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    SEC Form SC 13G filed by Rapport Therapeutics Inc.

    11/14/24 5:13:31 PM ET
    $RAPP
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $RAPP alert in real time by email
    SC 13G 1 arch-sch13g_18906.htm ARCH VENTURE FUND XII, L.P. - RAPPORT THERAPEUTICS, INC. -- SCH 13G

     

      

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

     

    SCHEDULE 13G

    Under the Securities Exchange Act of 1934

      (Amendment No. __)*

     

     

     

    Rapport Therapeutics, Inc.

    (Name of Issuer)

       

    Common Stock par value $0.001 per share

     

    (Title of Class of Securities)

      

    75383L102

     

    (CUSIP Number)

      

    September 30, 2024

     

    (Date of Event Which Requires Filing of This Statement)

     

     

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

    ☐   Rule 13d-1(b)

    ☐   Rule 13d-1(c)

    ☒   Rule 13d-1(d)

    * The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act, but shall be subject to all other provisions of the Act (however, see the Notes).

     

    CUSIP No.  75383L102

    13G Page 2 of 12 Pages    

    1  

    NAMES OF REPORTING PERSON(S)

     

    ARCH Venture Fund XII, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
     

     5

     

    SOLE VOTING POWER

     

    0

     

      6  

    SHARED VOTING POWER

     

    3,728,738

     

      7  

    SOLE DISPOSITIVE POWER

     

    0

     

      8  

    SHARED DISPOSITIVE POWER

     

    3,728,738

     

    9  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    3,728,738

     

       
    10  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    11  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      

    10.2%

     

       

     12

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     
     

    CUSIP No.  75383L102

    13G Page 3 of 12 Pages    

    1  

    NAMES OF REPORTING PERSON(S)

     

    ARCH Venture Partners XII, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
     

     5

     

    SOLE VOTING POWER

     

    0

     

      6  

    SHARED VOTING POWER

     

    3,728,738

     

      7  

    SOLE DISPOSITIVE POWER

     

    0

     

      8  

    SHARED DISPOSITIVE POWER

     

    3,728,738

     

    9  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    3,728,738

     

       
    10  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    11  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      

    10.2%

     

       

     12

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     
     

    CUSIP No.  75383L102

    13G Page 4 of 12 Pages    

    1  

    NAMES OF REPORTING PERSON(S)

     

    ARCH Venture Partners XII, LLC

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
     

     5

     

    SOLE VOTING POWER

     

    0

     

      6  

    SHARED VOTING POWER

     

    3,728,738

     

      7  

    SOLE DISPOSITIVE POWER

     

    0

     

      8  

    SHARED DISPOSITIVE POWER

     

    3,728,738

     

    9  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    3,728,738

     

       
    10  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    11  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      

    10.2%

     

       

     12

     

    TYPE OF REPORTING PERSON

       

    OO

     

       

     
     

    CUSIP No.  75383L102

    13G Page 5 of 12 Pages    

     

    1  

    NAMES OF REPORTING PERSON(S)

     

    Keith Crandell

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States of America

      

       
    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
     

     5

     

    SOLE VOTING POWER

     

    0

     

      6  

    SHARED VOTING POWER

     

    3,728,738

     

      7  

    SOLE DISPOSITIVE POWER

     

    0

     

      8  

    SHARED DISPOSITIVE POWER

     

    3,728,738

     

    9  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    3,728,738

     

       
    10  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    11  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      

    10.2%

     

       

     12

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

     
     

    CUSIP No.  75383L102

    13G Page 6 of 12 Pages    

     

    1  

    NAMES OF REPORTING PERSON(S)

     

    Steven Gillis

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States of America

      

       
    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
     

     5

     

    SOLE VOTING POWER

     

    0

     

      6  

    SHARED VOTING POWER

     

    3,728,738

     

      7  

    SOLE DISPOSITIVE POWER

     

    0

     

      8  

    SHARED DISPOSITIVE POWER

     

    3,728,738

     

    9  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    3,728,738

     

       
    10  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    11  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      

    10.2%

     

       

     12

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

     
     

    CUSIP No.  75383L102

    13G Page 7 of 12 Pages    

     

    1  

    NAMES OF REPORTING PERSON(S)

     

    Kristina Burow

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States of America

      

       
    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
     

     5

     

    SOLE VOTING POWER

     

    0

     

      6  

    SHARED VOTING POWER

     

    3,728,738

     

      7  

    SOLE DISPOSITIVE POWER

     

    0

     

      8  

    SHARED DISPOSITIVE POWER

     

    3,728,738

     

    9  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    3,728,738

     

       
    10  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    11  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      

    10.2%

     

       

     12

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

     
     

    CUSIP No.  75383L102

    13G Page 8 of 12 Pages    

     

    1  

    NAMES OF REPORTING PERSON(S)

     

    Robert Nelsen

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States of America

      

       
    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
     

     5

     

    SOLE VOTING POWER

     

    0

     

      6  

    SHARED VOTING POWER

     

    3,728,738

     

      7  

    SOLE DISPOSITIVE POWER

     

    0

     

      8  

    SHARED DISPOSITIVE POWER

     

    3,728,738

     

    9  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    3,728,738

     

       
    10  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    11  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      

    10.2%

     

       

     12

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

     
     

    CUSIP No.  75383L102

    13G Page 9 of 12 Pages    

     

    Item 1(a). Name of Issuer

     

    Rapport Therapeutics, Inc. (the “Issuer”).

     

     

    Item 1(b). Address of Issuer's Principal Executive Offices

     

    1325 Boylston Street, Suite 401, Boston, MA 02215

     

     

    Item 2(a). Name of Person Filing

     

    ARCH Venture Fund XII, L.P. (“AVF XII”); ARCH Venture Partners XII, L.P. (“AVP XII LP”); ARCH Venture Partners XII, LLC (“AVP XII LLC”) (collectively, the “Reporting Entities” and individually, each a “Reporting Entity”); and Keith Crandell (“Crandell”), Robert Nelsen (“Nelsen”), Kristina Burow (“Burow”) and Steven Gillis (“Gillis”) (collectively, the “Investment Committee” and individually, each a “Committee Member”). The Reporting Entities and the Committee Members collectively are referred to as the “Reporting Persons”.

     

     

    Item 2(b). Address of Principal Business Office or, if none, Residence

     

    8755 W. Higgins Road, Suite 1025, Chicago, IL 60631

     

     

    Item 2(c). Citizenship

     

    Each of AVF XII and AVP XII LP are limited partnerships organized under the laws of the State of Delaware. AVP XII LLC is a limited liability company organized under the laws of the State of Delaware. Each Committee Member is a US citizen.

     

     

    Item 2(d). Title of Class of Securities

     

    Common stock, par value $0.001 per share.

     

     

    Item 2(e). CUSIP Number

     

    75383L102

     

     

    Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a:

     

    Not Applicable.

     

     

    Item 4. Ownership

     

    (a)

    Amount beneficially owned:

     

    AVF XII is the record owner of 3,728,738 shares of Common Stock (the “Record Shares”) as of September 30, 2024. AVP XII LP, as the sole general partner of AVF XII, may be deemed to beneficially own the AVF XII Shares. AVP XII LLC, as the sole general partner of AVP XII LP may be deemed to beneficially own the Record Shares. As committee members of AVP XII LLC, each Committee Member may also be deemed to share the power to direct the disposition and vote of the Record Shares.

     

    (b)

    Percent of class:

     

    See line 11 of the cover sheets. The percentages set forth on the cover sheet for each Reporting Person is based upon 36,576,457 shares of common stock outstanding as of November 6, 2024, as reported on the Issuer’s Form 10-Q as filed with the Securities and Exchange Commission on November 7, 2024.

       

     

     
     

    CUSIP No.  75383L102

    13G Page 10 of 12 Pages    

     

     

    (c) Number of shares as to which such person has:

      (i)

    Sole power to vote or to direct the vote:

     

    See line 5 of the cover sheets.

         
      (ii)

    Shared power to vote or to direct the vote:

     

    See line 6 of the cover sheets.

         
      (iii)

    Sole power to dispose or to direct the disposition:

     

    See line 7 of the cover sheets.

         
      (iv)

    Shared power to dispose or to direct the disposition:

     

    See line 8 of the cover sheets.

         

    Each Reporting Person disclaims beneficial ownership of such shares of Common Stock except for the shares, if any, such Reporting Person holds of record.

      

     

    Item 5. Ownership of Five Percent or Less of a Class

    Not Applicable.

     

     

    Item 6. Ownership of More than Five Percent on Behalf of Another Person

     

    Not Applicable.

     

     

    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company

     

    Not Applicable.

     

     

    Item 8. Identification and Classification of Members of the Group

     

    Not Applicable.

     

     

    Item 9. Notice of Dissolution of Group

     

    Not Applicable.

     

     

    Item 10. Certifications

     

    Not Applicable.

      

     

     
     

    CUSIP No.  75383L102

    13G Page 11 of 12 Pages    

     

     

    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated:    November 14, 2024

    ARCH VENTURE FUND XII, L.P.

     

    By:       ARCH Venture Partners XII, L.P.

    its General Partner

     

    By:       ARCH Venture Partners XII, LLC

    its General Partner

     

    By:                    *               

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, L.P.

     

    By:       ARCH Venture Partners XII, LLC

    its General Partner

     

    By:                           *                    

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, LLC

     

    By:                               *                                

    Keith Crandell

    Managing Director

     

     

     

                                      *                                 

    Keith Crandell

     

     

                                      *                                 

    Robert Nelsen

     

     

                                      *                                 

    Kristina Burow

      

     

                                      *                                 

    Steven Gillis

     

     

     

     

    * By:   /s/ Mark McDonnell                  

    Mark McDonnell as

    Attorney-in-Fact

     

     

    *       This Schedule 13G was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24 to the Form 3 relating to the beneficial ownership of shares of Neumora Therapeutics, Inc. by the Reporting Persons filed with the Securities Exchange Commission on September 14, 2023 and incorporated herein in its entirety by reference.

     

     
     

    CUSIP No.  75383L102

    13G Page 12 of 12 Pages    

     

     

    Exhibit 1

     

    AGREEMENT

     

    Pursuant to Rule 13d-1-(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of stock of Rapport Therapeutics, Inc.

     

    This Agreement may be executed in any number of counterparts, each of which shall be deemed an original.

     

     

    Dated:    November 14, 2024

    ARCH VENTURE FUND XII, L.P.

     

    By:       ARCH Venture Partners XII, L.P.

    its General Partner

     

    By:       ARCH Venture Partners XII, LLC

    its General Partner

     

    By:                    *               

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, L.P.

     

    By:       ARCH Venture Partners XII, LLC

    its General Partner

     

    By:                           *                    

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, LLC

     

    By:                                *                                

    Keith Crandell

    Managing Director

     

     

     

                                      *                                 

    Keith Crandell

     

     

                                      *                                 

    Robert Nelsen

     

     

                                      *                                 

    Kristina Burow

      

     

                                      *                                 

    Steven Gillis

     

     

     

     

    * By:   /s/ Mark McDonnell                  

    Mark McDonnell as

    Attorney-in-Fact

     

     

    *             This Agreement of Joint Filing was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24 to the Form 3 relating to the beneficial ownership of shares of Neumora Therapeutics, Inc. by the Reporting Persons filed with the Securities Exchange Commission on September 14, 2023 and incorporated herein in its entirety by reference.

     

     

     

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    • Rapport Therapeutics Inc. filed SEC Form 8-K: Results of Operations and Financial Condition, Financial Statements and Exhibits

      8-K - Rapport Therapeutics, Inc. (0002012593) (Filer)

      5/8/25 7:15:09 AM ET
      $RAPP
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    $RAPP
    Insider Trading

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    • Chief Scientific Officer Bredt David sold $81,262 worth of shares (8,500 units at $9.56), decreasing direct ownership by 2% to 452,142 units (SEC Form 4)

      4 - Rapport Therapeutics, Inc. (0002012593) (Issuer)

      5/19/25 4:30:28 PM ET
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    • Chief Scientific Officer Bredt David sold $81,310 worth of shares (8,500 units at $9.57), decreasing direct ownership by 2% to 460,642 units (SEC Form 4)

      4 - Rapport Therapeutics, Inc. (0002012593) (Issuer)

      4/16/25 5:00:04 PM ET
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    • SEC Form 4 filed by Chief Medical Officer Sevigny Jeffrey

      4 - Rapport Therapeutics, Inc. (0002012593) (Issuer)

      4/3/25 5:00:07 PM ET
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    $RAPP
    Analyst Ratings

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    • Citizens JMP initiated coverage on Rapport Therapeutics

      Citizens JMP initiated coverage of Rapport Therapeutics with a rating of Mkt Outperform

      4/8/25 9:31:03 AM ET
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    • TD Cowen initiated coverage on Rapport Therapeutics

      TD Cowen initiated coverage of Rapport Therapeutics with a rating of Buy

      7/2/24 8:03:15 AM ET
      $RAPP
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    • Jefferies initiated coverage on Rapport Therapeutics with a new price target

      Jefferies initiated coverage of Rapport Therapeutics with a rating of Buy and set a new price target of $35.00

      7/2/24 7:51:37 AM ET
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    $RAPP
    Leadership Updates

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    • Rapport Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update

      Results of positron emission tomography (PET) trial and second multiple ascending dose (MAD-2) trial support RAP-219's transformative potential for epilepsy and other central nervous system (CNS) disorders Continued momentum in the Phase 2a trial of RAP-219 in patients with refractory focal epilepsy, with topline results expected in the third quarter of 2025Expect to initiate a Phase 2a trial in patients with bipolar mania in the third quarter of 2025, with topline results expected in the first half of 2027  Appointed recognized translational and clinical drug development leader, Jeffrey Sevigny, M.D., as chief medical officer  Ended the year with $305.3 million in cash, cash equivalents, an

      3/11/25 7:00:00 AM ET
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    • Rapport Therapeutics Announces Appointment of Dr. Jeffrey Sevigny as Chief Medical Officer to Drive Clinical Strategy and Precision Medicine Development

      BOSTON and SAN DIEGO, March 03, 2025 (GLOBE NEWSWIRE) -- Rapport Therapeutics, Inc. (NASDAQ:RAPP), a clinical-stage biotechnology company dedicated to the discovery and development of small molecule precision medicines for patients suffering from central nervous system (CNS) disorders, today announced the appointment of Dr. Jeffrey Sevigny as chief medical officer (CMO), effective immediately. A physician-scientist with more than 15 years of leadership in translational and clinical drug development, Dr. Sevigny has spearheaded groundbreaking research across neuroscience and rare diseases. His experience spans the full spectrum of development, from discovery to late-stage clinical trials an

      3/3/25 7:00:00 AM ET
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    • Rapport Therapeutics Reports Third Quarter Financials and Provides Business Update

      Biotech industry leaders added to the Board of Directors, bringing deep expertise in drug discovery, neuroscience clinical development, and operational leadershipRAP-219 MAD-2 and PET trials ongoing; topline data expected in Q1 2025Actively recruiting patients for Phase 2a trial of RAP-219 in focal epilepsy; trial on track and topline data expected in mid-2025 Investigational New Drug Application (IND) in diabetic peripheral neuropathic pain placed on clinical hold while the Company addresses U.S. Food and Drug Administration (FDA) Phase 2a trial protocol feedback Ended the quarter with $320.7 million in cash, cash equivalents, and short-term investments, excluding restricted cash, which is

      11/7/24 7:00:00 AM ET
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    Large Ownership Changes

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    • SEC Form SC 13G filed by Rapport Therapeutics Inc.

      SC 13G - Rapport Therapeutics, Inc. (0002012593) (Subject)

      11/14/24 5:13:31 PM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Amendment: SEC Form SC 13G/A filed by Rapport Therapeutics Inc.

      SC 13G/A - Rapport Therapeutics, Inc. (0002012593) (Subject)

      11/14/24 3:11:15 PM ET
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    • SEC Form SC 13G filed by Rapport Therapeutics Inc.

      SC 13G - Rapport Therapeutics, Inc. (0002012593) (Subject)

      11/13/24 12:26:41 PM ET
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      Biotechnology: Pharmaceutical Preparations
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