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    SEC Form SC 13G/A filed by Zai Lab Limited (Amendment)

    2/14/23 6:24:55 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ZLAB alert in real time by email
    SC 13G/A 1 dp188767_sc13ga-4.htm FORM SC 13G/A

     

    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

     

    SCHEDULE 13G/A

     

    (Amendment No. 4)*

     

    Under the Securities Exchange Act of 1934

     

    Zai Lab Limited

    (Name of Issuer)

     

    Ordinary shares, par value US$0.000006 per share

    (Title of Class of Securities)

     

    98887Q104**

    (CUSIP Number)

     

    December 31, 2022

    (Date of Event which Requires Filing of this Statement)

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

      ☐ Rule 13d-1(b)

     

      ☐ Rule 13d-1(c)

     

      ☒ Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    **There is no CUSIP number assigned to the Ordinary Shares. CUSIP number 98887Q104 has been assigned to the American Depositary Shares (“ADSs”) of the Issuer, which are quoted on the Nasdaq Stock Exchange under the symbol “ZLAB.” Each ADS represents 10 Ordinary Shares.

     

    The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

    CUSIP No. 98887Q104

     

    1. 

    NAMES OF REPORTING PERSON

     

    Qiming Corporate GP IV, Ltd.

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)       ☐

    (b)       ☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    79,229,320(1)

    6.

    SHARED VOTING POWER

     

    None

    7. 

    SOLE DISPOSITIVE POWER

     

    79,229,320(1)

    8. 

    SHARED DISPOSITIVE POWER

     

    None

    9. 

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    79,229,320(1)

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11. 

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    8.1%(2)

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    CO

     

    (1) As of the date of this 13G/A filing, Qiming Corporate GP IV, Ltd. is the general partner of Qiming Managing Directors Fund IV, L.P. and Qiming GP IV, L.P. Qiming Managing Directors Fund IV, L.P. holds approximately 3.06% of the equity interest of QM11 Limited. Qiming GP IV, L.P. is the general partner of Qiming Venture Partners IV, L.P., which holds approximately 96.94% of the equity interest of QM11 Limited. QM11 Limited is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (2) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023.

     

    2 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    Qiming Managing Directors Fund IV, L.P. 

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    None

    6.

    SHARED VOTING POWER

     

    2,425,051(3) 

    7.

    SOLE DISPOSITIVE POWER

     

    None

    8.

    SHARED DISPOSITIVE POWER

     

    2,425,051(3) 

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    ‎2,425,051(3) 

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    ‎0.3%(4)‎

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    PN

     

    (3) As of the date of this 13G/A filing, Qiming Managing Directors Fund IV, L.P. holds approximately 3.06% of the equity interest of QM11 Limited, which is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (4) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023. 

     

    3 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    Qiming GP IV, L.P.

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    None

    6.

    SHARED VOTING POWER

     

    76,804,269(5)

    7.

    SOLE DISPOSITIVE POWER

     

    None

    8.

    SHARED DISPOSITIVE POWER

     

    ‎76,804,269(5)

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    76,804,269(5)

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    7.8%(6)‎

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    PN

     

    (5) As of the date of this 13G/A filing, Qiming GP IV, L.P. is the general partner of Qiming Venture Partners IV, L.P., which owns approximately 96.94% of the equity interest of QM11 Limited, which is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (6) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023. 

     

    4 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    Qiming Venture Partners IV, L.P.

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    None

    6.

    SHARED VOTING POWER

     

    76,804,269(7)

    7.

    SOLE DISPOSITIVE POWER

     

    None

    8.

    SHARED DISPOSITIVE POWER

     

    76,804,269(7)

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    76,804,269(7)

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    7.8%(8)‎

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    PN

     

    (7) As of the date of this 13G/A filing, Qiming Venture Partners IV, L.P. holds approximately 96.94% of the equity interest of QM11 Limited, which is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (8) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023.

     

    5 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    QM11 Limited

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Hong Kong

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    79,229,320

    6.

    SHARED VOTING POWER

     

    None

    7.

    SOLE DISPOSITIVE POWER

     

    79,229,320

    8.

    SHARED DISPOSITIVE POWER

     

    None

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    79,229,320

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    8.1%(9) 

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    CO

     
    (9) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023.

    6 

     

    Item 1.

     

      (a) Name of Issuer

     

    Zai Lab Limited (the “Issuer”)

     

      (b) Address of Issuer’s Principal Executive Offices

     

    The Issuer’s principal executive offices are located at 4560 Jinke Road, Bldg.1, 4F, Pudong, Shanghai, China 201210 and 314 Main Street 4th Floor, Suite 100 Cambridge, MA, USA 02142.

     

    Item 2.

     

      (a) Name of Person Filing

     

    Qiming Corporate GP IV, Ltd.

    Qiming Managing Directors Fund IV, L.P.

    Qiming GP IV, L.P.

    Qiming Venture Partners IV, L.P.

    QM11 Limited

     

      (b) Address of the Principal Office or, if None, Residence

     

    The registered address of each of Qiming Corporate GP IV, Ltd., Qiming Managing Directors Fund IV, L.P., Qiming GP IV, L.P. and Qiming Venture Partners IV, L.P. is M&C Corporate Services Limited, P.O. Box 309GT, Ugland House, South Church Street, George Town, Grand Cayman, Cayman Islands.

     

    The registered address of QM11 Limited is Units 4205-06, 42nd Floor, Gloucester Tower, the Landmark, 15 Queen’s Road Central, Hong Kong.

     

      (c) Citizenship

     

    Qiming Corporate GP IV, Ltd., Qiming Managing Directors Fund IV, L.P., Qiming GP IV, L.P. and Qiming Venture Partners IV, L.P. are organized in Cayman Islands.

     

    QM11 Limited is a company organized in Hong Kong.

     

      (d) Title of Class of Securities

     

    Ordinary Shares, par value of $0.000006 per share (the "Ordinary Shares").

     

      (e) CUSIP Number

     

    There is no CUSIP number assigned to the Ordinary Shares. CUSIP number 98887Q104 has been assigned to the American Depositary Shares (“ADSs”) of the Issuer, which are quoted on the Nasdaq Stock Exchange under the symbol “ZLAB.” Each ADS represents 10 Ordinary Shares.

     

    Item 3. Statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c):

     

    Not applicable.

     

    Item 4. Ownership.

     

    7 

     

    The information required by Items 4(a) - (c) is set forth in Rows 5 - 11 of the cover page for each Reporting Person and is incorporated herein by reference.

     

    Item 5. Ownership of Five Percent or Less of a Class.

     

    Not applicable.

     

    Item 6. Ownership of More than Five Percent on Behalf of Another Person.

     

    Not applicable.

     

    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.

     

    Not applicable.

     

    Item 8. Identification and Classification of Members of the Group.

     

    Not applicable.

     

    Item 9. Notice of Dissolution of Group.

     

    Not applicable.

     

    Item 10. Certification.

     

    Not applicable.

     

    8 

     

    SIGNATURE

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: February 14, 2023

     

      Qiming Corporate GP IV, Ltd.
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Managing Directors Fund IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming GP IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Venture Partners IV, L.P.

    By: Qiming GP IV, L.P.,

    its General Partner

    By: Qiming Corporate GP IV, Ltd.,

    General Partner of Qiming GP IV., L.P.

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

      QM11 Limited
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Director

    9 

     

    JOINT FILING AGREEMENT

     

    In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, each of the undersigned agrees that (i) this statement on Schedule 13G has been adopted and filed on behalf of each of them and (ii) all future amendments to such statement on Schedule 13G will, unless written notice to the contrary is delivered as described below, be jointly filed on behalf of each of them. This agreement may be terminated with respect to the obligations to jointly file future amendments to such statement on Schedule 13G as to any of the undersigned upon such person giving written notice thereof to each of the other persons signatory hereto, at the principal office thereof.

     

    Dated: February 13, 2019

     

      Qiming Corporate GP IV, Ltd.
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Managing Directors Fund IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming GP IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Venture Partners IV, L.P.

    By: Qiming GP IV, L.P.,

    its General Partner

    By: Qiming Corporate GP IV, Ltd.,

    General Partner of Qiming GP IV., L.P.

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

      QM11 Limited
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Director

    10 

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      - Findings support advancement of ZL-6201 into Investigational New Drug (IND)-enabling studies in 2025 as a potential first-in-class and best-in-class antibody-drug conjugate (ADC) treatment for patients with leucine-rich repeat-containing protein 15 (LRRC15)-positive solid tumors - Data from preclinical studies suggest ZL-1222, a novel anti-PD-1/interleukin-12 (IL-12) immunocytokine, induces potent anti-tumor activity through cis-activation of T cells in the tumor microenvironment and efficiently blocks PD-1/PD-L1 signaling pathway with improved systemic safety Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688)) will present new data from studies evaluating two of its internally developed, next-g

      4/25/25 1:12:00 PM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Zai Lab to Present Data from Phase 1 Trial of DLL3-Targeted Antibody-Drug Conjugate (ADC) ZL-1310 at 2025 ASCO Annual Meeting

      - Zai Lab will highlight potential of ZL-1310 as a promising, best-in-class Delta-like ligand (DLL3-targeted) ADC for patients with extensive-stage small cell lung cancer (ES-SCLC) - Investor conference call and webcast to discuss data and clinical trial plans on June 2, 2025, at 7:00 a.m. CT / 8:00 a.m. ET / 8:00 p.m. HKT Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688)) today announced that updated data from an ongoing, global Phase 1a/1b clinical trial (NCT06179069) evaluating ZL-1310, the Company's potential first-in-class and best-in-class, Delta-like ligand (DLL3) antibody-drug conjugate (ADC) for the treatment of extensive-stage small cell lung cancer (ES-SCLC), will be presented during a

      4/23/25 10:56:00 AM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
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    $ZLAB
    Large Ownership Changes

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    • SEC Form SC 13G filed by Zai Lab Limited

      SC 13G - Zai Lab Ltd (0001704292) (Subject)

      11/14/24 11:11:39 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Amendment: SEC Form SC 13G/A filed by Zai Lab Limited

      SC 13G/A - Zai Lab Ltd (0001704292) (Subject)

      11/8/24 10:52:38 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    • SEC Form SC 13G/A filed by Zai Lab Limited (Amendment)

      SC 13G/A - Zai Lab Ltd (0001704292) (Subject)

      6/6/24 9:54:34 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    SEC Filings

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    • SEC Form 144 filed by Zai Lab Limited

      144 - Zai Lab Ltd (0001704292) (Subject)

      5/9/25 11:35:52 AM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
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    • SEC Form 10-Q filed by Zai Lab Limited

      10-Q - Zai Lab Ltd (0001704292) (Filer)

      5/8/25 6:11:34 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    • Zai Lab Limited filed SEC Form 8-K: Results of Operations and Financial Condition, Financial Statements and Exhibits

      8-K - Zai Lab Ltd (0001704292) (Filer)

      5/8/25 6:09:14 AM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
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    $ZLAB
    Analyst Ratings

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    • Scotiabank initiated coverage on Zai Lab with a new price target

      Scotiabank initiated coverage of Zai Lab with a rating of Sector Outperform and set a new price target of $55.00

      3/7/25 8:00:31 AM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Zai Lab downgraded by BofA Securities with a new price target

      BofA Securities downgraded Zai Lab from Buy to Neutral and set a new price target of $36.10 from $29.00 previously

      3/3/25 7:38:45 AM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
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    • Morgan Stanley initiated coverage on Zai Lab with a new price target

      Morgan Stanley initiated coverage of Zai Lab with a rating of Overweight and set a new price target of $47.50

      12/14/23 7:54:36 AM ET
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      Biotechnology: Pharmaceutical Preparations
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    $ZLAB
    Insider Trading

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    • Officer Smiley Joshua L converted options into 7,145 units of American Depositary Shares and sold $111,044 worth of American Depositary Shares (3,354 units at $33.11), increasing direct ownership by 6% to 67,345 units (SEC Form 4)

      4 - Zai Lab Ltd (0001704292) (Issuer)

      4/7/25 4:48:47 PM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chief Legal Officer Edmondson Frazor Titus Iii converted options into 5,032 units of American Depositary Shares and sold $62,044 worth of American Depositary Shares (1,874 units at $33.11), increasing direct ownership by 12% to 30,375 units (SEC Form 4)

      4 - Zai Lab Ltd (0001704292) (Issuer)

      4/7/25 4:48:35 PM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
      Health Care
    • Chairperson & CEO Du Ying converted options into 6,750 units of American Depositary Shares and sold $97,503 worth of American Depositary Shares (2,945 units at $33.11), increasing direct ownership by 0.80% to 479,851 units (SEC Form 4)

      4 - Zai Lab Ltd (0001704292) (Issuer)

      4/7/25 4:48:25 PM ET
      $ZLAB
      Biotechnology: Pharmaceutical Preparations
      Health Care