• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • Settings
  • RSS Feeds
PublishDashboard
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlertsPublish with Us
    Company
    AboutQuantisnow PlusContactJobsAI employees
    Legal
    Terms of usePrivacy policyCookie policy

    Amendment: SEC Form SC 13D/A filed by Prime Medicine Inc.

    11/22/24 5:32:53 PM ET
    $PRME
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $PRME alert in real time by email
    SC 13D/A 1 arch-sch13d_18909.htm ARCH VENTURE FUND XII, L.P. - PRIME MEDICINE -- SCH 13D/A(#1)

     

      

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

      

     

     

    SCHEDULE 13D

     

     

     

     

    Under the Securities Exchange Act of 1934

    (Amendment No. 1)*

     

     

     

     

    Prime Medicine, Inc. 

    (Name of Issuer)

     

     

         Common Stock, $0.00001 par value    

    (Title of Class of Securities)

     

     

        74168J101   

    (CUSIP Number)

     

     

    Mark McDonnell

    ARCH Venture Management, LLC

    8755 W. Higgins Road Suite 1025

          Chicago, IL 60631     

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

     

     

        November 12, 2024   

    (Date of Event which Requires Filing of this Statement)

     

     

     

    *The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐ 

     

     

     

     

    Persons who respond to the collection of information contained in this form are not
    required to respond unless the form displays a currently valid OMB control number.

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 2 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Fund X, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    WC

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     

     

     

    CUSIP No. 74168J101

    13D Page 3 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Fund X Overage, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    WC

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     

     

     

    CUSIP No. 74168J101

    13D Page 4 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Fund XII, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    WC

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 5 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Partners X, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     

     

    CUSIP No. 74168J101

    13D Page 6 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Partners X Overage, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     

     

     

    CUSIP No. 74168J101

    13D Page 7 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Partners XII, L.P.

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    WC

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    PN

     

       

     

     

    CUSIP No. 74168J101

    13D Page 8 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Partners X, LLC

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    OO

     

       

     

     

     

    CUSIP No. 74168J101

    13D Page 9 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    ARCH Venture Partners XII, LLC

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Delaware

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    OO

     

       

     

     

     

    CUSIP No. 74168J101

    13D Page 10 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    Robert Nelsen

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    55,142 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    55,142 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,511,736 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES  

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

      

     

     

    CUSIP No. 74168J101

    13D Page 11 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    Keith Crandell

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

     

     

     

    CUSIP No. 74168J101

    13D Page 12 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    Kristina Burow

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

     

     

     

    CUSIP No. 74168J101

    13D Page 13 of 22 Pages    

     

    1  

    NAME OF REPORTING PERSONS

     

    Steven Gillis

     

       
    2  

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

     

     

     

     

    (a) ☐

    (b) ☐

    3  

    SEC USE ONLY

     

     

     

       
    4  

    SOURCE OF FUNDS

      

    AF

     

       
    5  

    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)     

     

     

     

       ☐
    6  

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    United States

      

       
    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH  

     7

     

    SOLE VOTING POWER

     

    0 Shares

     

      8  

    SHARED VOTING POWER

     

    15,456,594 Shares

     

      9  

    SOLE DISPOSITIVE POWER

     

    0 Shares

     

      10  

    SHARED DISPOSITIVE POWER

     

    15,456,594 Shares

     

    11  

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    15,456,594 Shares

     

       
    12  

    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES     

     

     

     

       ☐
    13  

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      

    11.8%

     

       

     14

     

    TYPE OF REPORTING PERSON

       

    IN

     

       

     

     

     

     

    CUSIP No. 74168J101

    13D Page 14 of 22 Pages    

     

     

     

     

    Item 1.Security and Issuer.

     

    This statement relates to the Common Stock, $0.00001 par value per share (the “Common Stock”), of Prime Medicine, Inc. (the “Issuer”) having its principal executive office at 21 Erie St., Cambridge, MA 02139 USA.

     

     

    Item 2.IDENTITY AND BACKGROUND.

     

    (a)This statement is being filed by (1) ARCH Venture Fund X, L.P. (“AVF X”), (2) ARCH Venture Partners X, L.P. (“AVP X LP”) which is the sole general partner of AVF X, (3) ARCH Venture Partners X, LLC (“AVP X LLC”) which is the sole general partner of AVP X LP and AVP X Overage LP (defined below), (4) ARCH Venture Fund X Overage, L.P. (“AVF X Overage”), (5) ARCH Venture Partners X Overage, L.P. (“AVP X Overage LP”), which is the sole general partner of AVF X Overage, (6) ARCH Venture Fund XII, L.P. (“AVF XII”), (7) ARCH Venture Partners XII, L.P. (“AVP XII LP”) which is the sole general partner of AVF XII, (8) ARCH Venture Partners XII, LLC (“AVP XII LLC”) which is the sole general partner of AVP XII LP, (9) Keith Crandell (“Crandell”), (10) Robert Nelsen (“Nelsen”), (11) Kristina Burow (“Burow”), and (12) Steven Gillis (“Gillis”, and together with Nelsen, Crandell and Burow, referred to individually as “Committee Member” or collectively as either the “AVP X Investment Committee Members” or the “AVP XII Investment Committee Members”). Each of the individuals and entities above shall be referred to herein as a “Reporting Person” and collectively as the “Reporting Persons”.

     

    (b)The business address of each of the Reporting Persons is 8755 West Higgins Road, Suite 1025, Chicago, IL, 60631.

     

    (c)The principal business of AVP X LP is to act as the general partner of AVF X, the principal business of AVP X Overage LP is to act as the general partner of AVF X Overage, and the principal business of AVP XII is to act as the general partner of AVF XII. The principal business of AVP X LLC is to act as the general partner of AVP X LP and AVF X Overage LP, and the principal business of AVP XII LLC is to act as the general partner of AVP XII LP. AVP X Investment Committee Members and AVP XII Investment Committee Members act as investment committee members of AVP X LLC and AVP XII LLC, respectively, and as managing directors or investment committee members of a number of affiliated partnerships with similar businesses.

     

    (d)During the five years prior to the date hereof, none of the Reporting Persons has been convicted in a criminal proceeding.

     

    (e)During the five years prior to the date hereof, none of the Reporting Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction ending in a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, Federal or State securities laws or finding any violation with respect to such laws.

     

    (f)Each of AVF X, AVP X LP, AVF X Overage, AVP X Overage LP, AVF XII and AVP XII LP, are limited partnerships organized under the laws of the State of Delaware. Each of AVP X LLC and AVP XII LLC is a limited liability company organized under the laws of the State of Delaware.  Each Committee Member is a US citizen.

     

     

     

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 15 of 22 Pages    

     

     

     

    Item 5.INTEREST OF SECURITIES OF THE ISSUER.

     

    (a)AVF X is the record owner of 6,128,297 shares of Common Stock (“AVF X Record Shares”). AVP X LP, as the sole general partner of AVF X LP, may be deemed to beneficially own the AVF X Record Shares.  AVP X LLC, as the sole general partner of AVP X LP, may be deemed to beneficially own the AVF X Record Shares. 

    AVF X Overage is the record holder of 6,128,297 shares of Common Stock (“AVF X Overage Record Shares”).  AVP X Overage LP, as the sole general partner of AVF X Overage, may be deemed to beneficially own the AVF X Overage Record Shares.  AVP X LLC, as the sole general partner of AVP X Overage LP, may be deemed to beneficially own the AVF X Overage Record Shares. 

     

    AVF XII is the record holder of 3,200,000 shares of Common Stock (“AVF XII Record Shares”).  AVP XII LP, as the sole general partner of AVF XII LP, may be deemed to beneficially own the AVF XII Record Shares.  AVP XII LLC, as the sole general partner of AVP XII LP, may be deemed to beneficially own the AVF XII Overage Record Shares.

     

    By virtue of their relationship as affiliated entities who have overlapping general partners and investment committee members, each of the Committee Members and direct and indirect general partners of AVF X, AVF X Overage and AVF XII may be deemed to share the power to direct AVF X Record Shares, AVF Overage X Record Shares and AVF XII Record Shares (collectively the “Record Shares”). 

     

    Nelsen and his related trusts are also the owner of 16,080 shares of common stock of the Issuer and is the holder of vested options to purchase 39,062 shares of Common Stock (“Nelsen Options”).

     

    Each Reporting Person disclaims beneficial ownership of the Record Shares except for the shares, if any, held of record by such Reporting Person.

     

    The percentage of outstanding Common Stock of the Issuer which may be deemed to be beneficially owned by each Reporting Person (other than Nelsen) is set forth on Line 13 of such Reporting Person’s cover sheet.  Such percentage was calculated based on the 131,160,842 shares of Common Stock reported by the Issuer to be outstanding on October 31, 2024 in the Issuer’s Form 10-Q filed with the Securities and Exchange Commission on November 12, 2024. For Nelsen, the Nelsen Options were included in the number of shares of Common Stock outstanding.

     

    (b)Regarding the number of shares as to which such person has:

     

    (i)sole power to vote or to direct the vote: See line 7 of cover sheets.

     

    (ii)shared power to vote or to direct the vote: See line 8 of cover sheets.

     

    (iii)sole power to dispose or to direct the disposition: See line 9 of cover sheets.

     

    (iv)shared power to dispose or to direct the disposition: See line 10 of cover sheets.

     

    (c)None of the Reporting Persons has effected any transaction in the Common Stock during the last 60 days. This Amendment No. 1 is being filed voluntarily due to an issuance of securities by the Issuer as reported on the Issuer’s 10-Q filed with the Securities and Exchange Commission on November 12, 2024, which caused the percentage of outstanding Common Stock of the Issuer deemed to be beneficial owned by the Reporting Persons to reduce by one percent or more.

     

    (d)No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, shares beneficially owned by any of the Reporting Persons.

     

    (e)Not applicable.

     

     

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 16 of 22 Pages    

     

     

     

     

     

    Item 6.CONTRACTS, ARRANGEMENTS, UNDERTAKINGS OR RELATIONSHIPS WITH RESPECT TO SECURITIES OF THE ISSUER.

     

    AVF X and AVF X Overage are parties to that certain Amended and Restated Investors’ Rights Agreement, dated April 20, 2021, the “Investor Rights Agreement”), which is attached as Exhibit 4.1+ to the Issuer’s Form S-1 filed on September 23, 2022. Effective as of the closing of the Issuer’s initial public offering, the covenants relating to delivery of financial statements and inspection rights set forth in Section 3 were terminated and rights of first offer were terminated. Pursuant to the Investor Rights Agreement, AVF X and AVF X Overage have certain registration rights with respect to its Common Stock. Specifically, the Issuer has granted demand, piggyback and Form S-3 registration rights, which will terminate upon the earlier of (i) with respect to each stockholder, such date on which all registrable shares held by such stockholder may immediately be sold during any three-month period pursuant to Rule 144 of the Securities Act of 1933, as amended, (ii) the occurrence of a deemed liquidation event, as defined in the Issuer’s amended and restated certificate of incorporation, as currently in effect, and (iii) the fifth anniversary of the IPO.

     

    The foregoing description of the Investor Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of such agreement filed as an exhibit to this Schedule 13D and is incorporated herein by reference.

     

    Item 7.Material to be Filed as Exhibits.

     

    Exhibit 1 - Agreement of Joint Filing

     

    Exhibit 2 - Agreement of Joint Filing

     

    Exhibit 3 - Amended and Restated Investors' Rights Agreement, dated April 20, 2021, as amended, by and among the Issuer and certain of its stockholders (incorporated by reference to Exhibit 4.1+ to the Issuer's Registration Statement on Form S-1 (File No.), as filed with the Securities and Exchange Commission on September 23, 2022)

     

     

     

     

     

     

     

     

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 17 of 22 Pages    

     

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Date:    November 22, 2024

     

    ARCH VENTURE FUND X, L.P.

     

    By:        ARCH Venture Partners X, L.P.

    its General Partner

     

    By:     ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

    ARCH VENTURE PARTNERS X, L.P.

     

    By:        ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

    ARCH VENTURE PARTNERS X, LLC

     

    By:                         *                         

           Keith Crandell

            Managing Director

     

     

    ARCH VENTURE FUND X OVERAGE, L.P.

     

    By:        ARCH Venture Partners X Overage, L.P.

    its General Partner

    .

    By:     ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

    ARCH VENTURE PARTNERS X OVERAGE, L.P.

     

    By:       ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

     

    CUSIP No. 74168J101

    13D Page 18 of 22 Pages    

     

     

     

     

    ARCH VENTURE PARTNERS X, LLC

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

     

                              *                             

    Kristina Burow

     

                              *                             

    Keith Crandell

     

                              *                             

    Steven Gillis

     

                              *                             

    Robert Nelsen

     

     

     

    * By:   /s/ Mark McDonnell              

    Mark McDonnell

    Attorney-in-Fact

     

     

    *       This Schedule 13D was executed by Mark McDonnell pursuant to Powers of Attorney filed as Exhibit 24 and 24.1 to the Form 3 relating to the beneficial ownership of shares of Prime Medicine, Inc. by the Reporting Persons filed with the Securities Exchange Commission on October 19, 2022 and incorporated herein in its entirety by reference.

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 19 of 22 Pages    

     

     

    EXHIBIT 1

    AGREEMENT OF JOINT FILING

    Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need be filed with respect to the ownership by each of the undersigned of shares of Common Stock of Prime Medicine, Inc.

     

    This Agreement may be executed in any number of counterparts, each of which shall be deemed an original.

     

    Date:   November 22, 2024

    ARCH VENTURE FUND X, L.P.

     

    By:        ARCH Venture Partners IX, L.P.

    its General Partner

     

    By:     ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

    ARCH VENTURE PARTNERS X, L.P.

     

    By:        ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

    ARCH VENTURE PARTNERS X, LLC

     

    By:                         *                         

           Robert Nelsen

            Managing Director

     

     

    ARCH VENTURE FUND X OVERAGE, L.P.

     

    By:        ARCH Venture Partners X Overage, L.P.

    its General Partner

     

    By:     ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

    ARCH VENTURE PARTNERS X OVERAGE, L.P.

     

    By:       ARCH Venture Partners X, LLC

    its General Partner

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 20 of 22 Pages    

     

     

     

     

     

     

     

     

    ARCH VENTURE PARTNERS X, LLC

     

    By:                         *                         

    Robert Nelsen

    Managing Director

     

     

     

                              *                             

    Keith Crandell

     

                              *                             

    Robert Nelsen

     

                              *                             

    Kristina Burow

     

                              *                             

    Steven Gillis

     

     

     

    * By:  /s/ Mark McDonnell              

     Mark McDonnell

     Attorney-in-Fact

     

     

     

     

     

    *          This Agreement of Joint Filing was executed by Mark McDonnell pursuant to a Powers of Attorney filed as Exhibit 24 and 24.1 to the Form 3 relating to the beneficial ownership of shares of Prime Medicine, Inc. by the Reporting Persons filed with the Securities Exchange Commission on October 19, 2022 and incorporated herein in its entirety by reference.

     

     

     

     

     

     

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 21 of 22 Pages    

     

    Signature

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Date:    November 22, 2024

     

    ARCH VENTURE FUND XII, L.P.

     

    By:        ARCH Venture Partners XII, L.P.

    its General Partner

     

    By:     ARCH Venture Partners XII, LLC

    its General Partner

    By:                         *                         

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, L.P.

     

    By:       ARCH Venture Partners XII, LLC

    its General Partner

    By:                               *                         

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, LLC

     

    By:                                *                         

    Keith Crandell

    Managing Director

     

     

     

                              *                             

    Keith Crandell

     

                              *                             

    Robert Nelsen

     

                              *                             

    Kristina Burow

     

                              *                             

    Steven Gillis

     

     

     

     

     

     

     

    * By:  /s/ Mark McDonnell              

     Mark McDonnell

    Attorney-in-Fact

     

     

    *       This Schedule 13D was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24.4 to the Form 3 relating to the beneficial ownership of shares of Neumora Therapeutics, Inc. by the Reporting Persons filed with the Securities Exchange Commission on September 14, 2023 and incorporated herein in its entirety by reference.

     

     

     

     

     

     

     

     

    CUSIP No. 74168J101

    13D Page 22 of 22 Pages    

     

    EXHIBIT 2

     

    AGREEMENT OF JOINT FILING

    Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need be filed with respect to the ownership by each of the undersigned of shares of Common Stock of Prime Medicine, Inc.

     

    This Agreement may be executed in any number of counterparts, each of which shall be deemed an original.

     

    Date:    November 22, 2024

     

    ARCH VENTURE FUND XII, L.P.

     

    By:        ARCH Venture Partners XII, L.P.

    its General Partner

     

    By:     ARCH Venture Partners XII, LLC

    its General Partner

    By:                         *                         

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, L.P.

     

    By:       ARCH Venture Partners XII, LLC

    its General Partner

    By:                               *                         

    Keith Crandell

    Managing Director

     

     

    ARCH VENTURE PARTNERS XII, LLC

     

    By:                                *                         

    Keith Crandell

    Managing Director

     

     

     

                              *                             

    Keith Crandell

     

                              *                             

    Robert Nelsen

     

                              *                             

    Kristina Burow

     

                              *                             

    Steven Gillis

     

     

     

     

    * By:  /s/ Mark McDonnell      

     Mark McDonnell as

    Attorney-in-Fact

     

     

    *        This Agreement of Joint Filing was executed by Mark McDonnell pursuant to a Power of Attorney filed as Exhibit 24.4 to the Form 3 relating to the beneficial ownership of shares of Neumora Therapeutics, Inc. by the Reporting Persons filed with the Securities Exchange Commission on September 14, 2023 and incorporated herein in its entirety by reference.

     

     

     

     

     

     

    Get the next $PRME alert in real time by email

    Chat with this insight

    Save time and jump to the most important pieces.

    Recent Analyst Ratings for
    $PRME

    DatePrice TargetRatingAnalyst
    5/27/2025$1.50Buy → Neutral
    Citigroup
    5/20/2025Overweight → Neutral
    Analyst
    5/20/2025Buy → Neutral
    H.C. Wainwright
    12/10/2024$10.00Mkt Outperform
    JMP Securities
    5/20/2024$10.00Buy
    H.C. Wainwright
    5/16/2024$10.00Neutral → Buy
    Citigroup
    4/22/2024$17.00Buy
    Chardan Capital Markets
    4/8/2024Buy
    TD Cowen
    More analyst ratings

    $PRME
    Press Releases

    Fastest customizable press release news feed in the world

    See more
    • Prime Medicine to Participate in Upcoming Investor Conferences

      CAMBRIDGE, Mass., May 29, 2025 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (NASDAQ:PRME), a biotechnology company committed to delivering a new class of differentiated one-time curative genetic therapies, today announced that company management will participate in the following upcoming conferences: Jefferies Global Healthcare Conference: Fireside chat on Thursday, June 5, 2025, at 10:30 a.m. ET in New York, NY.Goldman Sachs 46th Annual Global Healthcare Conference: Fireside chat on Monday, June 9, 2025, at 2:40 p.m. ET in Miami Beach, FL. Live audio webcasts of each presentation will be available under "Events & Presentations" in the News & Events section of the Company's website at www.pr

      5/29/25 8:00:00 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine Announces Strategic Restructuring to Focus on Opportunities in Large Genetic Liver Diseases, Cystic Fibrosis, and Partnered Programs Alongside CEO Leadership Transition

      -- Initial positive data from Phase 1/2 clinical trial of PM359 in CGD provide clinical proof-of-concept for Prime Editing as a transformative gene editing technology -- -- On-track to file IND and/or CTA for Wilson's Disease and AATD programs in 1H 2026 and mid-2026, respectively; initial clinical data for both expected in 2027 -- -- Allan Reine, M.D., CFO, to succeed Keith Gottesdiener, M.D., as CEO; Jeff Marrazzo, member of the Board of Directors, named Executive Chair -- -- Implementing cost cutting measures to significantly reduce cash needs in advance of key data inflection points -- CAMBRIDGE, Mass., May 19, 2025 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (NASDAQ:PRME), a biotech

      5/19/25 8:31:00 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine Announces Breakthrough Clinical Data Showing Rapid Restoration of DHR Positivity After Single Infusion of PM359, an Investigational Prime Editor for Chronic Granulomatous Disease

      -- First ever clinical data supporting safety and efficacy of Prime Editing in humans -- -- Initial data from first patient dosed in Phase 1/2 trial finds single dose of PM359 led to 58% DHR positivity by Day 15 and 66% by Day 30, well above levels believed to be potentially curative -- -- Rapid engraftment observed in both neutrophils and platelets -- -- Encouraging safety profile; no serious adverse events related to PM359 -- -- Initiating efforts to explore continued clinical development opportunities for PM359 external to Prime Medicine -- CAMBRIDGE, Mass., May 19, 2025 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (NASDAQ:PRME), a biotechnology company committed to delivering a new cl

      5/19/25 8:30:00 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $PRME
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    See more
    • Prime Medicine downgraded by Citigroup with a new price target

      Citigroup downgraded Prime Medicine from Buy to Neutral and set a new price target of $1.50

      5/27/25 9:08:50 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine downgraded by Analyst

      Analyst downgraded Prime Medicine from Overweight to Neutral

      5/20/25 8:09:46 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine downgraded by H.C. Wainwright

      H.C. Wainwright downgraded Prime Medicine from Buy to Neutral

      5/20/25 8:09:36 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $PRME
    SEC Filings

    See more
    • Prime Medicine Inc. filed SEC Form 8-K: Submission of Matters to a Vote of Security Holders

      8-K - Prime Medicine, Inc. (0001894562) (Filer)

      6/5/25 4:11:50 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form DEFA14A filed by Prime Medicine Inc.

      DEFA14A - Prime Medicine, Inc. (0001894562) (Filer)

      5/19/25 9:12:31 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine Inc. filed SEC Form 8-K: Regulation FD Disclosure

      8-K - Prime Medicine, Inc. (0001894562) (Filer)

      5/19/25 9:09:57 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $PRME
    Leadership Updates

    Live Leadership Updates

    See more
    • Prime Medicine Announces Strategic Restructuring to Focus on Opportunities in Large Genetic Liver Diseases, Cystic Fibrosis, and Partnered Programs Alongside CEO Leadership Transition

      -- Initial positive data from Phase 1/2 clinical trial of PM359 in CGD provide clinical proof-of-concept for Prime Editing as a transformative gene editing technology -- -- On-track to file IND and/or CTA for Wilson's Disease and AATD programs in 1H 2026 and mid-2026, respectively; initial clinical data for both expected in 2027 -- -- Allan Reine, M.D., CFO, to succeed Keith Gottesdiener, M.D., as CEO; Jeff Marrazzo, member of the Board of Directors, named Executive Chair -- -- Implementing cost cutting measures to significantly reduce cash needs in advance of key data inflection points -- CAMBRIDGE, Mass., May 19, 2025 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (NASDAQ:PRME), a biotech

      5/19/25 8:31:00 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine Appoints Allan Reine, M.D., as Chief Financial Officer

      CAMBRIDGE, Mass., Jan. 05, 2024 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (NASDAQ:PRME), a biotechnology company committed to delivering a new class of differentiated one-time curative genetic therapies, today announced the appointment of Allan Reine, M.D., as the Company's Chief Financial Officer, effective January 17, 2024. A seasoned financial executive with over twenty years' experience in the biotechnology industry, Dr. Reine will be responsible for the company's financing strategy and investor relations, and will oversee all financial operations as Prime Medicine begins its transition into a clinical company. "I am delighted to welcome Allan to Prime Medicine. He brings tremendou

      1/5/24 8:00:00 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine Reports First Quarter 2023 Financial Results and Provides Business Updates

      -- New data further demonstrating ability of Prime Editing to correct causative mutation of CGD and highlighting potential of PASSIGE platform to multiplex edit CAR-T cells to be presented at ASGCT Annual Meeting -- -- Expanded Board of Directors with appointment of Jeff Marrazzo, former CEO of Spark Therapeutics -- -- Further extended intellectual property portfolio; U.S. PTO issued Prime Medicine's second patent, No. 11,643,652, and allowed third patent application, No. 17/751,599 -- -- Cash, cash equivalents, investments and restricted cash balance of $263.0 million as of March 31, 2023 -- CAMBRIDGE, Mass., May 11, 2023 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (NASDAQ:PRME)

      5/11/23 8:00:00 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $PRME
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • Large owner Liu David R. bought $33,590 worth of shares (21,000 units at $1.60), increasing direct ownership by 0.10% to 20,177,945 units (SEC Form 4)

      4 - Prime Medicine, Inc. (0001894562) (Issuer)

      6/12/25 4:49:34 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Chief Business Officer Brudnick Richard bought $23,790 worth of shares (20,000 units at $1.19) (SEC Form 4)

      4 - Prime Medicine, Inc. (0001894562) (Issuer)

      5/22/25 4:22:45 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Chief Technical Officer Lee Ann L. bought $113,000 worth of shares (100,000 units at $1.13) (SEC Form 4)

      4 - Prime Medicine, Inc. (0001894562) (Issuer)

      5/22/25 4:21:22 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $PRME
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    See more
    • Amendment: SEC Form SC 13D/A filed by Prime Medicine Inc.

      SC 13D/A - Prime Medicine, Inc. (0001894562) (Subject)

      11/22/24 5:32:53 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Amendment: SEC Form SC 13G/A filed by Prime Medicine Inc.

      SC 13G/A - Prime Medicine, Inc. (0001894562) (Subject)

      11/12/24 10:34:15 AM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form SC 13G filed by Prime Medicine Inc.

      SC 13G - Prime Medicine, Inc. (0001894562) (Subject)

      10/4/24 4:20:38 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $PRME
    Financials

    Live finance-specific insights

    See more
    • Prime Medicine Reports Third Quarter 2023 Financial Results and Provides Business Updates

      -- Presented new preclinical research across multiple programs, including proof-of-concept data from in vivo rodent and large animal studies, as well as updates on proprietary delivery systems -- -- Shared detailed safety evaluation of lead Prime Editors across multiple programs; preliminary off-target analyses did not identify off-target editing, supporting potential best-in-class safety profile -- -- Received U.S. FDA Rare Pediatric Drug designation for PM359 for CGD; initiated IND-enabling studies and remain on track to file IND application in 2024 -- -- Further extended intellectual property portfolio; U.S. PTO issued Prime Medicine's third patent, No. 11,795,452 --

      11/3/23 4:01:00 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • Prime Medicine Reports Second Quarter 2023 Financial Results and Provides Business Updates

      -- Presented new preclinical data demonstrating ability of Prime Editing to correct causative mutation of CGD and highlighting ability of PASSIGE™ platform to multiplex edit CAR-T cells at ASGCT Annual Meeting -- -- Entered strategic collaboration with Cimeio Therapeutics; multiplexing Cimeio's shielded variants with therapeutic edits may meaningfully expand reach of Prime Editing -- -- Cash, cash equivalents, investments and restricted cash balance of $221.1 million as of June 30, 2023 -- CAMBRIDGE, Mass., Aug. 07, 2023 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (NASDAQ:PRME), a biotechnology company committed to delivering a new class of differentiated one-time curative genetic therapie

      8/7/23 4:01:00 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care

    $PRME
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    See more
    • Large owner Liu David R. bought $33,590 worth of shares (21,000 units at $1.60), increasing direct ownership by 0.10% to 20,177,945 units (SEC Form 4)

      4 - Prime Medicine, Inc. (0001894562) (Issuer)

      6/12/25 4:49:34 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form 4 filed by Director Schenkein David P

      4 - Prime Medicine, Inc. (0001894562) (Issuer)

      6/5/25 6:14:03 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care
    • SEC Form 4 filed by Director Marrazzo Jeffrey D

      4 - Prime Medicine, Inc. (0001894562) (Issuer)

      6/5/25 6:13:50 PM ET
      $PRME
      Biotechnology: Biological Products (No Diagnostic Substances)
      Health Care