SEC Form SC 13G/A filed

2/8/21 10:35:30 AM ET

Biotechnology: Pharmaceutical Preparations

Health Care

Get the next $VRTX alert in real time by email

SC 13G/A 1 filing.txt SCHEDULE 13G Amendment No. 6 VERTEX PHARMACEUTICALS INC COMMON STOCK Cusip #92532F100 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [x] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #92532F100 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 2,394,198 Item 6: 0 Item 7: 13,506,870 Item 8: 0 Item 9: 13,506,870 Item 11: 5.194% Item 12: HC Cusip #92532F100 Item 1: Reporting Person - Abigail P. Johnson Item 2: (a) [ ] (b) [ ] Item 4: United States of America Item 5: 0 Item 6: 0 Item 7: 13,506,870 Item 8: 0 Item 9: 13,506,870 Item 11: 5.194% Item 12: IN Item 1(a). Name of Issuer: VERTEX PHARMACEUTICALS INC Item 1(b). Address of Issuer's Principal Executive Offices: 50 Northern Avenue Boston, MA 02210 USA Item 2(a). Name of Person Filing: FMR LLC Item 2(b). Address or Principal Business Office or, if None, Residence: 245 Summer Street, Boston, Massachusetts 02210 Item 2(c). Citizenship: Not applicable Item 2(d). Title of Class of Securities: COMMON STOCK Item 2(e). CUSIP Number: 92532F100 Item 3. This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c) and the person filing, FMR LLC, is a parent holding company in accordance with Section 240.13d-1(b)(1)(ii)(G). (Note: See Exhibit A). Item 4. Ownership (a) Amount Beneficially Owned: 13,506,870 (b) Percent of Class: 5.194% (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: 2,394,198 (ii) shared power to vote or to direct the vote: 0 (iii) sole power to dispose or to direct the disposition of: 13,506,870 (iv) shared power to dispose or to direct the disposition of: 0 Item 5. Ownership of Five Percent or Less of a Class. Not applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person. One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of VERTEX PHARMACEUTICALS INC. No one other person's interest in the COMMON STOCK of VERTEX PHARMACEUTICALS INC is more than five percent of the total outstanding COMMON STOCK. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. See attached Exhibit A. Item 8. Identification and Classification of Members of the Group. Not applicable. Item 9. Notice of Dissolution of Group. Not applicable. Item 10. Certifications. By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. February 5, 2021 Date /s/ Kevin M. Meagher Signature Kevin M. Meagher Duly authorized under Power of Attorney effective as of September 28, 2018, by and on behalf of FMR LLC and its direct and indirect subsidiaries* * This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on October 9, 2018, accession number: 0000315066-18-002414. Exhibit A Pursuant to the instructions in Item 7 of Schedule 13G, the following table lists the identity and Item 3 classification, if applicable, of each relevant entity that beneficially owns shares of the security class being reported on this Schedule 13G. Entity ITEM 3 Classification Crosby Advisors LLC N/A FIAM LLC IA Fidelity Institutional Asset Management Trust Company BK Fidelity Management & Research Company LLC IA Strategic Advisers LLC IA Abigail P. Johnson is a Director, the Chairman and the Chief Executive Officer of FMR LLC. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. Neither FMR LLC nor Abigail P. Johnson has the sole power to vote or direct the voting of the shares owned directly by the various investment companies registered under the Investment Company Act ("Fidelity Funds") advised by Fidelity Management & Research Company LLC ("FMR Co. LLC"), a wholly owned subsidiary of FMR LLC, which power resides with the Fidelity Funds' Boards of Trustees. FMR Co. LLC carries out the voting of the shares under written guidelines established by the Fidelity Funds' Boards of Trustees. This filing reflects the securities beneficially owned, or that may be deemed to be beneficially owned, by FMR LLC, certain of its subsidiaries and affiliates, and other companies (collectively, the "FMR Reporters"). This filing does not reflect securities, if any, beneficially owned by certain other companies whose beneficial ownership of securities is disaggregated from that of the FMR Reporters in accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998). RULE 13d-1(k)(1) AGREEMENT The undersigned persons, on February 5, 2021, agree and consent to the joint filing on their behalf of this Schedule 13G in connection with their beneficial ownership of the COMMON STOCK of VERTEX PHARMACEUTICALS INC at December 31, 2020. FMR LLC By /s/ Kevin M. Meagher Kevin M. Meagher Duly authorized under Power of Attorney effective as of September 28, 2018, by and on behalf of FMR LLC and its direct and indirect subsidiaries* Abigail P. Johnson By /s/ Kevin M. Meagher Kevin M. Meagher Duly authorized under Power of Attorney effective as of September 30, 2018, by and on behalf of Abigail P. Johnson* * This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on October 9, 2018, accession number: 0000315066-18-002414.

Get the next $VRTX alert in real time by email

Recent Analyst Ratings for

$VRTX

Date	Price Target	Rating	Analyst
5/7/2025		Outperform → Peer Perform	Wolfe Research
5/6/2025	$503.00	Outperform → Market Perform	Leerink Partners
4/22/2025	$535.00	Overweight	Cantor Fitzgerald
2/12/2025	$408.00 → $424.00	Sell → Hold	Canaccord Genuity
2/11/2025		Sell → Hold	Canaccord Genuity
1/30/2025	$460.00	Overweight → Equal Weight	Wells Fargo
12/20/2024	$600.00 → $535.00	Buy	H.C. Wainwright
12/19/2024		Outperform → Perform	Oppenheimer

More analyst ratings

SEC Form SC 13G/A filed

2/8/21 10:35:30 AM ET

$VRTX

Biotechnology: Pharmaceutical Preparations

Health Care

Get the next $VRTX alert in real time by email

Recent Analyst Ratings for

$VRTX

Date	Price Target	Rating	Analyst
5/7/2025		Outperform → Peer Perform	Wolfe Research
5/6/2025	$503.00	Outperform → Market Perform	Leerink Partners
4/22/2025	$535.00	Overweight	Cantor Fitzgerald
2/12/2025	$408.00 → $424.00	Sell → Hold	Canaccord Genuity
2/11/2025		Sell → Hold	Canaccord Genuity
1/30/2025	$460.00	Overweight → Equal Weight	Wells Fargo
12/20/2024	$600.00 → $535.00	Buy	H.C. Wainwright
12/19/2024		Outperform → Perform	Oppenheimer

More analyst ratings

SEC Form SC 13G/A filed

Crush Q3 2025 with the Best AI Executive Assistant

Recent Analyst Ratings for $VRTX

SEC Form SC 13G/A filed

Crush Q3 2025 with the Best AI Executive Assistant

Recent Analyst Ratings for $VRTX

$VRTX Analyst Ratings

Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

Vertex Pharma downgraded by Wolfe Research

Vertex Pharma downgraded by Leerink Partners with a new price target

Cantor Fitzgerald resumed coverage on Vertex Pharma with a new price target

$VRTX Leadership Updates

Live Leadership Updates

Vertex Appoints Nancy Thornberry to its Board of Directors

Vertex Appoints Michel Lagarde to its Board of Directors

Vertex Appoints E. Morrey Atkinson, Ph.D., to EVP and Chief Technical Operations Officer, Head of Biopharmaceutical Sciences and Manufacturing Operations

$VRTX Press Releases

Fastest customizable press release news feed in the world

Breaking Through: Systemic Genetic Medicines for Hard-to-Treat Cancers

Vertex to Announce Second Quarter 2025 Financial Results on August 4th

Precision Genetic Medicine Platform Could Disrupt Standard of Care in Metastatic Cancer, Other Indications of Unmet Needs

$VRTX Large Ownership Changes

This live feed shows all institutional transactions in real time.

SEC Form SC 13G/A filed by Vertex Pharmaceuticals Incorporated (Amendment)

SEC Form SC 13G/A filed by Vertex Pharmaceuticals Incorporated (Amendment)

SEC Form SC 13G/A filed by Vertex Pharmaceuticals Incorporated (Amendment)

$VRTX FDA approvals

Live FDA approvals issued by the Food and Drug Administration and FDA breaking news

January 30, 2025 - FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain

December 8, 2023 - FDA Approves First Gene Therapies to Treat Patients with Sickle Cell Disease

FDA Approval for TRIKAFTA (COPACKAGED) issued to VERTEX PHARMS INC

$VRTX SEC Filings

SEC Form 144 filed by Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated filed SEC Form 8-K: Other Events

Vertex Pharmaceuticals Incorporated filed SEC Form 8-K: Submission of Matters to a Vote of Security Holders

$VRTX Insider Trading

Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

New insider Mckechnie Duncan claimed ownership of 16,130 shares (SEC Form 3)

EVP, COO Arbuckle Stuart A covered exercise/tax liability with 37,243 shares, decreasing direct ownership by 37% to 63,368 units (SEC Form 4)

EVP, Chief Scientific Officer Altshuler David sold $22,084 worth of shares (52 units at $424.69), decreasing direct ownership by 0.22% to 23,281 units (SEC Form 4)

$VRTX Financials

Live finance-specific insights

Vertex to Announce Second Quarter 2025 Financial Results on August 4th

Vertex Reports First Quarter 2025 Financial Results

Vertex to Announce First Quarter 2025 Financial Results on May 5th

Recent Analyst Ratings for
$VRTX

Recent Analyst Ratings for
$VRTX

$VRTX
Analyst Ratings

$VRTX
Leadership Updates

$VRTX
Press Releases

$VRTX
Large Ownership Changes

$VRTX
FDA approvals

$VRTX
SEC Filings

$VRTX
Insider Trading

$VRTX
Financials