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    SEC Form SC 13G filed by Tyra Biosciences Inc.

    2/8/22 3:28:01 PM ET
    $TYRA
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $TYRA alert in real time by email
    SC 13G 1 d304292dsc13g.htm SC 13G SC 13G

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

     

    SCHEDULE 13G

    UNDER THE SECURITIES EXCHANGE ACT OF 1934

    (Amendment No.     )*

     

     

    Tyra Biosciences, Inc.

    (Name of Issuer)

    COMMON STOCK, $0.0001 PAR VALUE PER SHARE

    (Title of Class of Securities)

    90240B 106

    (CUSIP Number)

    December 31, 2021

    (Date of Event Which Requires Filing of this Statement)

     

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

    ☐ Rule 13d-1(b)

    ☐ Rule 13d-1(c)

    ☒ Rule 13d-1(d)

     

    *

    The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     


    CUSIP No. 90240B 106   SCHEDULE 13G   Page 2 of 8 Pages

     

      1.    

      NAMES OF REPORTING PERSONS

     

      Canaan XI L.P.

      2.  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

      (a)  ☐        (b)  ☒

     

      3.  

      SEC USE ONLY

     

      4.  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Cayman Islands

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

       5.    

      SOLE VOTING POWER

     

      3,936,595

       6.  

      SHARED VOTING POWER

     

      0

       7.  

      SOLE DISPOSITIVE POWER

     

      3,936,595

       8.  

      SHARED DISPOSITIVE POWER

     

      0

      9.    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      3,936,595

    10.  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

      ☐

    11.  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

      9.5% (1)

    12.  

      TYPE OF REPORTING PERSON

     

      PN

     

    (1)

    The percent of class was calculated based on 41,265,756 shares of common stock outstanding as of October 31, 2021, as disclosed in the Issuer’s Quarterly Report on Form 10-Q for the period ended September 30, 2021, as filed with the Securities and Exchange Commission on November 3, 2021.


    CUSIP No. 90240B 106   SCHEDULE 13G   Page 3 of 8 Pages

     

      1.    

      NAMES OF REPORTING PERSONS

     

      Canaan Partners XI LLC

      2.  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

      (a)  ☐        (b)  ☒

     

      3.  

      SEC USE ONLY

     

      4.  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Delaware

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

       5.    

      SOLE VOTING POWER

     

      3,936,595

       6.  

      SHARED VOTING POWER

     

      0

       7.  

      SOLE DISPOSITIVE POWER

     

      3,936,595

       8.  

      SHARED DISPOSITIVE POWER

     

      0

      9.    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      3,936,595

    10.  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

      ☐

    11.  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

      9.5% (1)

    12.  

      TYPE OF REPORTING PERSON

     

      OO


    CUSIP No. 90240B 106   SCHEDULE 13G   Page 4 of 8 Pages

     

      1.    

      NAMES OF REPORTING PERSONS

     

      Canaan 2020+ Co-Investment L.P. — Series 7

      2.  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

      (a)  ☐        (b)  ☒

     

      3.  

      SEC USE ONLY

     

      4.  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Delaware

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

       5.    

      SOLE VOTING POWER

     

      473,396

       6.  

      SHARED VOTING POWER

     

      0

       7.  

      SOLE DISPOSITIVE POWER

     

      473,396

       8.  

      SHARED DISPOSITIVE POWER

     

      0

      9.    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      473,396

    10.  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

      ☐

    11.  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

      1.1% (1)

    12.  

      TYPE OF REPORTING PERSON

     

      PN

     

    (1)

    The percent of class was calculated based on 41,265,756 shares of common stock outstanding as of October 31, 2021, as disclosed in the Issuer’s Quarterly Report on Form 10-Q for the period ended September 30, 2021, as filed with the Securities and Exchange Commission on November 3, 2021.


    CUSIP No. 90240B 106   SCHEDULE 13G   Page 5 of 8 Pages

     

      1.    

      NAMES OF REPORTING PERSONS

     

      Canaan Partners 2020+ Co-Investment LLC

      2.  

      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

      (a)  ☐        (b)  ☒

     

      3.  

      SEC USE ONLY

     

      4.  

      CITIZENSHIP OR PLACE OF ORGANIZATION

     

      Delaware

    NUMBER OF

    SHARES

     BENEFICIALLY 

    OWNED BY

    EACH

    REPORTING

    PERSON

    WITH

       5.    

      SOLE VOTING POWER

     

      473,396

       6.  

      SHARED VOTING POWER

     

      0

       7.  

      SOLE DISPOSITIVE POWER

     

      473,396

       8.  

      SHARED DISPOSITIVE POWER

     

      0

      9.    

      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

      473,396

    10.  

      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

     

      ☐

    11.  

      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

      1.1% (1)

    12.  

      TYPE OF REPORTING PERSON

     

      OO


    CUSIP No. 90240B 106   SCHEDULE 13G   Page 6 of 8 Pages

     

    Item 1.

    Issuer

    (a) Name of Issuer:

    Tyra Biosciences, Inc. (the “Issuer”)

    (b) Address of Issuer’s Principal Executive Offices:

    2656 State Street

    Carlsbad, CA 92008

     

    Item 2.

    Filing Person

    (a) – (c) Name of Persons Filing; Address; Citizenship:

     

      (i)

    Canaan XI L.P., a Cayman Islands limited partnership ( “Canaan XI”);

     

      (ii)

    Canaan Partners XI LLC, a Delaware limited liability company (“Canaan XI GP”);

     

      (iii)

    Canaan 2020+ Co-Investment L.P. — Series 7, a Delaware limited partnership (“Canaan Series 7”); and

     

      (iv)

    Canaan Partners 2020+ Co-Investment, LLC, a Delaware limited liability company (“Canaan 2020+ GP”).

    The address of the principal business office of each of the reporting persons is 2765 Sand Hill Road, Menlo Park, California 94025.

    (d) Title of Class of Securities:

    Common stock, $0.0001 par value per share, (the “Common Stock”)

    (e) CUSIP Number:

    90240B 106

     

    Item 3.

    If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:

    (a) ☐ Broker or dealer registered under Section 15 of the Act;

    (b) ☐ Bank as defined in Section 3(a)(6) of the Act;

    (c) ☐ Insurance company as defined in Section 3(a)(19) of the Act;

    (d) ☐ Investment company registered under Section 8 of the Investment Company Act of 1940;

    (e) ☐ An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

    (f) ☐ An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);

    (g) ☐ A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);

    (h) ☐ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

    (i) ☐ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940;

    (j) ☐ A non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J);

    (k) ☐ Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J), please specify the type of institution:

    If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution:


    CUSIP No. 90240B 106   SCHEDULE 13G   Page 7 of 8 Pages

     

    Item 4.

    Ownership.

    (a) and (b)

    Amount beneficially owned:

     

      (i)

    Canaan XI directly owns 3,936,595 shares of Common Stock, which represents approximately 9.5% of the outstanding shares of Common Stock.

     

      (ii)

    Canaan XI GP is the general partner of Canaan XI and may be deemed to beneficially own 3,936,595 shares of Common Stock, which represents approximately 9.5% of the outstanding shares of Common Stock.

     

      (iii)

    Canaan Series 7 directly owns 473,396 shares of Common Stock, which represents approximately 1.1% of the outstanding shares of Common Stock.

     

      (iv)

    Canaan 2020+ GP is the general partner of Canaan Series 7 and may be deemed to beneficially own 473,396 shares of Common Stock, which represents approximately 1.1% of the outstanding shares of Common Stock.

    (c) Number of shares as to which such person has:

     

         Number of Shares of Common Stock  

    Reporting Person

       (i)      (ii)      (iii)      (iv)  

    Canaan XI L.P.

         3,936,595        0        3,936,595        0  

    Canaan Partners XI LLC

         3,936,595        0        3,936,595        0  

    Canaan 2020+ Co-Investment L.P. — Series 7

         473,396        0        473,396        0  

    Canaan Partners 2020+ Co-Investment LLC

         473,396        0        473,396        0  

     

      (i)

    Sole power to vote or direct the vote

     

      (ii)

    Shared power to vote or to direct the vote

     

      (iii)

    Sole power to dispose or to direct the disposition of

     

      (iv)

    Shared power to dispose or to direct the disposition of

    The percent of class was calculated based on 41,265,756 shares of common stock outstanding as of October 31, 2021, as disclosed in the Issuer’s Quarterly Report on Form 10-Q for the period ended September 30, 2021, as filed with the Securities and Exchange Commission on November 3, 2021.

     

    Item 5.

    Ownership of Five Percent or Less of a Class.

    If this statement is being filed to report the fact that as of the date hereof the reporting persons have ceased to be the beneficial owner of more than five percent of the class of securities, check the following.  ☐

     

    Item 6.

    Ownership of More than Five Percent on Behalf of Another Person.

    Not applicable.

     

    Item 7.

    Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

    Not applicable.

     

    Item 8.

    Identification and Classification of Members of the Group.

    Not applicable.

     

    Item 9.

    Notice of Dissolution of Group.

    Not applicable.

     

    Item 10.

    Certification.

    Not applicable.


    CUSIP No. 90240B 106   SCHEDULE 13G   Page 8 of 8 Pages

     

    SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

    Date: February 8, 2022

     

    CANAAN XI L.P.
    By:   CANAAN PARTNERS XI LLC, its General Partner
    By:  

    /s/ Nancy Levenson

      Nancy Levenson, Attorney-in-Fact
    CANAAN PARTNERS XI LLC
    By:  

    /s/ Nancy Levenson

      Nancy Levenson, Attorney-in-Fact
    CANAAN 2020+ CO-INVESTMENT L.P. — SERIES 7
    By:   CANAAN PARTNERS 2020+ CO-INVESTMENT LLC, as its General Partner
    By:   CANAAN MANAGEMENT LLC, its Manager
    By:  

    /s/ John J. Pacifico

      John J. Pacifico, Chief Operating Officer
    CANAAN PARTNERS 2020+ CO-INVESTMENT LLC
    By:   CANAAN MANAGEMENT LLC, its Manager
    By:  

    /s/ John J. Pacifico

      John J. Pacifico, Chief Operating Officer
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    11/14/24 5:47:01 PM ET
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    Tyra Biosciences Reports Interim Clinical Proof-of-Concept Data for TYRA-300, an Investigational Oral FGFR3-Selective Inhibitor, in Phase 1/2 SURF301 Study in Patients with Metastatic Urothelial Cancer (mUC)

    - Encouraging preliminary anti-tumor activity observed in heavily pre-treated population - - At ≥ 90 mg QD, 6 out of 11 (54.5%) patients with FGFR3+ mUC achieved a confirmed partial response (PR), with 100% disease control rate and sustained duration of activity - - Positive safety results across all QD doses, with infrequent FGFR2/FGFR1-associated toxicities - - Conference call scheduled for October 25th, 2024, at 8AM EDT - CARLSBAD, Calif., Oct. 24, 2024 /PRNewswire/ -- Tyra Biosciences, Inc. (NASDAQ:TYRA), a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptor (FGFR) biology, ann

    10/24/24 6:21:00 PM ET
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    Tyra Biosciences to Host Conference Call on Interim Clinical Data of TYRA-300 from SURF301 Phase 1/2 Study on October 25, 2024, at 8am ET

    CARLSBAD, Calif., Oct. 23, 2024 /PRNewswire/ -- Tyra Biosciences, Inc. (NASDAQ:TYRA), a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptor (FGFR) biology, today announced that it will host a conference call and webcast on October 25, 2024 at 8:00 am ET to share interim clinical results of TYRA-300 from the SURF301 Phase 1/2 study in metastatic urothelial cancer (mUC). These data will be presented in a late-breaking oral presentation at the 36th EORTC-NCI-AACR (ENA) Symposium on Molecular Targets and Cancer Therapeutics, being held October 23-25, 2024, in Barcelona, Spain. Gary Ste

    10/23/24 4:05:00 PM ET
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    Tyra Biosciences Expands Development of TYRA-300, an Oral FGFR3 Selective Agent, into Achondroplasia

    - In preclinical models, TYRA-300 demonstrated significant increases in growth and bone length- -Phase 2 clinical study for pediatric achondroplasia planned to be initiated in 2024--Conference call and webcast today, March 1st, at 8:00 am ET- CARLSBAD, Calif., March 1, 2023 /PRNewswire/ -- Tyra Biosciences, Inc. (NASDAQ:TYRA), a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptors (FGFR) biology, today announced that it is expanding development of TYRA-300 into achondroplasia (ACH) based on positive preclinical results demonstrated in a study performed in collaboration with the Ima

    3/1/23 7:00:00 AM ET
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    Biotechnology: Pharmaceutical Preparations
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