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    SEC Form S-8 filed by Prime Medicine Inc.

    2/28/25 8:21:49 AM ET
    $PRME
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $PRME alert in real time by email
    S-8 1 prime-2025sx8.htm S-8 Document

    As filed with the Securities and Exchange Commission on February 28, 2025
    Registration No. 333-
    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549
    FORM S-8
    REGISTRATION STATEMENT
    Under
    The Securities Act of 1933
    Prime Medicine, Inc.
    (Exact name of registrant as specified in its charter)
    Delaware 84-3097762
    (State or other jurisdiction of
    incorporation or organization)
     
    (I.R.S. Employer
    Identification Number)
    60 First Street
    Cambridge, MA 02141
    (617) 465-0013
    (Address of Principal Executive Offices)
    Prime Medicine, Inc. 2022 Stock Option and Incentive Plan
    (Full Title of the Plan)
    Keith Gottesdiener, M.D.
    President and Chief Executive Officer
    Prime Medicine, Inc.
    60 First Street
    Cambridge, MA 02141
    (617) 465-0013
    (Name, address, including zip code, and telephone number, including area code, of agent for service)
    Copies to:
    Kingsley L. Taft, Esq.
    Marishka DeToy, Esq.
    Goodwin Procter LLP
    100 Northern Avenue
    Boston, Massachusetts 02210
    (617) 570-1000
    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
    Large accelerated filer
    ☐
    Accelerated
    filer
    ☐
    Non-accelerated filer
    ☒
    Smaller reporting company
    ☒
    Emerging growth company
    ☒
    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐ 



    PART I
    INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
    This Registration Statement on Form S-8 (this “Registration Statement”) is being filed for the purpose of registering an additional 6,558,042 shares of common stock, par value $0.00001 per share (“Common Stock”) of Prime Medicine, Inc. (the “Registrant”) available for issuance under the Registrant’s 2022 Stock Option and Incentive Plan, as amended (the “2022 Plan”).
    These additional shares of Common Stock are of the same class as other securities relating to the 2022 Plan for which the Registrant’s Registration Statements on Form S-8 (File No. 333-267953, File No. 333-270400, and File No. 333-277567), filed with the Securities and Exchange Commission (the “SEC”) on October 19, 2022, March 9, 2023, and March 1, 2024, respectively, are effective (collectively, the “Earlier Registration Statements”).
    Pursuant to General Instruction E to Form S-8 regarding registration of additional securities, the contents of the Earlier Registration Statements, except for “Item 8. Exhibits”, are incorporated herein by reference, except to the extent supplemented, amended or superseded by the information set forth herein. Only those items of Form S-8 containing new information not contained in the Earlier Registration Statements are presented herein.

    PART II
    INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
    Item 8. Exhibits.
    The exhibits to this Registration Statement are listed in the Exhibit Index attached hereto and incorporated by reference herein.



    EXHIBIT INDEX
    Exhibit
    number
    Description of exhibit
    4.1
    Third Amended and Restated Certificate of Incorporation of Prime Medicine, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on October 24, 2022)
    4.2
    Certificate of Amendment to Third Amended and Restated Certificate of Incorporation of Prime Medicine, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on June 12, 2024)
    4.3
    Second Amended and Restated Bylaws of Prime Medicine, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on May 21, 2024).
    4.4
    Specimen Common Stock Certificate (incorporated by reference to Exhibit 4.2 to the Registrant’s Registration Statement on Form S-1/A (File No. 333-267579), filed with the SEC on October 17, 2022)
    4.5
    Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on February 16, 2024)
    5.1*
    Opinion of Goodwin Procter LLP
    23.1*
    Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm
    23.2*
    Consent of Goodwin Procter LLP (included in Exhibit 5.1)
    24.1*
    Power of Attorney (included on signature page)
    99.1
    2022 Stock Option and Incentive Plan and forms of award agreements thereunder (Incorporated by reference to Exhibit 10.2 to the registrant’s Registration Statement on Form S-1, as amended (File No. 333-267579) filed on October 17, 2022
    107*
    Filing Fee Table
    *Filed herewith.



    SIGNATURES
    Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on the 28th day of February 2025.
    PRIME MEDICINE, INC.
     
    By:
    /s/ Keith Gottesdiener
    Keith Gottesdiener
    President and Chief Executive Officer

    POWER OF ATTORNEY AND SIGNATURES
    KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of Keith Gottesdiener, Allan Reine, and Carman Alenson as such person’s true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for such person in such person’s name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.
    Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
    Name TitleDate
      
    /s/ Keith Gottesdiener
    President, Chief Executive Officer and Director
    (Principal Executive Officer)
    February 28, 2025
    Keith Gottesdiener
    /s/ Allan Reine
    Chief Financial Officer
    (Principal Financial Officer)
    February 28, 2025
    Allan Reine
    /s/ Carman Alenson
    Chief Accounting Officer
    (Principal Accounting Officer)
    February 28, 2025
    Carman Alenson
    /s/ Thomas CahillDirectorFebruary 28, 2025
    Thomas Cahill
    /s/ Wendy ChungDirectorFebruary 28, 2025
    Wendy Chung
    /s/ Kaye FosterDirectorFebruary 28, 2025
    Kaye Foster
    /s/ Michael Kelly
    DirectorFebruary 28, 2025
    Michael Kelly
    /s/ Jeff Marrazzo
    DirectorFebruary 28, 2025
    Jeff Marrazzo
    /s/ Robert Nelsen
    Director
    February 28, 2025
    Robert Nelsen
    /s/ David Schenkein
    Director
    February 28, 2025
    David Schenkein

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