to have voting, investment and dispositive power with respect to the securities held by LVPIII. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCPIII and may each be deemed to share voting, investment and dispositive power with respect to these securities and (ii) 2,404 shares are held by a trust. Juliet Tammenoms Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Tammenoms Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.

    (3)

    Based on (i) 24,419,349 shares of Common Stock outstanding as of April 25, 2022, as reported by the Issuer in the 10K/A, plus (ii) an aggregate of 1,477,125 shares of Common Stock underlying the Series A warrants held by LVPIII which are exercisable within 60 days of the date hereof.


    SCHEDULE 13D

     

    Item 2.

    Identity and Background.

     

    (a)

    This Amendment No. 4 (“Amendment”) is filed by Longitude Venture Partners III, L.P. (“LVPIII”), Longitude Capital Partners III, LLC (“LCPIII”), Longitude Prime Fund, L.P. (“LPF”), Longitude Prime Partners, LLC (“LPP” and together with LVPIII, LCPIII and LPF, the “Reporting Entities”), Patrick G. Enright (“Enright”) and Juliet Tammenoms Bakker (“Tammenoms Bakker” and together with Enright, the “Managing Members”). This Amendment amends and supplements the Schedule 13D originally filed with the United States Securities and Exchange Commission (the “Commission”) on November 25, 2019, as amended by Amendment No.1 filed with the SEC on February 10, 2020, Amendment No. 2 filed with the SEC on November 8, 2021 and Amendment No. 3 filed with the SEC on February 4, 2022 (collectively, the “Original Schedule 13D”). The Reporting Entities and the Managing Members are collectively referred to as the “Reporting Persons.” Joshua Richardson, a reporting person on the Original Schedule 13D, is no longer a member of LCPIII or LPP, and accordingly, is no longer a Reporting Person. The agreement among the Reporting Persons to file jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act is attached to the Original Schedule 13D as Exhibit 1. Each Reporting Person disclaims beneficial ownership of all securities reported in this Statement except to the extent of such Reporting Person’s pecuniary interest therein, other than those securities reported herein as being held directly by such Reporting Person. Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13D remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original Schedule 13D.

     

    Item 5.

    Interest in Securities of the Issuer.

    Item 5 of the Original Schedule 13D is hereby amended to add the following language:

    (a) and (b) See Items 7-11 of the cover pages of this Amendment and Item 2 above.

    (c)

    On April 27, 2022, LVPIII effected a pro rata distribution without additional consideration of 1,964,771 shares of Common Stock to (i) LCPIII, its general partner and (ii) its limited partners. LCPIII then effected a pro rata distribution without additional consideration of the shares that it received in connection with such distribution to its members.

    On April 27, 2022, LPF effected a pro rata distribution without additional consideration of 175,000 shares of Common Stock to (i) LPP, its general partner and (ii) its limited partners. LPP then effected a pro rata distribution without additional consideration of the shares that it received in connection with such distribution to its members.


    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

    Dated: May 6, 2022

     

    LONGITUDE VENTURE PARTNERS III, L.P.
    By:   LONGITUDE CAPITAL PARTNERS III, LLC
    Its:   General Partner
    By:  

    /s/ Cristiana Blauth Oliveira

      Cristiana Blauth Oliveira, Authorized Signatory
    LONGITUDE CAPITAL PARTNERS III, LLC
    By:  

    /s/ Cristiana Blauth Oliveira

      Cristiana Blauth Oliveira, Authorized Signatory
    LONGITUDE PRIME FUND, L.P.
    By:   LONGITUDE PRIME PARTNERS, LLC
    Its:   General Partner
    By:  

    /s/ Cristiana Blauth Oliveira

      Cristiana Blauth Oliveira, Authorized Signatory
    LONGITUDE PRIME PARTNERS, LLC
    By:  

    /s/ Cristiana Blauth Oliveira

      Cristiana Blauth Oliveira, Authorized Signatory

    /s/ Patrick G. Enright

    Patrick G. Enright

    /s/ Juliet Tammenoms Bakker

    Juliet Tammenoms Bakker
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      – Oral presentation of MOMENTUM pivotal phase 3 data in myelofibrosis patients who are symptomatic and anemic – – Poster presentation to highlight improved transfusion independence, symptoms and spleen volume of these myelofibrosis patients who also present with thrombocytopenia – Sierra Oncology, Inc. (NASDAQ:SRRA), a late-stage biopharmaceutical company on a mission to deliver transformative therapies for rare cancers, today announced two abstracts have been accepted into the program for the 2022 Annual Meeting of the European Hematology Association (EHA). An abstract presenting the full data from the pivotal phase 3 MOMENTUM study in myelofibrosis patients who are symptomatic and anemi

      5/12/22 10:00:00 AM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
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    $SRRA
    Analyst Ratings

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    • HC Wainwright & Co. reiterated coverage on Sierra Oncology with a new price target

      HC Wainwright & Co. reiterated coverage of Sierra Oncology with a rating of Buy and set a new price target of $51.00 from $35.00 previously

      1/31/22 9:32:16 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Cantor Fitzgerald reiterated coverage on Sierra Oncology with a new price target

      Cantor Fitzgerald reiterated coverage of Sierra Oncology with a rating of Overweight and set a new price target of $39.00 from $33.00 previously

      11/30/21 8:05:31 AM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • HC Wainwright & Co. reiterated coverage on Sierra Oncology with a new price target

      HC Wainwright & Co. reiterated coverage of Sierra Oncology with a rating of Buy and set a new price target of $35.00 from $29.00 previously

      11/5/21 12:45:48 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    SEC Filings

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    • SEC Form 15-12G filed by Sierra Oncology Inc.

      15-12G - Sierra Oncology, Inc. (0001290149) (Filer)

      7/11/22 4:01:52 PM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
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    • SEC Form EFFECT filed by Sierra Oncology Inc.

      EFFECT - Sierra Oncology, Inc. (0001290149) (Filer)

      7/8/22 12:15:18 AM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
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    • SEC Form EFFECT filed by Sierra Oncology Inc.

      EFFECT - Sierra Oncology, Inc. (0001290149) (Filer)

      7/8/22 12:15:23 AM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
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    • Sierra Oncology Announces Momelotinib Achieved Statistically Significant Benefit on Symptoms, Anemia and Splenic Size in the Pivotal MOMENTUM Study for Myelofibrosis

      —New Drug Application submission planned for second quarter of 2022— —Full data set to be presented at an upcoming medical meeting— Sierra Oncology, Inc. (NASDAQ:SRRA), a late-stage biopharmaceutical company dedicated to delivering targeted therapies for rare cancers, today announced positive topline data from the pivotal Phase 3 MOMENTUM study—a global, randomized, double-blind clinical trial evaluating momelotinib (MMB) in myelofibrosis patients who are symptomatic and anemic and previously treated with an approved JAK inhibitor. The trial met all of its primary and key secondary endpoints. "These data are extremely exciting and everything we had hoped to see from the trial," said Step

      1/25/22 7:00:00 AM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Sierra Oncology Signs Exclusive Global In-Licensing Agreement with AstraZeneca for Novel BET Inhibitor to Expand Myelofibrosis Pipeline

       —Combination study to build upon momelotinib's differentiated potential as a cornerstone myelofibrosis therapy-— Sierra Oncology, Inc. (NASDAQ:SRRA), a late-stage biopharmaceutical company on a mission to deliver targeted therapies that treat rare forms of cancer, today announced it has acquired an exclusive global license from AstraZeneca (NASDAQ:AZN) for AZD5153, a potent and selective BRD4 BET inhibitor with a novel bivalent binding mode. Sierra plans to initiate a Phase 2 study examining momelotinib in combination with AZD5153 in myelofibrosis patients in the first half of 2022. "This global in-licensing deal is of two-fold importance to Sierra's long-term strategy. First, it brings

      8/5/21 4:05:00 PM ET
      $AZN
      $SRRA
      Biotechnology: Pharmaceutical Preparations
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    $SRRA
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

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    • SEC Form 4: Vivo Opportunity, Llc returned $183,123,160 worth of shares to the company (3,329,512 units at $55.00)

      4 - Sierra Oncology, Inc. (0001290149) (Issuer)

      7/1/22 4:59:45 PM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4: Orbimed Advisors Llc returned $108,062,350 worth of shares to the company (1,964,770 units at $55.00)

      4 - Sierra Oncology, Inc. (0001290149) (Issuer)

      7/1/22 4:50:05 PM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • SEC Form 4: Ashiya Mona returned $108,062,350 worth of shares to the company (1,964,770 units at $55.00)

      4 - Sierra Oncology, Inc. (0001290149) (Issuer)

      7/1/22 4:46:16 PM ET
      $SRRA
      Biotechnology: Pharmaceutical Preparations
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